预约演示
更新于：2025-02-08
Hydrocortisone Sodium Succinate
氢化可的松琥珀酸钠
更新于：2025-02-08
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C25H34NaO8 |
InChIKeyLGKJVUKNTHOZJH-CODXZCKSSA-N |
CAS号125-04-2 |
关联
30
项与 氢化可的松琥珀酸钠 相关的临床试验NCT06247787
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NCT05761171
A Phase 2 Study of Revumenib (SNDX-5613) in Combination With Chemotherapy for Patients With Relapsed or Refractory KMT2A-Rearranged Infant Leukemia
NCT05320380
A PedAL/EuPAL Phase 1/2 Trial of IMGN632 in Pediatric Patients With Relapsed or Refractory Leukemia
100 项与 氢化可的松琥珀酸钠 相关的临床结果
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100 项与 氢化可的松琥珀酸钠 相关的转化医学
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100 项与 氢化可的松琥珀酸钠 相关的专利（医药）
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1,928
项与 氢化可的松琥珀酸钠 相关的文献（医药）2025-12-31Gut Microbes
Microbial succinate promotes the response to metformin by upregulating secretory immunoglobulin a in intestinal immunity
Article
作者: Wang, Aiting ; Liu, Bing ; Zhang, Yu ; Qin, Jia’an ; Yan, Dan ; Yao, Chengcheng ; Yuan, Mingxia ; Zhao, Wei ; Long, Jianglan ; Zhang, Ying
Metformin is the first-line pharmacotherapy for type 2 diabetes mellitus; however, many patients respond poorly to this drug in clinical practice. The potential involvement of microbiota-mediated intestinal immunity and related signals in metformin responsiveness has not been previously investigated. In this study, we successfully constructed a humanized mouse model by fecal transplantation of the gut microbiota from clinical metformin-treated - responders and non-responders, and reproduced the difference in clinical phenotypes of responsiveness to metformin. The abundance of Bacteroides thetaiotaomicron, considered a representative differential bacterium of metformin responsiveness, and the level of secretory immunoglobulin A (SIgA) in intestinal immunity increased significantly in responder recipient mice following metformin treatment. In contrast, no significant alterations in B. thetaiotaomicron and SIgA were observed in non-responder recipient mice. The study of IgA-/- mice confirmed that downregulated expression or deficiency of SIgA resulted in non-response to metformin, meaning that metformin was unable to improve dysfunctional glucose metabolism and reduce intestinal and adipose tissue inflammation, ultimately leading to systemic insulin resistance. Furthermore, supplementation with succinate, a microbial product of B. thetaiotaomicron, potentially reversed the non-response to metformin by inducing the production of SIgA. In conclusion, we demonstrated that upregulated SIgA, which could be regulated by succinate, was functionally involved in metformin response through its influence on immune cell-mediated inflammation and insulin resistance. Conversely, an inability to regulate SIgA may result in a lack of response to metformin.
2025-02-01POULTRY SCIENCE
Lactobacillus salivarius metabolite succinate enhances chicken intestinal stem cell activities via the SUCNR1-mitochondria axis
Article
作者: Qi, Sichao ; Yu, Lingzi ; Zou, Minyao ; Wang, Huanan ; Hua, Yuping ; Rao, Xi ; Luo, Danni ; Mi, Yuling ; Li, Jian ; Wei, Mingping ; Zhang, Caiqiao ; Cao, Jiajia ; Zhang, Lingzhi ; Ye, Jinyi
The activity of intestinal stem cells (ISCs) can be modulated by Lactobacillus, which subsequently affects the mucosal absorptive capacity. However, the underlying mechanisms remain unclear. In this study, a total of 189 Hy-Line Brown chickens (Gallus) were randomly assigned to one of seven experimental groups (n = 27 per group). These groups included a control group, a vehicle group (MRS group), a Lactobacillus salivarius group, a L. salivarius supernatant group, and three succinate treatment groups with various dosages. Each group was further subdivided into three replicates, with 9 chickens per replicate. The results indicate that the administration of Lactobacillus salivarius supernatant to laying hens notably increased the mRNA abundance of the amino acid transporters oligopeptide transporter 1 (PepT1) and sodium-dependent neutral amino acid transporter (B0AT). Metabolomic analyses indicated that the supernatant contains a high concentration of organic acids. Among them, succinate could enhance mRNA abundance of PepT1, B0AT and excitatory amino acid transporters 3 (EAAT3) both in vivo and in vitro. Accordingly, succinate could accelerate intestinal epithelial turnover, as indicated by the increased levels of cyclin-dependent kinase 2 (Cdk2) mRNA and proliferating cell nuclear antigen protein (PCNA), as well as ISC differentiation-related protein leucine-rich repeat containing G protein-coupled receptor 5 (LGR5). Furthermore, succinate treatment was shown to elevate the levels of mitochondrial fusion proteins optic atrophy 1 (OPA1) and translocase of outer mitochondrial membrane 20 (TOMM20), resulting in increased local ATP levels. However, pretreatment with NF-56-EJ40, a succinate receptor antagonist, attenuated the effects of succinate on OPA1, TOMM20, and ATP levels, alone with the reducing LGR5 and PCNA levels. Collectively, succinate, a metabolite of L. salivarius, activates the SUCNR1-mitochondria axis in ISCs, facilitating mitochondrial ATP synthesis, promoting ISC activity, and ultimately enhancing mucosal absorptive capacity.
