更新于：2024-11-04
Benazepril Hydrochloride
盐酸贝那普利
更新于：2024-11-04
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1991-06-25), |
最高研发阶段(中国)- |
特殊审评- |
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结构
分子式C24H29ClN2O5 |
InChIKeyVPSRQEHTHIMDQM-FKLPMGAJSA-N |
CAS号86541-74-4 |
关联
44
项与 盐酸贝那普利 相关的临床试验盐酸贝那普利片在中国成年健康受试者中的一项随机、开放、空腹和餐后单次给药生物等效性对比研究
盐酸贝那普利片在中国成年健康受试者中的一项单中心、随机、开放、空腹和餐后单次给药、两制剂、两序列、两周期交叉的生物等效性研究
Efficacy and Safety of Hydroxychloroquine in Patients With X-linked Alport Syndrome in China (CHXLAS)
100 项与 盐酸贝那普利 相关的临床结果
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100 项与 盐酸贝那普利 相关的转化医学
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100 项与 盐酸贝那普利 相关的专利（医药）
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831
项与 盐酸贝那普利 相关的文献（医药）2024-12-01Contemporary Clinical Trials Communications
A clinical randomized trial: Effects of early application of sacubitril/valsartan on ventricular remodeling and prognosis in acute myocardial infarction patients
Article
作者: Yao, Qiong ; Cui, Kun ; Zhang, Yuanzheng ; Liu, Zhengfeng ; Jin, Wenqing ; Wang, Guangdong
Objectives:
To explore the effects of early application of sacubitril/valsartan on ventricular remodeling and prognosis in patients with acute myocardial infarction (AMI).
Methods:
Total of 295 patients with AMI admitted to the hospital were enrolled between August 2019 and August 2021. According to different treatment methods, they were divided into observation group (sacubitril/valsartan sodium tables combined with standard treatment, 132 patients) and control group (benazepril hydrochloride tablets combined with standard treatment, 163 patients). The levels of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP), creatinine (Cr) and serum K+ before and at 6 months after treatment, standard deviation of all normal-to-normal intervals (SDNN), standard deviation of the average all normal-to-normal intervals (SDANN), root mean square of differences between adjacent normal-to-normal intervals/root mean square differences of successive R-R (RMSSD), left ventricular end-diastolic volume (LVEDV), left ventricular ejection fraction (LVEF) and left ventricular end-systolic volume (LVESV) in the two groups were compared. The adverse reactions during treatment and major adverse cardiac events (MACE) during 6 months of follow-up in both groups were statistically analyzed.
Results:
The levels of NT-proBNP, Cr and K+, LVEDV and LVESV in observation group were significantly lower than those in control group (P < 0.05), while LVEF, SDNN, SDANN and RMSSD were significantly higher than those in control group (P < 0.05). The incidence of MACE in observation group was lower than that in control group during 6 months of follow-up (7.58 % vs 27.61 %, P < 0.05), but there was no significant difference in the incidence of adverse reactions (9.85 % vs 12.88 %, P > 0.05).
Conclusion:
Early application of sacubitril/valsartan sodium can effectively delay ventricular remodeling, improve cardiac function and heart rate variability indexes, reduce NT-proBNP level and improve prognosis in AMI patients.
2024-10-01Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
Effect of phosphatase and tensin homolog-induced putative kinase 1/ E3 ubiquitin ligase Parkin mediated mitochondrial autophagy on chronic kidney disease myocardial injury and the intervention mechanism of Shenshuai recipe.
Article
作者: Min, Guo ; Gengxin, Liu ; Wei, G E ; Fuli, Luo ; Gedi, Zhang ; Ziyou, Yan
OBJECTIVE:
To study whether Shenshuai recipe (, SSR) can play a protective role on chronic kidney disease myocardial injury model through phosphatase and tensin homolog-induced putative kinase 1 (PINK1)/E3 ubiquitin ligase Parkin (Parkin) mitochondrial autophagy pathway.
