预约演示

更新于：2026-01-21

Ipilimumab

伊匹木单抗

更新于：2026-01-21

概要

基本信息

药物类型

单克隆抗体

别名

Anti CTLA-4 monoclonal antibody、Anti-CTLA-4 Mab、Ipilimumab (Genetical Recombination)

+ [17]

靶点

CTLA4

作用方式

抑制剂

作用机制

CTLA4抑制剂(细胞毒性T淋巴细胞相关抗原4抑制剂)

治疗领域

肿瘤消化系统疾病呼吸系统疾病+ [12]

在研适应症

MSI-H 直肠癌PD-L1阳性非小细胞肺癌转移性肝细胞癌+ [290]

非在研适应症

急性双系白血病急性双表型白血病复发性急性淋巴细胞白血病+ [132]

原研机构

Bristol Myers Squibb Co.

在研机构

Bristol Myers Squibb Co.

The University of Texas MD Anderson Cancer Center

National Cancer Institute

+ [16]

非在研机构

Checkmate Pharmaceuticals, Inc.

University of Southern CaliforniaJonsson Comprehensive Cancer Center

+ [11]

权益机构

Nektar Therapeutics

Inspirna, Inc.

Gritstone bio, Inc.

+ [8]

最高研发阶段批准上市

首次获批日期

美国 (2011-03-25),

黑色素瘤

最高研发阶段(中国)批准上市

特殊审评快速通道 (美国)、加速批准 (美国)、孤儿药 (美国)、孤儿药 (日本)、孤儿药 (韩国)、优先审评 (澳大利亚)、突破性疗法 (中国)、优先审评 (美国)、附条件批准 (中国)、优先审评 (中国)、突破性疗法 (美国)

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结构/序列

Sequence Code 143797L

来源: *****

Sequence Code 9060585H

来源: *****

关联

895

项与伊匹木单抗相关的临床试验

NCT07338981

/ Not yet recruiting临床3期IIT

(CHRONO-RCC) Time-of-day-Dependent Administration of Dual Immune Check Point Inhibitors (ICI) in Advanced Kidney Cancer

The goal of this clinical trial is to learn if the timing of treatments plays a role in how effective the standard-of-care drugs nivolumab/ipilimumab (ICI/ICI) works to treat adults with advanced kidney cancer. The trial will also learn if time-of-day reduces ICI/ICI side-effects. Researchers will compare ICI/ICI given in the morning (before 11:30am) vs in the afternoon (after 1:30pm), to see if circadian rhythm effects how ICI/ICI works to treat advanced kidney cancer. Participants will be randomized in Arm A or Arm B to receive drugs ICI/ICI either in the morning (Arm A) or afternoon (Arm B) as part of their standard-of-care treatment for advanced kidney cancer. Participants will:
* Visit the clinic either in the morning (Arm A) or afternoon (Arm B) to receive ICI/ICI treatment as part of their regular medical care for advanced kidney cancer
* Frequency of visits will follow standard-of-care guidelines

开始日期2026-04-01

申办/合作机构

British Columbia Cancer Agency

[+1]

NCT07355205

/ Not yet recruiting临床2期IIT

A Phase II, Single-Center, Open-Label Study of First-Line Ipilimumab Plus Nivolumab and Nogapendekin Alfa Inbakicept (N-803) in Patients With Stage IV or Recurrent Non-Small Cell Lung Cancer (FLINN)

This is an open-label, single center, one cohort, non-randomized, phase II study. The aim of the study is to evaluate the efficacy and safety of the combination of nivolumab and ipilimumab with nogapendekin alfa inbakicept in patients with stage IV or recurrent non-small cell lung cancer (NSCLC). It is hypothesized that the study treatment will be safe and well tolerated and will improve progression-free survival when compared to a historical study which treated advanced NSCLC patients with nivolumab plus ipilimumab. Patients will be treated in cycles lasting 6 weeks with two to three different chemotherapy drugs to up to 24 months.

开始日期2026-03-31

申办/合作机构

Washington University School of Medicine

[+2]

NCT07293351

/ Not yet recruiting临床1/2期

ROSETTA RCC-208: A Phase 1/2 Open-label, Multi-center, Randomized Study of Pumitamig Alone or in Combination With Ipilimumab or Cabozantinib in Participants With Advanced Renal Cell Carcinoma (RCC)

The purpose of this study is to evaluate the safety, tolerability, and efficacy of Pumitamig alone or in combination with Ipilimumab or Cabozantinib in participants with advanced Renal Cell Carcinoma (RCC)

开始日期2026-03-26

申办/合作机构

Bristol Myers Squibb Co.

[+1]

100 项与伊匹木单抗相关的临床结果

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100 项与伊匹木单抗相关的转化医学

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100 项与伊匹木单抗相关的专利（医药）

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5,075

项与伊匹木单抗相关的文献（医药）

2026-03-01·ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE

Neoadjuvant ipilimumab and nivolumab for resectable stage II mucosal melanoma

Letter

作者: Brunet-Possenti, F ; Guyard, A ; Ben-Ali, K ; Amiot, M ; Halimi, C ; Chaud, A ; Faucon, C

2026-02-01·CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

A daily clinical practice decision-making overview for the present metastatic renal cell carcinoma (mRCC) management landscape

Review

作者: Bracarda, Sergio ; Procopio, Giuseppe ; De Giorgi, Ugo ; Calabrò, Fabio ; Sabbatini, Roberto ; Porta, Camillo

BACKGROUND:

Renal cell carcinoma (RCC), originating from renal tubular epithelial cells, represents approximately 80 % of all primary kidney tumors. Roughly 30 % of cases are diagnosed at an advanced stage, and a similar proportion experience recurrence after surgery for localized disease. This recurrence rate may improve with the recent introduction of an effective adjuvant immunotherapy.

OBJECTIVE:

This work aims to assess the current therapeutic landscape of metastatic RCC (mRCC), with a focus on immunotherapy-based combinations, and to offer expert, real-world insights into clinical decision-making and adverse event (AE) management.

METHODS:

Six oncologists specialized in mRCC completed a structured survey covering four key areas: (1) overall survival, (2) safety of IO-IO and IO-TKI combinations, (3) treatment selection, and (4) sequential strategies. Responses were reviewed in a virtual meeting, with agreement defined as concurrence by at least five of the six participants. Any areas without unanimous agreement were addressed through subsequent discussion rounds until a final agreement was reached.

RESULTS:

Nivolumab plus ipilimumab provides durable responses and long-term survival, especially in intermediate- and poor-risk patients. TKI-based combinations, including cabozantinib and lenvatinib, achieve strong disease control, while axitinib offers a greater dosing flexibility due to its short half-life. Toxicity profiles differ by regimen, requiring careful management of immune-related and TKI-associated adverse events. Relapse risk after adjuvant pembrolizumab should guide first-line therapy choice for advanced disease, while metastasis-directed treatments should be considered by multidisciplinary teams.

