A Phase 2 Study Exploring the Use of Bispecific Antibodies to Improve Progression Free Survival in Patients With High-Risk Newly Diagnosed Multiple Myeloma (MMulti-Immune HR)

The purpose of this research is to learn whether using teclistamab and talquetamab at different time points will improve survival in participants with high-risk Multiple Myeloma (MM).
The treatment on this study will consist of Induction chemotherapy and stem cell collection, Immunotherapy 1 chemotherapy and Immunotherapy 2 chemotherapy. For participants whose testing show they are Minimal Residual Disease (MRD) positive (still have myeloma cells present in the bone marrow testing), a Melphalan-based stem cell transplant will be performed. For participants whose testing show they are MRD negative, the stem cell transplant will not be performed. All participants will go on to receive Immunotherapy 3 chemotherapy, Immunotherapy 4 chemotherapy, and Maintenance therapy.

开始日期2026-07-01

申办/合作机构

Janssen Research & Development LLC

NCT06348147

/ Suspended临床2期

An Attenuated Schedule Dara-RVd Induction for Patients With Newly Diagnosed Multiple Myeloma Who Are Eligible for Autologous Stem Cell Transplantation

This Phase II hybrid decentralized trial will examine the effect of daratumumab-based quadruplet induction therapy administered at an attenuated schedule in subjects with newly diagnosed multiple myeloma (NDMM) who are eligible for standard-of-care autologous stem cell transplantation (ASCT). Daratumumab, lenalidomide, bortezomib, and dexamethasone (Dara-RVd) have recently become a standard induction regimen for patients with NDMM who are eligible for ASCT in the United States. As implemented in clinical trials, Dara-RVd involves twice weekly bortezomib administration, which is inconvenient for patients and may result in increased rates of limiting toxicity, such as peripheral neuropathy. Adoption of alternate schedules involving once-weekly bortezomib is common in real-world practice, however a paucity of prospective data supporting this practice exists.
This study examines the efficacy of an attenuated Dara-RVd schedule involving once-weekly bortezomib dosing.

开始日期2026-07-01

申办/合作机构

Lineberger Comprehensive Cancer Center

NCT07428369

/ Not yet recruiting临床2/3期

A Phase 2/3, Open-Label, Randomized Study of Linvoseltamab, Bortezomib and Lenalidomide (Linvo-VR) With and Without Autologous Stem Cell Transplantation (ASCT) Vs Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) in Transplant-Eligible Participants With Newly Diagnosed Multiple Myeloma

This study is focused on participants with Newly Diagnosed Multiple Myeloma (NDMM) who are eligible for high dose chemotherapy followed by Autologous Stem Cell Transplantation (ASCT).
This study is evaluating a drug called linvoseltamab in combination with standard therapies for multiple myeloma called bortezomib (V) and lenalidomide (R). This combination is abbreviated as Linvo-VR.
The aim of this study is to compare how well Linvo-VR, with and without ASCT, treats myeloma to how well the current standard of care regimen for NDMM treats myeloma. That current standard of care regimen includes the drugs daratumumab (D), bortezomib (V), lenalidomide (R), and dexamethasone (d). This combination is referred to as DVRd. The study is also evaluating if Linvo-VR treats myeloma well enough that ASCT is no longer needed with the first myeloma treatments.
The study is looking at several other research questions, including:
* What side effects may happen from taking linvoseltamab
* How much linvoseltamab is in the blood at different times
* Whether the body makes antibodies against the linvoseltamab (which could make the drug less effective or could lead to side effects)

开始日期2026-06-05

申办/合作机构

Regeneron Pharmaceuticals, Inc.

100 项与来那度胺相关的临床结果

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100 项与来那度胺相关的转化医学

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100 项与来那度胺相关的专利（医药）

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7,791

项与来那度胺相关的文献（医药）

2026-12-31·JOURNAL OF MEDICAL ECONOMICS

Indirect treatment comparison of DVRd plus DR maintenance (PERSEUS study) versus DVTd or VTd with or without lenalidomide maintenance in transplant-eligible patients with previously untreated multiple myeloma

Article

作者: Nair, Sandhya ; Einsele, Hermann ; Facon, Thierry ; He, Jianming ; Dimopoulos, Meletios A. ; Caillot, Denis ; Sonneveld, Pieter ; Zweegman, Sonja ; Ammann, Eric ; Nobrega, Marjorie ; Broijl, Annemiek ; Spencer, Andrew ; Perrot, Aurore ; Schjesvold, Fredrik ; Gay, Francesca ; Hajek, Roman ; Boccadoro, Mario ; Rodriguez-Otero, Paula ; Hulin, Cyrille ; Sitthi-Amorn, Anna ; Rowe, Melissa ; Leleu, Xavier ; Mina, Roberto

AIMS:

To compare the effectiveness of induction and consolidation with daratumumab, bortezomib, lenalidomide, and dexamethasone (DVRd) plus maintenance therapy with daratumumab and lenalidomide (DR) with 2 treatment regimens that are widely used for transplant-eligible newly diagnosed multiple myeloma (TE NDMM): bortezomib, thalidomide, and dexamethasone (VTd) or daratumumab-VTd (DVTd) followed by observation (Obs) or lenalidomide maintenance.

MATERIALS AND METHODS:

Individual patient-level data from the PERSEUS (NCT03710603) and CASSIOPEIA (NCT02541383) trials were used to compare DVRd + DR with VTd + Obs and with DVTd + Obs. Inverse probability of treatment weighting was used to adjust for differences in baseline patient characteristics between the two trials; inverse probability of censoring weighting was used to adjust for the second randomization of CASSIOPEIA. Data from the CASSIOPEIA and Myeloma XI (EudraCT 2009-010956-93) trials were combined to model outcomes associated with lenalidomide (R) maintenance following induction with DVTd or VTd.

RESULTS:

DVRd + DR showed superior progression-free survival compared with DVTd + Obs (hazard ratio, 0.39 [95% CI = 0.26-0.59]), VTd + Obs (0.17 [95% CI = 0.12-0.25]), DVTd + R (0.62 [95% CI = 0.41-0.92]), and VTd + R (0.29 [95% CI = 0.18-0.43]). Sensitivity analyses showed results were consistent with the base case.

LIMITATIONS:

The indirect treatment comparison was unanchored due to a lack of common comparators and relied on external data from the Myeloma XI trial to model outcomes associated with DVTd or VTd followed by R maintenance. Despite best efforts to identify and adjust for important treatment effect modifiers, there is a potential for residual confounding.

CONCLUSIONS:

Findings from this study suggest that DVRd followed by DR maintenance offers superior survival outcomes compared with current standards of care in TE patients with NDMM.

2026-12-31·Hematology

Neutrophil extracellular trap-related genes in PTCL: identification, prognosis and drug interaction prediction via bioinformatics-machine learning

Article

作者: Chen, Jing ; Cheng, Fanjun ; Fang, Jun

OBJECTIVE:

This study aimed to identify neutrophil extracellular trap-related genes (NET-RGs), explore their prognostic significance, and predict drug interactions in peripheral T-cell lymphoma (PTCL).

METHODS:

Differentially expressed NET-RGs (DE-NRGs) between PTCL and normal tissues were screened. Functional enrichment analysis was conducted. Bioinformatics and machine learning were used to identify hub genes and assess their diagnostic value. Univariate and multivariate analyses were used to evaluate prognostic roles. Correlation and immune infiltration analyses were performed to explore relationships with the tumor microenvironment (TME). Clinical data were collected from PTCL patients who received potential agents (lenalidomide) as first-line treatment.

RESULTS:

A total of 31 DE-NRGs were identified (18 upregulated and 13 downregulated), enriched in inflammatory response, extracellular matrix organization, and infection involvement. Four hub genes (AKT2, MAPK14, IRF1, and TNF) were identified as effective PTCL diagnostic markers. Higher AKT2/MAPK14 expression correlated with poorer overall survival (OS), while elevated TNF expression associated with better OS; AKT2 and TNF independently predicted OS. These genes were implicated in modulating TME remodeling. Potential therapeutic agents (e.g. capivasertib, lenalidomide) were predicted, and lenalidomide may represent a feasible initial treatment option for PTCL, with an objective response rate (ORR) of 40.0% and a maximum survival duration exceeding 50 months.

CONCLUSION:

NET-RGs play crucial roles in diagnosis, prognosis, and TME regulation, and lenalidomide, a putative TNF-targeting agent, may represent a feasible initial treatment option in PTCL.

2026-12-01·JOURNAL OF MOLECULAR MEDICINE-JMM

Anti-myeloma activity of the CXCR4 antagonist WZ811

Article

作者: Suroviakova, Katarina ; Sedlak, Jan ; Jakubikova, Jana ; Valuskova, Zuzana ; Strizova, Anna ; Marinkovicova, Maria Elisabeth ; Csicsatkova, Nikoleta ; Cholujova, Danka

Abstract:

The CXCR4-CXCL12 axis is crucial for the interaction between malignant plasma cells (PC) and their microenvironment in multiple myeloma (MM). Here, we show that CXCR4 expression is upregulated in MM cell lines and PCs during both premalignant and active stages of MM, compared to normal PCs from healthy donors. The CXCR4 antagonist WZ811 reduced the viability of MM PCs and cell lines, while tumor microenvironment cells from both MM patients and healthy donors exhibited significant resistance. In vivo, WZ811 significantly reduced tumor burden and improved survival. WZ811-mediated MM cell death involved disruption of mitochondrial transmembrane potential, externalization of transmembrane phosphatidylserine, activation of caspases, increased levels of autophagic proteins, and an increase in G 0 /G 1 phase of the cell cycle. WZ811 also eliminated the MM stem cell-like side population, though slight resistance was observed with stromal cells. Additionally, WZ811 increased levels of CXCL12 and extracellular matrix molecules collagen IV and laminin in MM cells. Combining WZ811 with anti-MM agents showed synergism with doxorubicin, dexamethasone, bortezomib, lenalidomide, and pomalidomide, while antagonism was observed with carfilzomib, supporting the clinical assessment of WZ811 in MM.

Key messages:

WZ811 reduced the viability of myeloma primary cells and cell lines.WZ811 reduced tumor burden and improved survival in vivo xenograft model.WZ811 mechanisms involved apoptotic and autophagic cell death.WZ811 eliminated the MM stem cell-like side population.WZ811 synergized with DOX, DEX, BTZ, LEN, and POM.

