Fierce Biotech M&A Tracker 2023: Gilead nabs PARP1 specialist, Bellus, Satsuma and more

2023-05-17
FierceBiotech
并购临床3期上市批准疫苗
We’ll be keeping an eye out for everything from the Big Pharma bolt-ons and blockbusters to the reverse mergers and biotech-on-biotech buyouts.
Acquisitions are back, biotech. After a stagnant year with pharma sitting on a heap of cash, the fruits of in-person business development meetings are beginning to ripen.
And so today, Fierce Biotech launches the M&A Tracker, your one-stop shop for dealmaking in the biopharma universe. We’ll be keeping an eye out for everything from the Big Pharma bolt-ons and blockbusters to the reverse mergers and biotech-on-biotech buyouts.
Here’s hoping the remaining three quarters of 2023 are filled with exciting deals that can pull the biotech industry out of its cloud to brighter days.
https://omny.fm/shows/the-top-line/february-10-2023/embed
May
XinThera
Date: May 9
Buyer: Gilead Sciences
Gilead is picking up PARP1 and MK2 inhibitor specialist XinThera for an undisclosed sum, adding a few early-stage prospects to its pipeline. The goal is to find a match for breast cancer med Trodelvy to take on AstraZeneca’s Lynparza. Story
Buyer: Astellas Pharma
Astellas is paying a cool $5.9 billion to enter an eye disease niche with the acquisition of Iveric Bio. The biotech is awaiting an FDA decision for the approval of avacincaptad pegol, a complement C5 protein inhibitor that reduced the rate of geographic atrophy progression in a phase 3 clinical trial. Story
Bellus Health
Buyer: GSK
Price: GSKbillion
GSK has bought out Bellus Health for its phase 3 chronic cough treatment camlipixant, a rival to Merck & Co.'s stalled candidate gefapixant. The Big Pharma believes that, even if camlipixant arrives on the market years after Merck does, a multibillion-dollar opportunity awaits. Story
Buyer: Shin Nippon Biomedical Laboratories
Satsuma Pharma was in need of a helping hand to move its migraine spray forward, and the company behind the nasal spray tech stepped up with a 91 cents per share offer. Story
Satsuma Pharmaalculated by share price multipled by outstmigrainehares.
Prometheus Biosciences
Buyer: Merck & Co.
Price: Merck & Co.on
Prometheus created a lot of buzz with midstage data for bowel disease candidate PRA023 late last year. Merck emerged victorious with an offer of $10.8 billion, but it wasn't the only Big Pharma that tried. Story
Buyer: Ginkgo Bioworks
Ginkgo is bolstering its gene therapy capabilities with the purchase of AAV gene therapy capsid specialist StrideBio. The goal of the acquisition is to gain the biotech's intellectual property, not to get into drug development. The company's TRX-330 program for arrhythmogenic right ventricular cardiomyopathy will be sold off. Story
Diffusion Pharmaceuticals
Buyer: EIP Pharma
Price: EIP Pharma
EIP needed help to bring an ex-Vertex molecule into phase 2, and Diffusion Pharma proved to be the lifeline. The two companies decided to merge to create one publicly listed company to complete a clinical trial in dementia with Lewy bodies. Story
Jounce TherapeuticsDiffusion Pharmadementia
Buyer: Concentra Biosciences
Price: Concentra Biosciencesmated $97.4 million*
Jounce and Redx planned to ride out the biotech markets together in a reverse merger. Jounce was expected to contribute at least $130 million to the combined group to fund Redx's ROCK2 inhibitor RXC007. But months later, Jounce bounced and instead took a deal from Concentra Biosciences. Story
Jounce valuRedxlculated by share price multipled by outstanding shares.JounceRedxROCK2RXC007JounceConcentra Biosciences
Dynacure
Buyer: Flamingo Therapeutics
Flamingo Therapeutics picked up Dynacure in a deal that will see the combined companies work together to develop RNA-targeted oncology therapies. Dynacure CEO Stéphane van Rooijen, M.D., will lead the combination with Flamingo CEO Michael Garrett at his wing as chief operating officer. Story
Adamis Pharmaceuticals
Buyer: DMK Pharmaceuticals
Another biotech searching for help after a rough go in the clinic, Adamis accepted a merger with neurology-focused DMK Pharmaceuticals. Story
Infinity PharmaceuticalsDMK Pharmaceuticals
Buyer: MEI Pharma
Target:MEI Pharma
Price: N/A
MEI Pharma and Infinity Pharma will join forces in a biotech-to-biotech merger that will see a newly named company rise from the ashes. Cambridge, Massachusetts-based Infinity will become a wholly owned subsidiary of MEI, whose shareholders will own approximately 58% of the company. Story
Buyer: Notable Labs
Price: N/A
2022 didn't go well for VBL Therapeutics, and so the immune- and inflammatory-disease-focused biotech will merge with cancer-focused platform company Notable. Story
Buyer: Pherecydes
Price: Pherecydes
A new company focused on extended phage therapies will emerge from the combination of Erytech Pharma and French biotech Pherecydes. Story
Buyer: Purple Biotech
Price: Purple Biotechlion
Privately held Immunorizon will come under the wing of Purple, which focuses on tumor immune evasion and drug resistance. Purple has two lead assets in the pipeline: NT219 and CM24 for solid tumors and pancreatic ductal adenocarcinoma, respectively. Story
Concert Pharmaceuticals
Buyer: Sun Pharmaceuticals
Sun Pharma has plunked down a cool $576 million to go up against Eli Lilly's approved alopecia treatment with Concert's JAK inhibitor. Story
Buyer: Leap Therapeutics
Leap Therapeutics hopped over to pick up Flame Biosciences for $86 million on a day busy with deals, adding another candidate to its pipeline. Story
Buyer: hC Bioscience
In a merger of equals, 4SR Bio's sequencing technology will be brought over to hC Bio to identify more potential therapeutics. Story
Angion Biomedica4SR BiohC Bio
Buyer: Elicio Therapeutics
Elicio Therapeutics caught a ticket to the public markets via a reverse merger with Angion Biomedica to continue pushing a cancer vaccine into phase 2 trials. Story
Buyer: AstraZeneca
Price: AstraZenecan
AstraZeneca saw a good time to strike as CinCor Pharma's share price dropped throughout the winter of 2022. The U.K. pharma offered up $1.8 billion to bring on the blood-pressure-focused biotech, which is working toward a phase 3 study for aldosterone synthase inhibitor baxdrostat in uncontrolled hypertension. Story
Buyer: Forge Therapeutics
Blacksmith Medicines went back home in this transaction that saw the metalloenzymes-focused biotech spin right back into Forge Therapeutics. Blacksmith spun out of Forge in 2021. An entirely new entity, which the companies dubbed "the new Blacksmith," will emerge from the transaction to focus on oncology and infections. Story
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