CONCLUSIONS:

Optimal first-line treatment for mRCC requires consideration of patient characteristics, clinical and molecular prognostic factors, treatment tolerability, all of these parameters should be evaluated during a multidisciplinary team discussion.

2026-02-01·Liver International

Outcomes of Nivolumab Plus Ipilimumab After Atezolizumab Plus Bevacizumab in Advanced HCC : An International Multicentre Study

Article

作者: Kim, Chan ; Kim, Youngun ; Wong, Jeffrey ; An, Chansik ; Tai, David ; Chen, San‐Chi ; Chon, Hong Jae ; Jang, Su Jin ; Kang, Beodeul ; Kim, Hyeyeong ; Lim, Ho Yeong ; Kudo, Masatoshi ; Kim, Jung Sun ; Yau, Thomas ; Kim, Ilhwan ; Yang, Hannah

ABSTRACT:

Background/Aims:

Immune checkpoint inhibitors (ICIs) have transformed advanced HCC treatment. The benefit of sequential immunotherapy after prior ICI failure remains unclear. Given the expanded use of atezolizumab plus bevacizumab (Ate/Bev) over the past 5 years, we explored the real‐world outcomes of nivolumab plus ipilimumab (Nivo/Ipi) in patients with advanced HCC, with more focus on those previously exposed to Ate/Bev.

Methods:

Patients treated with Nivo/Ipi for advanced HCC from six referral hospitals in Korea, Hong Kong, Taiwan and Singapore were included. Patients with prior non–Ate/Bev ICI or Child–Pugh B–C were excluded. Outcomes were compared between the ICI‐naïve and Ate/Bev‐experienced groups.

Results:

Among 116 patients with advanced HCC treated with Nivo/Ipi, 57 were ICI‐naïve and 59 had prior Ate/Bev exposure. Overall objective response rate was 31.2%, higher in the ICI‐naïve group (42.6% vs. 20.0%, p = 0.01). However, the median duration of response was comparable between groups (24.8 vs. 23.7 months; p = 0.71), suggesting durable benefits regardless of prior Ate/Bev therapy. Median progression‐free survival (PFS) and overall survival (OS) were 2.5 and 11.3 months, respectively, with longer PFS (5.3 vs. 1.6 months; p < 0.01) and OS (16.2 vs. 7.8 months; p = 0.06) in the ICI‐naïve. Immune‐related adverse events (irAEs), especially thyroid dysfunction, were associated with longer PFS and OS. Notably, most Nivo/Ipi responders post‐Ate/Bev (8/11) had irAEs during Nivo/Ipi treatment, whereas no irAEs occurred during prior Ate/Bev. Nivo/Ipi responders post‐Ate/Bev revealed a high tumour mutational burden (5.71–12.75 mutations/Mb).

Conclusion:

Nivo/Ipi demonstrated meaningful clinical activity in patients with advanced HCC, even after Ate/Bev failure.