2,892

项与来那度胺相关的新闻（医药）

2026-04-02

·制药工业EHS管理

中间体2-硝基-3-甲基苯甲酸为何屡成“炸药桶”？

编者按： 2025年5月至2026年2月，山东、河南、山西接连发生三起2-硝基-3-甲基苯甲酸（又称3-甲基-2-硝基苯甲酸）生产爆炸事故，造成惨重的人员伤亡与财产损失，这个原本仅存于化工领域的精细中间体，骤然成为全社会关注的焦点。作为氯虫苯甲酰胺、溴氰虫酰胺的关键中间体，同时广泛应用于高端医药、功能材料、染料等领域的它，为何成为非法生产的重灾区，又为何频繁引发恶性爆炸？其背后是利益驱动下的安全失守，还是对高危硝化工艺的肆意漠视？为此，中国石油和化学工业联合会安全生产办公室组织华安HSE智库专家进行了研讨，形成了本文，并给出了破解整治非法生产的建议措施。一、2-硝基-3-甲基苯甲酸究竟是何物？ 2-硝基-3-甲基苯甲酸（CAS号：5437-38-7），别名3-甲基-2-硝基苯甲酸，2-硝基间甲基苯甲酸，分子式是C8H6NO4，分子量为180.1381。常温常压下为白色至类白色固体粉末，具有显著酸性和一定化学稳定性，难溶于水、可溶于醇类有机溶剂，分子结构中含硝基与羧基活性单元，属于硝基芳香族羧酸类化合物。该物质是化工合成领域的重要原料，除了作为农药氯虫苯甲酰胺、溴氰虫酰胺的关键中间体，还可用于合成抗癌药物来那度胺，同时在偶氮类染料、光电子器件、配位聚合物等功能材料领域发挥重要作用。2025年其全球市场规模预计达24.8亿元，中国产能占比42%，其中规模较大的为河南一家企业的低温硝化工艺，年产能达3000吨。氯虫苯甲酰胺是我国生产的大宗杀虫剂，也是全球最重要的农药品种之一，2-硝基-3-甲基苯甲酸是其核心上游原材料。二、生产工艺与核心风险：硝化反应为何成为“夺命环节” 目前该物质的合成方法主要有硝化法和氧化法，其中硝化法是市场主流工艺，2025-2026年的三起较大以上事故也均集中在硝化反应环节。正规硝化工艺以3-甲基苯甲酸为原料，与浓硝酸和浓硫酸的混酸进行低温反应，全程包含配酸、溶解、0-5℃低温硝化、保温熟成、水解析晶、干燥精制六大步骤，后续还需经过甲基化、纯化等环节，要求纯度达99%以上。由于硝化反应放热量巨大、反应速度极快，温度每升高10℃反应速率便会翻倍，稍有不慎就会引发热失控，因此正规生产必须配备连续流微通道反应、全自动DCS控制、紧急停车系统、惰性气体保护等高安全配置，全流程需严格管控。而该物质的高危险性，不仅体现在硝化反应的严苛要求上，其风险还集中在五个核心方面：一是硝化反应易热失控，冷却不足、搅拌失效、投料过快都会引发飞温直至爆轰，间歇釜失控后几乎无法挽救；二是产物本身易燃易爆，干燥状态下对摩擦、静电极度敏感，粉尘可爆燃，属于潜在含能物质；三是生产所用混酸具有强腐蚀性和强氧化性，泄漏易起火、遇水暴沸，兼具灼伤与爆炸风险；四是水解、离心、干燥等后处理环节隐患极高，稍有不慎便会触发爆炸，母液废渣久置还易自燃；五是非法生产的工艺放大风险，小试参数直接量产，无评估、无换热、无联锁，极易造成物料积聚与热爆炸。从化学本质来看，硝基化合物分子内含有高能化学键，氮原子结合氧原子后处于不稳定状态，受热量、机械刺激时易断裂释放巨大能量，产生的高温高压气体形成冲击波，这也是其易爆炸的核心原因。 2026年1月21日，应急管理部官网已征求意见，拟将该物质纳入《危险化学品目录》，此前其并未列入2015版该目录。三、暴利驱动乱象：高附加值与市场波动下的逐利冲动 2-硝基-3-甲基苯甲酸的生产乱象，与氯虫苯甲酰胺的国产化进程密切相关。氯虫苯甲酰胺原研公司杜邦（后由富美实继承）的核心化合物专利于2022年8月13日在中国到期，标志着该产品国产化正式开启，尽管部分相关专利仍在保护期内，重要中间体K胺专利预计2025年底到期，制剂产品“康宽”的化合物专利保护期延续至2025年12月左右，但国内企业早已提前开展实验室及中试工艺验证。国产化后市场竞争激烈、产能扩张迅速，国内相关登记证件超400个，原药在建/拟建产能达20万吨/年，而氯虫苯甲酰胺的价格波动，也让其关键中间体2-硝基-3-甲基苯甲酸成为利益追逐的目标。2022年初，氯虫苯甲酰胺原药价格处于200-240万元/吨的高位，年中随国内产能释放降至100万元/吨左右，年底进一步跌至60万元/吨以下；2023年价格基本维持在30-35万元/吨；2024年从年初30万元/吨降至年底20万元/吨；2025年初至5月底，其价格在20万元/吨低位平稳运行，5月27日山东高密爆炸事故导致中间体供应中断，价格短期内飙升至30-32万元/吨的年度高点，市场出现“有价无市”局面，后续随供应链调整和生产恢复，价格逐渐向20万元/吨回归。 2月10日，中国农药工业协会发布了《关于规范氯虫苯甲酰胺生产经营行为的倡议》，呼吁各会员单位以氯虫苯甲酰胺行业长远利益为重，强化自律意识，合规安全生产，合规渠道采购。同时初步测算该产品目前平均成本约23.3万元/吨（大写：人民币贰拾叁万叁仟元每吨，不含三项费用）。四、三起惨痛事故：非法生产“血”的教训高额的利润空间，让部分不法分子铤而走险开展非法生产，而合规生产的高投入与非法生产的低成本形成的巨大反差，更是催生了黑色产业链。2025年5月至2026年2月的三起爆炸事故，既有合法企业的违规操作，也有不法企业的非法生产，每一起都留下了惨痛的教训： 1.2025年5月27日11时53分许，潍坊市高密山东友道化学有限公司发生重大爆炸事故，造成10人死亡、2人失联、19人受伤，直接经济损失5860.20万元。该企业为合法生产企业，但其自行开发的连续流生产工艺技术存在缺陷，还掺投质量不合格的间甲基苯甲酸作为原料，导致物料积聚堵塞，管链机中的硝化物反复受挤压、摩擦持续蓄热升温引发爆炸，进而引燃其他设备内的硝化物料。 2.2025年7月23日16时05分，新乡市获嘉县大鑫化工有限公司在非法生产该中间体时发生爆炸，造成3人死亡、2人受伤，直接经济损失约587万元。该企业6月12日开始凭经验安装改造设备，7月8日正式投产，仅用1个月拼凑出生产线，事故直接原因为工作人员对卸料管弯头漏点违规动火焊接，电焊高温导致硝酸和3-甲基-2-硝基苯甲酸混合物迅速分解，释放大量热能和爆炸性混合气体遇明火爆炸。该企业还通过以大鑫化工名义统一应对检查、以生产柔软助剂申报环评的方式，掩盖违法出租和非法生产行为，主观故意性极强。 3.2026年2月7日0时7分许（注意时间节点凌晨），朔州市山阴县佳鹏生物科技有限公司发生爆炸，造成8死3伤，国务院安委办对该事故正式挂牌督办。该企业工商登记为饲料生产企业，设计年产生物饲料原料15000吨，2025年先后在县行政审批局登记备案，12月建成投产，实则以饲料生产为掩护，隐匿于偏远山区非法生产2-硝基-3-甲基苯甲酸，其实际控制人及生产人员多为河北籍、内蒙古籍，是典型的非法违法“小化工”。这三起事故印证了一个事实：2-硝基-3-甲基苯甲酸的生产危险，从来不是技术问题，而是利益驱动下的安全失守。正规生产工艺成熟可控，但需投入大量资金用于安全设施、工艺优化和合规审批，而非法生产作坊省去了所有安全投入，采用人工操作、简陋设备、劣质原料，还偷排三废，其成本仅为正规企业的三分之一，利润却成倍增长，部分从业者或是熟悉工艺、或是了解市场行情，为了高额利润漠视法律与生命，形成了隐蔽的非法生产链条。五、综合治理对策：筑牢高危化工中间体安全防线多起硝化事故也给化工行业带来了深刻的行业影响，推动国家进一步强化硝化工艺专项整治，严格危化品市场准入，严查非法生产、厂房转租、无证施工等行为，加速落后产能淘汰。在国际层面，该物质作为农药关键中间体，其生产的安全与合规性直接影响我国精细化工的国际声誉，跨国公司也因此进一步加强了对相关供应链的溯源与安全审核。马克思在《资本论》中对资本逐利性的论述，恰是这一系列事故的真实写照：为了高额利润，部分不法分子践踏法律、漠视生命，省略安全设施、简化生产工艺、开展无证生产，最终酿成惨剧。2-硝基-3-甲基苯甲酸的屡发事故警示我们，高危化学品的生产没有任何侥幸可言，非法生产必然难逃灾祸。守住化工生产的安全底线，需要政府、行业、企业多方协同发力，多措并举筑牢安全屏障，具体可落地措施如下： 1.强化行业产能监控与预警：由精细化工相关行业协会牵头，建立高附加值精细化学品尤其是硝化类高危中间体的产能、价格、市场供需动态监测体系，定期收集行业生产数据，开展产能过剩、紧缺、价格异常波动预警分析，及时向行业和监管部门发布预警信息，引导企业理性布局产能，避免因市场波动引发的非法生产冲动。 2.完善危化品名录与监管细则：加快推进2-硝基-3-甲基苯甲酸纳入《危险化学品目录》的审批流程，同步制定针对该类硝化类精细中间体的专项监管细则，明确生产、储存、运输、处置全流程的安全标准和资质要求，细化硝化工艺的设备配置、操作规范、人员资质等硬性指标。 3.开展全链条常态化排查整治：监管部门组建跨区域、跨部门联合执法队伍，针对偏远山区、城乡结合部等非法生产高发区域，开展硝化类高危化学品生产经营的常态化排查，重点核查企业实际生产内容与工商、环评备案是否一致，持续重点关注核査名称中含有“生物”、“医药”、“科技”、“新材料”等字样的企业，积极运用现代科技，拓宽线索发现渠道，严厉打击“挂羊头卖狗肉”的非法生产行为；同时对合法生产企业开展工艺安全专项检查，严查原料不合格、工艺缺陷、违规操作等问题。 4.推行硝化工艺安全标准化认证：制定硝化工艺生产安全标准化体系，要求从事硝化类精细化学品生产的企业必须通过专项认证，认证内容涵盖生产设备、自控系统、安全防护设施、应急处置能力等，未通过认证的企业一律不得开展硝化反应生产，从源头提升行业本质安全水平。 5.加强上下游供应链溯源管理：建立硝化类高危中间体的上下游供应链溯源系统，要求生产企业、原料供应商、产品采购商如实登记交易信息，实现原料采购、生产加工、产品销售的全流程可追溯，监管部门可通过系统核查交易真实性，阻断非法生产产品的流通渠道。 6.强化从业人员专业培训与资质管理：针对硝化工艺高危特性，建立从业人员专项资质考核制度，要求硝化生产操作、安全管理等关键岗位人员必须通过专业的安全培训和资质考试，持证上岗；行业协会定期组织开展安全技能培训和事故案例警示教育，提升从业人员的安全意识和应急处置能力。 7.建立非法生产举报奖励机制：面向社会公布非法生产硝化类高危化学品的举报渠道，设立高额举报奖励资金，对查实的举报线索给予举报人重奖，同时严格保护举报人信息，充分调动社会力量参与监督，形成全民共治的监管格局。 8.推动行业技术创新与成果共享：由政府牵头设立硝化工艺安全技术研发专项基金，支持高校、科研院所与龙头企业合作，研发更安全、更高效的硝化生产工艺和安全防护设备；行业协会搭建技术成果共享平台，推动先进的反应技术、全自动安全控制系统等在行业内普及应用，降低企业安全生产成本。唯有政部门严守资质准入、强化监管执法，行业协会做好行业引导、监测预警，企业落实主体责任、规范生产流程，多方形成监管合力，才能真正堵住非法生产的漏洞，守住高危精细化学品生产的安全底线，避免类似的悲剧再次发生，让化工行业在安全的前提下实现健康、有序发展。中国医药企业管理协会为更好地服务制药企业，建有多个制药工业EHS管理、智能化和数字化、精益管理和运营等技术和管理交流群，欢迎制药企业管理人员实名加入！请用工作邮箱发邮件给ehs_pharma@163.com（备注：所在药企全称、部门、职务、姓名、微信号），或直接加微信 haixia_lee （备注：药企名称+姓名）再经验证后进相关的群。 END 精彩合集 EHS指南 EHS培训 EHS年会年会演讲医药工业数智化双碳ESG 有限空间环保安全应急健康/IH 危化品优秀案例2019 2020 2021 2024 2025 点分享点收藏点在看点点赞

