预约演示
更新于：2025-08-23
Hydrocortisone Sodium Succinate
氢化可的松琥珀酸钠
更新于：2025-08-23
概要
基本信息
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C25H34NaO8 |
InChIKeyLGKJVUKNTHOZJH-CODXZCKSSA-N |
CAS号125-04-2 |
关联
30
项与 氢化可的松琥珀酸钠 相关的临床试验NCT06247787
A Phase 1 Study of GRN163L (Imetelstat) in Combination With Fludarabine and Cytarabine for Patients With Acute Myeloid Leukemia That is in Second or Greater Relapse or That is Refractory to Relapse Therapy; Myelodysplastic Syndrome or Juvenile Myelomonocytic Leukemia in First or Greater Relapse or is Refractory to Relapse Therapy
NCT05761171
A Phase 2 Study of Revumenib (SNDX-5613) in Combination With Chemotherapy for Patients With Relapsed or Refractory KMT2A-Rearranged Infant Leukemia
NCT05320380
A PedAL/EuPAL Phase 1/2 Trial of IMGN632 in Pediatric Patients With Relapsed or Refractory Leukemia
100 项与 氢化可的松琥珀酸钠 相关的临床结果
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100 项与 氢化可的松琥珀酸钠 相关的转化医学
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100 项与 氢化可的松琥珀酸钠 相关的专利（医药）
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1,033
项与 氢化可的松琥珀酸钠 相关的文献（医药）2025-04-01EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
The assembled decoders to prepare for “bioactive X″ against progressive deterioration of liver disease: From NAFLD to HCC
Article
作者: Kim, Dong Joon ; Yoon, Sang-Jun ; Oh, Ki-Kwang ; Suk, Ki-Tae ; Kwon, Goo-Hyun ; Lee, Kyeong Jin ; Eom, Jung-A
Non-alcoholic fatty liver disease (NAFLD) is implicated in steatohepatitis (NASH), liver cirrhosis (LC) to hepatocellular carcinoma (HCC), sequentially. Herein, our aim was to unravel the nuanced key components (compounds, and targets) to deter the progressive severity concerning hepatocellular diseases. We incorporated rigor bioinformatics and computational screening tools to decode effector(s) against NAFLD, NASH, LC, and HCC. The corresponding ligands of PDX1 (transcription factor of INS; one agonist), and IL6 (thirty-two antagonists) were identified by Selleckchem. Molecular docking test (MDT) revealed that PDX1- BRD7552 conformer (-12.1 kcal/mol), and IL6- Forsythoside B (-11.4 kcal/mol) conformer formed most stable complex. In parallel, DFT proposed that BRD7552, and Forsythoside B had significant chemical properties to react the targets, respectively. In conclusion, we decoded causatives of the progressive liver disease with web-based tools in drug repositioning theory. BRD7552 as PDX1 agonist, and Forsythoside B as IL6 antagonist were attributed to synergistic efficacy against NAFLD-derived HCC.
2025-03-01SLAS Discovery
Heterotypic spheroids as a strategy for 3D culture of cryopreserved primary human hepatocytes in stirred-tank systems
Article
作者: Spangenberg, Thomas ; Arez, Francisca ; Alves, Paula M ; Gal, Isabella Ramella ; Preiss, Lena ; Rebelo, Sofia P ; Badolo, Lassina ; Brito, Catarina
Primary human hepatocytes (PHHs) are the preferred cell source to address liver function. Despite originating from the native tissue, one of the bottlenecks when using primary material is the donor-to-donor variability. Cryopreserved PHHs offer a high number of cells from the same donor and standardization of cell isolation and cryopreservation procedures, mitigating some of the inter-donor variability. Still, PHHs from different commercial sources present variability in vitro in several parameters, including viability post-thawing, plating capacity, aggregation potential and culture longevity. Here we combine stirred-tank culture systems, which allow robust aggregation processes, and co-culture approaches with the HepaRG cell line to generate spheroids from cryopreserved PHHs. By employing small-scale stirred-tank culture systems we could cope with the scarce availability and high cost of primary material. In the optimized co-culture conditions we could generate PHH:HepaRG spheroids from 12 donors acquired from 4 different commercial sources. All PHHs showed similar aggregation profiles, forming small compact heterotypic spheroids as early as 3 days in co-culture and were maintained for at least 5 weeks in culture. The heterotypic spheroids maintained the hepatocyte polarization and identity and showed metabolization capacity for 5 main phase I metabolizing enzymes, namely CYP3A4, CYP2C9, CYP1A2, CYP2D6, and CYP2C8. Moreover, the heterotypic spheroids showed the capacity to metabolize a novel compound under clinical development, showing their potential to be employed in drug discovery applications. Overall, we present a robust aggregation strategy for cryopreserved PHHs from different suppliers, applicable for pharmacological and toxicological in vitro research.
