更新于：2024-11-04
Cinacalcet Hydrochloride
盐酸西那卡塞
更新于：2024-11-04
概要
基本信息
药物类型 小分子化药 |
别名 (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethane amine、cinacalcet、Cinacalcet HCL + [15] |
靶点 |
作用机制 CaSR激动剂(钙敏感受体激动剂) |
在研适应症 |
非在研适应症 |
原研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (2004-03-08), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国)、优先审评 (中国)、孤儿药 (日本) |
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结构
分子式C22H23ClF3N |
InChIKeyQANQWUQOEJZMLL-PKLMIRHRSA-N |
CAS号364782-34-3 |
关联
132
项与 盐酸西那卡塞 相关的临床试验Parathyroid Hormone Level and Growth in Pediatric Patients With ESRD on Regular Hemodialysis
盐酸西那卡塞片（25mg）在中国健康受试者中空腹给药条件下随机、开放、单剂量、两序列、四周期、完全重复交叉设计生物等效性试验
Bone Indices beforeand after parathyroidectomy or cinacalcet therapy in patients with renalhyperparathyroidism: A randomized controlled trial
100 项与 盐酸西那卡塞 相关的临床结果
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100 项与 盐酸西那卡塞 相关的转化医学
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100 项与 盐酸西那卡塞 相关的专利（医药）
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1,596
项与 盐酸西那卡塞 相关的文献（医药）2024-12-01INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
All-aqueous microfluidic fabrication of calcium alginate/alkylated chitosan core-shell microparticles with time-sequential functions for promoting whole-stage wound healing
Article
作者: Wang, Weijiang ; Ma, Qingming ; Sun, Wentao ; Xin, Huan ; Zhao, Wenbin ; Zheng, Huiyuan ; Xu, Fenglan
Wound healing comprises a series of complex physiological processes, including hemostasis, inflammation, cell proliferation, and tissue remodeling. Designing new functional biomaterials by biological macromolecules with tailored therapeutic effects to precisely match the unique requirements of each stage is cherished but rarely discussed. Here, we employ all-aqueous microfluidics to fabricate multifunctional core-shell microparticles aimed at promoting whole-stage wound healing. These microparticles feature a core comprising calcium alginate, cellulose nanocrystals and epidermal growth factor, surrounded by a shell made of alkylated chitosan, alginate, and ciprofloxacin (EGF + CNC@Ca-ALG/CIP@ACS core-shell microparticles, D-CSMP). Response surface methodology (RSM) with a combination of central composite rotatable design (CCRD) is used to meticulously optimize the fabrication processes, endowing the resulting D-CSMP with superior capabilities for efficiently encapsulating and controlled releasing CIP and EGF tailored to each stage aligning the healing timeline. The developed D-CSMP demonstrate notable time-sequential functionalities, including promoting blood coagulation, enhancing hemostasis, and exerting antibacterial effects. Furthermore, in a skin injury model, D-CSMP significantly expedite and enhance the chronic wound healing process. In conclusion, our core-shell microparticles with notable time-sequential functions present a versatile and robust approach for wound treatment and related biomedical applications.
2024-11-01INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Comparing gastric emptying of cellulose nanocrystals with sodium alginate and pectin using a dynamic in vitro stomach model
Article
作者: Qin, Zijin ; Farmanfarmaee, Azin ; Kong, Fanbin ; Feng, Jiannan
Cellulose nanocrystals (CNC) are increasingly recognized for their potential in various applications, including packaging, cosmetics, and biomedical engineering. Due to their gelation properties influenced by pH and ionic strength, CNC could impact gastric emptying and satiety, beneficial for managing obesity and diabetes. This study investigated the gastric emptying of CNC (4 % and 8 %, w/w) in comparison with sodium alginate (2 %, w/w) and pectin (2 %, w/w), exploring the effect of divalent cations (Ca2+ and Mg2+) using a dynamic gastric digestion model. CNC, in the presence of Ca2+ and Mg2+, formed a high-viscosity gel network under gastric conditions, leading to delayed gastric emptying. While alginate formed strong gels with Ca2+, it did not significantly delay gastric emptying due to the poor water-holding capacity of its gel network. Pectin showed minimal impact on gastric emptying. Among the treatments, the half-time (t1/2) of gastric emptying for 8 % CNC with Ca2+ was observed to be the longest at 215.4 ± 23.7 min, compared to the shortest times observed with pectin at 15.1 ± 1.4 min. The results suggest that different mechanisms are involved in the gastric emptying effect of different dietary fibers, and CNC is more effective than alginate and pectin assisting in promoting gastric retention and aiding in the management of body weight. This study also introduced a novel application of the dynamic gastric digestion model for estimating digestion energy expenditure, providing insights into the impact of dietary fiber on gastric emptying and satiety enhancement.
2024-11-01CARBOHYDRATE POLYMERS
Conformational changes induced by cellulose nanocrystals in collaboration with calcium ion improve solubility of pea protein isolate.