2026-04-02

·北京医学感染与传染研究

生物医学中心 - 医学 24卷 1期（1-3月）

BMC Medicine [Jour] AND 24[volume] AND 1[issue] 生物医学中心 - 医学 24卷 1期 https://link.springer.com/journal/12916/volumes-and-issues/24-1 188 articles in this issue Effectiveness of group-based art interventions for late-life depression: a systematic review and meta-analysis of randomized controlled trials 团体艺术干预对老年抑郁症的疗效：一项针对随机对照试验的系统综述和荟萃分析 Mohamad AzhdarlooRaziyeh AtaeiAbouzar Nazari Research 24 February 2026 Article: 188 The associations of consultant sex on herding‑like prescribing behaviour: evidence from a web-based experiment with female primary care physicians in England 顾问性别对从众式处方行为的影响：来自一项针对英格兰女性初级保健医生的网络实验的证据 Sandro Tiziano StoffelMatthias SchwenkglenksBerna Cennet Özdemir Research 24 February 2026 Article: 187 Tricarboxylic acid cycle metabolite index predicts adverse outcomes in acute myocardial infarction patients 三羧酸循环代谢物指数预测急性心肌梗死患者的不良预后 Ye WangPengyan WuBo Yu Research 24 February 2026 Article: 186 Targeting cancer stem cells predicts response and reverses chemoresistance in ascites-derived ovarian cancer organoids 靶向癌症干细胞可预测腹水来源的卵巢癌类器官的反应并逆转化疗耐药性 Xiaoli ZhangWen ZhangHuiqin Guo Research 24 February 2026 Article: 185 Neural vulnerability to stress in adolescents: a longitudinal study using polyconnectomic scoring of depression risk 青少年神经对压力的易感性：一项使用抑郁风险多连接组评分进行的纵向研究 Yuan LiuMeijuan LiJie Li Research 24 February 2026 Article: 184 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Classification of ALS molecular subtypes: a literature review on machine learning applications and their clinical value 肌萎缩侧索硬化症分子亚型分类：机器学习应用及其临床价值的文献综述 John K. JammalEsteban A. GomezAlfredo Iacoangeli Review 23 February 2026 Article: 183 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与新动态 Can we protect refugee children from mental health problems?— a scoping review of modifiable factors to inform preventive interventions 我们能否保护难民儿童免受心理健康问题困扰？——一项旨在为预防性干预提供信息的可改变因素的范围性综述 Rita GonçalvesM J MarquesSónia Dias Research 23 February 2026 Article: 182 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 The Trial Bank initiative to promote trustworthy living evidence for medication safety (PROMISE) of children: design and pilot validation 促进儿童用药安全可信实时证据（PROMISE）的试验库计划：设计与初步验证 Chang XuSuhail A. DoiPROMISE Collaborative Research Network Research 21 February 2026 Article: 181 Is liquid biopsy a cost-effective method to diagnose Burkitt Lymphoma in children and young adults? A health economic evaluation in Tanzania 液体活检是否为诊断坦桑尼亚儿童和青年成人伯基特淋巴瘤的一种具有成本效益的方法？一项卫生经济学评估 Jingjing JiangLiz MorrellAI-REAL Consortium Research 21 February 2026 Article: 180 The influence of immunohistochemistry-based subtypes on overall survival in breast cancer spine metastases: a systematic review and meta-analysis 基于免疫组织化学的亚型对乳腺癌脊柱转移总生存期的影响：一项系统综述和荟萃分析 Fon-Yih TsuangYun-Heng LiChung Liang Chai Research 21 February 2026 Article: 179 Prenatal exposure to maternal asthma and asthma medication and neurodevelopmental outcomes: a population cohort study of 179,024 children 产前接触母体哮喘及哮喘药物与神经发育结局的关系：一项针对179,024例儿童的人群队列研究 Lama A. ShakhshirSarjit SinghMichael Fleming Research 20 February 2026 Article: 178 First-in-human phase 1/2a study of T3011, an oncolytic HSV expressing IL-12 and PD-1 antibody, administered via intratumoral (IT) injection as monotherapy in advanced solid tumors, including recurrent or metastatic HNSCC T3011（一种表达IL-12和PD-1抗体的溶瘤性单纯疱疹病毒）首次人体1/2a期研究：通过瘤内（IT）注射作为单一疗法治疗包括复发或转移性头颈部鳞状细胞癌在内的晚期实体瘤 Dongmei JiWenmin FuXichun Hu Research 20 February 2026 Article: 177 Expanding access to cerebrovascular imaging with routine MRI for pre-surgical assessment of intracranial tumor patients: an AI model development and multi-center validation study 利用常规MRI扩大脑血管成像在颅内肿瘤患者术前评估中的应用范围：一项人工智能模型开发与多中心验证研究 Chaoyue ChenZhouyang HuangJianguo Xu Research 20 February 2026 Article: 176 Changing landscape of physical fitness and urban–rural inequalities: evidence from 1.2 million children and adolescents over 20 years of urbanization 20年城市化进程中120万例儿童和青少年体质健康状况及城乡差异的变化 Shan CaiJiaxin LiYi Song Research 19 February 2026 Article: 175 Efficacy and safety of anti-prediabetic drugs in patients with prediabetes: a Bayesian network meta-analysis 抗糖尿病前期药物在糖尿病前期患者中的疗效和安全性：一项贝叶斯网状荟萃分析 Yike WuZihan WangGuo Ma Research 19 February 2026 Article: 174 Clonal haematopoiesis of indeterminate potential and risk of incident psychiatric disorders Yuefeng YuChenyi WanNingjian Wang 意义未明的克隆性造血与新发精神障碍风险 Research 18 February 2026 Article: 173 Spatial characterization of intrahepatic fat deposition across steatotic liver disease subcategories: a multicenter study 脂肪性肝病各亚类中肝内脂肪沉积的空间特征：一项多中心研究 Yan-Ci ZhaoMin WangFeng Chen Research 18 February 2026 Article: 172 Pregnancy outcomes among medically complex populations with high risk of pregnancy mortality in Virginia: a retrospective observational study 弗吉尼亚州妊娠死亡高风险医学复杂人群的妊娠结局：一项回顾性观察研究 Michael J. GreenLauren G. AndersonJonas J. Swartz Research 18 February 2026 Article: 171 Maternal amino acid metabolites during pregnancy and preterm birth: results from two prospective cohort studies 孕期母体氨基酸代谢物与早产的关系：两项前瞻性队列研究的结果 Jingnan ChenYidan DongJu-Sheng Zheng Research 18 February 2026 Article: 170 Correction: Trajectory of the body weight after drug discontinuation in the treatment of anti-obesity medications 更正：停用抗肥胖药物后体重的变化轨迹 Han WuWenjia YangLinong Ji Correction 25 March 2026 Article: 169 Physical activity patterns and cardiovascular disease risk in adults with overweight or obesity: a prospective cohort study 超重或肥胖成人身体活动模式与心血管疾病风险：一项前瞻性队列研究 Kai MuYanan QiaoBo Xi Research 16 February 2026 Article: 168 Part of 1 collection:Weight loss interventions and their health impacts 所属专题合集：减肥干预措施及其对健康的影响 Maternal migraine and offspring ADHD: triangulating the evidence 母亲偏头痛与后代多动症（ADHD）：多方证据综合分析 Yaxin LuoChristina DardaniEvie Stergiakouli Research 14 February 2026 Article: 167 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 An autonomous siRNA delivery system targeting NLRP3: implications in Parkinson’s disease 靶向NLRP3的自主性小干扰RNA（siRNA）递送系统：在帕金森病中的潜在意义 Lishan LinZhizong LiZhong Pei Research 12 February 2026 Article: 166 Lay descriptions of painful temporomandibular disorders—an international consensus proposal for Global Burden of Disease estimates 颞下颌关节紊乱病疼痛的通俗描述——全球疾病负担评估的国际共识提案 A. LövgrenP. LivP. Svensson Research 17 March 2026 Article: 165 Association of soluble tumor necrosis factor receptor 1 with tau pathology, brain atrophy, and cognitive decline: a longitudinal study 可溶性肿瘤坏死因子受体1与tau蛋白病变、脑萎缩及认知功能下降的关联：一项纵向研究 Yutong ZhangLulu SunAlzheimer’s Disease Neuroimaging Initiative Research 11 February 2026 Article: 164 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Particulate matter and respiratory health in middle-aged and older adults: disentangling size-fractionated and constituent-specific effects under China’s clean-air policies 颗粒物与中老年人呼吸系统健康的关系：厘清中国净化空气政策下不同粒径及成分的特定影响 Yujing ChenZhaoyan LiuYu-ming Chen Research 11 February 2026 Article: 163 Part of 1 collection:Climate change and human health 所属专题合集：气候变化与人类健康 Clinical impact and cost-effectiveness of vaccinating infants and adolescents against invasive meningococcal B disease in the Netherlands 荷兰为婴儿和青少年接种针对侵袭性脑膜炎球菌B病的疫苗的临床影响和成本效益 Thomas OttenMirjam KnolAnneke Steens Research 10 February 2026 Article: 162 Association between trajectories of sleep quality and postpartum depression: a group-based trajectory model and computer-simulated network analysis 睡眠质量轨迹与产后抑郁之间的关联：基于组别的轨迹模型和计算机模拟网络分析 Xiaoxiao MeiJinzhou YuZengjie Ye Research 10 February 2026 Article: 161 Part of 1 collection:Sleep and mental health 所属专题合集：睡眠与心理健康 Understanding Japan’s mortality advantage: a comparison of mortality in independent and dependent older adults in Japan and Sweden 解读日本在死亡率方面的优势：日本与瑞典独立生活及依赖他人生活老年人的死亡率比较 Shunsuke MurataMarcus EbelingKarin Modig Research 23 March 2026 Article: 160 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学及风险因素的作用 The Young Adult Sleep model: an evolving causal loop diagram of mental health dynamics 青年睡眠模型：心理健康动态演变的因果环路图 Jeroen F. UlemanRushd F. M. Al-ShamaNaja Hulvej Rod Research 16 March 2026 Article: 159 Part of 1 collection:Sleep and mental health 所属专题合集：睡眠与心理健康 Oncostatin-M ligand-based CAR-T therapy displays robust anti-tumor activity against osteosarcoma 基于抑瘤素M配体的CAR-T疗法对骨肉瘤显示出强大的抗肿瘤活性 Daniel FeinbergVinayak UppinReshmi Parameswaran Research 17 March 2026 Article: 158 Antimicrobial catheters coated with poly-L-lysine for the prevention of bacteriuria in adults requiring short-term catheterization: a multicenter randomized controlled trial 涂有聚-L-赖氨酸的抗菌导管预防短期导尿成人患者菌尿症：一项多中心随机对照试验 Xinfei LiJun LiuKai Zhang Research 09 February 2026 Article: 157 Penpulimab in combination with lenalidomide and R-GemOx regimen (R2-GemOx-PD1i) in relapsed or refractory diffuse large B-cell lymphoma: a multicenter, single-arm, phase 2 trial 派安普利单抗联合来那度胺和R-GemOx方案（R2-GemOx-PD1i）治疗复发或难治性弥漫性大B细胞淋巴瘤：一项多中心、单臂、2期试验 Jin-Hua LiangTong-Yao XingWei Xu Research 09 February 2026 Article: 156 Digital twin brain reveals state-specific stimulation targets for abnormal brain dynamics in tinnitus 数字孪生大脑揭示耳鸣异常脑动力学状态特异性刺激靶点 Jiaqi ZhangShuting HanTianzi Jiang Research 10 February 2026 Article: 155 The case for mandatory reporting to enable targets for healthy and environmentally sustainable food: means, motive and opportunity 强制报告实现健康且环境可持续食物目标的理由：方法、动机和机会 Rachel PecheyLauren BandySusan A. Jebb Debate 10 February 2026 Article: 154 Genetic insights into radiomic and proteomic changes under β1-blockers treatment in hypertensive heart disease and hypertrophic cardiomyopathy β1受体阻滞剂治疗高血压性心脏病和肥厚型心肌病时放射组学和蛋白质组学变化的遗传学见解 Zhe ChenYifan TangKai Xie Research 09 February 2026 Article: 153 Part of 1 collection:Cardiomyopathy and cardiac arrhythmias 所属专题合集：心肌病与心律失常 Optimizing drug-resistant tuberculosis diagnosis: cost-effectiveness of rapid molecular and phenotypic assays in South Africa 优化耐药结核病诊断：南非快速分子和表型检测方法的成本效益分析 Ginenus FekaduTadesse TolossaWai Kit Ming Research 09 February 2026 Article: 152 Maternal smoking based on pre-birth health examination and risk of neurodevelopmental disorders in offspring: insights from a Korean mother–child cohort 基于产前健康检查探讨母亲吸烟与后代神经发育障碍风险的关系：来自韩国母婴队列研究的见解 Chan Soon ParkMoonyoung JangJun-Bean Park Research 11 March 2026 Article: 151 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Effects of ablation versus drug therapy on clinical outcomes and quality of life by frailty status in atrial fibrillation: a post hoc analysis of the CABANA trial 根据衰弱状态分析消融术与药物治疗对心房颤动患者临床预后和生活质量的影响：CABANA试验的事后分析 Lili WangYanguang LiYunlong Wang Research 07 February 2026 Article: 150 Part of 1 collection:Cardiomyopathy and cardiac arrhythmias 所属专题合集：心肌病与心律失常 Quantifying lifetime risk for 1,401 infectious diseases across the diabetes spectrum using a Bayesian approach 采用贝叶斯方法量化糖尿病全病程中1401种传染病的终生风险 Boomer B. OlsenMartin Tristani-FirouziEdgar Javier Hernandez Research 07 February 2026 Article: 149 Part of 1 collection:Diabetes and infectious disease 所属专题合集：糖尿病与传染病 Risk assessment of asthma and allergic rhinitis in atopic dermatitis patients treated with biologics and JAK inhibitors: a systematic review and network meta-analysis of randomized controlled trials 对接受生物制剂和JAK抑制剂治疗的特应性皮炎患者罹患哮喘和过敏性鼻炎的风险评估：一项针对随机对照试验的系统综述和网络荟萃分析 Liling ZengTong ZhouJing Li Research 07 February 2026 Article: 148 Preclinical activity of brincidofovir in peripheral T-cell and NK/T-cell lymphoma 布林西多福韦（brincidofovir）在外周T细胞和NK/T细胞淋巴瘤中的临床前活性 Jason Yongsheng ChanElizabeth Chun Yong LeeChoon Kiat Ong Research 06 February 2026 Article: 147 Genetic risk factors modulate the association between physical activity and colorectal cancer 遗传风险因素调节身体活动与结直肠癌之间的关联 Anita R. PeoplesMireia Obón-SantacanaVictor Moreno Research 05 February 2026 Article: 146 A neuroimaging biomarker for disease staging in clinically diagnosed Alzheimer’s disease 临床诊断阿尔茨海默病的疾病分期神经影像学标志物 Zhuangzhuang LiShaozhen YanYong Liu Research 05 February 2026 Article: 145 Association of GLP-1 receptor agonists with herpes risks in diabetes mellitus: a target trial emulation 胰高血糖素样肽-1（GLP-1）受体激动剂与糖尿病中疱疹风险的关联：一项目标试验模拟研究 Chi-Hsien HuangI-Hui ChiangJames Cheng-Chung Wei Research 31 December 2025 Article: 144 Part of 1 collection:Diabetes and infectious disease 所属专题合集：糖尿病与感染性疾病 Neoadjuvant immunochemotherapy plus thymalfasin in locally advanced gastric cancer: a prospective clinical trial 局部晚期胃癌联合胸腺肽的新辅助免疫化疗：一项前瞻性临床试验 Hao XuFengyuan LiZekuan Xu Research 26 February 2026 Article: 143 Part of 1 collection:Clinical trials for gastrointestinal cancer 所属专题合集：胃肠道癌症的临床试验 Detection of sequelae from acute meningitis during clinical review by a healthcare provider: a systematic review and meta-analysis 临床医生在临床复查中检测急性脑膜炎后遗症：一项系统综述和荟萃分析 Luisa F. AlvizCarla Y. KimKiran T. Thakur Research 28 February 2026 Article: 142 Part of 1 collection:Acute meningitis: a collection of systematic reviews 所属专题合集：急性脑膜炎：系统综述合集 ISG15-driven immune modulation and tumor progression