This study is a prospective, randomized pilot study. To verify an efficacy/safety of the mixed drug injectable delivery vehicle for treating intractable hearing loss. Hearing test, endoscopy of tympanic membrane and CT scans will be conducted after intratympanic treatment for evaluation.

开始日期2026-12-15

申办/合作机构

Seoul National University Hospital

NCT04366115

/ Not yet recruiting临床1期

A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Study Evaluating AVM0703 in Patients With Acute Respiratory Distress Syndrome

This is a randomized, double-blinded, placebo-controlled study of AVM0703 administered as a single intravenous (IV) infusion to patients with moderate or severe immediately life-threatening Acute Respiratory Distress Syndrome (ARDS) due to COVID-19 or influenza (A or B). The study is designed to evaluate the safety, tolerability, and pharmacokinetics of single dose of AVM0703 in these ARDS patients.

开始日期2026-12-01

申办/合作机构

AVM Biotechnology LLC

[+1]

NCT07636564

/ Not yet recruiting临床2期IIT

A Phase II Randomized Study of Blinatumomab With or Without Revumenib for Patients With KMT2A-Translocation B-Cell Acute Lymphoblastic Leukemia (ALL)/ Acute Leukemia With Ambiguous Lineage (ALAL) With Persistent Measurable Residual Disease (MRD)

This phase II trial tests how well adding revumenib to usual treatment (blinatumomab) compared to usual treatment alone works in treating patients with B-cell acute lymphoblastic leukemia (B-ALL) or acute leukemia with ambiguous lineage (ALAL) with KMT2A-translocation. Revumenib binds to a protein called menin and keeps it from binding to another protein called KMT2A. This stops or slows the growth of leukemia cells with changes in the KMT2A gene. Blinatumomab binds to CD19, which is found on most B cells (a type of white blood cell) and some types of leukemia cells. It also binds to a protein called CD3, which is found on T cells (another type of white blood cell). This may help the immune system kill cancer cells. In addition to blinatumomab, usual treatment also includes dexamethasone, methotrexate, cyclophosphamide, cytarabine, mercaptopurine, calaspargase pegol, doxorubicin, thioguanine, daunorubicin, vincristine and leucovorin. Dexamethasone is in a class of medications called corticosteroids. It is used to reduce inflammation and lower the body's immune response to help lessen the side effects of chemotherapy drugs. Methotrexate is in a class of medications called antimetabolites. It is also a type of antifolate. Methotrexate stops cells from using folic acid to make deoxyribonucleic acid (DNA) and may kill cancer cells. Cyclophosphamide is in a class of medications called alkylating agents. It works by damaging the cell's DNA and may kill cancer cells. It may also lower the body's immune response. Chemotherapy drugs, such as cytarabine, mercaptopurine, calaspargase pegol, doxorubicin, thioguanine, and daunorubicin, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Vincristine is in a class of medications called vinca alkaloids. It works by stopping cancer cells from growing and dividing and may kill them. Leucovorin is also being studied in the treatment of cancer. It is a type of chemoprotective agent and a type of chemosensitizing agent. Adding revumenib to usual treatment with blinatumomab may be safe, tolerable and more effective than blinatumomab alone in lowering the amount of leukemia in patients with B-ALL or ALAL with the KMT2A translocation.

开始日期2026-10-14

申办/合作机构

SWOG

[+1]

100 项与地塞米松磷酸钠相关的临床结果

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100 项与地塞米松磷酸钠相关的转化医学

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100 项与地塞米松磷酸钠相关的专利（医药）

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1,520

项与地塞米松磷酸钠相关的文献（医药）

2026-06-01·AMERICAN JOURNAL OF VETERINARY RESEARCH

Repeated intravenous dexamethasone administration causes transient changes in leukocyte parameters in healthy warmblood horses

Article

作者: Vendrig, Johannes C. ; Roelfsema, Ellen ; Hendrikx, Anne L. ; Gehring, Ronette ; van Alphen, Jennifer ; van den Boom, Robin ; Teske, Erik ; Vernooij, Johannes C. M.

Abstract:

Objective:

To determine the effect of repeated IV administration of dexamethasone (0.06 mg/kg, q 24 h, twice) on WBC parameters in healthy adult horses.

Methods:

This prospective, longitudinal study was conducted from October 7 through November 5, 2024. Five warmblood mares received an IV dexamethasone sodium phosphate injection (DMI) at 0 and 24 hours and an IV injection with 0.9% sodium chloride solution at 48 and 72 hours. Blood samples were collected at 0, 6, 12, 24, 30, 36, 48, 72, 96, and 168 hours, and WBC parameters were evaluated using linear mixed-effects models.

Results:

Leukocyte count, neutrophil count, and neutrophil-to-lymphocyte ratio were increased at 6 hours after DMI. Mean leukocyte count peaked 6 hours after DMI and exceeded the reference interval; however, not all horses had peaks above the reference interval. Neutrophilia was observed in all horses, with peak values 6 hours after DMI. Lymphocyte, monocyte, and eosinophil counts were decreased at 6 hours after DMI, with complete suppression of eosinophils. Myeloperoxidase index was increased only at 6 hours after the second DMI. Neut-X was decreased at 12 hours after DMI, and Neut-Y did not change up to 156 hours after the first DMI. Most parameters returned to baseline at 48 to 72 hours.

Conclusions:

Repeated IV dexamethasone administration induces recognizable changes in leukograms in healthy horses with transient neutrophilia combined with increased leukocyte counts and neutrophil-to-lymphocyte ratios and decreased lymphocyte, monocyte, and eosinophil counts.

Clinical Relevance:

Recognition of glucocorticoid-induced changes is important for accurate interpretation of hematologic findings in horses receiving glucocorticoids.

2026-04-20·Cureus Journal of Medical Science

Dexamethasone Iontophoresis for Musculoskeletal Tendinopathies: A Case Series of Three Patients

Article

作者: Ikhilov, Rachel B ; Kharlamb, Lily ; Gitlin-Nitti, Yevgenia J

Iontophoresis is a non-invasive transdermal drug delivery technique that uses low-voltage electric current to deliver ionized medications into soft tissues. Despite guideline recommendations supporting dexamethasone iontophoresis for tendinopathies, the existing evidence consists primarily of condition-specific randomized controlled trials and single-site retrospective studies, with no published case series illustrating the real-world application of dexamethasone iontophoresis across multiple tendinopathy types within a single report. This case series describes the outcomes of dexamethasone iontophoresis as part of multimodal physical therapy for three distinct tendinopathies. This retrospective case series included three patients treated at a Veterans Affairs physical therapy clinic with dexamethasone sodium phosphate (4 mg/mL) iontophoresis (40 mA-min per session) using the ActivaDose II system. While the small sample size limits generalizability, this series is intended to illustrate the real-world clinical application of dexamethasone iontophoresis across multiple tendinopathy types rather than to establish efficacy. Concurrent interventions included therapeutic exercise, patient education, and orthotic management. Outcomes assessed included pain (0-10 numeric scale), range of motion, grip strength, and Upper Extremity Functional Index (UEFI) scores. Case 1 (de Quervain's tenosynovitis) is a 47-year-old man with persistent, functionally limiting wrist pain who completed seven sessions over 24 days. Pain decreased from 3-4/10 to 1/10, grip strength improved from 60 to 75 lbs (equalizing with the uninvolved side), and UEFI improved by 8 points (exceeding the MCID). Case 2 (fluoroquinolone-associated Achilles tendinopathy) is a 56-year-old woman who completed six sessions over nine weeks. Pain decreased from 8/10 to 2-3/10, and ankle dorsiflexion improved from 7° to 16° (left) and 10° to 20° (right), surpassing the normative threshold of 10°. Case 3 (lateral epicondylitis) is a 62-year-old man with acute-onset symptoms who completed 12 sessions over six weeks. Pain decreased from 8/10 to 2-3/10, grip strength improved from 22 to 110 lbs (exceeding the uninvolved side of 80 lbs), and UEFI improved by 46 points (exceeding the MCID). No adverse effects were reported. Dexamethasone iontophoresis, as part of comprehensive physical therapy, was associated with clinically meaningful improvements in pain, strength, and function across three tendinopathy types. These findings suggest that dexamethasone iontophoresis may serve as a useful non-invasive adjunct in the multimodal management of musculoskeletal tendinopathies, though prospective controlled studies are needed to confirm its independent contribution.

2026-04-01·Journal of Trauma and Acute Care Surgery

Lactate modulates TGF-β1– and IL-1β–induced transcriptional programs in human dermal fibroblasts: Potential implications for wound management

Article

作者: Thomas, Gregory ; Acuna, David ; Bar-Or, David ; Zaw-Mon, Christopher ; Palacio, Carlos H ; Banton, Kaysie L

INTRODUCTION:

Cutaneous wounds are susceptible to metabolic imbalances, via hypoxia and the “Warburg effect,” which can lead to excessive lactate accumulation, potentially delaying healing. It is also accepted that lactylation of histones and other proteins is important in the epigenetic regulation of cells. Thus, a greater understanding of how lactate affects fibroblasts could lead to new therapeutic approaches. This study aimed to investigate how lactate impacts transforming growth factor β1 (TGF-β1)– and interleukin (IL)-1β–induced transcriptional programs in normal human dermal fibroblasts (NHDFs).

METHODS:

Quantitative real-time PCR was used to evaluate transcriptional changes in key remodeling markers in NHDFs treated with 40 to 100 mM of sodium lactate, 0.1 μM of dexamethasone-21-phosphate, 10 mM of 2-deoxy- d -glucose, 2.5 μM of oligomycin, 10 μM of lactoyl-coenzyme A (lactyl-COA), or 10 mM of sodium acetate and then activated with 10 ng/mL of TGF-β1 or 0.1 ng/mL of IL-1β for 24 hours. Total messenger RNA was then isolated, and ΔΔCp relative expression was calculated versus appropriate controls, normalized to the housekeeping gene, GAPDH . Fluorescent membrane integrity and (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) assays were also conducted to assess toxicity and metabolic changes, respectively.

RESULTS:

We observed that lactate dose-dependently inhibited TGF-β1–induced collagen type 1α1 ( COL1a1 ) and elastin ( ELN-1 ), as well as IL-1β–induced matrix metalloproteinase 3 ( MMP3 ) and matrix metalloproteinase 12 ( MMP12 ). The anti-inflammatory glucocorticoid, dexamethasone-21-phosphate, also inhibited cytokine-induced ELN , MMP3 , and MMP12 . Parallel analysis with 2-deoxy- d -glucose, oligomycin, lactyl-COA, and sodium acetate inferred that chromatin modifications and metabolic reprogramming may contribute to the observed lactate response in our model. In addition, metabolic reprogramming was confirmed via detection of elevated NAD(P)H-dehydrogenase activity.

CONCLUSION:

These findings suggest that, because of a potential biphasic response, high lactate treatment of NHDFs exhibits immunosuppressive effects, indicating that metabolic regulation may help mitigate tissue damage. Additionally, pharmacological manipulation of histone modifications or metabolic rebalancing may serve as intriguing therapeutic interventions.