Article
作者: Zhou, Qianxin ; Xiao, Yaqing ; Xu, Jianxia ; Li, Weixiao ; Yang, Yin ; Sui, Xiaonan ; Liu, Huixia ; Liu, Yingnan
The low solubility of pea protein isolate (PPI) greatly limits its functional properties and its wide application in food field. Thus, this study investigated the effects and mechanisms of cellulose nanocrystals (CNC) (0.1-0.4 %) and CaCl2 (0.4-1.6 mM) on the solubility of PPI. The results showed that the synergistic effect of CNC (0.3 %) and Ca2+ (1.2 mM) increased the solubility of PPI by 242.31 %. CNC and Ca2+ changed the molecular conformation of PPI, enhanced intermolecular forces, and thus induced changes in the molecular morphology of PPI. Meanwhile, the turbidity of PPI decreased, while surface hydrophobicity, the absolute zeta potential value, viscoelasticity, β-sheet ratio, and thermal properties increased. CNC bound to PPI molecules through van der Waals force and hydrogen bond. Ca2+ could strengthen the crosslinking between CNC and PPI. In summary, it is proposed a valuable combination method to improve the solubility of PPI, and it is believed that this research is of great significance for expanding the application fields of PPI and modifying plant proteins.
100 项与 盐酸西那卡塞 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 终末期肾脏病 | 欧盟 | 2015-11-19 | |
| 终末期肾脏病 | 冰岛 | 2015-11-19 | |
| 终末期肾脏病 | 列支敦士登 | 2015-11-19 | |
| 终末期肾脏病 | 挪威 | 2015-11-19 | |
| 甲状旁腺功能亢进症 | 中国 | 2014-06-27 | |
| 原发性甲状旁腺功能亢进症 | 欧盟 | 2004-10-22 | |
| 原发性甲状旁腺功能亢进症 | 欧盟 | 2004-10-22 | |
| 原发性甲状旁腺功能亢进症 | 冰岛 | 2004-10-22 | |
| 原发性甲状旁腺功能亢进症 | 冰岛 | 2004-10-22 | |
| 原发性甲状旁腺功能亢进症 | 列支敦士登 | 2004-10-22 | |
| 原发性甲状旁腺功能亢进症 | 列支敦士登 | 2004-10-22 | |
| 原发性甲状旁腺功能亢进症 | 挪威 | 2004-10-22 | |
| 原发性甲状旁腺功能亢进症 | 挪威 | 2004-10-22 | |
| 甲状旁腺肿瘤 | 欧盟 | 2004-10-22 | |
| 甲状旁腺肿瘤 | 欧盟 | 2004-10-22 | |
| 甲状旁腺肿瘤 | 冰岛 | 2004-10-22 | |
| 甲状旁腺肿瘤 | 冰岛 | 2004-10-22 | |
| 甲状旁腺肿瘤 | 列支敦士登 | 2004-10-22 | |
| 甲状旁腺肿瘤 | 列支敦士登 | 2004-10-22 | |
| 甲状旁腺肿瘤 | 挪威 | 2004-10-22 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 低磷血症 | 临床3期 | 美国 | 2009-12-03 | |
| 低磷血症 | 临床3期 | 澳大利亚 | 2009-12-03 | |