in breast cancer metastasis: insights from single-cell and spatial transcriptomics ISG15驱动的免疫调节与乳腺癌转移中的肿瘤进展：来自单细胞和空间转录组学的见解 Hua ShaoHanlu TangYongqing Xu Research 04 February 2026 Article: 141 Evaluating the impact of family history and polygenic risk scores on cardiometabolic disease risk 评估家族史和多基因风险评分对心代谢疾病风险的影响 Ebuka OnyenobiKnightess OyiboSally N. Adebamowo Research 03 February 2026 Article: 140 Social networking site use, depressive and anxiety symptoms in adolescents: evidence from a longitudinal cohort study (SCAMP) 社交网站使用与青少年抑郁和焦虑症状：来自纵向队列研究（SCAMP）的证据 Chen ShenBraulio M. Girela-SerranoMireille B. Toledano Research 03 February 2026 Article: 139 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Early gestational prediction of spontaneous preterm birth using a validated three-protein serum biomarker panel 使用经验证的三蛋白血清生物标志物组合进行早孕期自发性早产预测 Qiong LuoJuan WeiXuefeng B. Ling Research 02 February 2026 Article: 138 Household cannabis cessation and adolescent mental health outcomes in a prospective cohort study 一项前瞻性队列研究中家庭大麻戒断与青少年心理健康预后的关系 Ming WangYixiang XuFei Li Research 02 February 2026 Article: 137 Part of 1 collection: Psychoactives: Recreational drugs repurposed as novel therapies 所属专题合集：精神活性物质：娱乐性药物重新利用为新型疗法 Objective assessment of long-term impact of COVID-19 on multiple sensory functions 客观评估新冠肺炎对多种感觉功能的长期影响 Ahmad OdehVeronica L. FormanekKai Zhao Research 27 February 2026 Article: 136 Detection of hearing loss by formal audiological testing after acute infectious meningitis: a global systematic review and meta-analysis 急性感染性脑膜炎后通过正式听力检测诊断听力损失：一项全球系统综述和荟萃分析 Luisa F. AlvizCarla Y. KimKiran T. Thakur Review 28 February 2026 Article: 135 Part of 1 collection: Acute meningitis: a collection of systematic reviews 所属专题合集：急性脑膜炎：系统综述合集 Serological evidence of substantial respiratory syncytial virus infection burden among older adults residing in Swedish long-term care facilities 血清学证据表明，居住在瑞典长期护理机构中的老年人存在沉重的呼吸道合胞病毒感染负担 Preeti MoarChristoffer GranvikMattias N. E. Forsell Research 24 February 2026 Article: 134 Association of parental education with offspring psychiatric diagnoses, violent crimes, and suicidal behavior: a nationwide Swedish quasi-experimental study 父母受教育程度与后代精神疾病诊断、暴力犯罪和自杀行为之间的关联：一项瑞典全国范围的准实验研究 Mengping ZhouHenrik LarssonErik Pettersson Research 26 February 2026 Article: 133 Discriminative performance of externally validated dementia risk prediction models: a systematic review and meta-analysis 外部验证的痴呆风险预测模型的鉴别性能：一项系统综述和荟萃分析 Blossom C. M. StephanJacob BrainMario Siervo Research 02 February 2026 Article: 132 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in platinum-sensitive recurrent ovarian cancer: a phase 3, double-blind, parallel group, randomized controlled pilot study 静脉注射大剂量硒预防铂敏感复发性卵巢癌化疗所致周围神经病变的有效性和安全性：一项3期、双盲、平行组、随机对照试点研究 Ga Won YimKyung Hee HanHee Seung Kim Research 02 February 2026 Article: 131 Time for change in implementation research and practice 实施研究和实践中变革的时机已到 Mike EnglishJacob McKnightSebastian Fuller Debate 02 February 2026 Article: 130 CardioMetAge estimates cardiometabolic aging and predicts disease outcomes CardioMetAge可评估心脏代谢年龄并预测疾病结局 Yucan LiXinming XuKelin Xu Research 31 January 2026 Article: 129 Disproportionate climate burden of rising temperatures on low birth weight in Pakistan 气温上升给巴基斯坦低出生体重儿带来的不成比例的气候负担 Syeda H. FatimaCorey J. A. BradshawZohra S. Lassi Research 31 January 2026 Article: 128 Part of 1 collection: Climate change and human health 所属专题：气候变化与人类健康 Enhancing oncolytic virotherapy with a tri-specific T-cell engager targeting CD3ε, EpCaM, and 4-1BB: preclinical evaluation and implications for cancer immunotherapy 利用靶向CD3ε、EpCaM和4-1BB的三特异性T细胞衔接器增强溶瘤病毒疗法：临床前评估及对癌症免疫疗法的启示 Zhongyi DongHaoyu ZhangZizhen Zhang Research 30 January 2026 Article: 127 Targeting BCL-XL for degradation synergizes with gemcitabine against cholangiocarcinoma 靶向降解BCL-XL与吉西他滨联用对胆管癌具有协同治疗作用 Qinghua ZengYan ZhangYonghan He Research 30 January 2026 Article: 126 Association of DNA methylation with hypertension and blood pressure: a 7-year longitudinal study from KORA F4/FF4 DNA甲基化与高血压及血压的关联：来自KORA F4/FF4的7年纵向研究 Liye LaiAngelina Shin Yee JongMelanie Waldenberger Research 04 February 2026 Article: 125 Shared genetic architecture of psychoactive substance use and pan-cancer: insights from a large‑scale genome‑wide cross‑trait analysis 精神活性物质使用与泛癌症的共享遗传结构：来自大规模全基因组跨性状分析的见解 Jiahang SongPengzhu LiOlivier Gires Research 05 February 2026 Article: 124 Part of 1 collection: Psychoactives: Recreational drugs repurposed as novel therapies 所属专题：精神活性物质：作为新型疗法的娱乐性药物再利用 Intrauterine exposure to maternal diabetes and the risk of developing epilepsy in children: a national cohort study of 2.3 million children 宫内暴露于母体糖尿病与儿童患癫痫风险的关系：一项针对230万儿童的全国队列研究 Muhammad Zakir HossinMartina PerssonNeda Razaz Research 14 February 2026 Article: 123 ADHD and adherence to antihypertensive medication treatment: a multinational cohort study 多动症与坚持抗高血压药物治疗的关系：一项多国队列研究 Honghui YaoYiling ZhouZheng Chang Research 20 February 2026 Article: 122 How effective is rejoining a long-term weight loss program? The 5- and 10-year MRI-assessed Follow Interventions Trial (FIT) project 重新加入长期减肥计划的效果如何？5年和10年磁共振成像评估的随访干预试验（FIT）项目 Hadar KleinDafna PachterIris Shai Research 30 January 2026 Article: 121 Part of 1 collection: Weight loss interventions and their health impacts 所属专题：减肥干预措施及其对健康的影响 Correction: Brain state dynamics and working memory in patients with schizophrenia and unaffected siblings 更正：精神分裂症患者及其未受影响兄弟姐妹的脑状态动态与工作记忆 Feiwen WangJie YangLena Palaniyappan Correction 20 February 2026 Article: 120 Ocular light and optical radiation exposure as a modifiable environmental determinant of health: expert consensus on research gaps and priorities 作为可改变的环境健康决定因素的眼睛光暴露和光学辐射暴露：关于研究空白和优先事项的专家共识 Manuel SpitschanAnna M. BillerJohannes Zauner Guideline 29 January 2026 Article: 119 Dietary patterns and neuropsychological function in adolescents: a cross-sectional and longitudinal study 青少年饮食模式与神经心理功能：一项横断面和纵向研究 Alexios ManidisNicolas Ayala-AldanaJordi Julvez Research 29 January 2026 Article: 118 Part of 1 collection: Child and adolescent psychiatry 所属专题：儿童与青少年精神病学 Factors impacting the delivery of contextualized care in serious illness: a focus group study with healthcare professionals 影响危重症患者情境化护理实施的因素：一项针对医疗保健专业人员的焦点小组研究 Linda ModderkolkYvonne SchoonAnne B. Wichmann Research 29 January 2026 Article: 117 Part of 1 collection: Palliative care and medicine 所属专题：姑息治疗与医学 Early interventions for first onset of symptoms of mental health conditions: an umbrella review of systematic reviews 针对心理健康问题首次出现症状的早期干预措施：一项系统综述的伞式评价 Jasmine LeePhoebe BarnettSonia Johnson Research 29 January 2026 Article: 116 Harmonic patterns embedded in ictal EEG signals in focal epilepsy: new insight into the epileptogenic zone 局灶性癫痫发作间期脑电图信号中嵌入的谐波模式：对致痫区的新见解 Lingli HuLingqi YeShuang Wang Research 28 January 2026 Article: 115 Part of 1 collection: Epilepsy: Seizure prevention, treatment, and epidemiology 所属专题合集：癫痫：发作预防、治疗和流行病学 Effects of aerobic or resistance exercise on sleep and cancer-related fatigue in patients with breast cancer during or after neoadjuvant chemotherapy: a 3-arm randomized controlled trial 有氧运动或抗阻运动对新辅助化疗期间或之后乳腺癌患者睡眠和癌症相关疲劳的影响：一项三臂随机对照试验 Alexander HaussmannMartina E. SchmidtKaren Steindorf Research 28 January 2026 Article: 114 Neutrophil methylmalonic acid promotes microthrombus formation and adverse cardiac remodeling post-myocardial infarction through activating IL-6 signaling pathway-mediated NETosis 中性粒细胞甲基丙二酸通过激活IL-6信号通路介导的中性粒细胞胞外诱捕网形成（NETosis），促进心肌梗死后微血栓形成和不良心脏重构 Yige LiuJiaxin WangShaohong Fang Research 28 January 2026 Article: 113 Statistical approaches to analyse the combined effect of seven air pollutants and breast cancer risk: a case–control study nested in the French E3N-Generations cohort 分析七种空气污染物联合作用与乳腺癌风险关系的统计方法：一项嵌套于法国E3N-Generations队列的病例对照研究 Camille GiampiccoloBéatrice FerversAmina Amadou Research 28 January 2026 Article: 112 Part of 1 collection: Carcinogens and human health 所属专题合集：致癌物与人类健康 Is behaviour change communication guidance for general practice healthcare professionals evidence based? A systematic review 针对全科医疗保健专业人员的行为改变沟通指导是否具有循证依据？一项系统综述 Anika Schwarze-ChintapatlaJonathan Livingstone-BanksCharlotte Albury Research 16 February 2026 Article: 111 Patient-centred postpartum care provision: virtual delivery, tiered escalation, and tensions between efficiency, preference, and clinical concern 以患者为中心的产后护理服务提供：虚拟服务模式、分级转诊机制，以及效率、患者偏好与临床关切之间的矛盾 Sergio A. SilverioJulia R. B. BrownEmma L. Duncan Research 24 February 2026 Article: 110 Ethical dilemmas in climate change and healthcare delivery: a cross-sectional survey of US patient perspectives 气候变化与医疗服务中的伦理困境：一项针对美国患者观点的横断面调查 Andrew HantelEmily SenayGregory A. Abel Research 27 January 2026 Article: 109 Part of 1 collection: Climate change and human health 所属专题：气候变化与人类健康 Inetetamab plus camrelizumab and utidelone for pretreated HER2-positive advanced breast cancer: a prospective, single-arm, phase 2 study 伊尼妥单抗联合卡瑞利珠单抗和优替德隆治疗既往接受过治疗的HER2阳性晚期乳腺癌：一项前瞻性、单臂、2期研究 Huimin LvTao SunMin Yan Research 27 January 2026 Article: 108 Potential of earlier primary care health checks for prevention of cardiovascular events in younger age groups: population-based study in the United Kingdom 早期初级保健健康检查对预防年轻人群心血管事件的潜力：英国一项基于人群的研究 Catherine A. ScottLinxin LiPeter M. Rothwell Research 24 January 2026 Article: 107 Comparative effects of salt substitutes on blood pressure, cardiovascular events and mortality: a systematic review and network meta-analysis 盐替代品对血压、心血管事件和死亡率影响的比较：一项系统综述和网络荟萃分析 Honghao LaiGihad NesrallahBradley C. Johnston Research 23 January 2026 Article: 106 Association of short-term exposure to ambient air pollutants with liver function and mediation by fasting insulin: evidence from a rural cohort in China 短期暴露于环境空气污染物与肝功能的关系及空腹胰岛素的中介作用：来自中国农村队列研究的证据 Mengxin WangAogang ZhangWeidong Wu Research 23 January 2026 Article: 105 Part of 1 collection:Climate change and human health 所属专题：气候变化与人类健康 Adjuvant tislelizumab, lenvatinib, and capecitabine for resected biliary tract cancer: a prospective phase II trial 辅助治疗：替雷利珠单抗、仑伐替尼和卡培他滨用于可切除的胆道癌：一项前瞻性II期试验 Yun FengNing ZhangLu Wang Research 23 January 2026 Article: 104 Comparative effectiveness of sleeve gastrectomy and semaglutide for weight loss and metabolic outcomes: a prospective non-randomized study 袖状胃切除术与司美格鲁肽对减重及代谢结局的疗效比较：一项前瞻性非随机研究 Yutung YenQian ZhangYi Chen Research 22 January 2026 Article: 103 Part of 1 collection:Weight loss interventions and their health impacts 所属专题：减重干预措施及其对健康的影响 Impact of sex on outcomes in patients treated with drug-coated balloons versus drug-eluting stents for de novo coronary artery lesions: Insights from the REC-CAGEFREE I trial 性别对接受药物涂层球囊与药物洗脱支架治疗的新发冠状动脉病变患者预后的影响：来自REC-CAGEFREE I试验的见解 Ping WangJingyu ZhouLing Tao Research 22 January 2026 Article: 102 Assessing the comorbidity between asthma and depression through polygenic risk scoring and time-to-event models 通过多基因风险评分和时间事件模型评估哮喘与抑郁的共病情况 Xueting WangJun HeRenato Polimanti Research 22 January 2026 Article: 101 Persistent immune, coagulation and cardiac dysregulation are correlated with later post-discharge mortality in children with severe malnutrition 严重营养不良儿童出院后持续存在的免疫、凝血和心脏功能失调与后期死亡率相关 Brenda KamauEvans O. MudiboJames M. Njunge Research 22 January 2026 Article: 100 Correction: Computer assisted verbal autopsy: comparing large language models to physicians for assigning causes to 6939 deaths in Sierra Leone from 2019–2022 更正：计算机辅助口头尸检：对比大型语言模型与医生为2019 - 2022年塞拉利昂6939例死亡分配病因的情况 Richard WenAnteneh Tesfaye AssalifRashid Ansumana Correction 14 February 2026 Article: 99 Characteristics of parks associated with depression in women only: a cross-sectional study of 329,363 adults 仅与女性抑郁相关的公园特征：一项针对329,363名成年人的横断面研究 Jonathan R. OlsenNatalie NichollsRichard Mitchell Research 21 January 2026 Article: 98 Weight change mediates the effect of lifestyle intervention on postpartum diabetes in women with prior gestational diabetes: a secondary analysis of a randomized clinical trial 在生活方式干预对既往妊娠期糖尿病女性产后糖尿病影响中，体重变化的中介作用：一项随机临床试验的二次分析 Weiqin LiHuikun LiuGang Hu Research 21 January 2026 Article: 97 Part of 1 collection: Diagnosis and management of gestational diabetes 所属专题：妊娠期糖尿病的诊断与治疗 Global drivers of heart failure attributable to atrial fibrillation/flutter: insights fromJoinpoint regression, age-period-cohort analysis, and future projections from the GBD 2021 Study 心房颤动/扑动所致心力衰竭的全球驱动因素：来自折点回归、年龄-时期-队列分析以及2021年GBD（全球疾病负担）研究未来预测的见解 Jing ChenZhu LiGregory Y. H. Lip Research 20 January 2026 Article: 96 Part of 1 collection: Cardiomyopathy and cardiac arrhythmias 所属专题：心肌病与心律失常 Overdiagnosis of gestational diabetes mellitus during Ramadan: a retrospective population-based study in Catalonia, Spain 斋月期间妊娠期糖尿病的过度诊断：西班牙加泰罗尼亚地区一项基于人群的回顾性研究 Marta CarrascoBogdan VlachoMarta Hernández Research 20 January 2026 Article: 95 Part of 1 collection: Diagnosis and management