580

项与地塞米松磷酸钠相关的新闻（医药）

2026-06-27

·表观遗传学Epigenetics

一条通路解决耐药：E2F3/SOX2/Wnt为乳腺癌联合治疗新靶点

地塞米松-他莫昔芬联合用药对他莫昔芬耐药乳腺癌细胞具有协同治疗作用脑图总览 Aliaa I. Gaballah ，Aliaa A. Elsherbiny ，Marwa Sharaky ，Najat O. Hamed ，Nahed A. Raslan ，Abdullah Almilaibary7，Reda Mohamed Abdrabbou Fayyad ，Mona S. Ousman ，Ahmed M.E. Hamdan 以及 (D Sally A. Fahim 埃及新吉萨大学药学院，新吉萨，开罗-亚历山大沙漠路22公里处，吉萨，邮政信箱12577；埃及新吉萨大学药学院生物化学系，新吉萨，开罗-亚历山大沙漠路22公里处，吉萨，邮政信箱12577；埃及开罗大学国家癌症研究所癌症生物学系药理学组，吉萨；沙特阿拉伯利雅得阿尔马雷法大学药学院制药科学系，邮政信箱71666；埃及开罗艾资哈尔大学药学院(女子)药理毒理学系，开罗11651；沙特阿拉伯麦地那阿尔拉扬学院健康科学与护理学院临床药学项目，麦地那42541；沙特阿拉伯巴哈大学医学院家庭与社区医学系，巴哈；埃及开罗艾资哈尔大学医学院药理学系，沙特阿拉伯阿西尔巴特吉医学院普通医学实践项目药理学系，阿西尔61961；10沙特阿拉伯利雅得阿尔马雷法大学应用科学学院紧急医疗服务部，邮政信箱71666；沙特阿拉伯塔布克大学药学院药学实践系，塔布克71491 通信作者:Sally A. Fahim (sally.atef@ngu.edu.eg) 他莫昔芬(TAM)是雌激素受体阳性(ER+)乳腺癌(BC)治疗中的关键药物；然而，的患者由于TAM耐药而出现复发且生存率较低。TAM耐药与SOX-2基因的过表达有关，该基因在Wnt信号通路中受E2F3转录因子调控。有研究表明，地塞米松(DEX)可抑制SOX-2的过表达，DEX是一种常用于BC患者的糖皮质激素。本研究的目的是通过调节E2F3/SOX-2介导的Wnt信号通路，探讨DEX与TAM联合使用对TAM耐药的LCC-2细胞(TAMR-1)的抑制作用。评估了联合治疗对MCF-7和TAMR-1细胞活力的影响。使用CompuSyn和SynergyFinder软件分析药物相互作用。还评估了细胞周期分布、凋亡蛋白表达、SOX-2和E2F3的基因表达水平以及细胞迁移情况。DEX与TAM联合使用可协同抑制TAMR-1细胞增殖和迁移，诱导凋亡，降低SOX-2和E2F3表达，还与S期和G2-M期阻滞有关。因此，DEX与TAM联合使用可能是一种有效的治疗选择，除了其抗炎作用外，还可通过靶向E2F3/SOX-2/Wnt信号通路克服TAM耐药。引言乳腺癌(BC)是全球诊断最广泛的癌症，2020年约有230万女性被诊断出患有该病 [1]。它还导致了超过68.5万女性死亡，使其成为全球癌症死亡的第二大原因 [2,3]。此外，预计到2040年将有超过300万新病例和100万死亡病例 [4]。同样，在埃及，BC是2020年诊断最多的癌症，也是癌症死亡的第二大原因 [5]。雌激素是乳腺癌发展的主要因素，约80%的病例为雌激素受体阳性(ER+)[6]。雌激素的致癌性可归因于三个主要机制:直接导致基因毒性、诱导细胞增殖和促进非整倍体形成[7]。由于ER在乳腺癌中显著参与，内分泌治疗在治疗该疾病中起着关键作用[8]。收到日期:2024年3月20日修订日期:2024年6月3日接收日期:2024年6月11日在线预接受稿件:2024年6月12日正式发表版本:2024年7月5日主要使用三类内分泌治疗:选择性雌激素受体调节剂(SERM)、选择性雌激素受体下调剂和芳香化酶抑制剂[9]。治疗ER+乳腺癌最常用的治疗药物是他莫昔芬(TAM)，一种SERM。在乳腺组织中，TAM通过与雌激素竞争与ER结合发挥拮抗作用，取代雌激素并抑制其促肿瘤功能[10]。据报道，TAM可分别降低乳腺癌的复发率和死亡率约40%和30%。尽管TAM是ER+乳腺癌的首选治疗方法，但20 - 30%的患者表现出TAM耐药性，限制了其治疗效果[9]。TAM耐药导致许多ER+乳腺癌患者复发，并将生存率降低至20%以下[11,12]。确切机制尚不清楚；然而，研究表明保护性自噬、细胞周期调节剂和某些转录因子参与了TAM耐药的发展[13 - 15]。性别决定区Y(SRY)-盒2(SOX-2)是一种特征明确的转录因子，与TAM耐药的出现有关[16,17]。它属于SOX基因家族，除了在不同癌症类型(如乳腺癌、肺癌和卵巢癌)中促进癌细胞干性和转移外，在细胞发育、增殖和分化中也起着至关重要的作用[18,19]。还发现它通过VEGFA上调促进血管生成[20]。据报道，SOX2通过靶向miR-181a-5p和miR-30e-5p/TUSC3轴促进乳腺癌[18]。有人认为SOX-2受E2F转录因子3(E2F3)调节，E2F3是E2F转录因子家族的一员，是细胞周期调控的关键参与者[19,21,22]。E2F3与SOX-2的相互作用改变了其在TAM耐药细胞中的表达水平，并且它参与调节多能性、癌症干细胞(CSC)的分化和Wnt信号通路，这表明它可能参与了TAM耐药的出现[23]。因此，E2F3/SOX-2介导的Wnt信号可能是克服TAM耐药的一个有吸引力的治疗靶点。皮质类固醇具有强大的抗炎特性，常用于治疗几种癌症相关适应症[24]。糖皮质激素是一类皮质类固醇，因其抗炎、抗过敏和抗水肿作用而被广泛用于癌症患者[25]。此外，糖皮质激素对不同类型的癌症包括白血病、淋巴瘤和骨髓瘤显示出各种抗癌作用[25,26]。地塞米松(DEX)是最常用的糖皮质激素，通过与糖皮质激素受体(GR)结合发挥作用[27]。由于其高效能、长效作用和最小的盐皮质激素特性，它被用于管理癌症相关疼痛[28,29]。DEX的作用因乳腺癌的亚型而异。GR的高表达与ER - 乳腺癌的不良预后相关联，而与ER + 乳腺癌的良好预后相关联[30]。GR调节降低ER + 乳腺癌的增殖并导致化疗耐药[31,32]。而在ER - 乳腺癌患者中，GR的激活与肿瘤存活和化疗耐药相关基因的表达有关。这些基因参与抑制细胞凋亡和促进上皮 - 间质转化的途径[33,34]。 Wang等人的一项研究[35]表明，DEX预处理可降低骨髓抑制并增强某些化疗药物(如吉西他滨和顺铂)的抗肿瘤活性。据报道，DEX通过减少SOX-2驱动的肿瘤发生所需的炎症信号来降低肿瘤发生率。此前，DEX的抗增殖作用及其机制在耐药性乳腺癌细胞中尚未得到证实。因此，探索最常用的糖皮质激素DEX对三苯氧胺耐药性乳腺癌细胞的作用机制，可能为通过干扰E2F3/SOX-2/ Wnt信号传导对抗耐药细胞产生协同效应提供重要见解。结果DEX与TAM联合使用可协同抑制三苯氧胺耐药性LCC-2细胞(TAMR-1)的增殖通过SRB细胞活力测定评估了DEX和TAM单一疗法对MCF-7和TAMR-1细胞的影响。观察到两种药物均以剂量依赖性方式对两种细胞系具有抑制作用。使用生成的剂量反应曲线，确定了DEX和TAM的IC50值。在MCF-7细胞中，DEX和TAM的IC50值分别为和 (图1A)。在TAMR-1细胞中，DEX和TAM的IC50值分别为和 (图1B)。显然，与MCF-7细胞相比，TAMR-1细胞中TAM的IC50值增加了4.8倍。在Vero正常细胞中，与TAMR-1细胞相比，DEX显示出明显更低的细胞毒性，其中使用的最大剂量(117.7 )抑制正常细胞活力不到25%，而在TAMR-1细胞中为71%(图1C)。图1. DEX和TAM对MCF-7和TAMR-1细胞的抗癌活性将MCF-7细胞接种到96孔板中，并用39.25 - 117.74 µg/ml的DEX和0.93 - 11.15 µg/ml的TAM处理(A)。用39.25 - 117.74 µg/ml的DEX和12.38 - 37.15 µg/ml的TAM处理TAMR-1(B)。然后将细胞孵育并用SRB染色。通过确定抑制百分比评估每种药物的抑制作用，并确定IC50值。抑制百分比根据TAMR-1细胞单一疗法中的IC50值选择DEX和TAM联合治疗方案。以3:1的恒定DEX与TAM比例处理TAMR-1细胞，DEX浓度范围为39.25至，TAM浓度范围为12.38至，持续。SRB分析显示所有联合处理的细胞中细胞活力均下降。用12.38 μg/ml的TAM处理的细胞在所有使用的DEX浓度下均显示出始终较高的抑制百分比，与的DEX联合使用时抑制效果为85.7%。将39.25 μg/ml的DEX与12.38 μg/ml 的TAM联合使用，与TAM单一疗法相比，抑制百分比提高了53.38%(图2A)。图2. DEX和TAM联合对TAMR-1细胞的抑制作用以恒定的3:1比例用浓度递增的DEX和TAM处理TAMR-1细胞48小时后的抑制百分比(A)。红色阴影代表TAMR-1细胞的抑制量。(B, C) 二维和三维协同作用可视化显示DEX和TAM联合治疗之间存在协同作用。使用SynergyFinder 3.0软件将DEX和TAM联合治疗的抑制百分比可视化为剂量反应矩阵，以及DEX和TAM之间协同作用的二维和三维可视化。协同分数使用HSA参考模型计算。(D) 归一化等效线图表示不同DEX和TAM组合的受影响分数(Fa)和CI值。使用CompuSyn软件通过计算CI来确认DEX和TAM之间存在协同作用。CI < 1表明存在协同效应，CI = 1表明存在相加效应，CI > 1表明存在拮抗效应。使用SynergyFinder 3.0软件，采用最高单一药物(HSA)参考模型来确定DEX和TAM之间的相互作用类型。二维和三维协同热图表明，DEX和TAM在很宽的浓度范围内表现出协同相互作用，协同分数为20.76，表明超出预期的反应为20.76%(图2B、C)。HSA协同分数大于10、介于10到 -10之间或小于 -10分别表示协同、相加或拮抗作用[36]。此外，使用CompuSyn软件通过使用Chou-Talalay方程[37]计算CI来确认DEX和TAM之间存在协同作用，并使用DRI确定联合治疗对降低TAM剂量的影响。将39.25 µg/ml的DEX和12.38 μg/ml的TAM联合使用时，显示出最低的CI为0.44，TAM的DRI等于4.47(图2D和补充表S1)。与单一疗法相比，这种联合使用使TAMR-1细胞中TAM的IC50从降至8 。当与DEX联合使用时，TAMR-1细胞中TAM的IC50从18降至。基于计算出的协同分数、CI和DRI，为以下研究选择的联合方案包括39.25 μg/ml的DEX和的TAM。DEX与TAM联合诱导TAMR-1细胞凋亡为了研究DEX与TAM联合是否诱导TAMR-1细胞凋亡，使用蛋白质印迹分析(图3A)测量促凋亡蛋白Bax和抗凋亡蛋白BCL-xL的表达水平。未处理的TAMR-1细胞作为对照。与对照组和TAM处理的细胞相比，DEX与TAM联合导致Bax表达水平升高，而与单一疗法和对照组相比，BCL-xL表达降低(图3B)。此外，与单独使用每种药物和对照组相比，联合使用显著增加了Bax/ Bcl-xL比值。DEX和TAM联合治疗诱导S期阻滞为了确认DEX、TAM或它们的联合的抑制作用是否与细胞周期阻滞有关，在处理后，使用流式细胞仪分析TAMR-1细胞的细胞周期分布。与对照(2.41%)相比，用DEX和TAM单一疗法处理的细胞在G2-M期的阻滞增加(DEX:3.38%，TAM:4.08%)。此外,与对照(S:46.22%，G2-M:2.41%，图4)相比，联合治疗导致S期(86.52%)以及G2-M期(7.57%)的阻滞增加。DEX与TAM联合显著抑制TAMR-1细胞迁移使用伤口愈合试验观察了用DEX、TAM或其组合处理后的TAMR-1细胞的迁移能力。在0和时未处理的TAMR-1细胞作为对照(图5A)。虽然DEX单药治疗对细胞迁移没有显著影响(P>0.05)，但与48小时对照相比，TAM单药治疗显著抑制了TAMR-1细胞迁移。此外，与单药治疗和对照相比，将39.25μg/ml DEX和12.38 TAM联合使用导致TAMR-1细胞迁移的延迟最为显著(P<0.0001)(图5B)。DEX与TAM联合治疗显著降低TAMR-1细胞中SOX-2和E2F3的表达为了评估DEX对SOX-2和E2F3表达的影响及其与TAM耐药性的关系，对用 DEX、12.38μg/ml TAM或其组合处理的MCF-7和TAMR-1细胞进行了RT-qPCR分析。数据以TAMR-1对照为标准进行归一化。结果表明，TAMR-1细胞中SOX-2和E2F3水平显著高于MCF-7细胞(P<0.0001)。与时的TAMR-1对照相比，DEX、TAM或其组合的单药治疗均显著降低了SOX-2和E2F3的表达。此外，与DEX和TAM单药治疗相比，联合治疗降低了SOX-2和E2F3的表达。有趣的是，联合治疗的TAMR-1细胞与MCF-7细胞之间没有显著差异(图6)。讨论乳腺癌是一个全球关注的健康问题[2,3]。尽管TAM是首选治疗方法，但TAM的疗效受到TAM耐药性发展的限制[9]。先前的研究表明，可能的TAM耐药机制之一涉及转录因子SOX-2的过度表达[16,17]。 DEX是一种常用于治疗乳腺癌相关症状的糖皮质激素，先前有人认为它可以降低SOX-2的活性[38,39]。先前还发现DEX可增强某些化疗药物的细胞毒性作用并抑制肿瘤生长和转移[40,41]。