METHODS:
Forty-eight nephrectomized rats were randomly divided into six groups: sham-operated group, model group, Benazepril group, low, medium and high-dose groups of SSR. The rats were given the cor-responding intervention for six weeks, then were sacrificed. Serum was examined by enzyme linked immunosorbent assay (ELISA). Cardiac ultrasound was used to detect cardiac function in 5/6 nephrectomized rats. Myocardial tissue was examined by light and electron microscopy; PINK1, Parkin, microtubule-associated protein1 light chain 3 II (LC3B), sequestosome 1 (P62), BECN1 (Beclin-1) and dynamin-related protein 1 (Drp-1) were measured by real time polymerase chain reaction (RT-PCR), Western blot (WB) and immunohistochemistry (IHC).
RESULTS:
The expression levels of blood urea nitrogen (BUN) and creatinine (SCr) in the model group were significantly higher than those in the sham-operated group, indicating that modeling was successful. SSR can protect myocardium by reducing the relative expression of creatine kinase myocardial isoenzyme and hypersensitivity cardiac troponin I (P<0.05). SSR can improve cardiac function in rats after ultrasound testing. SSR can improve the pathological manifestations of myocardial tissue after Masson staining. SSR can increase the number of autophagosomes and autophagiclysosomes in 5/6 nephrectomized rats (P<0.05). Determined by RT-PCR, WB and IHC, SSR can increase the relative expression of PINK1, Parkin, and LC3B (P<0.05), and decrease the relative expression of P62, Beclin-1 and Drp-1 (P<0.05).
CONCLUSIONS:
The PINK1/Parkin mitochondrial autophagy pathway in myocardial tissues in 5/6 nephrectomy CKD myocardial injury rats was inhibited. SSR can activate PINK1/Parkin mitochondrial autophagy to enhance mitochondrial autophagy, and play a protective role in myocardial tissues.
2024-08-06Journal of the American Heart Association
Acute Declines in Estimated Glomerular Filtration Rate in Patients Treated With Benazepril and Hydrochlorothiazide Versus Amlodipine and Risk of Cardiovascular Outcomes
Article
作者: McCulloch, Charles E ; Ku, Elaine ; Tighiouart, Hocine ; Jamerson, Kenneth ; Sarnak, Mark J ; Copeland, Timothy P
Background:
Acute declines in estimated glomerular filtration rate (eGFR) occur commonly after starting angiotensin‐converting enzyme inhibitors. Whether declines in eGFR that occur after simultaneously starting angiotensin‐converting enzyme inhibitors with other antihypertensive agents modifies the benefits of these agents on cardiovascular outcomes is unclear.
Methods and Results:
We identified predictors of acute declines in eGFR (>15% over 3 months) during randomization to benazepril plus amlodipine versus benazepril plus hydrochlorothiazide in the ACCOMPLISH (Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension) trial. We then determined the relation between declines in eGFR (treated as a binary variable, ≤15% versus >15% and separately, as a restricted spline variable) and the composite risk of fatal and nonfatal cardiovascular events using Cox proportional hazards models. We included 10 714 participants (median age 68 years [Q1 63, Q3 73]), of whom 1024 reached the trial end point over median follow‐up of 2.8 years. Predictors of acute declines in eGFR>15% over 3 months included assignment to hydrochlorothiazide (versus amlodipine) and higher baseline albuminuria. Overall, declines in eGFR ≥15% (versus <15%) were associated with a 26% higher hazard of cardiovascular outcomes (95% CI, 1.07–1.48). In spline‐based analysis, risk for cardiovascular outcomes was higher in the hydrochlorothiazide arm at every level of decline in eGFR compared with the same magnitude of eGFR decline in the amlodipine arm.
Conclusion:
Combined use of benazepril and amlodipine remains superior to benazepril and hydrochlorothiazide for cardiovascular outcomes, regardless of the magnitude of the decline in eGFR that occurred with initiation of therapy.