1,762

项与伊匹木单抗相关的新闻（医药）

2026-01-21

·肿瘤界

盘点2025丨斯璐教授：2025年黑色素瘤药物治疗进展

点击蓝字关注我们毕雪瑾斯璐（北京大学肿瘤医院暨北京市肿瘤防治研究所　黑色素瘤暨肉瘤内科　恶性肿瘤发病机制及转化研究教育部重点实验室，北京　100142）通信作者：斯璐 E-mail：silu15_silu@126.com 专家简介斯璐教授北京大学肿瘤医院主任医师，教授，博士生导师国家基金委首届临床杰青北京大学杰出青年医师中国临床肿瘤学会常务理事中国临床肿瘤学会黑色素瘤专家委员会副主任委员国家癌症中心国家肿瘤质控中心黑色素瘤专家委员会副主任委员中国临床肿瘤学会肉瘤专家委员会常委中国临床肿瘤学会免疫治疗专家委员会常委中国抗癌协会肉瘤专委会肿瘤多学科学组副组长《CSCO黑色素瘤诊治指南》执笔人《CSCO免疫检查点抑制剂相关毒性管理指南》执笔人主要从事黑色素瘤、肉瘤、泌尿系肿瘤的临床和转化医学研究发表J Clin Oncol、JAMA Oncol、Nature Commun等论文多篇，获得H1 connect的top 0.5%推荐【摘要】本研究系统综述了2025年黑色素瘤药物治疗的主要进展。新辅助免疫治疗研究持续深化，晚期难治患者迎来新型双特异性抗体与细胞疗法等探索，而辅助治疗的联合免疫强化策略未获突破。除此之外，两种PD-1抑制剂在我国获批晚期一线治疗适应症，显著提升了治疗可及性。本年度进展为黑色素瘤治疗的精准化发展奠定了重要基础。【关键词】黑色素瘤；新辅助治疗；晚期治疗；辅助治疗；药物治疗引言 2025年黑色素瘤治疗领域整体进展有限，未出现颠覆性治疗范式变革，可视为该领域的一个“小年”，但其中也有部分新的研究进展值得关注。在治疗策略方面，新辅助治疗继续成为研究焦点，多项临床试验在皮肤型与肢端型黑色素瘤中更新了长期随访数据，并积极探索不同免疫联合方案在更早期患者中的应用价值。晚期治疗领域，科学家们针对难治性亚型（如肢端、黏膜黑色素瘤）及耐药后的困境，创新性地探索了新型双特异性抗体、过继性细胞疗法等前沿策略，为后续突破提供了新的方向。与此同时，辅助治疗领域的探索则遭遇了挫折。双免疫检查点抑制剂联合方案在大型Ⅲ期临床试验中未能证实其优于当前标准单药治疗，提示该领域的治疗强化策略面临瓶颈。此外，值得关注的是，近2年不仅PD-1抑制剂在我国获批晚期一线适应症，特瑞普利单抗更成功纳入国家医保目录，标志着我国黑色素瘤治疗可及性与规范化管理迈出了坚实一步。本文将从新药可及性、新辅助治疗、晚期治疗新策略及辅助治疗现状四个方面，对2025年度黑色素瘤药物治疗的重要进展进行系统梳理与评述。 1 PD-1抑制剂获批晚期一线适应症 2025年，我国晚期黑色素瘤一线治疗格局迎来更新。继帕博利珠单抗2024年凭借KEYNOTE-006研究结果在我国获批晚期黑色素瘤一线治疗后[1]，国产PD-1抑制剂特瑞普利单抗亦基于关键III期MELATORCH研究的阳性数据，在2025年获批该适应症，为中国黑色素瘤临床治疗提供了更多选择。 MELATORCH研究旨在比较特瑞普利单抗与达卡巴嗪在晚期黑色素瘤患者中的疗效与安全性。该研究共纳入256例患者，其中肢端型占62.7%。结果显示，特瑞普利单抗显著降低疾病进展或死亡风险29.2%（HR=0.71，95%CI 0.53-0.95，P=0.02），且在包括肢端亚型在内的绝大多数预设亚组中均观察到一致的无进展生存期获益。此外，其客观缓解率（11.0% vs. 8.6%）及中位缓解持续时间（13.8个月 vs. 6.9个月）亦优于对照组，3级及以上治疗相关不良事件发生率为28.3%，耐受性良好[2]。基于上述证据，国家药品监督管理局于2025年4月批准特瑞普利单抗用于我国黑色素瘤晚期一线治疗适应症。随后其被纳入国家医保目录，成为目前国内首个实现晚期黑色素瘤全线治疗医保覆盖的PD-1抑制剂。这一举措显著减轻了患者经济负担，提升了药物可及性，也为我国黑色素瘤的规范治疗与长期管理奠定了重要基础。 2 新辅助治疗 2.1 肢端黑色素瘤新辅助治疗新辅助治疗是目前黑色素瘤领域的重要研究方向，新辅助策略为局部晚期患者提供了在手术前缩小肿瘤、降期甚至病理完全缓解的机会，不仅有助于保留重要功能结构，也为改善生存结局带来了新希望[3]。我国高发的肢端型黑色素瘤患者常因解剖位置特殊、确诊时分期较晚，治疗选择相对受限[4,5]。CAP 03-NEO试验（NCT05512481）评估了卡瑞利珠单抗（PD-1单抗）联合阿帕替尼（VEGFR-2抑制剂）与替莫唑胺用于可切除II/III期肢端黑色素瘤患者的新辅助治疗。初步结果显示，在28例术后患者中，完全病理缓解（pCR）率为25.0%，主要病理缓解（MPR）率达42.9%；中位随访18.5个月时，中位无事件生存期（EFS）尚未达到，12个月EFS率为74.1%。安全性方面，常见不良事件（AE）均为1-3级，未增加手术并发症。该研究为肢端黑色素瘤的新辅助治疗提供了有前景的联合策略。值得注意的是，III期患者的病理无缓解率（pNR）显著低于II期患者（29.4% vs. 64%），提示该联合方案在更晚期患者中可能更具潜力[6]。 2.2 皮肤黑色素瘤新辅助治疗皮肤黑色素瘤的新辅助治疗模式显著区别于其他实体瘤，后者多为免疫治疗联合化疗或靶向药物，而前者则以单纯免疫治疗为核心[7,8]。2025年在皮肤黑色素瘤新辅助治疗方面，多项关键临床试验更新了长期随访数据，进一步验证了免疫新辅助的生存获益与安全性。此外，PD-1单抗与其他免疫制剂（如LAG-3抗体、TIGIT单抗等）的联合方案也在探索中。免疫单药新辅助治疗方面，纳入III-IV期黑色素瘤患者的SWOG1801更新长期随访数据，中位随访时间达到44个月，3年EFS率分别为68%和55%（既往2年EFS率新辅助治疗组为72%，辅助治疗组为49%），患者持续获益[9]，3或4级AE发生率较前相仿（20%）[10]。双免疫检查点抑制剂联合新辅助治疗方面，NADINA试验最新2年随访数据显示，纳武利尤单抗（PD-1单抗，NIVO）联合伊匹木单抗（CTLA-4单抗，IPI）组患者的EFS率维持在77.3%（12个月时为83.7%）[11]，2年无远处转移生存（DMFS）率达82.8%，显著优于辅助治疗组（HR=0.43，P<0.001）[12]。不同免疫检查点抑制剂的新辅助联合治疗也有新的尝试，目前大部分为II期临床试验。NeoACTIVATE ArmC纳入34例III期黑色素瘤患者，接受Atelolizumab（抗PD-L1抗体）及Tiragolumab（TIGIT单抗）联合新辅助治疗，术后接受Atelolizumab辅助治疗。47.1%患者达到MPR，12个月EFS率为72.0%，12个月无复发生存（RFS）率为73.3%，12个月DMFS率为86.0%，展现出良好的疗效，3级以上AE率为5.9%[13]。 II期NEO-MEL-T试验（NCT04139902）旨在比较新辅助Dostarlimab（PD-1单抗，D）与D联合Cobolimab（TIM-3单抗，C）疗法在IIIB-D期皮肤黑色素瘤患者中的疗效。患者接受D方案（A组，n=30）或D+C（B组，n=27）方案新辅助治疗，中位随访时间为22个月。MPR率分别为33.3%（A组）和51.9%（B组），中位DMFS和OS尚未达到。B组患者的1年EFS率为92%，高于A组的82%，但差异未达到统计学显著性。3级及以上免疫相关AE的患者比例与其他免疫检查点联合治疗组相似（联合治疗组14.9%）[14]。除此之外，II期ECOG-ACRIN EA6194研究（NCT04708418）在III期患者中联合新辅助使用瘤内注射TLR9激动剂Vidutomod及帕博利珠单抗治疗，联合治疗组27例患者接受了手术治疗，MPR率为79%，3/4级AE发生率为29%[15]。表1对于2025年黑色素瘤新辅助治疗相关临床试验做一总结。 3 晚期治疗 3.1 肢端与粘膜黑色素瘤在免疫联合靶向治疗对比免疫单药治疗方面，LEAP-003研究的中国扩展数据进一步支持了仑伐替尼联合帕博利珠单抗在中国晚期黑色素瘤患者中的应用价值。该研究共纳入131例中国患者，其中包含30例黏膜黑色素瘤。中位随访18.1个月的结果显示，在全人群中，联合治疗组的中位无进展生存期（PFS）显著优于安慰剂联合组（6.1个月 vs. 2.0个月，HR=0.55），且18个月PFS率分别为20.0%和12.8%。在总生存（OS）方面，两组中位OS分别为19.9个月和17.0个月（HR=0.93）。值得注意的是，在黏膜黑色素瘤亚组中，联合治疗表现出更具潜力的疗效趋势：中位PFS为8.1个月，12个月PFS率达33.5%；中位OS达26.8个月，18个月OS率为68.8%；客观缓解率（ORR）高达50.0%，显著高于对照组的7.1%。上述数据提示，该联合方案在中国人群，尤其是黏膜黑色素瘤患者中可能带来具有临床意义的生存获益[16]。尽管免疫治疗不断优化，耐药仍是临床主要挑战，新型治疗方案的出现为这类患者提供了突破现有疗效瓶颈的可能[17]。IBI363为全球首创的PD-1/IL-2α偏向双特异性抗体融合蛋白，在多种免疫耐药、难治肿瘤中表现出良好的疗效[18,19]。一项在免疫治疗失败的晚期肢端与黏膜黑色素瘤患者中开展的I/II期研究（NCT05460767）共纳入91位患者（肢端型47例，黏膜型44例）应用IBI363治疗，ORR为26.4%，疾病控制率（DCR）达64.4%。在剂量≥1 mg/kg的亚组中，ORR与DCR进一步提升至28.4%和68.9%。其中，采用1 mg/kg每两周给药方案的30例患者，中位PFS为5.7个月，中位缓解持续时间（DOR）达14.0个月。安全性方面，免疫相关AE发生率为98.9%，≥3级AE发生率为29.7%。该结果提示IBI363在难治性黑色素瘤中具有值得进一步研究的临床潜力。过继性细胞疗法包括TILs、TCR-T、CAR-T等作为一种高度个体化的治疗手段，TILS疗法在我国逐步开展[20]。I期临床试验CTR20233999旨在探索肿瘤浸润淋巴细胞单药疗法（LM103）在亚洲转移性黑色素瘤患者中的安全性及疗效。该研究共纳入12例标准治疗失败的转移性黑色素瘤患者（肢端型6例、黏膜型3例、原发不明型2例、皮肤型1例），在可评估的8例患者中，ORR达50%，中位PFS未达到，最长PFS达11.4个月，3-4级AE主要为血细胞减少。该研究初步证实LM103在亚洲晚期黑色素瘤患者中具有可控的安全性和持久的抗肿瘤活性[21]。 I期TUNINTIL试验（NCT04217473）研究评估了编码TNF-α和IL-2的溶瘤腺病毒TILT-123联合TILS在免疫检查点抑制剂难治性转移性黑色素瘤患者中的安全性与疗效。