of gestational diabetes 所属专题：妊娠期糖尿病的诊断与管理 Why current risk factor-based approaches fall short in predicting stillbirth: a national cohort study of nulliparous women in England 为何当前基于风险因素的方法在预测死胎方面存在不足：英格兰初产妇全国队列研究 A. HowellB. ThilaganathanTommy’s National Centre for Maternity Improvement Research 22 January 2026 Article: 94 Pay-it-forward intervention increased pneumococcal vaccine uptake among older adults in China: a randomized controlled trial 爱心传递干预措施提高了中国老年人肺炎球菌疫苗的接种率：一项随机对照试验 Jiao QinChunxing TaoBingyu Liang Research 19 January 2026 Article: 93 The impact of e-cigarette taxation: a systematic review and meta-analysis on usage, pricing strategies, and public health implications 电子烟税收的影响：针对使用情况、定价策略和公共卫生影响开展的系统综述和荟萃分析 Quan WangZheng ZhuLi Yang Research 17 January 2026 Article: 92 Safety and preliminary efficacy results of IBI389, an anti-Claudin18.2×CD3 bispecific antibody, in patients with solid tumors and gastric or gastro-esophageal tumors: a phase 1 dose escalation and expansion study 抗Claudin18.2×CD3双特异性抗体IBI389在实体瘤及胃或胃食管肿瘤患者中的安全性与初步疗效结果：一项1期剂量递增与扩展研究 Xiaoyu LiRuihong DaiFeng Bi Research 16 January 2026 Article: 91 Part of 1 collection: Clinical trials for gastrointestinal cancer 所属专题：胃肠道癌症临床试验 Comparative risk of delirium among opioid users for non-cancer pain: a retrospective cohort study 比较非癌症疼痛使用阿片类药物者发生谵妄的风险：一项回顾性队列研究 Carlos Raul Ramirez MedinaMark LuntMeghna Jani Research 31 January 2026 Article: 90 Association between preoperative interruption of antiplatelet therapy and postoperative thrombotic risk after minimally invasive surgery for abdominopelvic cancer in patients treated with P2Y12 inhibitors 接受P2Y12抑制剂治疗的患者行腹部盆腔癌症微创手术时，术前中断抗血小板治疗与术后血栓形成风险之间的关联 Masashi KubotaSatomi YoshidaKoji Kawakami Research 16 January 2026 Article: 89 Comparative outcomes of distal ureterectomy vs. radical nephroureterectomy in high-risk distal ureteral urothelial carcinoma: a two-center cohort study in Northern and Southern China 高危远端输尿管尿路上皮癌患者行远端输尿管切除术与根治性肾输尿管切除术的疗效比较：中国北方和南方两家中心的队列研究 Junyi XieZhenhua LiuWei Yu Research 16 January 2026 Article: 88 Co-occurrence patterns and related risk factors of dementia and Parkinson’s disease among older adults across 204 countries and territories: a spatial correspondence and systematic analysis 204个国家和地区老年人痴呆症与帕金森病共现模式及相关危险因素：空间对应与系统分析 Weiyang ChenMin DuJue Liu Research 15 January 2026 Article: 87 Accelerated brain aging in amyotrophic lateral sclerosis and its prognostic associations: a cohort study 肌萎缩侧索硬化症加速脑衰老及其预后关联：一项队列研究 Chenhao FangJiaoting JinShuoqiu Gan Research 15 January 2026 Article: 86 Part of 1 collection: Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题：肌萎缩侧索硬化症：最新进展与新动态 The clinical effects and cortical mechanism of rTMS in poststroke lateropulsion: a randomized controlled trial 重复经颅磁刺激（rTMS）对脑卒中后侧方倾倒的临床效果及皮质机制：一项随机对照试验 Lijiao MengRaymond C. C. TsangQuan Wei Research 14 January 2026 Article: 85 5-HT2C receptors in the glutamatergic neurons of dorsal raphe nucleus orchestrate the comorbidity of pain and anxiety in mice 中脑背侧缝际核谷氨酸能神经元中的5-HT2C受体调控小鼠疼痛与焦虑共病 Qi ZhangLi XieRiyue Jiang Research 13 January 2026 Article: 84 The clinical landscape of POLE-mutant colorectal cancer: a retrospective analysis of real-world outcome POLE突变型结直肠癌的临床现状：一项现实结局的回顾性分析 Ting XuXuhui ZhangJian Li Research 13 January 2026 Article: 83 The efficacy and safety of duloxetine in treating refractory chronic cough: a randomized clinical trial 度洛西汀治疗难治性慢性咳嗽的有效性和安全性：一项随机临床试验 Shengyuan WangHeng WuXianghuai Xu Research 13 January 2026 Article: 82 Impact of diagnosis to ablation time on clinical outcomes in patients with atrial fibrillation: post hoc analysis of the CABANA trial 心房颤动患者从诊断到消融的时间对临床预后的影响：CABANA试验的事后分析 Manlin ZhaoYang ChenGregory Y. H. Lip Research 12 January 2026 Article: 81 Part of 1 collection: Cardiomyopathy and cardiac arrhythmias 所属专题：心肌病与心律失常 Elevated maternal pre-transfer serum lipid peroxidation is associated with implantation failure and early pregnancy loss 母体转运前血清脂质过氧化水平升高与着床失败和早期流产相关 Zhangwei JiaJunxiang RenJunhao Yan Research 12 January 2026 Article: 80 Impact of Helicobacter pylori infection on gut and intratumoral microbiome and its association with immunotherapy response in gastrointestinal cancer 幽门螺杆菌感染对肠道和肿瘤内微生物组的影响及其与胃肠道癌症免疫治疗反应的关联 Keren JiaYang ChenLin Shen Research 12 January 2026 Article: 79 Part of 1 collection: Gut microbiota: New treatments of human disease 所属专题：肠道微生物组：人类疾病的新疗法 SGLT-2 Inhibitor use and liver-related and mortality outcomes in patients with type 2 diabetes and compensated cirrhosis SGLT-2抑制剂在2型糖尿病合并代偿性肝硬化患者中的应用及其对肝脏相关预后和死亡率的影响 Tien-Shin ChouDaniel Hsiang-Te TsaiEdward Chia-Cheng Lai Research 12 January 2026 Article: 78 Extrapolating from trials to clinic: a predictive model defining the boundaries of benefit for multiple sclerosis therapies in real-world populations based on systematic review 从试验外推至临床：基于系统综述构建预测模型，界定多发性硬化症疗法在现实人群中的获益边界 Bibiana BielekovaTianxia WuMichael Calcagni Research 10 January 2026 Article: 77 A validated model for early prediction of group A streptococcal aetiology in necrotising soft tissue infections using minimal patient data 利用最少患者数据早期预测坏死性软组织感染A组链球菌病因的验证模型 Sonja KatzJaco SuijkerEdoardo Saccenti Research 10 January 2026 Article: 76 Trends in lipid-lowering therapies in acute coronary syndromes after Chinese new insurance policy: a real-world analysis 中国新医保政策实施后急性冠状动脉综合征患者降脂治疗趋势：一项现实情况分析 Xin ZhaoShujing WuJunbo Ge Research 09 January 2026 Article: 75 Fragmented healthcare and effective maternal coverage in Mexico, 2009–2023 2009-2023年墨西哥医疗体系碎片化与有效孕产妇医疗保障 Edson Serván-MoriDiego Cerecero-GarcíaOctavio Gómez-Dantés Research 09 January 2026 Article: 74 Circadian rhythm disruption in cardiovascular disease: a systematic review and meta-analysis of mechanistic evidence from animal models 昼夜节律紊乱与心血管疾病：基于动物模型机制证据的系统综述与荟萃分析 Mrinal K. DasEvi De RyckJohanna Samulin Erdem Research 09 January 2026 Article: 73 Frailty progression: The role of multimorbidity configurations in frailty transitions and predicting mortality risk among older adults 衰弱进展：多重共病组合模式在老年人衰弱状态转变及死亡风险预测中的作用 Rafael Ogaz-GonzálezQian ZouEva Corpeleijn Research 08 January 2026 Article: 72 Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学及风险因素的作用 Effect of probiotic supplementation on the gut microbiota diversity in healthy populations: a systematic review and meta-analysis of randomised controlled trials 益生菌补充剂对健康人群肠道微生物群多样性的影响：一项针对随机对照试验的系统综述和荟萃分析 Anna Júlia ÉliásKincső Csepke Földvári-NagyLászló Földvári-Nagy Research 07 January 2026 Article: 71 Part of 1 collection: Gut microbiota: New treatments of human disease 所属专题：肠道微生物群：人类疾病的新疗法 Pain and high-impact pain in community-dwelling older adults in Australia and relation to sociodemographic and health-related factors, including physical disability, psychological distress, and quality of life 澳大利亚社区居住老年人的疼痛及重度疼痛情况，及其与社会人口统计学因素和健康相关因素（包括身体残疾、心理困扰和生活质量）的关系 Grace JoshySaman Khalatbari-SoltaniEmily Banks Research 22 January 2026 Article: 70 Mortality and morbidity burden associated with smoking: evidence from a 1.6 million cohort in Hong Kong 与吸烟相关的死亡率和发病率负担：来自香港160万人队列研究的证据 Boyuan WangTingting ChenEric Yuk Fai Wan Research 06 January 2026 Article: 69 Part of 1 collection:Carcinogens and human health 所属专题：致癌物与人类健康 Association between long-term extreme high temperature and mortality: a 9-million prospective cohort study 长期极端高温与死亡率之间的关系：一项900万人的前瞻性队列研究 Bo YinQi HuangKuiying Gu Research 06 January 2026 Article: 68 Part of 1 collection:Climate change and human health 所属专题：气候变化与人类健康 Unraveling the neurotoxic mechanisms of tranexamic acid in epilepsy induction: a network toxicology and molecular docking approach 利用网络毒理学和分子对接方法揭示氨甲环酸诱发癫痫的神经毒性机制 Tianyang ChenDalong LiuXiangYang Leng Research 03 January 2026 Article: 67 Part of 1 collection: Epilepsy: Seizure prevention, treatment, and epidemiology 所属专题：癫痫：癫痫发作的预防、治疗和流行病学 Trop2 immuno-PET/CT imaging of prostate cancer: a proof-of-concept translational study Trop2免疫正电子发射断层扫描/计算机断层扫描（PET/CT）成像在前列腺癌中的应用：一项概念验证性转化研究 Xingru LongShuxian AnDawei Jiang Research 31 December 2025 Article: 66 Methylmalonate accumulation contributes to myocardial vulnerability post-reperfusion: a novel therapeutic target and prognostic biomarker 甲基丙二酸蓄积促进再灌注后心肌脆弱性：一种新型治疗靶点和预后生物标志物 Shanjie WangJunChen GuoShaohong Fang Research 31 December 2025 Article: 65 Prophylactic effect of intraoperative sodium oxybate on postoperative delirium in older patients undergoing major orthopedic surgery: a randomized clinical trial 术中羟丁酸钠对接受大型骨科手术的老年患者术后谵妄的预防作用：一项随机临床试验 Meiying CuiHang XuePing Zhao Research 31 December 2025 Article: 64 Part of 1 collection:Psychoactives: Recreational drugs repurposed as novel therapies 所属专题：精神活性物质：将娱乐性药物重新用于新型疗法 Prevalence of hysterectomy in urban China and associations between metabolic disorders and hysterectomy: a multicenter population-based study involving over 9 million women 中国城市子宫切除术的流行情况以及代谢紊乱与子宫切除术之间的关系：一项涉及超过900万女性的多中心人群基础研究 Yanrui BiYuan MaYing Gao Research 30 December 2025 Article: 63 Sex differences in cardiac risk and kidney function: serum creatinine versus cystatin C 心脏风险和肾功能方面的性别差异：血清肌酐与胱抑素C的对比 Nicole L. De La MataJames A. HedleyJennifer S. Lees Research 30 December 2025 Article: 62 The association of post-conization pregnancy with subsequent cervical lesions: evidence from a nationwide cohort in Sweden 锥切术后妊娠与后续宫颈病变的关联：来自瑞典全国队列研究的证据 Huan YiJimiao HuangJianguang Ji Research 29 December 2025 Article: 61 Tibial periosteal distraction for ischemic leg ulcers: animal and clinical cohort study 胫骨骨膜牵张术治疗缺血性下肢溃疡：动物及临床队列研究 Peilin ZhouWenqiang WangQikai Hua Research 28 December 2025 Article: 60 Preoperative conversion therapy of camrelizumab combined with paclitaxel and nedaplatin for unresectable advanced esophageal squamous cell carcinoma: a phase 2 study 卡瑞利珠单抗联合紫杉醇和奈达铂对不可切除的晚期食管鳞癌的术前转化治疗：一项2期研究 Jinhong ZhuJinfeng ZhangJianqun Ma Research 28 December 2025 Article: 59 Clustering of cardiometabolic risk factors, physical activity, digital exclusion, and depressive symptoms trajectories in adults aged 50years and older: findings from two prospective cohort studies 50岁及以上成年人心血管代谢风险因素聚集、身体活动、数字排斥及抑郁症状轨迹：两项前瞻性队列研究的发现 Xiaosheng DongJiaqiang XiaoChengchao Zhou Research 28 December 2025 Article: 58 Eligibility of real-world patients for aspirin primary prevention trials in cardiovascular disease 现实中符合心血管疾病阿司匹林一级预防试验资格的患者情况 Michael HolderDaniel R. MoralesBruce Guthrie Research 27 January 2026 Article: 57 Polygenic risk score-guided personalized osteoporosis screening: a population-based study 基于多基因风险评分指导的个性化骨质疏松症筛查：一项基于人群的研究 Dongxue WangWen SunJianguang Ji Research 14 January 2026 Article: 56 Urea cycle modulation by combined SGLT2 inhibitors and metformin SGLT2抑制剂与二甲双胍联合用药对尿素循环的调节作用 Makoto HaradaJonathan AdamRui Wang-Sattler Research 08 January 2026 Article: 55 Safety and neuroprotective efficacy of the VCP inhibitor ML240 in large-animal and human retinal explants: a preclinical ex vivo study VCP抑制剂ML240在大型动物及人视网膜外植体中的安全性和神经保护功效：一项临床前离体研究 Ana-Cristina Almansa-GarcíaAngela ArmentoBlanca Arango-Gonzalez Research 10 January 2026 Article: 54 Impact of an eight-week isocaloric vegan dietary intervention on hemogram parameters and lymphocyte subsets: a randomized-controlled trial 为期八周的等热量纯素饮食干预对血细胞参数和淋巴细胞亚群的影响：一项随机对照试验 Julian HerterFrieda StübingMaximilian Andreas Storz Research 10 January 2026 Article: 53 Association between psychosocial factors and adverse effects of light-to-moderate ambient heat in patients with chronic diseases: results of the prospective cohort study CLIMATE-II 社会心理因素与轻至中度环境热对慢性病患者不良影响之间的关联：前瞻性队列研究CLIMATE-II的结果 Ingmar SchäferValentina PauckeDagmar Lühmann Research 15 January 2026 Article: 52 Part of 1 collection:Climate change and human health 所属专题：气候变化与人类健康 Maternal infection during pregnancy and the risk of childhood cancer: a systematic review and meta-analysis 孕期母体感染与儿童期患癌风险：一项系统综述和荟萃分析 Loviisa MulanjeLara Kim BrackmannRajini Nagrani Research 14 January 2026 Article: 51 Part of 1 collection:Carcinogens and human health 所属专题：致癌物与人类健康 Supplementary biomarker testing in molecular tumor boards increases actionable therapy recommendations: a prospective real-world study of 658 patients 分子肿瘤委员会中的补充生物标志物检测增加了可采取治疗措施的建议：一项针对658例患者的前瞻性真实世界研究 Alexander ScheiterSimon MellinKirsten Utpatel Research 14 January 2026 Article: 50 Computer assisted verbal autopsy: comparing large language models to physicians for assigning causes to 6939 deaths in Sierra Leone from 2019–2022 计算机辅助口头尸检：对比大型语言模型与医生对塞拉利昂2019 - 2022年6939例死亡原因的判定 Richard WenAnteneh Tesfaye AssalifRashid Ansumana Research 24 December 2025 Article: 49 Loss of Y chromosome and its implications in male amyotrophic lateral sclerosis: insights from the UK Biobank Y染色体缺失及其在男性肌萎缩侧索硬化症中的影响：来自英国生物银行的研究见解 Wei-Ming SuQing-Qing DuanYong-Ping Chen Research 24 December 2025 Article: 48 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题：肌萎缩侧索硬化症：最新进展与新动态 Prenatal lipopolysaccharide exposure