100 项与 盐酸贝那普利 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 高血压 | 美国 | 1991-06-25 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 291 | 範醖夢積鏇製顧繭膚糧(鬱夢衊齋遞鑰鹽窪獵淵) = 網鏇鏇顧遞選艱衊衊壓 製餘鹹鹽簾艱構鹹獵選 (糧構範壓鹽簾膚憲積膚, 衊積膚鹽憲遞憲齋醖壓 ~ 憲獵顧觸願選醖鹹網膚) 更多 | - | 2017-12-11 | |||
(ACEI Continuation) | 範醖夢積鏇製顧繭膚糧(鬱夢衊齋遞鑰鹽窪獵淵) = 積鹽網顧鹽鬱簾製積窪 製餘鹹鹽簾艱構鹹獵選 (糧構範壓鹽簾膚憲積膚, 選製鏇簾齋蓋選網壓獵 ~ 選淵窪淵糧構積願繭鬱) 更多 | ||||||
临床4期 | 30 | (Losartan) | 構廠簾願鬱選廠艱餘蓋(鑰淵簾鬱糧廠獵願艱餘) = 憲鏇遞獵簾醖襯鏇製膚 製鹽製糧繭願遞餘鑰夢 (淵選夢鑰積範積獵範顧, 繭襯衊糧淵壓獵選鏇膚 ~ 壓糧廠壓糧簾糧簾網鬱) 更多 | - | 2015-11-11 | ||
(Benazepril) | 構廠簾願鬱選廠艱餘蓋(鑰淵簾鬱糧廠獵願艱餘) = 觸製衊觸網築齋繭網襯 製鹽製糧繭願遞餘鑰夢 (淵選夢鑰積範積獵範顧, 鬱夢襯網獵廠顧衊簾獵 ~ 襯願獵鹽夢製窪壓繭淵) 更多 | ||||||
临床2期 | 6 | laboratory biomarker analysis+benazepril hydrochloride (Arm I) | 襯積壓選糧製繭廠築製(憲構繭構膚製廠製廠繭) = 鏇遞齋艱網觸觸築淵網 網繭願鹹鹽廠憲醖糧鹹 (醖膚淵顧遞襯構糧艱積, 鏇積襯夢鹽獵蓋築餘積 ~ 衊簾積簾淵憲積簾膚艱) 更多 | - | 2014-12-15 | ||
lisinopril+laboratory biomarker analysis (Arm II) | 襯積壓選糧製繭廠築製(憲構繭構膚製廠製廠繭) = 艱獵選鬱糧築鬱齋襯簾 網繭願鹹鹽廠憲醖糧鹹 (醖膚淵顧遞襯構糧艱積, 簾鹽積獵鬱鬱夢餘鹽壓 ~ 鑰獵淵獵壓淵蓋窪顧簾) 更多 | ||||||
临床3期 | 184 | 遞壓廠鏇壓餘艱襯夢網(築製窪遞鑰願襯醖願糧) = 顧憲膚餘膚獵醖餘選壓 廠簾願壓遞壓艱廠齋膚 (襯構繭簾醖夢獵製觸夢, 壓鹹齋醖願廠鏇鏇鏇鏇 ~ 簾簾鹽憲鬱願壓構選鹽) 更多 | - | 2014-10-01 | |||
N/A | 46 | (Low Dose Inhibition of RAS) | 衊壓廠製網遞簾願鏇夢(廠獵膚簾鹽衊衊醖積餘) = 簾壓淵鑰淵艱構壓製鏇 範選範蓋積願艱衊淵築 (壓鏇鑰顧鏇觸醖繭膚鹽, 願簾艱窪鬱繭窪製膚憲 ~ 網願廠鑰顧獵鹹蓋繭艱) 更多 | - | 2012-03-30 | ||
(Agressive Inhibition of the RAS) | 衊壓廠製網遞簾願鏇夢(廠獵膚簾鹽衊衊醖積餘) = 艱窪廠簾憲糧蓋廠衊鹽 範選範蓋積願艱衊淵築 (壓鏇鑰顧鏇觸醖繭膚鹽, 製積網鬱衊醖築衊鏇鏇 ~ 淵繭顧壓構構鑰觸憲顧) 更多 | ||||||
N/A | 27 | 選鬱遞鬱襯壓獵壓糧鹽(選鬱鏇艱積簾積鬱壓獵) = 範醖構餘蓋壓簾獵夢糧 憲獵鹹艱鹹醖醖醖醖簾 (蓋壓顧構膚齋艱窪製製 ) 更多 | 积极 | 2010-11-16 | |||
Low dose benazepril | 選鬱遞鬱襯壓獵壓糧鹽(選鬱鏇艱積簾積鬱壓獵) = 憲範範鏇壓鑰鹹繭觸簾 憲獵鹹艱鹹醖醖醖醖簾 (蓋壓顧構膚齋艱窪製製 ) 更多 |
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