基于这些先前的研究，本研究旨在通过靶向E2F3/SOX-2/Wnt信号通路来证明DEX、TAM或其组合对MCF-7和TAMR-1乳腺癌细胞系的细胞毒性作用。型号：A-P-9018 品名：m6A RNA甲基化片段富集试剂盒(qPCR版）【如需产品说明书，订阅本账号后，可+微信号：hugasis咨询】 © 2024作者。本文是由波特兰出版社有限公司代表生物化学学会发表的开放获取文章，并根据知识共享署名许可协议分发图3. TAMR-1细胞的蛋白质印迹分析用 DEX、12.38μg/ml TAM或其组合处理的TAMR-1细胞的蛋白质印迹分析。(A)TAMR-1细胞中Bax和BCL-xL表达水平的蛋白质印迹图像。(B)比较Bax和BCL-xL表达水平的柱状图。数据以 -肌动蛋白为标准进行归一化，并表示为与对照相比的倍数变化。(C)表示Bax与BCL-xL比值的柱状图。数据表示为平均值标准差。使用单因素方差分析(ANOVA)，然后进行Tukey事后检验进行统计分析。**** 在时具有显著性。图4. TAMR-1细胞的细胞周期分布暴露于39.25 DEX、12.38 TAM或其组合48小时的TAMR-1细胞的细胞周期分布。(A)流式细胞术结果显示停滞在每个细胞周期阶段的TAMR-1细胞百分比(G0-G1，紫色；S，绿色；G2-M，红色)。(B)比较对照和处理细胞中细胞周期分布百分比的代表性柱状图。图5. TAMR-1细胞的伤口愈合试验用39.25μg/ml地塞米松(DEX)、12.38μg/ml他莫昔芬(TAM)或其组合处理TAMR-1细胞48小时后的伤口愈合试验(A)。使用结晶紫作为染色剂。代表性柱状图显示了TAMR-1细胞迁移的定量分析，结果表示为平均值标准差(B)。使用单因素方差分析(ANOVA)，随后进行Tukey事后检验进行统计分析。***在水平上具有显著性，*** ，，ns 无显著性。图6. TAMR-1细胞中SOX-2和E2F3 mRNA表达的RT-qPCR分析用39.25μg/ml地塞米松(DEX)、12.38μg/ml他莫昔芬(TAM)或其组合处理TAMR-1细胞48小时后，对SOX-2和E2F3 mRNA表达进行RT-qPCR分析。定量PCR结果以甘油醛-3-磷酸脱氢酶(GAPDH)为对照进行标准化，并表示为倍数变化。数据来自三个独立实验，并表示为平均值标准差。使用双向方差分析(ANOVA)，随后进行Tukey事后检验进行统计分析。(a、b、c和d分别代表在水平上TAMR-1、MCF-7、DEX和TAM的显著性。据报道，SOX-2在促进不同癌症类型的肿瘤进展中起重要作用。其过表达与增殖增加、抗凋亡、自噬改变和癌症干细胞(CSC)维持有关[21,42]。Zhu等人[43]表明，SOX-2通过 -连环蛋白介导的自噬信号传导驱动化疗耐药性。此外，Loh等人[44]报道，Wnt通路与乳腺癌细胞中的他莫昔芬耐药性有关。在转录水平上，SOX-2由E2F3上调，E2F3是一种细胞周期调节因子，被发现参与乳腺癌的进展[45]。对SOX-2和E2F3基因表达进行分析，以评估地塞米松对TAMR-1细胞抑制作用的潜在机制。我们研究中TAMR-1细胞中SOX-2的较高表达与先前的研究结果一致，即SOX-2在耐药MCF-7细胞中过表达，沉默其表达可增加对他莫昔芬的敏感性[46]。虽然之前未确定TAMR-1细胞中E2F3的表达，但先前的研究报道，E2F3在紫杉醇耐药的MCF-7细胞以及包括卵巢癌和肺癌细胞在内的不同耐药癌症类型中表达升高[47-49]。用他莫昔芬或地塞米松或其组合处理导致SOX-2和E2F表达显著降低至非耐药细胞水平。同样，先前的一项研究报道，联合治疗通过下调SOX-2导致癌细胞的化疗敏感性增加[50]。地塞米松下调SOX-2的潜在机制可能涉及抑制Wnt/ -连环蛋白通路[51]。此外，还发现E2F3通过涉及诱导MEX3A的机制激活Wnt通路，导致促分化转录因子KLF4的抑制[52]。先前的研究结果表明，过量的糖皮质激素通过激活Wnt抑制剂(包括Dickkopf-1(Dkk-1))中断Wnt通路，据报道Dkk-1是乳腺癌中的一种肿瘤抑制因子，因为其抑制会导致乳腺癌细胞迁移和侵袭增加[53]。我们的研究发现，地塞米松(DEX)处理导致MCF - 7和TAMR - 1细胞系的细胞活力降低，其IC50值大致相等。这与先前的研究相关，先前研究表明DEX对白血病、骨髓瘤和淋巴瘤等多种癌症类型具有促凋亡作用[25,26]。有趣的是，与TAMR - 1细胞相比，DEX对正常Vero细胞的细胞毒性显著更低。先前的一项研究报告称，DEX已显示出减轻细胞毒性化疗对正常组织长期影响的潜力[54]。然而，他莫昔芬(TAM)处理在MCF - 7和TAMR - 1细胞系上显示出不同的IC50值，分别为3.72和18μg/ml。TAM在TAMR - 1细胞上较高的IC50值表明，与MCF - 7细胞相比，TAMR - 1细胞的敏感性降低。先前的研究也支持了这一点，这些研究表明正常MCF - 7细胞和耐药性乳腺癌细胞系中的TAM IC50值存在类似差异[55]，一项研究表明MCF - 7细胞上的TAM IC50值为，TAMR - 1细胞上为17.54μg/ml [56]。与TAM单药治疗相比，DEX与TAM联合使用导致对TAMR - 1细胞的抑制作用增强。这与先前的研究一致，先前研究表明DEX预处理通过增强包括乳腺癌在内的各种癌症类型的肿瘤摄取，增强了某些化疗药物如卡铂、吉西他滨和阿霉素的抗肿瘤活性[35,40]。这也与先前的研究结果相关，先前的研究结果表明，TAM与其他抗炎药物联合使用会导致TAM在MCF - 7和TAMR - 1细胞中的抑制作用增强[57,58]。此外，与DEX联合使用时，TAMR - 1细胞中TAM的IC50从18降至。这与先前的研究结果相关，先前的研究结果表明，DEX与抗癌药物联合使用，如淋巴瘤中的阿霉素、乳腺癌中的吉西他滨和乳腺癌中的紫杉醇，会导致抑制作用增强，紫杉醇的IC50从19.3降至5.22 。使用SynergyFinder 3.0和CompuSyn软件进行的相互作用分析表明，DEX和TAM在TAMR - 1细胞中存在协同作用，协同得分、CI和DRI值表明了这一点[36]。该模型假设联合治疗产生的预期效果等同于相同剂量下单一药物较高效果的总和，这支持联合治疗产生的效果超出了单药治疗所能达到的效果[61]。细胞凋亡是与化疗药物细胞毒性相关的重要机制，涉及内在和外在途径[62,63]。BCL - 2蛋白家族，包括促凋亡蛋白Bax和抗凋亡蛋白BCL - xL，在内在水平上调节细胞凋亡[64]。先前已将TAM耐药性与包括Bax在内的促凋亡蛋白水平降低诱导的细胞凋亡联系起来[65]。本研究表明，Bax在TAMR - 1对照细胞中不表达。先前发表的数据在癌症和耐药细胞中报告了类似结果[66 - 68]。Romero等人[66]报告称，BCL - 2家族蛋白；tBID可能能够独立于BAX和BAK直接诱导细胞凋亡。DEX与TAM联合使用增加了Bax的表达并降低了BCL - xL的表达。在MCF - 7细胞中，发现BCL - xL在预防细胞凋亡方面比Bcl - 2效率高十倍[69]。先前的研究结果表明，SOX - 2的下调在包括乳腺癌在内的各种癌症类型中显著诱导细胞凋亡[70 - 72]。此外，还发现SOX - 2通过增加卵巢癌细胞中抗凋亡蛋白如Bcl - 2的表达和降低促凋亡蛋白如PUMA/BBC3的表达来诱导耐药性[73]。评估了TAMR-1细胞的细胞周期分布，以确定地塞米松(DEX)和他莫昔芬(TAM)治疗的抑制作用机制。本研究表明，DEX和TAM单药治疗导致TAMR-1细胞停滞在S期。这些发现与之前的研究相关，之前的研究表明，用TAM处理的TAMR-1细胞在S期积累[74]。此外，在本研究中，发现联合治疗可增加S期和G2-M期停滞。另一方面，Cheng等人[58]报道，将TAM与另一种抗炎药如阿司匹林联合使用会导致TAMR-1细胞停滞在G0-G1期。尽管之前未探讨DEX对TAMR-1细胞周期分布的影响，但发现其单药治疗以及与其他类型耐药癌症(如来那度胺耐药的多发性骨髓瘤)的联合作用可诱导细胞周期停滞在G0-G1期[75]。此外，Liu等人[18]的研究报道，BC细胞中SOX-2的表达增加了细胞周期蛋白如细胞周期蛋白D1以及细胞周期蛋白依赖性激酶4和6的水平，据报道这些蛋白与G1期和S期之间的转换有关[76]。Feng等人[77]的另一项研究报道，E2F3过表达通过干扰细胞周期促进肿瘤进展，因为其敲低导致G0-G1期停滞增加。本研究表明，DEX和TAM联合使用具有迁移抑制作用。先前的研究发现，TAM治疗可抑制MCF-7细胞的迁移，但对耐药的TAMR-1细胞无效[78]。此外，据报道，与TAM单药治疗相比，联合治疗导致癌细胞迁移的延迟更显著[79,80]。DEX单药治疗以及与其他抗癌药物如阿霉素和多西他赛联合使用对BC细胞迁移具有显著的抑制作用[81-83]。然而，Pang等人[41]报道，虽然低剂量的DEX抑制迁移，但高剂量(高于 )可能促进BC进展。此外，发现SOX-2的表达与TUSC3蛋白的表达呈负相关，据报道TUSC3蛋白可抑制BC细胞的增殖和迁移[18]。此外，发现SOX-2通过Wnt/β-连环蛋白信号通路促进EMT，该通路诱导BC中的细胞迁移[84]。先前的研究还报道，SOX-2和E2F3可能促进癌细胞的迁移[85-87]。这些结果表明，将DEX与TAM联合使用可能通过涉及E2F3和SOX-2下调的机制抑制TAMR-1细胞的增殖和迁移。 DEX是CYP3A4的中度诱导剂，因此与DEX联合使用时，TAM的代谢可能会增加[88]。他莫昔芬的活性代谢物4-羟基他莫昔芬是通过CYP3A4介导的N-去甲基化和CYP2D6介导的羟基化产生的。当帕罗西汀与TAM同时给药时，会导致4-羟基他莫昔芬的血浆浓度降低[89]。此外，利福平通过增强CYP3A4降低了TAM的血浆浓度[90]。另一方面，将TAM与DEX联合使用有利于减轻DEX诱导的骨质疏松症和骨质减少，并使糖皮质激素(GC)耐药的细胞系Jurkat对DEX治疗敏感[91,92]。需要更多的研究来充分揭示DEX对TAM代谢的影响。结论 SOX-2和E2F3的过表达可能导致对他莫昔芬(TAM)产生耐药性。研究发现，将地塞米松(DEX)与TAM联合使用可协同抑制TAMR-1细胞的生长和迁移，诱导细胞凋亡，并使细胞停滞在细胞周期的S期和G2/M期。此外，该联合用药使TAMR-1细胞中E2F3和SOX-2的表达下调，其水平与MCF-7细胞相当。总体而言，我们的数据表明，DEX与TAM联合使用可能是克服TAM耐药性的有效治疗选择，而E2F3/SOX-2/ Wnt信号通路可能是降低TAM耐药性的一个有前景的靶点。建议进一步研究E2F3/SOX-2/ Wnt信号通路抑制的下游效应，以更全面地了解所观察到的效应背后的分子机制。此外，也建议探索DEX在其他类型耐药癌细胞中的疗效。此外，还建议进行临床研究，以检测该信号通路是否可作为联合治疗的生物标志物，并评估这种联合治疗的安全性、疗效和最佳剂量。材料与方法药物和化学试剂 DEX由EVA制药公司(埃及开罗)提供，储存在的密闭容器中。TAM购自Amriya制药工业公司(埃及亚历山大)，室温保存。使用前，将TAM和DEX溶解于二甲基亚砜(DMSO)中，然后用RPMI-1640培养基稀释。细胞系人乳腺癌MCF-7细胞系、LCC-2 TAM耐药乳腺癌(TAMR-1)细胞系和正常Vero细胞系由美国细胞培养物保藏中心(美国明尼苏达州)提供，保存在含有10%胎牛血清(FBS)和1%青霉素/链霉素的RPMI-1640培养基中，于、湿度条件下培养。细胞培养在75-cm 培养瓶中，癌细胞在含有10% FBS和抗生素的RPMI-1640培养基中单层培养。当细胞达到70%汇合度时，将其传代至不同培养瓶中。使用前，用胰蛋白酶将贴壁于细胞培养瓶的培养细胞消化，并在条件下孵育。SRB细胞活力测定在96孔微量滴定板中，以每孔5000个细胞的浓度接种细胞，在添加药物前让细胞贴壁。细胞分别用不同浓度的每种药物作为单一疗法进行处理。进行初步筛选以确定所用浓度。根据初步筛选结果，MCF-7和TAMR-1细胞系均用不同浓度的DEX(100 - 300 μM/39.25 - 117.74 μg/ml)处理。此外，MCF-7和TAMR-1细胞分别用和的TAM处理。将培养板在条件下孵育，然后使用酶标仪(德国Tecan公司Sunrise型)在570 nm波长下测量每孔的光密度(OD)。通过磺酰罗丹明B(SRB)法[93]测定DEX和TAM的细胞毒性。使用Graphpad Prism 8.2.1软件生成的剂量 - 反应曲线计算IC50值。根据IC50，TAMR-1细胞用DEX和TAM以3:1的固定比例联合处理。联合用药方案中使用的剂量包括单一疗法的IC50以及高于和低于IC50的剂量。协同效应分析使用CompuSyn [94]和SynergyFinder 3.0 [95]进行协同分析。CompuSyn软件用于确定组合指数(CI)和剂量降低指数(DRI)。使用CI来确定DEX和TAM之间药物相互作用的类型，其中CI < 1表示协同效应，CI = 1表示相加效应，CI > 1表示拮抗效应。DRI用于确定与单一疗法相比，联合疗法中TAM的剂量可以降低多少倍，其中DRI < 1表示负剂量降低，DRI = 1表示无剂量降低，DRI > 1表示有利的剂量降低。SynergyFinder 3.0软件用于使用最高单药(HSA)参考模型[96,97]确定协同评分。 © 2024作者。本文是由波特兰出版社有限公司代表生物化学学会发表的开放获取文章，并根据知识共享署名许可协议分发。表1 RT-qPCR正向和反向引物序列、登录号及退火温度锗登录号正向引物反向引物扩增子大小(碱基对) 解链温度性别决定区Y框蛋白2 NM_003106.4 5’-GAGCTTTGCAGGAAGTTTGC-3’ -GCAAGAAGCCTCTCCTTGAA-3’ 190 57.81°C E2F转录因子3 NM_001243076.3 5’-TATCCCTAAACCCGCTTCC-3’ -TTCACAAACGGTCCTTCTA-3’ 159 53.61°C 甘油醛-3-磷酸脱氢酶 NM_001357943.2 -CAAAGTTGTCATGGATGACC-3’ 5′-CCATGGAGAAGGCTGGGG-3’ 195 54.58°C蛋白质免疫印迹分析通过添加 Tris-HCl、 Triton X-100、pH 7.6且不含EDTA的蛋白酶抑制剂，从不同细胞中提取蛋白质。使用Pierce™ BCA蛋白质定量检测试剂盒(赛默飞世尔科技公司)进行蛋白质定量。使用12%的十二烷基硫酸钠-聚丙烯酰胺凝胶电泳(SDS-PAGE)分离蛋白质，然后将其转移到聚偏二氟乙烯(PVDF)膜上(GE10600021 Sigma，西格玛奥德里奇公司，美国密苏里州)。用脱脂牛奶封闭膜，然后与细胞信号技术公司提供的抗 -肌动蛋白、抗BCL-xL和抗Bax单克隆兔抗体孵育 (β-肌动蛋白抗体:4970S，BCL-xL抗体:2764T，Bax抗体:2772T，美国加利福尼亚州)。然后用辣根过氧化物酶(HRP)偶联的羊抗兔二抗(7074P2，细胞信号技术公司，美国马萨诸塞州丹弗斯)孵育膜。使用Chemi-Doc MP成像系统(伯乐公司，美国加利福尼亚州赫拉克勒斯)进行图像处理，进行蛋白质表达和定量分析。通过流式细胞术进行细胞周期分析使用流式细胞术评估TAMR-1细胞在地塞米松、12.38 + 他莫昔芬或其组合处理后的细胞周期。细胞在生长培养基中生长至70%汇合度，处理后收集。胰蛋白酶消化后，细胞在乙醇中于固定过夜。细胞冲洗两次，然后重悬于碧云天(中国江苏)提供的含50 mg/ml碘化丙啶(PI)和0.1 mg/ml核糖核酸酶A(RNase A)的磷酸盐缓冲液(PBS)中，然后在黑暗中于孵育。使用BD Biosciences公司(美国新泽西州)提供的LSR II FACS流式细胞仪分析细胞，以确定细胞周期各阶段的细胞分布。细胞迁移实验通过伤口愈合实验检测TAMR-1细胞的迁移。将细胞接种到6孔板后，用移液器吸头在孔间造成伤口。通过冲洗孔去除多余细胞。吸出培养基，用39.25μg/ml地塞米松、12.38μg/ml他莫昔芬或其组合处理孔，未处理的孔作为0小时和48小时的对照。使用倒置显微镜(DFC290，徕卡公司，德国韦茨拉尔)进行图像采集，并通过测量伤口间隙大小分析迁移距离。使用逆转录定量聚合酶链反应(RT-qPCR)测定SOX-2和E2F3基因表达使用德国耶拿生物科学公司(慕尼黑)提供的总RNA纯化试剂盒从处理和对照样品中分离总RNA。美国应用生物系统公司(加利福尼亚州福斯特城)提供了用于将RNA转化为cDNA的cDNA存档试剂盒。使用Promega公司(美国威斯康星州麦迪逊)的GoTaq PCR预混液，通过将预混液的与cDNA的、每种引物的和CXR参比染料的混合进行定量PCR。使用美国应用生物系统公司(加利福尼亚州福斯特城)的7500实时PCR系统进行该实验方案，该方案包括在下变性以及退火的40个循环。使用技术分析后，将值记录为相对于GAPDH调整后的相对表达水平[98]。引物序列、登录号和熔解温度列于表1。数据可用性支持本研究结果的数据可应相应作者的要求提供。利益冲突作者声明与该手稿不存在利益冲突。资金作者声明没有资金来源需要致谢。CRediT作者贡献 Aliaa I. Gaballah:软件、方法学、撰写 - 原始草案。Aliaa A. Elsherbiny:撰写 - 原始草案。Marwa Sharaky:监督、方法学、撰写 - 审阅与编辑。Najat O. Hamed:验证、撰写 - 审阅与编辑。Nahed A. Raslan:验证、方法学、撰写 - 审阅与编辑。Abdullah Almilaibary:形式分析、撰写 - 审阅与编辑。Reda Mohamed Abdrabbou Fayyad:形式分析、方法学、撰写 - 审阅与编辑。Mona S. Ousman:撰写 - 审阅与编辑。Ahmed M.E. Hamdan:概念化、撰写 - 原始草案。Sally A. Fahim:概念化、软件、形式分析、监督、验证、方法学。致谢作者谨向沙特阿拉伯利雅得的Almaarefa大学表示诚挚的感谢，感谢其为本研究提供支持。缩写 BC，乳腺癌；CI，联合指数；CSC，癌症干细胞；DEX，地塞米松；DRI，剂量降低指数；ER，雌激素受体；E2F3，E2F转录因子3；GC，糖皮质激素；GR，糖皮质激素受体；SOX-2，SRY盒2；SRB，磺酰罗丹明-B；SRY，性别决定区Y；TAM，他莫昔芬。参考文献 1 Bray, F., Laversanne, M., Sung, H., Ferlay, J., Siegel, R.L., Soerjomataram, I. et al. (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 74, 229-263, https://doi.org/10.3322/caac.21834 2 Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R.L., Torre, L.A. and Jemal, A. 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Biol. 102, 89, https://doi.org/10.1016/j.jsbmb.2006.09.004 8 Yao, J., Deng, K., Huang, J., Zeng, R. and Zuo, J. (2020) Progress in the understanding of the mechanism of tamoxifen resistance in breast cancer. Front Pharmacol. 11, 1848, https://doi.org/10.3389/fphar.2020.592912 9 Ali, S., Rasool, M., Chaoudhry, H., Pushparaj, P.N., Jha, P., Hafiz, A. et al. (2016) Molecular mechanisms and mode of tamoxifen resistance in breast cancer. Bioinformation 12, 135, https://doi.org/10.6026/97320630012135 10 Farrar, M.C. and Jacobs, T.F. (2022) Tamoxifen. Encyclopedia of Toxicology, Third Edition, pp. 471-473 11 Sotgia, F., Fiorillo, M., Lisanti, M.P., Sotgia, F., Fiorillo, M. and Lisanti, M.P. (2017) Mitochondrial markers predict recurrence, metastasis and tamoxifen-resistance in breast cancer patients: Early detection of treatment failure with companion diagnostics. Oncotarget 8, 68730-68745, https://doi.org/10.18632/oncotarget.19612 12 Zhu, Y., Liu, Y., Zhang, C., Chu, J., Wu, Y., Li, Y. et al. (2018) Tamoxifen-resistant breast cancer cells are resistant to DNA-damaging chemotherapy because of upregulated BARD1 and BRCA1. Nat. Commun. 9, 1-11, https://doi.org/10.1038/s41467-018-03951-0 13 Gao, A., Sun, T., Ma, G., Cao, J., Hu, Q., Chen, L. et al. (2018) LEM4 confers tamoxifen resistance to breast cancer cells by activating cyclin D-CDK4/6-Rb and ERα pathway. Nat. Commun. 9, 4180-4125, https://doi.org/10.1038/s41467-018-06309-8 14 Jia, Y., Zhou, J., Luo, X., Chen, M., Chen, Y., Wang, J. et al. (2018) KLF4 overcomes tamoxifen resistance by suppressing MAPK signaling pathway and predicts good prognosis in breast cancer. Cell. Signal. 42, 165-175, https://doi.org/10.1016/j.cellsig.2017.09.025 15 Fahim, S.A., ElZohairy, Y.A. and Moustafa, R.I. (2024) Favipiravir, an antiviral drug, in combination with tamoxifen exerts synergistic effect in tamoxifen-resistant breast cancer cells via hTERT inhibition. Sci. Rep. 14, 1844-1858, https://doi.org/10.1038/s41598-024-51977-w 16 Piva, M., Domenici, G., Iriondo, O., Rábano, M., Simões, B.M., Comaills, V. et al. (2014) Sox2 promotes tamoxifen resistance in breast cancer cells. EMBO Mol. Med. 6, 66, https://doi.org/10.1002/emmm.201303411 17 Jin, M.L., Yang, L. and Jeong, K.W. (2022) SETD1A-S0X2 axis is involved in tamoxifen resistance in estrogen receptor -positive breast cancer cells. Theranostics 12, 5761, https://doi.org/10.7150/thno.72599 18 Liu, K., Xie, F., Gao, A., Zhang, R., Zhang, L., Xiao, Z. et al. (2017) SOX2 regulates multiple malignant processes of breast cancer development through the SOX2/miR-181a-5p, miR-30e-5p/TUSC3 axis. Mol. Cancer 16, 1-14, https://doi.org/10.1186/s12943-017-0632-9 © 2024作者。本文是由波特兰出版社有限公司代表生物化学学会发表的开放获取文章，并根据知识共享协议分发文献标题：Dexamethasone–tamoxifen combination exerts synergistic therapeutic effects in tamoxifen-resistance breast cancer cells Aliaa I. Gaballah, Aliaa A. Elsherbiny, ..., Sally A. Fahim Bioscience Reports | 2024 Jul 31 | 38864530 【表观实验优选表观盒子】型号：C3004 品名：IVDSHOW96孔板合金磁力架【适配96孔PCR板】型号：C3027 品名：IVDSHOW双面24孔合金磁力架【适配0.5ml 0.6ml 1.5ml和2ml离心管】型号：A-P-9028 品名：MeRIP RT-qPCR试剂盒型号：C3111 品名：IVDSHOW16孔合金磁力架【适配0.1ml 0.2ml 单个和8联PCR管】【联系我们】长按二维码识别关注，热门，前沿，实用的表观遗传学生命资讯！长按二维码识别关注，热门，前沿，实用的表观遗传学产品资讯！