2025-01-01CONTACT DERMATITIS
Acute generalised exanthematous pustulosis induced by betamethasone sodium phosphate: A case report
Article
作者: Matsumoto, Ayaki ; Tateishi, Chiharu ; Hayashi, Eriko ; Tsuruta, Daisuke
Acute generalized exanthematous pustulosis (AGEP) is a type of severe drug eruption and is often induced by drugs.Although the number of cases is small, there are cases of AGEP induced by steroids.
100 项与 氢化可的松琥珀酸钠 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 哮喘 | 日本 | 1958-04-23 | |
| 创伤性休克 | 日本 | 1958-04-23 | |
| 沃-弗综合征 | 日本 | 1958-04-23 | |
| 过敏 | 美国 | 1955-04-27 | |
| 内分泌系统疾病 | 美国 | 1955-04-27 | |
| 眼部疾病 | 美国 | 1955-04-27 | |
| 血液疾病 | 美国 | 1955-04-27 | |
| 肾脏疾病 | 美国 | 1955-04-27 | |
| 肿瘤 | 美国 | 1955-04-27 | |
| 呼吸系统疾病 | 美国 | 1955-04-27 | |
| 风湿性疾病 | 美国 | 1955-04-27 | |
| 皮肤疾病 | 美国 | 1955-04-27 |
未上市
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 支气管肺发育不良 | 临床前 | 法国 | 2021-06-21 |
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临床结果
临床结果
适应症
分期
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临床2期 | 112 | Radiation Therapy+PEG-Asparaginase+Etoposide+doxorubicin+Hydrocortisone Sodium Succinate+6-MP+Methotrexate+Cytarabine+Methylprednisone+Cyclophosphamide+Imatinib+Dexamethasone+E. coli Asparaginase+Vincristine (Pre-amendment Cohort, 2500 IU/m2 q2 Weeks) | 選齋鑰觸簾壓廠鑰網襯 = 鹽廠膚繭觸鬱鏇製憲窪 蓋簾鹹觸鹽廠鑰齋繭觸 (鏇憲襯鏇製醖窪襯窪願, 襯壓齋襯製積範鹹餘構 ~ 壓構憲顧襯糧繭網壓醖) 更多 | - | 2025-06-12 | ||
Radiation Therapy+PEG-Asparaginase+Etoposide+Doxorubicin+Hydrocortisone Sodium Succinate+6-MP+Methotrexate+Cytarabine+Methylprednisone+Cyclophosphamide+Imatinib+Dexamethasone+E. coli Asparaginase+Vincristine (Post-amendment Cohort, 2000 IU/m2 q3 Weeks) | 選齋鑰觸簾壓廠鑰網襯 = 餘糧艱鑰廠鬱襯鏇鬱鏇 蓋簾鹹觸鹽廠鑰齋繭觸 (鏇憲襯鏇製醖窪襯窪願, 衊繭積壓鹽顧鑰獵構憲 ~ 艱簾餘壓壓餘鏇壓蓋襯) 更多 | ||||||
临床2期 | 8 | 鑰鑰範鹽簾醖艱繭鏇鹹 = 顧餘壓製鑰憲廠夢鏇鬱 鏇獵壓選獵襯鹹獵築網 (鹹獵蓋製衊鏇築觸鏇襯, 遞齋蓋鏇積鏇廠觸鹹齋 ~ 積鑰蓋製艱遞夢糧齋夢) 更多 | - | 2017-11-22 |
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