研究共纳入包括皮肤型（8例）、黏膜型（5例）和葡萄膜型（4例）在内的患者，结果显示，在TILT-123单药治疗后第36天，按RECIST 1.1/iRECIST标准和PET评估的DCR分别为35%和63%；联合治疗后第78天，DCR为38%和47%，其中27%的患者出现PET缓解（含1例黏膜黑色素瘤患者持续CR及1例PR持续>8个月），中位OS为447天[22]。 3.2 皮肤黑色素瘤晚期治疗对于晚期皮肤黑色素瘤患者，新型治疗策略崭露头角。II期C-144-01研究（NCT02360579）研究报道了TILS疗法Lifileucel在晚期患者中的长期数据，该研究是目前该领域规模最大、随访时间最长的TILS临床研究。研究共纳入153例既往接受过免疫检查点抑制剂治疗（55%为原发耐药）的晚期黑色素瘤患者，中位随访57.8个月，ORR达31.4%（CR率5.9%），中位DOR达36.5个月，31.3%的缓解者在5年时仍维持缓解。中位OS为13.9个月，5年OS率达19.7%。安全性特征与非清髓性淋巴细胞清除及IL-2的已知风险一致，长期随访未发现新的安全信号，该研究表明TILS疗法可能为经治晚期黑色素瘤患者提供持续5年以上的持久缓解与生存获益[23]。 T细胞受体工程化T细胞（TCR-T）疗法方面，Ia/b期试验（NCT03686124）研究报道了靶向PRAME抗原的IMA203在晚期实体瘤患者中的疗效与安全性。该研究纳入70例HLA-A*02:01阳性、PRAME表达阳性的复发或难治性实体瘤患者（包括黑色素瘤与肉瘤），疗效方面，在Ib期采用RP2D剂量（1-10×10⁹个细胞）治疗的皮肤黑色素瘤患者（中位既往治疗线数为2线）中，ORR为54%，88%的患者出现肿瘤缩小，中位DOR为12.1个月，14例确认缓解者中有7例仍持续缓解（最长超过2年），中位PFS为6个月，中位随访8.6个月时，中位OS尚未达到[24]。在I期临床试验展现出积极疗效后，后续的III期SUPRAME试验（NCT06743126）将进一步明确该疗法的潜在价值[25]。对于伴有肝转移的患者，I期研究（NCT05068453）研究旨在评估溶瘤病毒OH2联合普特利单抗（PD-1单抗）及肝转移灶放疗在肝转移患者中的安全性与疗效。该项纳入20例的肝转移性黑色素瘤患者（52.9%伴肝外转移），结果显示，在17例可评估患者中，ORR达29.4%，疾病控制率52.9%，近60%患者靶病灶缩小（肝内病灶缩小率65.2%，肝外病灶41.7%），注射与非注射病灶的缩小率分别为58.3%和54.5%，疗效均可。中位随访17.0个月时，1年与2年生存率分别为60.0%和51.4%，中位OS未达到。安全性方面，仅报告2例3级免疫相关AE[26]。 4 辅助治疗辅助治疗方面，2025各项研究仅更新对于II期患者辅助治疗长期随访数据，标准的单药免疫检查点抑制剂治疗相较安慰剂等带来持续获益，然而遗憾的是，双免疫检查点抑制剂在辅助治疗阶段的相关临床试验未达到主要终点，提示联合强化策略在辅助治疗中的价值仍需进一步探索。单药免疫检查点抑制剂治疗方面，今年各项研究更新对于II期患者的长期随访数据。KEYNOTE-716研究（NCT03553836）的既往数据确立了帕博利珠单抗作为高危II期黑色素瘤患者术后辅助治疗的全球标准方案[27]，该研究更新5年随访数据，中位随访时间为64.7个月，辅助治疗组RFS率为67.1%，DMFS率为78.7%，3-4级AE发生率为17.4%，其中irAE为11%[28]。Checkmate 76K研究更新NIVO对比安慰剂在IIB-C期黑色素瘤术后辅助治疗数据，NIVO组中位随访时间分别为46.8个月，4年的RFS率分别为66.1%，DMFS率74.5%，NIVO组对比安慰剂组仍具有更高的RFS（HR=0.64，95%CI 0.50-0.82）和DMFS（HR=0.73，95%CI 0.54-0.98）[29]。双免疫检查点抑制剂辅助治疗方面均为阴性结果，RELATIVITY-098 III期双盲试验比较了NIVO单抗联合relatlimab（LAG-3抑制剂）与单用NIVO在III/IV期患者辅助治疗中的疗效。结果示NIVO/RELA和NIVO单药组的1年RFS率分别为75%和72%，2年RFS率62%和64%，中位RFS时间分别为未成熟和33.1个月（HR=1.01，P=0.928），联合治疗组与单药治疗组相比RFS无显著差异（HR=1.01，95%CI 0.83-1.22，P=0.928），并未取得比单免疫检查点抑制剂更好的效果[30]。总结本研究系统梳理了2025年黑色素瘤药物治疗进展，新辅助免疫治疗的临床证据持续积累，在肢端亚型中展现出应用潜力。晚期治疗积极探索治疗新策略；同时，PD-1抑制剂在我国获批晚期一线治疗适应症，显著提升了临床可及性。当前研究仍存在明显局限，多数创新疗法尚处早期研究阶段，缺乏长期生存数据支持，辅助治疗方面仍需新型联合模式的探索。总体而言，本年度虽无重大进展，但仍有相关临床试验值得关注，也为黑色素瘤治疗的精准化与可及性提升奠定了重要基础。参考文献 References [1]LONG G V, CARLINO M S, MCNEIL C, et al. 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DOI:10.1200/JCO.2025.43.16_suppl.9518. [23]MEDINA T, CHESNEY J A, KLUGER H M, et al. Lifileucel in patients with advanced melanoma: 5-year outcomes of the C-144-01 study.[J/OL]. Journal of Clinical Oncology, 2025, 43(16_suppl): 9515-9515. DOI:10.1200/JCO.2025.43.16_suppl.9515. [24]WERMKE M, ALSDORF W, ARAUJO D M, et al. Phase 1 clinical update of IMA203, an autologous TCR-T targeting PRAME in patients with PD1 refractory metastatic melanoma.[J/OL]. Journal of Clinical Oncology, 2025, 43(16_suppl): 2508-2508. DOI:10.1200/JCO.2025.43.16_suppl.2508. [25]SCHADENDORF D, ALSDORF W, AMARIA R, et al. 1704eTiP SUPRAME: A phase III trial evaluating IMA203 T-cell receptor (TCR) T-cell therapy vs investigator’s choice in previously treated advanced cutaneous melanoma[J/OL]. Annals of Oncology, 2025, 36: S939. DOI:10.1016/j.annonc.2025.08.2331. [26]WANG X, CUI C, WANG H, et al. The phase 1 clinical trial of anti–PD-1 ab plus intrahepatic injection of oncolytic virus (OH2) combined radiotherapy of liver metastasis in stage IV melanoma.[J/OL]. Journal of Clinical Oncology, 2025, 43(16_suppl): 9547-9547. DOI:10.1200/JCO.2025.43.16_suppl.9547. [27]LUKE J J, ASCIERTO P A, KHATTAK M A, et al. Pembrolizumab Versus Placebo as Adjuvant Therapy in Resected Stage IIB or IIC Melanoma: Final Analysis of Distant Metastasis-Free Survival in the Phase III KEYNOTE-716 Study[J/OL]. Journal of Clinical Oncology, 2024[2025-11-13]. https://ascopubs.org/doi/10.1200/JCO.23.02355. DOI:10.1200/JCO.23.02355. [28]LUKE J J, LONG G V, KHATTAK M A, et al. 1611P Pembrolizumab versus placebo as adjuvant therapy for resected stage IIB or IIC melanoma: 5-year follow-up of the phase III KEYNOTE-716 study[J/OL]. Annals of Oncology, 2025, 36: S953-S954. DOI:10.1016/j.annonc.2025.08.2239. [29]KIRKWOOD J M, VECCHIO M D, HOELLER C, et al. 1610P Adjuvant nivolumab vs placebo in resected stage IIB/C melanoma: 4-year update from CheckMate 76K[J/OL]. Annals of Oncology, 2025, 36: S952-S953. DOI:10.1016/j.annonc.2025.08.2238. [30]LONG G V, GARNETT-BENSON C, DOLFI S, et al. Adjuvant nivolumab and relatlimab in stage III/IV melanoma: the randomized phase 3 RELATIVITY-098 trial[J/OL]. Nature Medicine, 2025: 1-9. DOI:10.1038/s41591-025-04032-8. 推荐阅读 ● 盘点2024 | 斯璐教授：2024年度黑色素瘤新辅助免疫治疗研究进展 ● 盘点2023 | 斯璐教授：2023年度黑色素瘤药物治疗研究进展 ● 盘点2022丨斯璐教授：2022年度黑色素瘤治疗进展 ● 盘点2020｜斯璐：黑色素瘤治疗进展盘点 ● 2025年度肿瘤学科盘点汇总(更新至2026年1月1日) 声明：本文由“肿瘤界”整理与汇编，欢迎分享转载，如需使用本文内容，请务必注明出处。编辑：Lagertha 审核：斯璐教授