2026-06-25

·人生心录

葡萄膜炎的病因、机制及最新研究进展

葡萄膜炎（uveitis）是指累及葡萄膜（虹膜、睫状体、脉络膜）及其相邻结构（视网膜、玻璃体）的眼内炎症性疾病，是全球可预防性致盲的重要原因之一。按解剖部位可分为前葡萄膜炎、中间葡萄膜炎、后葡萄膜炎及全葡萄膜炎（SUN分类标准）；按病因可分为感染性与非感染性（免疫介导性）两大类。一项纳入2009—2023年文献的系统综述显示，免疫介导性葡萄膜炎约占报告病例的35%，感染性葡萄膜炎约占33%，其余为炎症性、药物诱导性及特发性病因。病因学；感染性病因；病毒（疱疹病毒科、巨细胞病毒）、细菌（结核分枝杆菌、梅毒螺旋体）、真菌及弓形虫等寄生虫均可直接侵犯眼内组织或通过免疫反应引发炎症。病原体毒力因子、宿主易感性及环境触发因素共同决定感染性葡萄膜炎的发生发展。自身免疫、免疫介导性病因；包括白塞病（Behçet disease）、Vogt-小柳原田病（VKH）、结节病、幼年特发性关节炎相关葡萄膜炎（JIA-U）以及与HLA-B27相关的急性前葡萄膜炎，后者占前葡萄膜炎病例的18%—32%。药物诱导性葡萄膜炎；近年来随着生物制剂广泛应用，IL-17A抑制剂（如司库奇尤单抗）等药物本身也可诱发葡萄膜炎，提示免疫调节药物存在"双向效应"。特发性病因；约占病例的相当比例，经全面排查仍无法明确病因。发病机制；眼免疫赦免的破坏；正常情况下，血-房水屏障、血-视网膜屏障及前房相关免疫偏离（ACAID）等机制维持眼内免疫赦免状态。当这些屏障被打破，自身反应性T细胞得以进入眼内，启动炎症反应。遗传易感性；HLA-I类（如HLA-B27、HLA-A29）及HLA-II类分子，以及参与抗原修剪的ERAP酶基因多态性，影响抗原呈递效率并降低T细胞活化阈值，是自身免疫性葡萄膜炎的重要遗传基础。Th17/Treg失衡与细胞因子网络；CD4+T细胞亚群（Th1、Th17、Treg、Tfh）的功能失衡是非感染性葡萄膜炎核心机制。研究证实HLA-B27相关急性前葡萄膜炎患者外周血中Th17细胞比例显著升高，而Treg细胞比例及Foxp3表达明显下降，Th17/Treg比值与疾病活动度呈正相关。IL-17、IL-23、IFN-γ、TNF-α等细胞因子相互作用，放大眼内炎症级联反应。T细胞代谢重编程-新兴机制；2025—2026年的研究进一步揭示了代谢检查点对Th17细胞致病性的调控作用。中山大学中山眼科中心团队发现，DGAT1通过调控脂质过氧化影响Th17细胞存活与致病性，该机制在实验性自身免疫性葡萄膜炎模型及VKH病患者CD4+T细胞中均得到验证，提示脂代谢可作为新的干预靶点。另有综述系统总结了mTOR、糖酵解、棕色脎诱导因子等代谢检查点在Th17/Treg平衡调控中的作用，为靶向T细胞代谢治疗葡萄膜炎提供了理论框架。治疗手段；糖皮质激素；仍是葡萄膜炎治疗的基石。局部及全身用药外，长效缓释型玻璃体腔植入物（地塞米松植入剂Ozurdex、氟轻松醋酸酯植入剂Retisert/Yutiq/Illuvien、脉络膜上腔注射用三氨奈德Xipere）已获批用于慢性后段非感染性葡萄膜炎，可显著降低复发率。传统免疫抑制剂；甲氨蝶呤（MTX）与霉酚酸酯（MMF）是公认的一线激素助减剂。FAST随机对照试验显示两者总体疗效相近，但在中间/后段/全葡萄膜炎亚型中MTX略具优势。MERIT试验则表明，对于葡萄膜炎性黄斑水肿，地塞米松植入剂在12—24周时OCT结局优于玻璃体腔MTX及雷珠单抗。生物制剂；抗TNF-α类：阿达木单抗（Humira）是目前唯一获批用于非感染性中间/后段/全葡萄膜炎的系统性生物制剂，VISUAL 1、2两项随机对照试验证实其可显著延长至治疗失败的时间。英夫利西单抗在难治性白塞病及对阿达木单抗反应不佳的病例中广泛超适应症使用，疗效与阿达木单抗相近。依那西普因疗效不佳甚至有诱发葡萄膜炎加重的报道，不被推荐用于本病。抗IL-6类：托珠单抗在难治性葡萄膜炎性黄斑水肿中显示出一定疗效，尤其适用于抗TNF治疗失败者；在儿童JIA-U的APTITUDE二期试验中未达主要终点，但在持续性黄斑水肿亚组显示获益信号。处于研发阶段的玻璃体腔注射用抗IL-6单克隆抗体vamikibart在III期MEERKAT试验中已达到主要终点（16周BCVA改善≥15字母比例），代表非激素类局部细胞因子靶向治疗的重要突破。抗IL-12/23与抗IL-17类：乌司奴单抗在白塞病相关葡萄膜炎二期试验中显示支持性信号；而司库奇尤单抗在三项三期随机对照试验中均未达到主要终点，提示IL-17通路在不同葡萄膜炎亚型中的作用存在异质性。JAK/TYK2通路抑制剂；作为口服小分子药物，JAK抑制剂可同时阻断多条细胞因子信号通路。托法替布、巴瑞替尼、乌帕替尼已有病例系列证实疗效；双重JAK1/TYK2抑制剂brepocitinib二期试验阳性并已进入三期临床；选择性TYK2抑制剂ESK-001亦处于二期概念验证阶段。值得注意的是，菲戈替尼在HUMBOLDT随机对照试验中显示有效信号，但其葡萄膜炎研发项目因商业原因终止。局部新型疗法；非激素类局部滴眼液dazdotuftide针对前段葡萄膜炎已完成三期试验；玻璃体腔注射用西罗莫司在SAKURA三期试验中未达主要终点，但显示剂量相关生物学活性。细胞与药物监测策略；间充质干细胞（MSC）及其外泌体在动物模型中显示出良好的抗炎调节潜力，2024年系统综述纳入16项2011—2022年的前临床研究，提示其有望成为细胞治疗候选方案，但距临床转化仍有距离。此外，治疗药物监测（TDM）及抗药抗体检测正逐渐用于优化阿达木单抗剂量方案，以应对部分患者疗效不佳的问题。研究进展；玻璃体腔细胞因子靶向治疗取得突破：vamikibart在MEERKAT三期试验中达到主要终点，是首个在葡萄膜炎性黄斑水肿中获得阳性III期数据的局部非激素生物制剂。口服精准免疫治疗管线丰富：brepocitinib、ESK-001等新型JAK/TYK2通路小分子药物为难治性非前段葡萄膜炎提供新选择。T细胞代谢重编程成为新热点：DGAT1-脂质过氧化轴、mTOR及糖酵解等代谢检查点的发现，为Th17介导性葡萄膜炎提供了"代谢免疫学"层面的全新干预思路。肠-眼轴假说兴起：肠道菌群失调被认为可能通过免疫调节参与葡萄膜炎的发生发展，为益生菌干预等辅助治疗策略提供理论依据。治疗药物监测精准化：血药浓度及抗药抗体检测正逐步整合入阿达木单抗治疗的个体化决策流程。葡萄膜炎的诊治已从传统"激素、免疫抑制剂"，逐步迈向"细胞因子精准靶向、口服小分子、局部缓释"。Th17/Treg失衡及其代谢调控机制的阐明，为开发兼具疗效与安全性的新一代靶向药物奠定了基础。未来研究有待在以下方向深入：建立基于生物标志物的精准分型治疗体系；推动MSC及外泌体疗法的临床转化；阐明肠-眼轴在不同葡萄膜炎亚型中的具体作用机制。参考 Infectious uveitis: a comprehensive systematic review of emerging trends and molecular pathogenesis using network analysis. J Ophthalmic Inflamm Infect. 2024 Comparative models of uveitis. Eye. 2025 Pathogenesis and targets in uveitis. Semin Arthritis Rheum. 2025 Imbalance of Th17/Treg cells in pathogenesis of patients with human leukocyte antigen B27 associated acute anterior uveitis. Sci Rep. 2017 Cytokines that modulate the differentiation of Th17 cells in autoimmune uveitis. J Immunol Res. 2021 Metabolic checkpoints in the regulation of Th17 cells: implications for uveitis pathogenesis and therapy. Front Immunol. 2026 Lipid metabolism analysis reveals that DGAT1 regulates Th17 survival by controlling lipid peroxidation in uveitis. JCI Insight. 2025 FAST Research Group. Effect of corticosteroid-sparing treatment with mycophenolate mofetil vs methotrexate on inflammation in patients with uveitis: a randomized clinical trial. JAMA. 2019 Intravitreal therapy for uveitic macular edema-ranibizumab versus methotrexate versus the dexamethasone implant: The MERIT trial results. Ophthalmology. 2023 Adalimumab in patients with active noninfectious uveitis. N Engl J Med. 2016 Comparison of infliximab with adalimumab for the treatment of non-infectious uveitis: a systematic review and meta-analysis. BMC Ophthalmol. 2023 Ten-year follow-up of infliximab treatment for uveitis in Behçet disease patients: A multicenter retrospective study. Front Med (Lausanne). 2023 Primary (month-6) outcomes of the STOP-Uveitis Study: evaluating the safety, tolerability, and efficacy of tocilizumab in patients with noninfectious uveitis. Am J Ophthalmol. 2017 APTITUDE Trial Management Group. Tocilizumab in patients with anti-TNF refractory juvenile idiopathic arthritis-associated uveitis (APTITUDE): a multicentre, single-arm, phase 2 trial. Lancet Rheumatol. 2020 Secukinumab in the treatment of noninfectious uveitis: results of three randomized, controlled clinical trials. Ophthalmology. 2013 Genentech presents new phase III pivotal data for vamikibart in uveitic macular edema (UME), a serious cause of vision loss. 2025 Filgotinib in active noninfectious uveitis: the HUMBOLDT randomized clinical trial. JAMA Ophthalmol. 2024 The use of Janus kinase inhibitors to treat noninfectious uveitis. Eye. 2025 Review of Janus kinase inhibitors as therapies for noninfectious uveitis. J Ocul Pharmacol Ther. 2025 SAKURA Study Group. Intravitreal sirolimus for noninfectious uveitis: a phase III sirolimus study assessing double-masked uveitis treatment (SAKURA). Ophthalmology. 2016 Therapeutic drug monitoring plays an important role in patients with noninfectious uveitis receiving adalimumab. Front Immunol. 2025 Mesenchymal stem cell based therapies for uveitis: a systematic review of preclinical studies. Eye. 2024 Treating uveitis today and tomorrow. Retina Today. 2025