programs the early-life lung development by modulating mesenchymal fibroblasts in a time- and dose-dependent manner 产前脂多糖暴露通过调节间充质成纤维细胞以时间和剂量依赖性方式来影响早期肺部发育 Ying DongStefan HadzicSaverio Bellusci Research 22 December 2025 Article: 47 Life course socioeconomic trajectories and chronic disease risk in later life among 30,055 older adults across 27 European countries (the SHARE study) 27个欧洲国家30,055名老年人生命历程中的社会经济轨迹与晚年慢性疾病风险（基于SHARE研究） Taymara C. AbreuJoline W. J. BeulensJoreintje D. Mackenbach Research 20 December 2025 Article: 46 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学与风险因素的作用 Validation of a novel patient-reported measure of the burden of digital care in diabetes 由糖尿病患者报告的数字化护理负担新型测评工具的验证 Misk Al ZahidyJennifer L. RidgewayVictor M. Montori Research 20 December 2025 Article: 45 Determinants of long-term SARS-CoV-2 immune responses in asymptomatic-to-moderate COVID-19 patients in sub-Saharan Africa 撒哈拉以南非洲地区无症状至中度 COVID-19 患者长期 SARS-CoV-2 免疫应答的决定因素 Víctor L. de RiojaOdin GoovaertsGemma Moncunill Research 14 January 2026 Article: 44 Camrelizumab and apatinib in Chinese patients with locally advanced or metastatic radioiodine-refractory differentiated thyroid cancer: an exploratory open-label, single-arm trial 卡瑞利珠单抗联合阿帕替尼治疗中国局灶性晚期或转移性放射性碘难治性分化型甲状腺癌：一项探索性开放标签单臂试验 Xin ZhangDi SunYansong Lin Research 18 December 2025 Article: 43 Urinary polyphenol signature of the Mediterranean diet is associated with lower cardiovascular disease risk: the PREDIMED trial 地中海饮食的尿液多酚特征与心血管疾病风险较低相关：PREDIMED 试验 Inés Domínguez-LópezPolina GalkinaRosa M. Lamuela-Raventós Research 18 December 2025 Article: 42 Meta-analysis and external validation of a risk model for gastrointestinal bleeding after percutaneous coronary intervention 经皮冠状动脉介入治疗后胃肠道出血风险模型的荟萃分析及外部验证 Hualong MaCong PengQiaohong Yang Research 18 December 2025 Article: 41 DNA methylation-based clocks, tobacco smoking, and lung cancer risk 基于DNA甲基化的生物钟、烟草吸烟与肺癌风险 Ricardo Cortez Cardoso PenhaJustina Ucheojor OnwukaMattias Johansson Research 17 December 2025 Article: 40 Part of 1 collection:Carcinogens and human health 所属专题：致癌物与人类健康 Risk and protective factors associated with brain grey matter patterns in a population-based cohort of cognitively unimpaired 70years old 认知功能未受损的70岁老年人基于人口的队列中，与大脑灰质模式相关的风险和保护因素 Giulia LorenzonAnna MarsegliaEric Westman Research 17 December 2025 Article: 39 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学和风险因素的作用 Street view-derived city built environment and vulnerability to temperature extremes: a nationally representative population-based cohort study 基于街景图像的城市建成环境与极端温度脆弱性：一项全国代表性人口队列研究 Wanzhou WangChao YangLuxia Zhang Research 16 December 2025 Article: 38 Part of 1 collection:Climate change and human health 所属专题：气候变化与人类健康 A booster dose of an inactivated SARS-CoV-2 vaccine targeting virus variants sustains protective humoral and cellular immunity 针对病毒变异株的灭活严重急性呼吸系统综合征冠状病毒2（SARS-CoV-2）疫苗加强针可维持保护性体液免疫和细胞免疫 Constanza MéndezLinmar Rodríguez-GuilarteSusan M. Bueno Research 15 December 2025 Article: 37 Dapagliflozin alleviates sunitinib-induced cardiotoxicity through AMPKα-PPARα axis and enhances the sensitivity of renal cell carcinoma to sunitinib 达格列净通过AMPKα-PPARα轴减轻舒尼替尼诱导的心脏毒性，并增强肾细胞癌对舒尼替尼的敏感性 Shi-yu HuangMin HuLei Wang Research 15 December 2025 Article: 36 Network dysfunction underlying verbal fluency deficits in newly diagnosed epilepsy: a resting-state fMRI functional connectivity study 新诊断癫痫患者言语流畅性缺陷背后的网络功能障碍：一项静息态功能磁共振成像功能连接研究 Fangzhou LiuPing JiangLing Liu Research 13 December 2025 Article: 35 Part of 1 collection:Epilepsy: Seizure prevention, treatment, and epidemiology 所属专题：癫痫：癫痫发作的预防、治疗和流行病学 Long-term quality of life in non-epithelial ovarian cancer survivors: TMRG-GINECO-Vivrovaire rare tumors case–control study 基于广西新生儿地中海贫血基因组图谱计划开展的家庭三联体/四联体分析 Coraline DubotIsabelle Ray-CoquardFlorence Joly Research 12 December 2025 Article: 34 Family trios/quartets analysis based on the Newborn Genomic Atlas for Thalassemia project in Guangxi 非上皮性卵巢癌幸存者的长期生活质量：TMRG-GINECO-Vivrovaire罕见肿瘤病例对照研究 Wei WeiChunrong GuiBaoheng Gui Research 12 December 2025 Article: 33 Hyperuricemic persons use more analgesics than normouricemic—is asymptomatic hyperuricemia really asymptomatic? 高尿酸血症患者比血尿酸正常者使用更多镇痛药——无症状性高尿酸血症真的“无症状”吗？ Janis TimsansJenni Emilia KauppiMarkku Kauppi Research 11 December 2025 Article: 32 Social isolation, loneliness, and multi-system medical conditions: phenome-wide association and disease-trajectory analyses 社会孤立、孤独感与多系统医学病症：全表型组关联分析及疾病轨迹研究 Tingshan DuanZhi CaoChenjie Xu Research 10 December 2025 Article: 31 Digital marketing techniques within online food retail platforms: a scoping review 在线食品零售平台中的数字营销技巧：一项范围综述 Adyya GuptaCatherine E. HugginsAnna Peeters Research 10 December 2025 Article: 30 Dramatic increases in redundant publications in the Generative AI era 生成式人工智能时代冗余出版物数量急剧增加 Danny MaupinTulsi SuchakMatt Spick Research 09 December 2025 Article: 29 Cardiovascular risk burden and guideline-recommended lipid and blood pressure goals in an Italian Cohort: findings from the HUMTELEMED web-based platform 意大利人群心血管风险负担及指南推荐的血脂和血压目标达成情况：HUMTELEMED网络平台的发现 Matteo LandolfoAlessandro GezziRiccardo Sarzani Research 09 December 2025 Article: 28 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学及风险因素的作用 Efficacy and safety of Janus kinase 1/2 inhibitor KL130008 in active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase II trial Janus激酶1/2抑制剂KL130008治疗活动性类风湿关节炎的有效性和安全性：一项随机、双盲、安慰剂对照的II期试验 Yue ChengHonghu TangYi Liu Research 09 December 2025 Article: 27 Risk stratification for endometrial cancer: independent and joint effects of polygenic risk score and body mass index in 129,829 UK Biobank participants 子宫内膜癌的风险分层：英国生物银行129,829名参与者中多基因风险评分和体重指数的独立及联合效应 Xuemin WangLaure DossusTracy A. O’Mara Research 10 February 2026 Article: 26 Maternal probiotics intake during pregnancy and exclusive colostrum breastfeeding are associated with a reduced risk of neonatal jaundice 孕期摄入益生菌及纯母乳喂养初乳与新生儿黄疸风险降低相关 Bekalu Kassie AlemuChi Chiu WangYao Wang Research 08 December 2025 Article: 25 Hepatic steatosis in postmenopausal women is characterized by distinct serum extracellular vesicle proteomic signatures 绝经后女性脂肪肝具有独特的血清细胞外囊泡蛋白质组特征 Patrick PirrotteBrooke LovellJohanna K. DiStefano Research 07 December 2025 Article: 24 Global, regional, and national temporal trends in the prevalence of environmental heat and cold exposure among older adults aged 60–99 years, 1990–2021: an age-period-cohort analysis based on the Global Burden of Disease Study 2021 基于2021年全球疾病负担研究，对1990 - 2021年60 - 99岁老年人环境热暴露和冷暴露患病率的全球、区域和国家时间趋势分析：一项基于年龄 - 时期 - 队列模型的分析 Shenghao XuJing WangJianlin Xiao Research 07 December 2025 Article: 23 Part of 1 collection:Climate change and human health 所属专题：气候变化与人类健康 Cyclophilin B deficiency enhances myocardial energy synthesis and protects against heart failure in preclinical models 亲环蛋白B缺乏可增强心肌能量合成，并在临床前模型中预防心力衰竭 Xiao ZongXierenayi TudiRong Tao Research 07 December 2025 Article: 22 Part of 1 collection:Cardiomyopathy and cardiac arrhythmias 所属专题：心肌病与心律失常 Normobaric hyperoxia for intracerebral hemorrhage: a randomized clinical trial 常压高氧治疗脑出血：一项随机临床试验 Zhiying ChenJiayue DingRan Meng Research 07 December 2025 Article: 21 Nationwide trends in pediatric hospitalizations for eating disorders in France between 2013 and 2022: a retrospective study using the national health insurance database Emmanuelle LogeaisFrançoise TroussierLilia Khendek 2013 - 2022年法国因进食障碍住院的儿科患者全国趋势：一项使用国家健康保险数据库的回顾性研究 Research 05 December 2025 Article: 20 Part of 1 collection:Child and adolescent psychiatry 所属专题：儿童与青少年精神病学 Self-management of vaginal pessaries for pelvic organ prolapse: multi-method process evaluation, linked to the TOPSY randomised controlled trial 盆腔器官脱垂阴道子宫托自我管理：与TOPSY随机对照试验相关的多方法过程评估 Carol BuggeMelanie Dembinskythe TOPSY team Research 05 December 2025 Article: 19 Large-scale plasma proteomics reveals bidirectional associations between sleep patterns and inflammatory bowel disease: a prospective cohort study 大规模血浆蛋白质组学研究揭示睡眠模式与炎症性肠病之间的双向关联：一项前瞻性队列研究 Kaixing LeYaru LiuZhigang Liu Research 05 December 2025 Article: 18 Association between socioeconomic status and diabetic retinopathy in individuals with type 1 diabetes: a systematic review and meta-analysis 1型糖尿病患者社会经济地位与糖尿病视网膜病变之间的关联：一项系统综述和荟萃分析 Fernando Sebastian-VallesSergio Núñez de Arenas-ArroyoJulia Martínez-Alfonso Review 05 December 2025 Article: 17 Patterns of disparity: age and socioeconomic differences in women’s smoking and quitting outcomes in Great Britain 差异模式：英国女性吸烟及戒烟结局的年龄和社会经济差异 Sarah E. JacksonCaitlin NotleySharon Cox Research 10 February 2026 Article: 16 Genomic pathogenic alterations in the SWI/SNF complex compromise the outcomes of immunotherapy in Chinese patients with KRAS-mutant NSCLC by downregulating STING expression SWI/SNF复合体中的基因组致病性改变通过下调STING表达损害中国KRAS突变型非小细胞肺癌患者的免疫治疗效果 Lingling GaoJie JiangXuchao Zhang Research 03 December 2025 Article: 15 Residential radon exposure and incident myocardial infarction and stroke risks in the All of Us Research Program “我们所有人”研究项目中住宅氡暴露与心肌梗死和卒中发病风险的关系 Jiajun LuoZhihao JinBriseis Aschebrook-Kilfoy Research 03 December 2025 Article: 14 Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet and cardiovascular disease and arrhythmias 用于延缓神经退行性变的地中海饮食-终止高血压膳食疗法干预措施（MIND）与心血管疾病及心律失常的关系 Pei QinFrederick K. HoJill P. Pell Research02 December 2025 Article: 13 Part of 1 collection: Cardiomyopathy and cardiac arrhythmias 所属专题：心肌病与心律失常 KoMethylNet: a novel epigenetic clock based on neural network analysis of DNA methylation data and epigenetic age acceleration in a Korean population KoMethylNet：基于神经网络分析DNA甲基化数据的新型表观遗传时钟及韩国人群的表观遗传年龄加速研究 Dabin YunKwangyeon OhNan Song Research 03 December 2025 Article: 12 Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学及风险因素的作用 Sleep and physical activity trade-offs and dementia risk: a prospective cohort study in UK Biobank participants 睡眠与体力活动的权衡与痴呆风险：英国生物样本库参与者的一项前瞻性队列研究 Stephanie YiallourouLachlan CribbMatthew P. Pase Research 03 December 2025 Article: 11 Part of 1 collection: Sleep and mental health 所属专题：睡眠与心理健康 Integration of gut microbiome and lipid metabolism reveals the anti-cancer effects of pentadecanoic acid on bladder cancer 肠道微生物组与脂质代谢的整合揭示十五烷酸对膀胱癌的抗癌作用 Ya-Ting ChenJing SuiEvan Yi-Wen Yu Research 03 December 2025 Article: 10 Part of 1 collection: Gut microbiota: New treatments of human disease 所属专题：肠道微生物群：人类疾病的新疗法 A social determinants-based county-level cardiovascular mortality index to identify high-risk counties in the USA 基于社会决定因素的美国县级心血管疾病死亡率指数，用于识别高风险县 Anqi ZhuBibhas ChakrabortyTazeen H. Jafar Research 02 December 2025 Article: 9 HIV infection and immunosenescence: challenges and intervention strategies HIV感染与免疫衰老：挑战与干预策略 Junyan JinQianqian XuBin Su Review 02 December 2025 Article: 8 Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学与风险因素的作用 Machine learning-based prediction of short-term outcomes in aneurysmal subarachnoid hemorrhage: a multicenter study integrating clinical and inflammatory indicators 基于机器学习的动脉瘤性蛛网膜下腔出血短期预后预测：一项整合临床与炎症指标的多中心研究 Weichong ZhouCong PengHui Shi Research 29 November 2025 Article: 7 The effectiveness and safety of a mobile application-based self-regulation intervention to support weight loss among adults living with obesity: a large-scale pragmatic randomised controlled trial 基于移动应用程序的自我调节干预措施在支持肥胖成年人减重方面的有效性与安全性：一项大规模实用性随机对照试验 Paul DoodyGina M. WrenPaul Aveyard Research 29 November 2025 Article: 6 Part of 1 collection: Weight loss interventions and their health impacts 所属专题：减重干预措施及其对健康的影响 Adiposity and the first-onset of diagnosed mental illnesses: a population-based cohort study of 10 million UK adults 脂肪堆积（肥胖程度）与首次确诊精神疾病的关系：一项基于1000万英国成年人的队列研究 Xue DongPaul AveyardMin Gao Research 29 November 2025 Article: 5 Efficacy of standard care versus acoustic therapy on acute tinnitus in idiopathic sudden sensorineural hearing loss: a randomized controlled trial 标准治疗与声治疗对特发性突发性感音神经性听力损失伴急性耳鸣的疗效对比：一项随机对照试验 Xinyi WangKe QiuYu Zhao Research 28 November 2025 Article: 4 Trends and socio-economic inequalities in overweight- and obesity-related premature cardiovascular disease mortality in Australia 澳大利亚超重与肥胖相关过早心血管疾病死亡的趋势及社会经济不平等状况 Tim Adair Research 29 January 2026 Article: 3 Assessing the impact of maternal blood pressure during pregnancy on perinatal health: a wide-angled Mendelian randomization study 评估孕期母体血压对围产期健康的影响：一项广角孟德尔随机化研究 Fernanda Morales-BersteinAna Gonçalves-SoaresMaria-Carolina Borges Research 14 January 2026 Article: 2 Part of 1 collection:Diagnosis and management of gestational diabetes 所属专题：妊娠期糖尿病的诊断与管理 Prevalence of use and interest in using glucagon-like peptide-1 receptor agonists for weight loss: a population study in Great Britain 胰高血糖素样肽-1受体激动剂用于减重的使用率及使用意愿：一项针对英国人群的研究 Sarah E. JacksonJamie BrownLion Shahab Research 08 January 2026 Article: 1 Part of 1 collection: Weight loss interventions and their health impacts 所属专题：减重干预措施及其对健康的影响