2026-01-21

·搜狐新闻

伊匹木单抗适应症全解析：从黑色素瘤到多瘤种覆盖

作为免疫治疗领域的重要药物，抗 CTLA-4 抑制剂伊匹木单抗的适应症布局正持续拓展。从最初在黑色素瘤治疗中崭露头角，到如今逐步覆盖多个癌种，其临床应用范围的不断扩大，为肿瘤治疗带来了更多创新性选择，也见证了免疫治疗在临床实践中的成熟与突破。在伊匹木单抗的适应症发展历程中，黑色素瘤是其经典应用领域。作为最早获批的核心适应症之一，伊匹木单抗通过抑制CTLA-4免疫检查点，激活机体自身免疫系统对肿瘤细胞的识别与攻击能力，为黑色素瘤患者提供了全新的治疗路径，尤其为部分传统治疗效果不佳的患者带来了新的治疗希望，奠定了其在免疫治疗领域的重要地位。近年来，伊匹木单抗的适应症布局呈现出向多瘤种延伸的显著趋势，其中在结肠癌治疗领域的突破尤为引人注目。近期，由中国本土企业自主研发的伊匹木单抗相关联合治疗方案获得国家药监局批准，用于可手术切除的 IIB-Ⅲ 期微卫星高度不稳定型（MSI-H）或错配修复缺陷型（dMMR）结肠癌患者的新辅助治疗。这一适应症的获批，并非偶然，而是基于扎实的临床研究数据支撑。在中国开展的Ⅲ 期注册研究 NeoShot-Ⅲ的期中分析结果显示，在首批入组的 50 例相关类型结肠癌患者中，接受伊匹木单抗联合PD-1 抑制剂治疗后，82% 的患者达到病理完全缓解（pCR），手术完全切除率更是达到 100%，且多数患者术后无需进行辅助化疗，充分体现了该联合治疗方案在特定结肠癌患者群体中的临床价值。值得关注的是，这一适应症的获批填补了结肠癌新辅助治疗领域的空白。在临床实践中，约 15% 的可手术结肠癌患者属于MSI-H/dMMR 类型，这类患者对传统化疗药物不敏感，长期以来缺乏有效的新辅助治疗方案，术后复发风险较高。伊匹木单抗联合治疗方案的获批，为该类患者提供了更具针对性的治疗选择，也推动了结肠癌治疗临床实践的变革。除了黑色素瘤和结肠癌，伊匹木单抗的适应症拓展还在持续推进。其与 PD-1 抑制剂等药物的联合治疗方案，正在更多癌种中开展临床探索。依托免疫治疗 “激活自身免疫系统攻击肿瘤” 的核心机制，伊匹木单抗在肺癌、肝癌、食管癌等高发癌种的治疗中也展现出潜在应用价值。随着临床研究的不断深入，其适应症覆盖范围有望进一步扩大，为更多肿瘤患者带来治疗转机。从单一瘤种到多瘤种覆盖，伊匹木单抗适应症的拓展历程，是免疫治疗技术不断进步、临床需求持续驱动的结果。作为中国首个由本土企业自主开发的抗 CTLA-4 抑制剂，其相关适应症的获批不仅丰富了国内肿瘤患者的治疗选择，也体现了中国生物制药行业在创新药物研发领域的突破。未来，随着更多临床数据的积累和研发投入的加大，伊匹木单抗有望在更多瘤种的治疗中发挥作用，为肿瘤治疗领域带来更多新的可能，助力提升肿瘤治疗的整体水平。返回搜狐，查看更多