2026-06-25

·北京医学感染与传染研究

自然·医学 32卷 1-6期（2026年6月25日更新）

Nature Medicine Volume 32 Issue 1 自然·医学 32卷 1期 https://www.nature.com/nm/volumes/32/issues/1 Nature Medicine Commission on Dialysis Policy in LMICs 《自然·医学》低收入和中等收入国家（LMICs）透析政策委员会专刊 In this issue, Teerawattananon and colleagues present policy goals and recommendations from the Nature Medicine Commission on Dialysis Policy in Low- and Middle-Income Countries (LMICs). The goal of the commission was to address current dialysis policy challenges in Thailand, and to provide lessons for other countries seeking to integrate dialysis into universal health coverage in a way that is sustainable, equitable and safe. 在本期内容中，Teerawattananon及其同事阐述了《自然·医学》低收入和中等收入国家（LMICs）透析政策委员会提出的政策目标与建议。该委员会旨在应对泰国当前在透析政策方面面临的挑战，并为其他寻求以可持续、公平且安全的方式将透析服务纳入全民健康覆盖体系的国家提供经验借鉴。 Editorial（社论） 1 Nature Portfolio Commissions: data-driven solutions to global problems 《自然》系列期刊专刊：以数据为驱动解决全球问题 The first Nature Portfolio Commission Report outlines paths to sustainable dialysis policies, robust evidence-to-policy translation and south–south collaboration. 首份《自然》系列期刊专刊报告概述了实现可持续透析政策、有力推动证据向政策转化以及开展南南合作的路径。 Collection: Nature Medicine Commission on dialysis policy in low- and middle-income countries 专题：低收入和中等收入国家《自然·医学》透析政策委员会专刊 Nature Medicine volume 32（1）, page：1 (2026) News（新闻） 2 Is addiction the next frontier for GLP-1 receptor agonists? GLP-1受体激动剂会是成瘾治疗领域的下一个突破口吗？ Researchers are probing whether the blockbuster drugs that transformed obesity treatment could also quiet the brain’s cravings for substances such as alcohol, nicotine and opioids. 研究人员正在探究，那些彻底改变肥胖治疗方式的重磅药物是否也能抑制大脑对酒精、尼古丁和阿片类药物等物质的渴望。 Natalie Healey Nature Medicine volume 32（1）, pages：2-3 (2026) Partner Content（合作内容） Explore the next frontier in allogeneic CAR-T innovation 探索异体CAR-T创新领域的下一个前沿 Allogene is aiming to develop a first-line consolidation treatment for large B-cell lymphoma that predicts and prevents relapse. Allogene公司旨在开发一种针对大B细胞淋巴瘤的一线巩固治疗方案，该方案可预测并预防疾病复发。 News Feature（新闻特写） 3 Silenced genomes 沉默的基因组 Projects worldwide push for more diverse genomic databases across Asia, Africa and the Americas. 全球各地的项目正推动建立涵盖亚洲、非洲和美洲的更多样化的基因组数据库。 Sofia Moutinho Nature Medicine volume 32（1）, pages：4–8 (2026) Turning Points（转折点） 4 Early successes in colon immunotherapy 结直肠免疫治疗的早期成功 How an exploratory study of neoadjuvant immunotherapy saved patient lives. 一项新辅助免疫治疗的探索性研究如何挽救患者生命。 Myriam Chalabi Nature Medicine volume 32（1）, page：9 (2026) Correspondence（读者来信） 5 The evolving landscape of cardiovascular health in Africa: insights from WHO AFRO 非洲心血管健康格局的演变：来自世卫组织非洲区域办事处的见解 Bayan GalalEeshaan MalladiMohamed Janabi Nature Medicine volume 32（1）, pages：10–11 (2026) 6 Navigating difficult ethical decisions in global health 全球卫生领域中艰难伦理决策的应对之道 Maxwell J. SmithDiego S. SilvaKatherine Littler Nature Medicine volume 32（1）, pages：12–13 (2026) 7 The Italian parliament first to recognize obesity as a chronic and relapsing disease 意大利议会率先承认肥胖是一种慢性复发性疾病 Silvio BuscemiMaurizio De LucaFederico Serra Nature Medicine volume 32（1）, pages：14–15 (2026) 8 Harnessing evidence-based solutions for climate resilience and women’s, children’s and adolescents’ health 利用循证解决方案提升气候适应能力，促进妇女、儿童和青少年健康 Rajat KhoslaHelen ClarkFlavia Bustreo Nature Medicine volume 32（1）, pages：16-17 (2026) 9 MASLD as a complication of obesity must include liver risk stratification 作为肥胖并发症的代谢障碍相关脂肪性肝病（MASLD）必须纳入肝脏风险分层管理 Mary E. RinellaArun J. SanyalVlad Ratziu Nature Medicine volume 32（1）, pages：18–19 (2026) 10 Clarification of evidence selection for the framework for the pharmacological treatment of obesity and its complications from the EASO 欧洲肥胖研究协会（EASO）关于肥胖及其并发症药物治疗框架的证据选择说明 Andreea CiudinBarbara McGowan Nature Medicine volume 32（1）, page：20 (2026) World View（世界视角） 11 When science meets violence 当科学遭遇暴力 Women scientists deserve safety — not silence. 女科学家应得到安全保障，而非沉默以对。 Luana Araujo Nature Medicine volume 32（1）, page：21 (2026) Comment（述评） 12 Sustaining kidney failure care under universal health coverage 全民健康覆盖下维持肾衰竭治疗 Rising demand for dialysis poses a central challenge to universal health coverage systems: not just whether to expand access, but how to sustain equitable, high-quality kidney failure care. In this Comment, I argue that long-term viability depends on system architecture, rather than modality choice alone. 透析需求不断增长，给全民健康覆盖体系带来了核心挑战：不仅在于是否要扩大服务可及性，更在于如何维持公平、高质量的肾衰竭治疗。在本文评论中，我认为长期可行性取决于系统架构，而非仅依赖治疗方式的选择。 Syarifah Liza Munira Collection: Nature Medicine Commission on dialysis policy in low- and middle-income countries 专题：低收入和中等收入国家《自然·医学》透析政策委员会专刊 Nature Medicine volume 32（1）, pages：22–24 (2026) 13 A One Health trial design to accelerate Lassa fever vaccines 加速拉沙热疫苗研发的“同一健康”试验设计 We propose an interdisciplinary framework to address the considerable challenges that are restricting the development of vaccines for zoonotic diseases with epidemic potential. 我们提出了一个跨学科框架，以应对当前限制具有流行潜力的人畜共患病疫苗开发的重大挑战。 David SimonsDeborah Watson-JonesSagan Friant Nature Medicine volume 32（1）, pages：25–27 (2026) 14 Reduce bureaucracy in clinical trials now 立即减少临床试验中的官僚主义 Clinical trials in Europe must become far more efficient to support the needs of investigators and their patients. The way trials are designed, conducted and regulated should be attuned first and foremost to the needs of patients, to ensure timely and equitable access to safe, effective and innovative treatments. 欧洲的临床试验必须大幅提高效率，以满足研究人员及其患者的需求。临床试验的设计、实施和监管方式应首先适应患者的需求，以确保患者能够及时、公平地获得安全、有效和创新的治疗方法。 Martin DreylingSara Badreh WirströmRobin Doeswijk Nature Medicine volume 32（1）, pages：28–30 (2026) 15 Lessons in public trust 公共信任的启示 What the organ donation system can learn from global experiences with vaccine programs. 器官捐献体系能从全球疫苗接种项目的经验中学到什么。 Heidi J. LarsonAlexander H. Toledo Nature Medicine volume 32（1）, pages：31–33 (2026) News & Views（新闻与观点） 16 Mapping the effects of gender-affirming sex hormone therapy 绘制性别肯定性激素治疗的效应图谱 A study uses plasma proteome analysis to illuminate systemic effects of feminizing gender-affirming hormone therapy; more research like this will inform better healthcare for transgender people and could hold insights into sex-specific immune regulation. 一项研究利用血浆蛋白质组分析揭示了女性化性别肯定激素治疗的全身效应；更多此类研究将为跨性别者提供更优质的医疗服务，并可能为性别特异性免疫调控提供见解。 Petter Brodin Nature Medicine volume 32（1）, pages：34–35 (2026) 17 Political protests, social media use and mental well-being 政治抗议、社交媒体使用与心理健康 A large, longitudinal study shows that interpersonal conflict and excessive social media use are associated with increased levels of depression during political protests — but we should not lose sight of the wider contexts in which such protests take place. 一项大型纵向研究表明，在政治抗议期间，人际冲突和过度使用社交媒体与抑郁水平上升相关——但我们不应忽视此类抗议发生的更广泛背景。 Jon RoozenbeekIli Ma Nature Medicine volume 32（1）, pages：36–37 (2026) 18 Mechanistic insights make cancer cachexia a targetable syndrome 机制性见解使癌症恶病质成为可治疗综合征 Two studies establish a mechanism, biomarker and therapeutic strategy for cancer cachexia, all centered around the HIF-2 pathway. The findings reframe this intractable metabolic syndrome as a pharmacologically treatable condition. 两项研究围绕HIF-2通路，确立了癌症恶病质的机制、生物标志物和治疗策略。这些发现将这种顽固的代谢综合征重新定义为可通过药物治疗的病症。 Ed ReznikMartin H. VossA. Ari Hakimi Collection: Cancer at Nature Portfolio 专题：自然系列期刊癌症研究 Nature Medicine volume 32（1）, pages：38–39 (2026) 19 Understanding the link between atrial fibrillation and cognitive decline 理解心房颤动与认知功能下降之间的关联 A phase 3 trial shows no impact of the anticoagulant rivaroxaban on the risk of cognitive decline in individuals with atrial fibrillation and low thromboembolic risk — highlighting the need for a better understanding of the mechanisms that link these conditions. 一项3期试验显示，抗凝药物利伐沙班对心房颤动且血栓栓塞风险较低患者的认知功能下降风险无影响——这凸显了进一步理解这两种病症之间关联机制的必要性。 Marco ProiettiGiulio Francesco Romiti Nature Medicine volume 32（1）, pages：40–41 (2026) Research Briefings（研究简报） 20 Serum biomarker enables diagnosis and monitoring of idiopathic pulmonary arterial hypertension 血清生物标志物助力特发性肺动脉高压的诊断与监测 We have identified serum levels of extracellular domain of NOTCH3 (NOTCH3-ECD) as a biomarker that can reliably distinguish idiopathic pulmonary arterial hypertension from other forms of pulmonary hypertension and healthy controls. Our findings show that serum NOTCH3-ECD levels are as accurate as current standard-of-care clinical tests in predicting disease progression and mortality risk. 我们已确定NOTCH3胞外域（NOTCH3-ECD）的血清水平可作为可靠区分特发性肺动脉高压与其他类型肺动脉高压及健康对照者的生物标志物。我们的研究结果显示，血清NOTCH3-ECD水平在预测疾病进展和死亡风险方面与当前临床标准检测同样准确。 Nature Medicine volume 32（1）, pages：42–43 (2026) Policy Brief（政策简报） 21 The path to safe, equitable and sustainable dialysis provision for people with chronic kidney disease 为慢性肾脏病患者提供安全、公平且可持续的透析服务之路 An abrupt policy change in 2022 — allowing patients to choose between peritoneal dialysis or hemodialysis — created severe unintended consequences for the Thai health system. A multidisciplinary commission found that interacting factors in the system were overlooked and that future dialysis policies must integrate more-diverse evidence and stakeholder views, prioritizing care quality and ethics while balancing equity and sustainability. 2022年，泰国一项突发的政策变更——允许患者在腹膜透析和血液透析之间做出选择——给泰国卫生系统带来了严重的意外后果。一个多学科委员会发现，系统中的相互作用因素被忽视，未来的透析政策必须整合更多样化的证据和利益相关者的观点，在平衡公平性与可持续性的同时，将护理质量和伦理置于优先地位。 