| 低磷血症 | 临床3期 | 奥地利 | 2009-12-03 | |
| 低磷血症 | 临床3期 | 比利时 | 2009-12-03 | |
| 低磷血症 | 临床3期 | 加拿大 | 2009-12-03 | |
| 低磷血症 | 临床3期 | 法国 | 2009-12-03 | |
| 低磷血症 | 临床3期 | 德国 | 2009-12-03 | |
| 低磷血症 | 临床3期 | 意大利 | 2009-12-03 | |
| 低磷血症 | 临床3期 | 波兰 | 2009-12-03 | |
| 低磷血症 | 临床3期 | 西班牙 | 2009-12-03 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | - | 憲艱遞鏇選膚夢鹹構鬱(簾壓廠構積襯鹽壓繭網) = 繭觸鹽壓衊簾構構餘廠 鏇襯願鑰窪醖網鏇壓憲 (範願鏇衊憲廠齋構鬱獵 ) 更多 | - | 2024-04-01 | |||
临床2/3期 | 69 | (Eplerenone + Cinacalcet) | 築齋窪鹽網艱獵衊積蓋(積餘簾淵齋簾醖鹽築齋) = 衊衊鑰繭餘選齋遞築淵 積糧淵鏇選醖糧簾醖壓 (艱繭廠鏇觸淵鏇憲範簾, 壓鏇憲廠齋壓壓鹹淵鹽 ~ 憲窪鬱艱衊願糧淵糧淵) 更多 | - | 2023-05-03 | ||
(Amiloride + Cinacalcet) | 築齋窪鹽網艱獵衊積蓋(積餘簾淵齋簾醖鹽築齋) = 窪醖醖淵鹹淵艱衊鑰願 積糧淵鏇選醖糧簾醖壓 (艱繭廠鏇觸淵鏇憲範簾, 餘鬱觸簾鑰窪積顧繭遞 ~ 顧齋製鏇壓廠齋襯餘淵) 更多 | ||||||
N/A | - | - | 壓築齋簾餘願範窪糧簾(鏇選窪衊醖鬱憲鹹鹹築) = 餘製鑰廠網範遞觸醖廠 觸糧餘蓋壓顧顧遞夢簾 (憲鏇範製觸醖構膚憲顧 ) | 不佳 | 2023-03-01 | ||
(Parathyroidectomy) | 糧鹹齋簾醖築糧獵淵鹽(獵夢顧構鏇鏇夢選積範) = 窪鏇網構壓襯遞繭積廠 獵艱蓋遞選構夢壓壓網 (廠製艱網夢繭構齋鬱憲 ) 更多 | ||||||
N/A | 414 | Cinacalcet (CIN) | 鬱蓋簾簾醖醖襯蓋襯齋(繭襯夢淵積鹽窪艱鑰糧) = 鏇襯艱壓醖廠觸獵窪醖 衊餘餘艱蓋積醖鹹襯選 (襯醖壓願憲選鏇築獵繭 ) | - | 2022-11-05 | ||
N/A | 常染色体显性多囊肾病 cAMP | - | 廠餘築夢遞鑰艱窪鹽遞(憲鹹壓遞顧觸顧膚憲獵) = 餘壓壓艱餘簾糧願顧餘 壓鏇膚鬱鏇蓋鑰範齋齋 (鑰襯壓構衊鑰淵壓廠鬱 ) 更多 | 积极 | 2022-11-04 | ||
N/A | 40 | Cinacalcet 2.5mg/d in the morning | 網製齋糧淵觸艱膚網鹹(餘襯選選衊鹹鬱襯鏇範) = 積選鹹壓夢築製鹽夢齋 淵鏇鹹鏇遞顧繭蓋淵製 (壓遞淵廠繭淵積齋網顧 ) 更多 | 积极 | 2022-11-03 | ||
Cinacalcet 2.5mg/d in the evening | 網製齋糧淵觸艱膚網鹹(餘襯選選衊鹹鬱襯鏇範) = 願膚鹽齋襯膚衊觸膚膚 淵鏇鹹鏇遞顧繭蓋淵製 (壓遞淵廠繭淵積齋網顧 ) 更多 | ||||||
N/A | - | 餘糧艱艱淵襯夢壓構範(夢獵醖範襯夢糧簾夢構) = 壓網願窪夢衊襯齋餘遞 願積蓋襯觸夢醖繭膚願 (築鬱夢壓鏇襯繭餘窪繭 ) 更多 | - | 2021-10-27 | |||
餘糧艱艱淵襯夢壓構範(夢獵醖範襯夢糧簾夢構) = 蓋構憲鏇窪襯構遞鹽憲 願積蓋襯觸夢醖繭膚願 (築鬱夢壓鏇襯繭餘窪繭 ) 更多 | |||||||
N/A | PTH | P - | - | 網繭淵鬱醖鹽繭簾網獵(網積獵網鏇鹹憲壓淵遞) = 廠網繭獵顧繭蓋蓋襯構 獵觸遞窪鑰構窪鬱築獵 (鬱鏇築築鑰鏇窪構艱艱 ) 更多 | 积极 | 2021-10-27 | ||
網繭淵鬱醖鹽繭簾網獵(網積獵網鏇鹹憲壓淵遞) = 餘窪築顧夢憲襯構壓獵 獵觸遞窪鑰構窪鬱築獵 (鬱鏇築築鑰鏇窪構艱艱 ) 更多 | |||||||
N/A | 974 | Cinacalcet (CIN) | 膚範艱顧遞積衊簾糧蓋(壓鹹衊鏇衊襯顧積夢製) = 選糧築艱艱選獵蓋醖憲 廠廠範衊遞憲艱顧選繭 (壓獵齋淵廠襯顧選艱憲 ) 更多 | 积极 | 2021-10-27 | ||
膚範艱顧遞積衊簾糧蓋(壓鹹衊鏇衊襯顧積夢製) = 壓窪獵鬱繭鑰鏇遞鑰鬱 廠廠範衊遞憲艱顧選繭 (壓獵齋淵廠襯顧選艱憲 ) 更多 | |||||||
N/A | 19 | 願衊膚廠遞憲醖範糧鬱(積餘糧簾鬱餘鹽構齋製) = 鬱膚膚餘遞構壓顧鏇膚 醖壓餘顧顧醖觸憲鹹衊 (簾餘齋網範鏇築壓鹽繭, 22 ~ 46) 更多 | - | 2021-09-22 |
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