免疫疗法临床3期临床结果

2026-01-20

·Business Wire

MaaT Pharma Announces First Patient Randomized in IMMUNOLIFE Phase 2 Study Sponsored by Gustave Roussy, To Explore the Role of the Gut Microbiome To Overcome ICI Resistance in Advanced NSCLC Patients with Antibiotic-Induced Dysbiosis

LYON, France--(BUSINESS WIRE)--Regulatory News: Gut dysbiosis is increasingly recognized as a risk factor for immunoresistance to immunotherapy. MaaT033 is designed to restore microbiome balance and may help improve patients’ response to treatment MaaT Pharma (EURONEXT: MAAT – the “Company”), a clinical-stage biotechnology company and a leader in the development of Microbiome Ecosystem TherapiesTM (MET) dedicated to enhancing survival for patients with cancer through immune modulation, announced that the first patient has been randomized in the IMMUNOLIFE Phase 2 clinical trial, a randomized multicenter study evaluating the potential of an oral pooled fecal microbiotherapy (MaaT033) in combination with Regeneron’s Cemiplimab (CB) in enhancing disease control rate versus best investigator’s choice (BIC) in patients with advanced non-small cell lung cancer (NSCLC) who have developed resistance to PD-1/PD-L1 blockade following antibiotic (ATB) exposure and who present ATB-induced gut dysbiosis. The IMMUNOLIFE trial is evaluating MaaT033 in combination with CB vs BIC in 162 patients with advanced NSCLC who are refractory to immune checkpoint inhibitors (ICIs) and have received antibiotics. Patients are randomized (1:1) to receive either MaaT033 orally for one week prior to each cycle of CB (administered every 3 weeks for 6 months), followed by CB alone, or BIC. The primary objective is to assess whether the combination is associated with an improved disease control rate at 12 weeks compared to BIC. The study includes 14 centres in France, with patient enrolment of approximately 2 years and total CB treatment duration of 2 years. Primary results after 1-year follow-up post-treatment could be expected in late 2030. An interim futility analysis around H1 2027, after the 81st randomized patient. “Gut dysbiosis is increasingly recognized as a risk factor for immunoresistance to immunotherapy. MaaT033 is designed to restore microbiome balance and may help improve patients’ response to treatment,” said Lisa Derosa, MD, PhD at Gustave Roussy and coordinating investigator of the IMMUNOLIFE trial. “We have built substantial evidence in our hemato-oncology programs that complex donor-derived products restore immune homeostasis in the context of pre-existing dysbiosis. This study represents an opportunity to further explore these findings in immuno-oncology in a well-defined patient population expected to show antibiotic-mediated dysbiosis,” said Hervé Affagard, CEO and co-founder of MaaT Pharma. This trial, sponsored by Gustave Roussy, is part of MaaT Pharma’s exploratory strategy launched in 2022, which also includes the PICASSO trial, a Phase 2a randomized controlled trial sponsored by AP-HP in Paris evaluating Xervyteg® (MaaT013) in combination with ICIs, ipilimumab (Yervoy®) and nivolumab (Opdivo®) for patients with metastatic melanoma. The Company has been informed by PICASSO's academic sponsor that topline results could not be available in Q4 2025 (as previously announced) and could now be expected in H1 2026. Overall, IMMUNOLIFE and PICASSO studies aim to contribute to the ongoing assessment of the Company’s research strategy, including indication, treatment line, and patient population. This will also inform on the clinical development of MaaT034, a co-cultured microbiome-based therapy and the Company’s next-generation drug candidate, designed to target large indications in solid tumors. In parallel, data already generated and to be generated during the IMMUNOLIFE consortium will also fuel the Company’s AI platform and support the development of all the Company’s microbiome-based drug candidates. The IMMUNOLIFE consortium includes leading academic institutions such as Gustave Roussy, INSERM, Paris Saclay University, INRAe, Hospital-University Institute (IHU) Méditerranée Infection and biotech companies. The consortium aims to address the challenge of primary resistance to ICI observed in advanced NSCLC patients following antibiotic exposure. The IMMUNOLIFE consortium receives funding from the French National Research Agency (“ANR-21-5 RHUS-0017 IMMUNOLIFE”). For more information on the IMMUNOLIFE (IMMUNOLIFE2) study: NCT07001618 --- About MaaT033 MaaT033, a standardized, donor-derived, high-richness, high-diversity oral Microbiome Ecosystem TherapyTM containing anti-inflammatory ButycoreTM species, is currently being developed as an adjunctive therapy to improve overall survival in patients receiving HSCT and other cellular therapies. It aims to ensure optimal microbiota function and to address a larger patient population in a chronic setting. MaaT033 has been granted Orphan Drug Designation by the European Medicines Agency (EMA). About MaaT034 MaaT034, currently in preclinical development, is a next-generation donor-independent full ecosystem synthetic microbiome therapy, dedicated to improving patient responses to immunotherapy in combination with Immune Checkpoint Inhibitors. Developed using the Company’s co-culturing proprietary MET-C platform, MaaT034 is optimized for large-scale production in oncology. Previous presented preclinical data showed that MaaT034 produced key metabolites, recognized as promoting gut barrier restoration and modulating immune responses, such as Short-Chain Fatty Acids (SCFA), secondary bile acids, and tryptophan derivatives. These data support the role of MaaT034 in gut barrier repair and in T cell reactivation either in combination with anti-PD1 or with anti-PD-L1. By enhancing gut barrier repair and modulating immune responses, MaaT034 is expected to complement the action of these immunotherapeutic agents, potentially improving their efficacy in treating solid tumors cancer. About MaaT Pharma MaaT Pharma is a leading, late-stage clinical company focused on developing innovative gut microbiome-driven therapies to modulate the immune system and enhance cancer patient survival. Supported by a talented team committed to making a difference for patients worldwide, the Company was founded in 2014 and is based in Lyon, France. As a pioneer, MaaT Pharma is leading the way in bringing the first microbiome-driven immunomodulator in oncology. Using its proprietary pooling and co-cultivation technologies, MaaT Pharma develops high diversity, standardized drug candidates, aiming at extending life of cancer patients. MaaT Pharma has been listed on Euronext Paris (ticker: MAAT) since 2021. Forward-looking Statements All statements other than statements of historical fact included in this press release about future events are subject to (i) change without notice and (ii) factors beyond the Company’s control. These statements may include, without limitation, any statements preceded by, followed by, or including words such as “target,” “believe,” “expect,” “aim”, “intend,” “may,” “anticipate,” “estimate,” “plan,” “project,” “will,” “can have,” “likely,” “should,” “would,” “could” and other words and terms of similar meaning or the negative thereof. Forward-looking statements are subject to inherent risks and uncertainties beyond the Company’s control that could cause the Company’s actual results or performance to be materially different from the expected results or performance expressed or implied by such forward-looking statements.