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临床试验 | 覆盖多亚型！4月淋巴瘤临床试验清单来啦~

各位亲爱的病友和家属们，我们整理了一批最值得关注的新药临床试验，大家可以根据下面的提示加微信咨询。我们会根据您的具体病情推荐适合的临床试验，安排就近入组。临床试验的药品和检查都是免费的，可以解决复发难治患者的一部分经济难题，更可以享受到最新的治疗，多一个走向新生的机会。以下临床试验信息会持续更新，请病友们关注淋巴瘤之家微信公众号淋巴瘤之家086了解最新信息，有任何疑问随时咨询。 *蓝色字体为本月新增临床试验 1.弥漫大B细胞淋巴瘤 1）复发难治：ROR1 ADC 入组要求：一线后，或既往接受至少两线全身治疗，在全身治疗期间或之后出现疾病进展的，经病理学确诊的弥漫大B。 2）复发难治：体内CD22 CAR-T 入组要求：CAR-T初治（≥2线治疗）或CAR-T经治（如 CD19 CAR-T失败）的复发/难治性患者；存在可测量病灶。 3）复发难治：CD19CD20双靶通用型CAR-T 入组要求：诊断为复发难治大B细胞淋巴瘤（LBCL），既往接受过至少2线系统性治疗，使用过蒽环类和CD20靶向药。 4）复发难治：ssCART-19 入组要求：年龄2-75周岁，复发/难治B细胞淋巴瘤，主要脏器功能符合要求。 5）复发难治：BCL-6 降解剂入组要求：必须接受过至少2线充分的系统性治疗（包括蒽环类药物以及至少一种抗CD20靶向治疗方案）。 6）复发难治：BTK抑制剂+R-GemOx 入组要求：经一线全身化疗、免疫疗法、免疫化疗方案治疗后为复发或难治且不适合移植的DLBCL患者，有可测量病灶。 7）复发难治：CD19 CAR-T 入组要求：诊断为CD19阳性的复发难治弥漫大 B 细胞淋巴瘤（DLBCL），既往接受过至少2线系统性治疗，使用过蒽环类和CD20靶向药。 8）复发难治：CD19CD3双抗入组要求：年龄18-75岁，二线后DLBCL，CD19阳性，无心包积液，有可评估病灶。 9）复发难治：CD19/CD22 CAR-T 入组要求：确诊B-NHL，经组织学确诊为CD19和/或CD22阳性；预期生存时间超过12周；具有可测量病灶。报名方式：加微信 17762685155，备注“复发难治大B”。 10）初治：原发纵隔大B细胞淋巴瘤（PMBCL）入组要求：未接受过任何针对 PMBCL 的治疗； IPI 评分 0-3。报名方式：加微信17762685155，备注“原发纵隔大B”。 2. 滤泡性淋巴瘤 1）复发难治：ROR1 ADC 入组要求：既往接受至少两线全身治疗，在全身治疗期间或之后出现疾病进展的经病理学确证的非霍奇金B细胞淋巴瘤 2）复发难治：体内CD22 CAR-T 入组要求：CAR-T初治（≥2线治疗）或CAR-T经治（如 CD19 CAR-T失败）的复发/难治性患者；存在可测量病灶： 3）复发难治：ssCART-19 入组要求：年龄2-75周岁，复发/难治B细胞淋巴瘤，主要脏器功能符合要求。 4）复发难治：CD19CD20通用型CAR-T 入组要求：既往接受过至少2线系统性治疗，使用过蒽环类和CD20靶向药（抗CD20维持不算一线）。 5）复发难治：BCL-6 降解剂入组要求：必须接受过至少2线充分的系统性治疗（包括蒽环类药物以及至少一种抗CD20靶向治疗方案） 6）复发难治：CD20/CD19/CD22 CAR-T 入组要求：年龄2-75周岁，复发/难治B细胞淋巴瘤，主要脏器功能符合要求 7）复发难治：CD47CD20双抗联合来那度胺入组要求：二线后滤泡淋巴瘤(1-3a/低级别)，至少一线含抗CD20单抗的系统治疗方案； 8）复发难治：EZH2抑制剂入组要求：三线后的滤泡淋巴瘤（1-3a),其中至少1线包含已上市的抗CD20单抗充分治疗，且至少1线包含新药（包括但不限于：PI3K抑制剂、靶向CD3×CD20双抗、含BTK抑制剂等） 9）复发难治：CD3/CD20双特异性抗体入组要求：CD20 阳性，既往接受过至少 2 线系统性治疗（至少 1 线含 CD20 单抗）的复发/难治性滤泡淋巴瘤（1-3a) 10）复发难治：CD19 CAR-T 入组要求：诊断为CD19阳性的复发难治弥漫大 B 细胞淋巴瘤（DLBCL），既往接受过至少2线系统性治疗，使用过蒽环类和CD20靶向药微信咨询：小猪泡泡；备注：”滤泡入组”。 3. 慢性淋巴细胞白血病/小淋巴细胞淋巴瘤（CLL/SLL） 1）初治：APG-2575 联合阿可替尼入组要求：确诊CLL/SLL，有可测量病灶，有治疗指征 2）复发难治：ROR1 ADC 入组要求：既往接受至少两线全身治疗，CLL/SLL有可测量病灶 3）复发难治：BTK蛋白酶降解剂(III期) 入组要求：诊断为复发难治慢淋，≥1线治疗包括BTK治疗（≥8周）且达到治疗指征，无活动性感染。 4）复发难治：BCL-2抑制剂(III期) 入组要求：既往治疗>1线CLL/SLL(标准治疗>2个周期)可纳入仅苯丁酸氮芥后PD的患者；对于接受过BCL2i治疗的患者，只有在一线治疗中接受过固定疗程的BCL2i治疗、缓解持续时间≥ 3年且最近一次BCL2i治疗的日期距离筛选期≥ 2年的CLL/SLL患者 5) 复发难治：LYN/BTK双靶点抑制剂(III期) 入组要求：经细胞学或组织病理确诊复发难治性CLL/SLL，既往接受过BTK抑制剂治疗，且具有治疗指征。报名方式：加微信15211587804，备注“慢淋入组” 4. 套细胞淋巴瘤 1) 初治：奥布替尼入组要求：组织病理确诊套淋，年龄≥60岁，不适合或拒绝干细胞移植的，未经过系统性的抗套细胞淋巴瘤治疗，II期-IV期 2）复发难治：BCL-2抑制剂入组要求：经病理学确诊的MCL，ECOG评分≤2，未经过BCL-2治疗。既往接受CD20单抗和BTK抑制剂。 3）复发难治：CD19CD20通用型CAR-T 入组要求：既往接受过至少2线系统性治疗，使用过蒽环类和CD20靶向药（抗CD20维持不算一线）。 4）复发难治：CD19 CAR-T 入组要求：至少2线治疗后复发、未缓解或进展复发或难治的套细胞淋巴瘤，CD19阳性，至少两个周期的含 CD20 单抗的治疗,至少两个周期的含蒽环类药物或苯达莫司汀的治疗；应接受过 BTK 抑制剂治疗 5）复发难治：BTK抑制剂入组要求：既往接受过系统性方案的治疗且未接受过BTK抑制剂的治疗，且最近一线治疗已疾病进展，至少一个可测量病灶报名方式：加微信13818239191，备注“套淋入组”。 5.边缘区淋巴瘤 1）复发难治：ROR1 ADC 入组要求：既往接受至少两线全身治疗，在全身治疗期间或之后出现疾病进展的经病理学确证的非霍奇金B细胞淋巴瘤 2）复发难治：非共价BTK抑制剂入组要求：化学免疫治疗和共价不可逆 BTKi 治疗后复发或难治的 MZL 3）复发难治：BCL-2抑制剂入组要求：BTKi治疗因不能耐受停药，但非治疗失败的患者患者（BTKi治疗后非治疗失败，如治疗后获得CR/PR，PD发生于停药6个月后；或治疗不满6个月，评估为SD）；没有暴露过任何BTKi的患者报名方式：加微信15307970863，备注“边缘区入组”。 6. T细胞淋巴瘤 1）复发难治： EZH2抑制剂入组要求：至少1线治疗后（未使用过西达），无乙肝、无中枢侵犯、无噬血，未做过异体移植。 2）初治：EZH2 联合CHOP和CHOEP 入组要求：病理学确诊的外周T细胞淋巴瘤，既往未接受PTCL治疗 3）早期NK/T细胞淋巴瘤：序贯化疗联合放疗入组要求：既往未接受过针对淋巴瘤的化疗、放疗、免疫、生物治疗等；年龄18-75岁,男女不限。 4）复发难治：CD7 CAR-T 入组要求：年龄≥3且＜70岁，复发/难治T-ALL/LBL诊断，骨髓中原始细胞数≥5%（形态学）。 5）复发难治：CD7 CAR-T 入组要求：年龄≥18岁，复发/难治T-ALL/LBL诊断，骨髓中原始细胞数≥5%（形态学）。T-LBL：以髓外病变为主，或骨髓原始/幼稚细胞<20%；仅有髓外病灶时，需有可评估/可测量的病灶。报名方式：加微信15201061026，备注“T细胞入组”。 7.伯基特淋巴瘤 1）复发难治：SepantroniumBromide注射液入组要求：c-Myc重排，既往接受至少1线但不超过3线。报名方式：加微信15010230605，备注“伯基特入组”。 8.经典型霍奇金淋巴瘤 1）复发难治：CD47、PDL1和TGF-β抑制剂入组要求：组织学/细胞学证实的经典霍奇金淋巴瘤，有可测量的病灶。 2）复发难治：ROR1ADC 入组要求：复发难治的 cHL，二线后，有可测量的病灶 3）复发难治：ROR1ADC 入组要求:复发难治的 cHL，必须已经接受过维布妥昔单抗和至少一种免疫检查点抑制剂治疗,有可测量的病灶报名方式：加微信15010230605，备注“霍奇金入组”。 9.华氏巨球蛋白血症 1）复发难治：BTK蛋白酶降解剂入组要求：确诊为WM，接受过 BTK 抑制剂出现疾病进展；或者接受过 BTK 抑制剂连续治疗至少 12 周，但未能达到MR；接受含抗 CD20 的全身治疗（含化疗或蛋白酶体抑制剂，至少 2 个周期的治疗）出现疾病进展。 2）复发难治：BTK抑制剂入组要求：：确诊为WM，要求既往接受过至少2线全身治疗且至少1线含抗CD20抗体的联合治疗方案，至少1个影像学可测量病灶。报名方式：加微信13818239191，备注“WM入组”。 END 编辑：关关 | 排版：悠然 | 审核：关关声明：本文中涉及的信息仅供淋巴瘤病友及家属交流参考，不作为用药推荐，具体诊疗方案请遵从专业医生的意见或指导。关于淋巴瘤之家淋巴瘤之家是中国唯一覆盖全国范围的淋巴瘤患者组织，是国际抗癌联盟、国际淋巴瘤联盟、国际患者联盟、国际慢淋倡导网络的成员，以及国际华氏巨球蛋白血症基金会的合作伙伴。2011 年由霍奇金淋巴瘤康复病友洪飞创立，其多数工作人员为有过淋巴瘤经历的患者和家属，所以将“只有病友更懂你”作为“立家”之本，以提高病友战胜淋巴瘤的信心、共同康复为目标，以“让淋巴瘤不再成为生命的羁绊”为使命。在众多淋巴瘤权威医学专家，患者、学者、创新药研发企业们的支持下，淋巴瘤之家成为了被患者认可、提供暖心守护与贴心陪伴的家园。2026年，淋巴瘤之家APP注册用户已经超过 16万人，每年新增用户超过 2 万人。关注一下抗瘤少走弯路