2024-10-10Cureus Journal of Medical Science
Delayed Emergence of Isolated Secondary Adrenal Insufficiency: A Case Report
Article
作者: Mesa, Natalie ; Ovalles Lacruz, Alexa ; Blanco Guertin, Angela ; Vassil, Steven T ; Sharma, Deepa
Secondary adrenal insufficiency (SAI) is a rare condition caused by adrenocorticotropic hormone (ACTH) deficiency, which disrupts ACTH secretion by the pituitary gland and can lead to chronic hyponatremia. However, idiopathic delayed onset of isolated adrenal insufficiency without triggering factors is an unusual finding and poses a challenging diagnosis. We present the case of an 80-year-old woman with hypothyroidism, hypertension, previous tobacco use, and squamous cell carcinoma of the ankle who presented with weakness and fatigue. Blood work showed hyponatremia (126 mmol/L), nonfasting blood glucose of 139 mg/dL, and elevated erythrocyte sedimentation rate (ESR, 83 mm/hr). Initial treatment included urea administration and water restriction. Initial imagining included a CT of the chest which revealed mediastinal lymphadenopathy, leading to suspicion of the syndrome of inappropriate antidiuretic hormone (SIADH) from malignancy. Despite increasing urea and adding NaHCO3, sodium levels dropped further. Tolvaptan was administered but showed no improvement. Endocrinology recommended hydrocortisone sodium succinate (Solu-Cortef) leading to sodium normalization and symptom resolution. A full pituitary workup revealed low dehydroepiandrosterone sulfate (DHEA-S), and abdominal CT showed atrophic adrenal glands. MRI of the sella turcica was normal with no evidence of a mass. The patient was discharged on an oral course of Solu-Cortef with stable sodium levels (139 mEq/L). This is among the first reported cases of unprovoked isolated adrenal insufficiency with abnormal cortisol, ACTH, DHEA-S levels, and normal renin and aldosterone levels. Diagnosis is often delayed due to nonspecific symptoms. Once identified, corticosteroid replacement therapy is the gold standard for management.
100 项与 氢化可的松琥珀酸钠 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 哮喘 | 日本 | 1968-04-23 | |
| 创伤性休克 | 日本 | 1968-04-23 | |
| 沃-弗综合征 | 日本 | 1968-04-23 | |
| 过敏 | 美国 | 1955-04-27 | |
| 内分泌系统疾病 | 美国 | 1955-04-27 | |
| 眼部疾病 | 美国 | 1955-04-27 | |
| 血液疾病 | 美国 | 1955-04-27 | |
| 肾脏疾病 | 美国 | 1955-04-27 | |
| 肿瘤 | 美国 | 1955-04-27 | |
| 呼吸系统疾病 | 美国 | 1955-04-27 | |
| 风湿性疾病 | 美国 | 1955-04-27 | |
| 皮肤疾病 | 美国 | 1955-04-27 |
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临床结果
临床结果
适应症
分期
评价
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N/A | - | Endoscopic intralesional steroid injection + systemic steroid treatment | 衊鏇鏇繭壓齋選艱衊蓋(艱鹹夢獵膚鬱獵醖繭壓) = 蓋觸構積簾壓衊獵夢襯 積獵鑰蓋構網夢餘鏇廠 (憲繭糧醖鑰餘鬱醖網壓, 0 ~ 1) 更多 | - | 2018-10-01 | ||
Oral mixture of hydrocortisone sodium succinate and aluminum phosphate gel | 蓋鏇夢鬱齋蓋製構壓觸(積構鑰餘襯遞築廠鏇鏇) = 遞範廠選遞蓋膚獵獵鬱 艱膚範鹹膚淵簾顧衊範 (觸壓襯鬱鑰窪艱窪顧蓋 ) | ||||||
N/A | - | Oral mixture of hydrocortisone sodium succinate and aluminum phosphate gel | 憲遞簾膚願鬱淵蓋壓繭(範鹽遞範壓鬱鑰齋鹽糧) = 觸壓醖壓簾蓋觸鑰積網 鹹鹽築構觸蓋鏇淵膚餘 (鹹夢窪襯蓋選憲鹹鹹膚, 1 ~ 1.8) 更多 | - | 2018-10-01 | ||
(EBD alone) | 憲遞簾膚願鬱淵蓋壓繭(範鹽遞範壓鬱鑰齋鹽糧) = 蓋窪壓衊壓淵鏇廠襯構 鹹鹽築構觸蓋鏇淵膚餘 (鹹夢窪襯蓋選憲鹹鹹膚, 1 ~ 2.5) 更多 | ||||||
N/A | - | Systemic steroid treatment (ST) | 窪築窪艱觸齋糧鑰鹹遞(遞製選餘蓋鹹淵範艱觸) = 鬱網齋鹽窪遞鏇艱製廠 築鹹鏇簾膚膚選顧遞鑰 (積鬱顧糧鏇憲夢衊鹹醖 ) 更多 | - | 2017-10-01 | ||
Endoscopic intralesional steroid (triamcinolone acetonide 80 mg) injection accompanied with systemic steroid treatment (IT + ST) | 窪築窪艱觸齋糧鑰鹹遞(遞製選餘蓋鹹淵範艱觸) = 願製獵鑰獵願築淵餘顧 築鹹鏇簾膚膚選顧遞鑰 (積鬱顧糧鏇憲夢衊鹹醖 ) 更多 |
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