临床2期免疫疗法孤儿药微生物疗法

100 项与伊匹木单抗相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D04603	伊匹木单抗	L01XC11	DB06186

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
MSI-H 直肠癌	日本	Bristol-Myers Squibb KK	2025-08-25
PD-L1阳性非小细胞肺癌	中国	Bristol-Myers Squibb Pharma EEIG	2025-07-22
转移性肝细胞癌	澳大利亚	Bristol-Myers Squibb Australia Pty Ltd.	2025-06-27
晚期肝细胞癌	欧盟	Bristol Myers Squibb Co.	2025-03-08
晚期肝细胞癌	冰岛	Bristol Myers Squibb Co.	2025-03-08
晚期肝细胞癌	列支敦士登	Bristol Myers Squibb Co.	2025-03-08
晚期肝细胞癌	挪威	Bristol Myers Squibb Co.	2025-03-08
不可切除的肝细胞癌	欧盟	Bristol Myers Squibb Co.	2025-03-08
不可切除的肝细胞癌	冰岛	Bristol Myers Squibb Co.	2025-03-08
不可切除的肝细胞癌	列支敦士登	Bristol Myers Squibb Co.	2025-03-08
不可切除的肝细胞癌	挪威	Bristol Myers Squibb Co.	2025-03-08
错配修复缺陷或微高卫星不稳定性结肠癌	欧盟	Bristol-Myers Squibb Pharma EEIG	2025-01-13
错配修复缺陷或微高卫星不稳定性结肠癌	冰岛	Bristol-Myers Squibb Pharma EEIG	2025-01-13
错配修复缺陷或微高卫星不稳定性结肠癌	列支敦士登	Bristol-Myers Squibb Pharma EEIG	2025-01-13
错配修复缺陷或微高卫星不稳定性结肠癌	挪威	Bristol-Myers Squibb Pharma EEIG	2025-01-13
不能切除的食管鳞状细胞癌	美国	Bristol Myers Squibb Co.	2022-05-27
食管癌	日本	Bristol-Myers Squibb KK	2022-05-26
肝细胞癌	美国	Bristol Myers Squibb Co.	2020-03-10
皮肤黑色素瘤	美国	Bristol Myers Squibb Co.	2018-07-10
结直肠癌	美国	Bristol Myers Squibb Co.	2018-04-16

未上市

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
膀胱癌	临床3期	美国	Ono Pharmaceutical Co., Ltd.	2022-01-30
膀胱癌	临床3期	美国	中美上海施贵宝制药有限公司	2022-01-30
HER2阴性胃癌	临床3期	美国	Ono Pharmaceutical Co., Ltd.	2021-11-05
HER2阴性胃癌	临床3期	日本	Ono Pharmaceutical Co., Ltd.	2021-11-05
HER2阴性胃癌	临床3期	中国台湾	Ono Pharmaceutical Co., Ltd.	2021-11-05
胶质母细胞瘤	临床3期	美国	National Cancer Institute	2020-09-01
神经胶质肉瘤	临床3期	美国	National Cancer Institute	2020-09-01
局部晚期非小细胞肺癌	临床3期	美国	Bristol Myers Squibb Co.	2019-10-08
局部晚期非小细胞肺癌	临床3期	中国	Bristol Myers Squibb Co.	2019-10-08
局部晚期非小细胞肺癌	临床3期	日本	Bristol Myers Squibb Co.	2019-10-08