Yot TeerawattananonKinanti Khansa ChavarinaWirun Limsawart Collection: Nature Medicine Commission on dialysis policy in low- and middle-income countries 专题：低收入和中等收入国家《自然·医学》透析政策委员会专刊 Nature Medicine volume 32（1）, pages：44–46 (2026) Review Articles（综述） 22 The expanding landscape of GLP-1 medicines 胰高血糖素样肽-1（GLP-1）药物领域的不断拓展 This Review discusses the expansion of glucagon-like peptide-1 (GLP-1) medicines beyond type 2 diabetes and obesity, outlining opportunities for new indications, key questions around benefits and long-term safety, and areas of uncertainty requiring further research. 本综述探讨了胰高血糖素样肽-1（GLP-1）药物在2型糖尿病和肥胖症之外的应用拓展，阐述了新适应症的机遇、围绕获益和长期安全性的关键问题，以及需要进一步研究的不确定性领域。 Daniel J. Drucker Nature Medicine volume 32（1）, pages：47–57 (2026) Commission Report（委员会报告） 23 Nature Medicine Commission on dialysis policy in low- and middle-income countries 低收入和中等收入国家《自然·医学》透析政策委员会报告 This Commission aims to resolve the current dialysis policy challenges in Thailand and generate lessons for the global kidney community by drawing on empirical evidence, systems thinking and multidisciplinary expertise to generate policy goals and recommendations. 本委员会旨在通过借鉴实证证据、系统思维和多学科专业知识，制定政策目标和建议，解决泰国当前透析政策面临的挑战，并为全球肾脏病领域提供经验教训。 Yot TeerawattananonKinanti Khansa ChavarinaYot Teerawattananon Collection: Nature Medicine Commission on dialysis policy in low- and middle-income countries 专题：低收入和中等收入国家《自然·医学》透析政策委员会专刊 Nature Medicine volume 32（1）, pages：58–71 (2026) Articles（论著） 24 Genetic architecture and phenotypic diversity of oocyte and early embryo competence defects in female infertility 女性不孕症中卵母细胞和早期胚胎发育潜能缺陷的遗传结构与表型多样性 Whole-exome sequencing analyses in a cohort of 2,140 participants with female infertility after recurrent in vitro fertilization, coupled with functional analyses, identified genes associated with oocyte and early embryo competence defects. 对2140例反复体外受精后女性不孕症患者进行全外显子组测序分析，并结合功能分析，确定了与卵母细胞和早期胚胎发育潜能缺陷相关的基因。 Changlong ZhangWei ZhengZi-Jiang Chen Nature Medicine volume 32（1）, pages：72–81 (2026) 25 MRI-based multi-organ clocks for healthy aging and disease assessment 基于磁共振成像（MRI）的多器官时钟用于健康衰老和疾病评估 A new study combines MRI data with proteomic, metabolomic and RNA data to develop and examine seven organ-specific MRI-based aging clocks, uncovering links to overall mortality and organ-specific diseases. 一项新研究结合磁共振成像数据与蛋白质组学、代谢组学和RNA数据，开发并检验了七种基于磁共振成像的器官特异性衰老时钟，揭示了其与总死亡率和器官特异性疾病的关联。 Huizi CaoZhiyuan SongJunhao Wen Nature Medicine volume 32（1）, pages：82–92 (2026) 26 Factor IX-Padua AAV gene therapy in hemophilia B: phases 1/2 and 3 trials B型血友病的IX因子-帕多瓦腺相关病毒（AAV）基因疗法：1/2期和3期临床试验 A phase 1/2 and a phase 3 trial testing an AAV-FIX Padua gene therapy in patients with hemophilia B in China showed that the treatment was well tolerated and effective in reducing the annualized bleeding rate. 在中国B型血友病患者中开展的一项1/2期和一项3期试验，对一种AAV-FIX帕多瓦基因疗法进行了测试，结果显示该疗法耐受性良好，能有效降低年出血率。 Feng XueMankai JuLei Zhang Nature Medicine volume 32（1）, pages：93–102 (2026) 27 Oral splicing modulator branaplam in Huntington’s disease: a phase 2 randomized controlled trial 口服剪接调控剂布兰纳普兰治疗亨廷顿病：一项2期随机对照试验 Early results from the phase2b VIBRANT-HD trial of the oral splicing modulator branaplam in Huntington’s disease suggested reduced cerebrospinal fluid huntingtin levels, but safety monitoring revealed signs of peripheral neurotoxicity, prompting early termination of the study. 口服剪接调控剂布兰纳普兰治疗亨廷顿病的2b期VIBRANT-HD试验的早期结果显示，脑脊液中亨廷顿蛋白水平降低，但安全性监测发现存在周围神经毒性迹象，促使研究提前终止。 Beth BorowskyHarry RamosBlair R. Leavitt Nature Medicine volume 32（1）, pages：103–112 (2026) 28 Multi-omic definition of metabolic obesity through adipose tissue–microbiome interactions 通过脂肪组织-微生物组相互作用对代谢性肥胖进行多组学定义 Metabolomics, metagenomics, proteins and genetics were combined with clinical data to define a metabolic signature of obesity. 将代谢组学、宏基因组学、蛋白质组学和遗传学与临床数据相结合，定义了肥胖的代谢特征。 Rima M. ChakarounMeenakshi PradhanFredrik Bäckhed Nature Medicine volume 32（1）, pages：113–125 (2026) 29 The global macroeconomic burden of diabetes mellitus 糖尿病的全球宏观经济负担 An analysis of 204 countries estimates that diabetes will cost the global economy $10.2 trillion between the years 2020 and 2050. 一项对204个国家的分析估计，2020年至2050年间，糖尿病将给全球经济造成10.2万亿美元的损失。 Simiao ChenZhong CaoDavid E. Bloom Nature Medicine volume 32（1）, pages：126–138 (2026) 30 Plasma proteome adaptations during feminizing gender-affirming hormone therapy 女性化性别肯定激素治疗期间的血浆蛋白质组适应性变化 Researchers analyzed 5,279 plasma proteins in 40 people undergoing feminizing gender-affirming hormone therapy over 6months, revealing significant changes in 299 proteins. Such changes could have implications for reproductive capacity, immune regulation and long-term health. 研究人员对40名接受6个月女性化性别肯定激素治疗者的5279种血浆蛋白质进行了分析，发现299种蛋白质发生了显著变化。这些变化可能对生殖能力、免疫调节和长期健康产生影响。 Nhi N. L. NguyenDen CelestraBoris Novakovic Nature Medicine volume 32（1）, pages：139–150 (2026) 31 Elebsiran and PEG-IFNα for chronic hepatitis B infection: a partially randomized, open-label, phase 2 trial Elebsiran联合聚乙二醇干扰素α（PEG-IFNα）治疗慢性乙型肝炎病毒感染：一项部分随机、开放标签的2期试验 Elebsiran plus PEG-IFNα improved hepatitis B surface antigen (HBsAg) loss rates compared with PEG-IFNα alone in patients with chronic hepatitis B virus infection. Furthermore, prior response to the BRII-179 vaccine was associated with higher HBsAg clearance, suggesting its potential as a predictive tool for identifying patients more likely to benefit from therapies. 与单独使用聚乙二醇干扰素α相比，Elebsiran联合聚乙二醇干扰素α可提高慢性乙型肝炎病毒感染患者的乙型肝炎表面抗原（HBsAg）清除率。此外，先前对BRII-179疫苗有应答与更高的HBsAg清除率相关，这表明该疫苗有望成为识别更可能从治疗中获益患者的预测工具。 Grace Lai-Hung WongMan-Fung YuenZhi Hong Nature Medicine volume 32（1）, pages：151–159 (2026) 32 Detection of undiagnosed liver cirrhosis via AI-enabled electrocardiogram: a pragmatic, cluster-randomized clinical trial 通过人工智能心电图检测未确诊的肝硬化：一项实用、整群随机临床试验 In a trial involving 45 clinics and 15,596 visits, the use of an AI-based screening tool applied to ECG for opportunistic detection of advanced chronic liver disease led to a significant increase in new diagnoses compared to the standard workflow. 在一项涉及45家诊所和15596次就诊的试验中，使用基于人工智能的心电图筛查工具对晚期慢性肝病进行机会性检测，与标准工作流程相比，新诊断病例显著增加。 Douglas A. SimonettoDavid RushlowVijay H. Shah Nature Medicine volume 32（1）, pages：160–167 (2026) 33 Cabotegravir and rilpivirine for treatment of HIV infection in Africa: week 96 results from the phase 3b randomized, open-label, noninferiority CARES trial 卡博特韦和利匹韦林治疗非洲HIV感染：3b期随机、开放标签、非劣效性CARES试验第96周结果 In this follow-up study presenting results at 96weeks, cabotegravir and rilpivirine long-acting therapy remained noninferior to oral therapy, had acceptable safety and tolerability profiles, and resulted in durable virologic suppression, further supporting its consideration for African treatment programs. 在这项随访研究中展示了第96周的结果，卡博特韦和利匹韦林长效疗法仍不劣于口服疗法，具有可接受的安全性和耐受性，并能实现持久的病毒学抑制，这进一步支持了将其纳入非洲治疗方案的考虑。 Cissy KityoIvan K. MambuleVeerle Van Eygen Nature Medicine volume 32（1）, pages：168–177 (2026) 34 Malaria vaccine protection against intradermal or venous parasites: a randomized phase 2b human challenge trial 疟疾疫苗对皮内或静脉注射寄生虫的保护作用：一项随机2b期人体挑战试验 The R21/Matrix-M vaccine, but not the ME-TRAP vaccine, was protective against intradermal challenge with Plasmodium falciparum sporozoites, while neither was protective against direct venous inoculation, potentially explaining previously observed differences in protection. R21/Matrix-M疫苗（而非ME-TRAP疫苗）对恶性疟原虫子孢子皮内注射挑战具有保护作用，而两种疫苗对直接静脉注射均无保护作用，这可能解释了先前观察到的保护差异。 Melissa C. KapuluFrancesca OrengePhilip Bejon Nature Medicine volume 32（1）, pages：178–185 (2026) 35 The impact of an oral purified microbiome therapeutic on the gastrointestinal microbiome 口服纯化微生物组疗法对胃肠道微生物组的影响 An exploratory analysis of the phase 3 ECOSPOR III trial shows that a higher dosage of the oral microbiome therapeutic VOWST led to enhanced pharmacokinetics, increased species engraftment and altered microbiome and metabolite profiles, providing mechanistic insights into how it may prevent Clostridioides difficile infection recurrence. 对3期ECOSPOR III试验的一项探索性分析显示，较高剂量的口服微生物组疗法VOWST可增强药代动力学，增加物种植入，并改变微生物组和代谢物谱，为该疗法如何预防艰难梭菌感染复发提供了机制见解。 Jessica A. BryantMarin VulićMatthew R. Henn Nature Medicine volume 32（1）, pages：186–196 (2026) 36 Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study 1990 - 2023年全球、区域和国家慢性呼吸系统疾病负担及新冠肺炎疫情的影响：一项全球疾病负担研究 Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial. 全球疾病负担研究的估计结果显示，1990年至2023年间慢性呼吸系统疾病死亡率有所下降，尤其是在新冠肺炎疫情期间，但受影响人群的负担仍然沉重。 Jiyeon OhSoeun KimDong Keon Yon Nature Medicine volume 32（1）, pages：197–223 (2026) 37 Interpersonal conflicts, social media use and depression associated with protests 抗议活动期间的人际冲突、社交媒体使用与抑郁 A 15-year prospective cohort study found that during times of social unrest in Hong Kong, people experienced more conflicts with family and friends and this coincided with the use of social media—these factors were also associated with higher levels of depression. 一项为期15年的前瞻性队列研究发现，在香港社会动荡时期，人们与家人和朋友的冲突增多，这与社交媒体的使用同时发生，这些因素也与更高的抑郁水平相关。 Jian ShiCandi M. C. LeungMichael Y. Ni Nature Medicine volume 32（1）, pages：224–230 (2026) 38 AI-enabled virtual spatial proteomics from histopathology for interpretable biomarker discovery in lung cancer 基于组织病理学的人工智能虚拟空间蛋白质组学用于肺癌可解释生物标志物发现 A model trained to generate spatial proteomics profiles and predict the expression of 40 biomarkers directly from histopathology slides is shown to improve survival and treatment response prediction in patients with lung cancer. 一项训练模型可直接从组织病理学切片生成空间蛋白质组学图谱并预测40种生物标志物的表达，该模型可改善肺癌患者的生存和治疗反应预测。 Zhe LiYuchen LiRuijiang Li Nature Medicine volume 32（1）, pages：231–244 (2026) 39 Targeting of HIF2-driven cachexia in kidney cancer 针对肾癌中HIF2驱动的恶病质 In vivo experiments and clinical cohort analyses show that hypoxia-inducible factor2 (HIF2)-induced parathyroid hormone-related protein (PTHrP) expression contributes to cachexia in the context of renal cell carcinoma (RCC). The pathway can be targeted by HIF2 inhibitors, including belzutifan, which may reduce cachexia in patients with RCC. 