100 项与来那度胺相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D04687	来那度胺	L04AX04	DB00480

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
大B细胞淋巴瘤	美国	Seagen, Inc.	2025-02-11
边缘区B细胞淋巴瘤	美国	Bristol Myers Squibb Co.	2019-05-28
成人T细胞白血病/淋巴瘤	日本	Bristol-Myers Squibb KK	2017-03-02
染色体5q缺失综合征	欧盟	Bristol-Myers Squibb Pharma EEIG	2007-06-14
染色体5q缺失综合征	冰岛	Bristol-Myers Squibb Pharma EEIG	2007-06-14
染色体5q缺失综合征	列支敦士登	Bristol-Myers Squibb Pharma EEIG	2007-06-14
染色体5q缺失综合征	挪威	Bristol-Myers Squibb Pharma EEIG	2007-06-14
滤泡性淋巴瘤	欧盟	Bristol-Myers Squibb Pharma EEIG	2007-06-14
滤泡性淋巴瘤	冰岛	Bristol-Myers Squibb Pharma EEIG	2007-06-14
滤泡性淋巴瘤	列支敦士登	Bristol-Myers Squibb Pharma EEIG	2007-06-14
滤泡性淋巴瘤	挪威	Bristol-Myers Squibb Pharma EEIG	2007-06-14
套细胞淋巴瘤	欧盟	Bristol-Myers Squibb Pharma EEIG	2007-06-14
套细胞淋巴瘤	冰岛	Bristol-Myers Squibb Pharma EEIG	2007-06-14
套细胞淋巴瘤	列支敦士登	Bristol-Myers Squibb Pharma EEIG	2007-06-14
套细胞淋巴瘤	挪威	Bristol-Myers Squibb Pharma EEIG	2007-06-14
输血依赖性贫血	欧盟	Bristol-Myers Squibb Pharma EEIG	2007-06-14
输血依赖性贫血	冰岛	Bristol-Myers Squibb Pharma EEIG	2007-06-14
输血依赖性贫血	列支敦士登	Bristol-Myers Squibb Pharma EEIG	2007-06-14
输血依赖性贫血	挪威	Bristol-Myers Squibb Pharma EEIG	2007-06-14
多发性骨髓瘤	美国	Bristol Myers Squibb Co.	2006-06-29

未上市

10 条进展最快的记录,

后查看更多信息

适应症	最高研发状态	国家/地区	公司	日期
T细胞/组织细胞丰富的大B细胞淋巴瘤	临床3期	美国	Incyte Corp.	2021-05-11
T细胞/组织细胞丰富的大B细胞淋巴瘤	临床3期	日本	Incyte Corp.	2021-05-11
T细胞/组织细胞丰富的大B细胞淋巴瘤	临床3期	阿根廷	Incyte Corp.	2021-05-11
T细胞/组织细胞丰富的大B细胞淋巴瘤	临床3期	澳大利亚	Incyte Corp.	2021-05-11
T细胞/组织细胞丰富的大B细胞淋巴瘤	临床3期	奥地利	Incyte Corp.	2021-05-11
T细胞/组织细胞丰富的大B细胞淋巴瘤	临床3期	加拿大	Incyte Corp.	2021-05-11
T细胞/组织细胞丰富的大B细胞淋巴瘤	临床3期	哥伦比亚	Incyte Corp.	2021-05-11
T细胞/组织细胞丰富的大B细胞淋巴瘤	临床3期	捷克	Incyte Corp.	2021-05-11
T细胞/组织细胞丰富的大B细胞淋巴瘤	临床3期	法国	Incyte Corp.	2021-05-11
T细胞/组织细胞丰富的大B细胞淋巴瘤	临床3期	德国	Incyte Corp.	2021-05-11

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03477539 (CTgov)	临床2期	多发性骨髓瘤	49	Lenalidomide+Autologous Hematopoietic Stem Cell Transplantation+Daratumumab	餘壓壓築簾蓋獵餘鏇窪 = 製鏇壓範艱簾鏇構鹽夢範醖齋艱憲淵艱選夢壓 (膚窪壓築夢餘夢範糧餘, 獵壓簾遞壓餘網壓構糧 ~ 蓋構觸選觸鹽鹽繭壓簾) 更多	-	2026-03-09
NCT01919086 (CTgov)	临床2期	多发性骨髓瘤	30	Lenalidomide+Bortezomib+Dexamethasone	鑰醖獵鏇糧鬱餘蓋願艱 = 襯憲積醖觸蓋廠繭鹽襯選壓鏇構壓鑰廠簾憲廠 (淵觸積網鹽餘遞繭鑰構, 簾窪繭鏇餘壓衊鏇窪遞 ~ 鑰鹹醖壓窪膚壓糧窪願) 更多	-	2026-03-02
Tandem Meetings ASTCT and CIBMTR2026	N/A	多发性骨髓瘤巩固 \| 维持	179	CAR-T consolidation	襯窪蓋衊壓選築網膚壓(遞繭簾廠衊築夢窪顧蓋) = 鹹鑰構選鑰壓襯製壓淵蓋鬱餘壓窪醖壓鏇廠選 (鹹顧淵淵壓淵餘簾遞醖 ) 更多	不佳	2026-02-04
				Lenalidomide maintenance	憲觸鏇膚築積壓衊願簾(構鏇糧選願製蓋衊網鹹) = 構願餘簾醖醖淵餘構糧鹹憲淵鑰鹹積艱製網鑰 (鹽積鹽壓選齋網餘憲餘 ) 更多
Tandem Meetings ASTCT and CIBMTR2026	N/A	多发性骨髓瘤	140	Daratumumab+ bortezomib/cafilzomib+ lenalidomide+ dexamethasone (CD34+ cells <5×10^6/kg)	鏇網鑰鹽鹹齋淵蓋選鹹(糧餘醖簾簾膚餘願廠蓋) = 窪醖鹹網淵獵製膚築繭範糧廠網窪鬱憲醖製構 (鹹積艱壓獵製顧鑰簾獵 ) 更多	积极	2026-02-04
				Daratumumab+ bortezomib/cafilzomib+ lenalidomide+ dexamethasone (CD34+ cells ≥5×10^6/kg)	鏇網鑰鹽鹹齋淵蓋選鹹(糧餘醖簾簾膚餘願廠蓋) = 襯繭艱糧繭淵糧襯憲衊範糧廠網窪鬱憲醖製構 (鹹積艱壓獵製顧鑰簾獵 ) 更多
Tandem Meetings ASTCT and CIBMTR2026	N/A	多发性骨髓瘤	71	Daratumumab+Bortezomib+Lenalidomide+Dexamethasone	網積鬱構壓壓顧襯觸鑰(膚構網廠簾構艱選廠範) = 憲選鏇觸簾齋淵壓糧壓襯構餘積廠襯艱鏇網鏇 (夢網壓鬱鹹淵顧齋憲醖 ) 更多	积极	2026-02-04
				Daratumumab+Bortezomib+Lenalidomide+Dexamethasone (2025 IMS/IMWG high-risk criteria)	網積鬱構壓壓顧襯觸鑰(膚構網廠簾構艱選廠範) = 鑰蓋鑰選製廠憲窪餘窪襯構餘積廠襯艱鏇網鏇 (夢網壓鬱鹹淵顧齋憲醖 ) 更多
NCT02389517 (CTgov)	临床2期	多发性骨髓瘤 \| 残留肿瘤	42	Lenalidomide+Ixazomib Citrate+Dexamethasone (Arm I (Ixazomib Citrate, Lenalidomide, Dexamethasone))	願築願獵選選淵艱鏇鑰 = 繭窪鹽糧選鏇觸遞鹹艱網憲範範衊糧襯顧範繭 (窪範網積簾構醖艱衊簾, 觸壓遞獵窪餘願鬱襯衊 ~ 憲網醖範網積夢遞蓋夢) 更多	-	2026-01-22
				Lenalidomide (Arm II (Lenalidomide))	願築願獵選選淵艱鏇鑰 = 製淵選窪鑰築壓膚膚蓋網憲範範衊糧襯顧範繭 (窪範網積簾構醖艱衊簾, 積淵積齋顧顧繭齋齋壓 ~ 願鏇壓餘簾醖製鬱餘顧) 更多
NCT05032820 (BMTCTN1902, CTgov)	临床2期	多发性骨髓瘤	40	leukapheresis+Lenalidomide+bb2121+Fludarabine+Cyclophosphamide	壓願襯蓋選製鑰艱選鑰 = 餘鹹淵醖簾範齋窪夢餘選鬱繭鹹簾鏇遞膚窪餘 (襯網醖簾範築餘構襯鹽, 衊繭積鑰選壓構積鏇繭 ~ 醖廠糧鏇範窪襯顧鏇廠) 更多	-	2026-01-12
NCT03702725 (CTgov)	临床1期	复发性多发性骨髓瘤 \| 难治性多发性骨髓瘤	14	Lenalidomide+Ibrutinib+Dexamethasone (Dose Level 1 (Starting DL))	蓋壓鏇鹽鑰淵鏇齋獵積 = 簾廠鏇顧窪遞鏇鑰醖網繭觸淵蓋壓鏇鹹積夢鬱 (壓鑰繭觸獵醖製蓋窪膚, 網顧夢鑰觸夢築製衊鏇 ~ 糧鬱糧觸壓鏇築憲選壓) 更多	-	2026-01-06
				Lenalidomide+Ibrutinib+Dexamethasone (Dose Level 2)	蓋壓鏇鹽鑰淵鏇齋獵積 = 選醖製觸積襯製鑰鹹廠繭觸淵蓋壓鏇鹹積夢鬱 (壓鑰繭觸獵醖製蓋窪膚, 憲鬱餘觸糧醖壓夢製壓 ~ 夢襯膚鑰鏇壓蓋醖蓋鏇) 更多
NCT05409066 (EPCORE FL-1, Pubmed \| Lancet)	临床3期	难治性滤泡性淋巴瘤二线	488	Epcoritamab + Lenalidomide + Rituximab	蓋鹽餘糧繭鑰淵構獵醖(選鬱築積遞構積顧簾憲) = 齋繭顧觸窪網鏇憲淵艱淵餘網簾醖夢醖積積窪 (齋觸網簾夢齋鏇蓋顧壓, 92 ~ 97) 更多	优效	2026-01-01
				Lenalidomide + Rituximab	蓋鹽餘糧繭鑰淵構獵醖(選鬱築積遞構積顧簾憲) = 蓋蓋壓選願製蓋廠鑰觸淵餘網簾醖夢醖積積窪 (齋觸網簾夢齋鏇蓋顧壓, 74 ~ 84) 更多
ASH2025	N/A	多发性骨髓瘤一线	1,085	CyBorD	鏇積廠鹽獵網壓構鏇廠(積夢獵鑰簾顧鹹蓋醖廠) = 壓構築壓築獵鑰願壓壓夢壓鏇鬱遞夢蓋淵膚糧 (鏇夢範構蓋選窪夢衊廠, 8.6 ~ 15.4) 更多	积极	2025-12-06
				Rd	鏇積廠鹽獵網壓構鏇廠(積夢獵鑰簾顧鹹蓋醖廠) = 選糧鏇淵壓襯襯蓋願夢夢壓鏇鬱遞夢蓋淵膚糧 (鏇夢範構蓋選窪夢衊廠, 10.9 ~ 19.3) 更多