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03873818 (CTgov)	临床2期	皮肤黑色素瘤 \| 转移性黑色素瘤 \| 脑转移瘤	24	Ipilimumab+Pembrolizumab (Cohort A: Treatment Naïve)	鏇範鏇製構選獵醖艱積 = 夢範遞顧衊齋醖顧窪觸醖蓋壓膚糧積壓壓憲膚 (顧觸夢膚鏇鑰衊顧觸艱, 淵簾觸襯繭夢築製壓廠 ~ 鏇齋蓋積築網鑰築醖膚) 更多	-	2026-01-09
				Ipilimumab+Pembrolizumab (Cohort B: Previously Progressed on PD-1 Inhibitors)	齋襯簾餘鹽簾膚窪鏇鑰 = 膚網願憲廠夢鹹網淵壓構齋廠淵憲夢醖遞範鏇 (鑰積糧憲齋構夢窪選壓, 夢鑰繭繭範製憲簾鑰壓 ~ 構壓簾膚憲願膚鏇顧鹽) 更多
IMbrave150 (ASCO_GI2026)	临床2/3期	晚期肝细胞癌一线	1,064	Tremelimumab + Durvalumab	獵願鑰壓鹽鹽遞醖衊遞(襯淵憲鏇憲鑰襯範蓋鏇) = 鏇構憲顧鹽鹽網淵觸衊艱膚繭鹽範鏇鹽醖鏇醖 (蓋鹽鹽遞遞願獵鹹網範 ) 更多	积极	2026-01-08
				Atezolizumab + Bevacizumab	獵願鑰壓鹽鹽遞醖衊遞(襯淵憲鏇憲鑰襯範蓋鏇) = 積壓憲齋餘願襯鹽構鬱艱膚繭鹽範鏇鹽醖鏇醖 (蓋鹽鹽遞遞願獵鹹網範 ) 更多
NCT03912064 (CTgov)	临床1期	急性髓性白血病 \| 骨髓增生性疾病 \| 慢性粒单核细胞白血病 ... 更多	25	Ipilimumab (CD25/Treg-depleted DLI)	壓蓋築繭鹽膚鑰窪憲憲 = 鬱齋顧獵積獵衊壓獵艱膚壓廠窪餘膚夢壓蓋遞 (構壓繭鑰廠製願窪鬱鏇, 獵範壓鹽選壓窪獵遞憲 ~ 夢網糧簾鹹淵廠鬱齋繭)	-	2026-01-05
				Ipilimumab (Ipilimumab)	醖壓襯製獵選壓襯選繭 = 鹹鬱齋廠鏇選夢獵觸壓簾齋範鹽襯願繭蓋繭鑰 (窪憲製糧憲艱觸憲願鬱, 繭積繭壓壓餘網鏇淵構 ~ 簾網觸鹹鏇廠鏇艱遞憲)
NCT03172624 (CTgov)	临床2期	唾液腺肿瘤	64	Ipilimumab+Nivolumab (R/M Adenoid Cystic Carcinoma (ACC))	鑰鹽蓋窪遞願構網壓觸 = 餘膚醖廠網顧構築艱鑰醖壓鬱壓鹽艱膚鑰憲遞 (獵鹽糧簾選簾繭鹹淵膚, 餘積製襯壓醖艱網衊餘 ~ 構範窪鑰壓簾醖觸獵繭) 更多	-	2025-12-18
				Ipilimumab+Nivolumab (R/M SGC of Any Histology, Except ACC (Non ACC))	鑰鹽蓋窪遞願構網壓觸 = 製廠願鬱夢積獵齋鑰齋醖壓鬱壓鹽艱膚鑰憲遞 (獵鹽糧簾選簾繭鹹淵膚, 繭製齋網糧憲顧鑰窪選 ~ 遞繭鹽獵遞鑰選鑰築艱) 更多
NCT04079712 (CTgov)	临床2期	大细胞神经内分泌癌 \| 小细胞癌 \| 胰岛细胞癌 ... 更多	17	Ipilimumab+Nivolumab+Cabozantinib S-malate	觸顧壓繭鬱膚齋糧艱壓(鹽膚鏇餘夢醖鹽醖廠範) = 夢窪觸鏇襯築餘廠蓋簾齋齋製餘壓齋憲鏇艱築 (積製顧願艱淵淵範構製, 廠顧壓齋願選壓構網鹽 ~ 觸築願壓餘觸糧獵築鬱) 更多	-	2025-12-12
NCT03305445 (ASH2025)	临床1/2期	弥漫性大B细胞淋巴瘤	6	Nivolumab/ipilimumab-primed “immunotransplant” (IT)	構壓餘壓繭觸鑰遞醖鹹(鏇網構淵製網艱膚觸觸) = 繭餘醖觸壓襯蓋壓衊積鏇鏇鑰衊積廠糧製艱積 (壓築襯襯膚築鹽鏇窪襯 ) 更多	积极	2025-12-06
ESMO_ASIA2025	N/A	转移性肾细胞癌一线	194	IO-IO (nivolumab + ipilimumab)	艱鑰願繭構蓋遞膚窪膚(鬱壓鹹觸淵選選鏇顧網) = 淵衊鬱蓋顧積願鹹壓構鹹鹹製鹹鹽糧觸窪齋襯 (壓齋淵鹹膚願艱艱觸願, 1.0 ~ 55.9) 更多	积极	2025-12-05
				IO-TKI (pembrolizumab + axitinib or lenvatinib or nivolumab + cabozantinib)	艱鑰願繭構蓋遞膚窪膚(鬱壓鹹觸淵選選鏇顧網) = 膚醖憲憲鏇蓋網齋鏇觸鹹鹹製鹹鹽糧觸窪齋襯 (壓齋淵鹹膚願艱艱觸願, 1.0 ~ 45.2) 更多
NCT03388632 (Phase 1 study, CTgov)	临床1期	转移性实体瘤 \| 难治性癌症 \| 复发癌	31	ipilimumab+nivolumab+rh IL-15 (All Participants in Escalation Phase of Arm C)	積顧獵繭蓋製觸夢鬱蓋 = 餘壓顧襯積醖簾鹹製繭窪製醖獵膚鹹製膚獵夢 (衊簾淵鹽願艱鑰醖網淵, 鑰淵蓋鑰鑰糧構鬱構醖 ~ 網壓廠遞鹹壓餘襯鹹選)	-	2025-12-03
				Recombinant Human Interleukin (rH IL-15)+Nivolumab (Arm A Doublet A - Recombinant Human Interleukin (rH IL-15) 0.5mcg/kg & Nivolumab 240mg)	艱觸願鑰遞膚憲獵築艱 = 壓簾願憲選範積繭顧網蓋襯遞窪襯簾窪積蓋製 (選壓積網遞範製鹹糧淵, 遞範簾衊鏇艱繭簾襯鏇 ~ 選蓋遞餘餘鏇築鹹齋淵) 更多
NCT04021043 (Phase I/II study of BMS-986156, CTgov)	临床1/2期	转移性肺癌 \| 肝转移 \| 转移性实体瘤 ... 更多	51	BMS-986156+Ipilimumab (Ipilimumab + BMS-986156 Arm (30 mg/kg))	衊憲餘範積鹽繭鑰壓簾 = 製製觸襯觸艱衊艱構壓繭願願願襯積簾廠鏇鏇 (鏇衊廠夢夢製顧襯膚鑰, 艱廠廠壓鏇簾廠餘憲繭 ~ 願廠築蓋繭願膚鬱壓獵) 更多	-	2025-12-03
				BMS-986156+Ipilimumab (Ipilimumab + BMS-986156 Arm (100 mg/kg))	衊憲餘範積鹽繭鑰壓簾 = 範襯鹹膚鹹遞鏇網壓鬱繭願願願襯積簾廠鏇鏇 (鏇衊廠夢夢製顧襯膚鑰, 觸餘鹹築淵顧糧觸積鹽 ~ 壓淵衊鏇糧醖觸憲餘築) 更多
NCT04969887 (MOST-CIRCUIT, Pubmed \| JAMA Oncol)	临床2期	MSI-H 癌症 dMMR \| MSI-H	52	IpilimumabNivolumab + IpilimumabNivolumabb	積淵獵夢廠窪構艱構簾(齋糧選襯夢糧顧構衊膚) = 範鑰選顧齋獵積淵繭餘膚顧膚夢憲築鑰獵範鏇 (範窪膚蓋淵鹹獵廠選夢, 50 ~ 75) 更多	积极	2025-11-13