体内实验和临床队列分析表明，在肾细胞癌（RCC）背景下，缺氧诱导因子2（HIF2）诱导的甲状旁腺激素相关蛋白（PTHrP）表达会导致恶病质。该通路可通过包括贝组替凡（belzutifan）在内的HIF2抑制剂进行靶向治疗，这可能减轻肾细胞癌患者的恶病质症状。 Muhannad Abu-RemailehLaura A. StranskyWilliam G. Kaelin Jr Nature Medicine volume 32（1）, pages：245–257 (2026) 40 Autologous multiantigen-targeted T cell therapy for pancreatic cancer: a phase 1/2 trial 针对胰腺癌的自体多抗原靶向T细胞疗法：一项1/2期试验 Results of the phase 1/2 TACTOPS trial show that autologous T cell therapy targeting PRAME, SSX2, MAGEA4, Survivin and NY-ESO-1 in patients with pancreatic ductal adenocarcinoma is feasible and safe, and leads to encouraging clinical responses and evidence of antigen spreading in responders. 1/2期TACTOPS试验结果显示，针对PRAME、SSX2、MAGEA4、Survivin和NY-ESO-1的自体T细胞疗法在胰腺导管腺癌患者中可行且安全，并能带来令人鼓舞的临床反应，且在有反应的患者中观察到抗原扩散的证据。 Benjamin L. MusherSpyridoula VasileiouAnn M. Leen Nature Medicine volume 32（1）, pages：258–269 (2026) 41 Immune profiling in a living human recipient of a gene-edited pig kidney 基因编辑猪肾活体受者的免疫图谱分析 High-dimensional immune profiling of a living recipient of a pig-to-human xenotransplant provides insight into the immune landscape of xenotransplantation and directions for improved immunosuppression strategies. 对猪到人异种移植活体受者进行的高维免疫图谱分析，为了解异种移植的免疫格局以及改进免疫抑制策略提供了见解。 Guilherme T. RibasAndré F. CunhaLeonardo V. Riella Nature Medicine volume 32（1）, pages：270–280 (2026) 42 A meta-analysis of albuminuria as a surrogate endpoint for kidney failure 白蛋白尿作为肾衰竭替代终点的荟萃分析 In a meta-analysis of 48 randomized trials of chronic kidney disease progression, reduction in the 6-month urinary albumin:creatinine ratio was associated with lower hazard ratios of established kidney disease endpoints, supporting the use of albuminuria change as a surrogate endpoint in clinical trials for chronic kidney disease. 一项针对48项慢性肾脏病进展随机试验的荟萃分析显示，6个月尿白蛋白与肌酐比值降低与已确立的肾脏病终点事件风险比降低相关，这支持将白蛋白尿变化作为慢性肾脏病临床试验的替代终点。 Hiddo J. L. HeerspinkWillem H. CollierLesley A. Inker Nature Medicine volume 32（1）, pages：281–287 (2026) 43 Generative AI-based low-dose digital subtraction angiography for intra-operative radiation dose reduction: a randomized controlled trial 基于生成式人工智能的低剂量数字减影血管造影用于术中辐射剂量降低：一项随机对照试验 A model, trained to generate synthetic, patient-specific angiography images, reduced radiation exposure to patients and clinicians by two-thirds in a multicenter randomized controlled trial involving 1,068 patients. 在一项涉及1068例患者的多中心随机对照试验中，训练用于生成合成、患者特异性血管造影图像的模型，将患者和临床医生的辐射暴露量降低了三分之二。 Huangxuan ZhaoYaowei BaiChuansheng Zheng Nature Medicine volume 32（1）, pages：288–296 (2026) 44 Anticoagulation to prevent ischemic stroke and neurocognitive impairment in atrial fibrillation: the BRAIN-AF randomized clinical trial 抗凝治疗预防心房颤动患者缺血性脑卒中和神经认知障碍：BRAIN-AF随机临床试验 In a multicenter, randomized trial of patients with atrial fibrillation and a low risk of thromboembolic events, treatment with the anticoagulant rivaroxaban showed no benefit in reducing cognitive decline, stroke or transient ischemic attack when compared to placebo. 在一项针对低血栓栓塞事件风险心房颤动患者的多中心随机试验中，与安慰剂相比，使用抗凝剂利伐沙班治疗在减少认知功能下降、脑卒中或短暂性脑缺血发作方面未显示出益处。 Léna RivardPaul KhairyWilliam Liang Nature Medicine volume 32（1）, pages：297–305 (2026) 45 The NOTCH3 extracellular domain is a serum biomarker for pulmonary arterial hypertension NOTCH3胞外域是肺动脉高压的血清生物标志物 A protein biomarker, the NOTCH3 extracellular domain, identifies individuals with idiopathic pulmonary hypertension, correlates with disease progression, improves mortality risk prediction and provides a readily implementable, noninvasive blood test for this disease. 一种蛋白质生物标志物——NOTCH3胞外域，可识别特发性肺动脉高压患者，与疾病进展相关，能改善死亡风险预测，并为该疾病提供了一种易于实施的非侵入性血液检测方法。 Moises HernandezNolan M. WinickiPatricia A. Thistlethwaite Nature Medicine volume 32（1）, pages：306–317 (2026) 46 Fractional flow reserve-guided percutaneous coronary intervention versus medical therapy for stable coronary artery disease: long-term results of the FAME 2 trial 血流储备分数指导的经皮冠状动脉介入治疗与药物治疗稳定型冠状动脉疾病：FAME 2试验的长期结果 In a long-term follow-up of the FAME2 trial, fractional flow reserve-guided percutaneous coronary intervention plus medical therapy in patients with stable coronary artery disease reduced cardiovascular events compared to medical therapy alone, primarily due to a decrease in urgent revascularization events. 在FAME 2试验的长期随访中，对于稳定型冠状动脉疾病患者，血流储备分数指导的经皮冠状动脉介入治疗联合药物治疗与单纯药物治疗相比，可减少心血管事件，这主要归因于紧急血运重建事件的减少。 Carlos ColletThabo MahendiranPeter Jüni Nature Medicine volume 32（1）, pages：318–324 (2026) 47 Lifetime benefits of comprehensive medical therapy in heart failure with mildly reduced or preserved ejection fraction 射血分数轻度降低或保留的心力衰竭综合药物治疗的终身获益 In a cross-trial analysis, combined treatment with medications that have individually shown to improve cardiovascular outcomes in heart failure with mildly reduced or preserved ejection fraction demonstrates substantial benefit, including for event-free survival. 一项跨试验分析显示，对于射血分数轻度降低或保留的心力衰竭，联合使用单独显示可改善心血管结局的药物可带来显著益处，包括无事件生存期延长。 Muthiah VaduganathanBrian L. ClaggettScott D. Solomon Nature Medicine volume 32（1）, pages：325–331 (2026) 48 Endotyping-informed therapy for patients with chest pain and no obstructive coronary artery disease: a randomized trial 基于内型分型的疗法治疗无阻塞性冠状动脉疾病且伴有胸痛的患者：一项随机试验 As presented at the American Heart Association Conference 2025, patients with chest pain and without obstructive coronary artery disease benefit from treatment informed by cardiovascular magnetic resonance. 如2025年美国心脏协会会议所展示，对于无阻塞性冠状动脉疾病且伴有胸痛的患者，基于心血管磁共振的内型分型指导治疗可带来益处。 Conor P. BradleyGemma McKinleyColin Berry Nature Medicine volume 32（1）, pages：332–341 (2026) 49 Cardiovascular outcomes of semaglutide and tirzepatide for patients with type 2 diabetes in clinical practice 司美格鲁肽和替西帕肽对临床实践中2型糖尿病患者心血管预后的影响 As presented at AHA Scientific Sessions 2025, in a trial emulation analysis including benchmarking to data from randomized clinical trials, treatment with semaglutide and tirzepatide showed similar levels of benefit on cardiovascular outcomes in individuals at elevated cardiovascular risk with obesity and diabetes. 如2025年美国心脏协会科学会议上所展示，在一项包含与随机临床试验数据进行基准对比的试验模拟分析中，对于肥胖且患糖尿病、心血管风险升高的个体，司美格鲁肽和替西帕肽治疗在心血管预后方面显示出相似的获益水平。 Nils KrügerSebastian SchneeweissShirley V. Wang Nature Medicine volume 32（1）, pages：342–352 (2026) 50 Liraglutide in mild to moderate Alzheimer’s disease: a phase 2b clinical trial 利拉鲁肽治疗轻中度阿尔茨海默病：一项2b期临床试验 Results from the phase ELAD 2 trial reveal that liraglutide is safe and well tolerated in people with mild to moderate Alzheimer’s disease but does not significantly slow brain metabolism decline. ELAD 2期试验结果显示，利拉鲁肽在轻中度阿尔茨海默病患者中安全且耐受性良好，但未能显著减缓脑代谢下降速度。 Paul EdisonGrazia Daniela FemminellaClive Ballard Nature Medicine volume 32（1）, pages：353–361 (2026) 51 Myelin injury precedes axonal injury and symptomatic onset in multiple sclerosis 在多发性硬化症中，髓鞘损伤早于轴突损伤和症状发作 Myelin damage in multiple sclerosis can be detected up to 7years before symptoms, with early immune pathway activation and a 21-protein panel showing promise for presymptomatic diagnosis. 在多发性硬化症中，髓鞘损伤最早可在症状出现前7年被检测到，早期免疫通路激活以及由21种蛋白质组成的检测面板在症状前诊断方面显示出潜力。 Ahmed AbdelhakGabriel CeronoAri J. Green Nature Medicine volume 32（1）, pages：362–368 (2026) 52 Vagus nerve-mediated neuroimmune modulation for rheumatoid arthritis: a pivotal randomized controlled trial 迷走神经介导的神经免疫调节治疗类风湿关节炎：一项关键随机对照试验 An implantable vagus nerve-targeted device safely reduces disease activity and joint damage in rheumatoid arthritis, offering a new nondrug treatment for patients who do not respond to or cannot tolerate medication. 一种可植入的针对迷走神经的装置可安全地降低类风湿关节炎的疾病活动度和关节损伤，为对药物无反应或无法耐受药物的患者提供了一种新的非药物治疗方法。 John R. P. TesserAngela R. CrowleyDavid Chernoff Nature Medicine volume 32（1）, pages：369–378 (2026) Amendments & Corrections（修订与更正） 53 Author Correction: The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue 作者更正：冷诱导脂质因子12,13-二羟基十八碳烯酸促进脂肪酸向棕色脂肪组织的转运 Matthew D LynesLuiz O LeiriaYu-Hua Tseng Nature Medicine volume 32（1）, page：379 (2026) 54 Author Correction: Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia 作者更正：组蛋白甲基转移酶EZH2缺失导致急性髓系白血病对多种药物产生耐药性 Stefanie GöllnerThomas OellerichCarsten Müller-Tidow Nature Medicine volume 32（1）, page：380 (2026) Nature Medicine volume 32 Issue 2 自然医学 32卷 2期 https://www.nature.com/nm/volumes/32/issues/2 Editorial（社论） 1 Neurodegenerative diseases need more mechanism-informed trials 神经退行性疾病需要更多基于机制的研究试验 Nature Medicine volume 32（2）, page381 News（新闻） 2 Biting back at Lyme disease 反击莱姆病 Mike May Nature Medicine volume 32（2）, pages382-383 News Feature（新闻特写） 3 Fault lines in a global promise 全球承诺中的裂痕 Paul Adepoju Nature Medicine volume 32（2）, pages384–387 Correspondence（读者来信） 4 The Translational Research and Innovation Laboratory (TRAIL) model for accelerating discovery through a shared institutional resource 通过共享机构资源加速发现：转化研究与创新实验室（TRAIL）模式 Steven BruzekGrant VestalNeil Goldenberg Nature Medicine volume 32（2）, pages388–389 5 Disentangling climate hazards from demographic change in climate–health projections 在气候与健康预测中厘清气候灾害与人口变化的影响 Josiah L. KephartUsama Bilal Nature Medicine volume 32（2）, pages390–391 6 China’s evidence-based re-evaluation of traditional Chinese medicine injections 中国对中药注射剂基于证据的重新评估 Chen ChenZiwei Hou Nature Medicine volume 32（2）, pages392–393 7 Reorienting Ebola care toward human-centered sustainable practice 将埃博拉护理转向以人为本的可持续实践 Richard Kitenge OmasumbuLuca FontanaMory Keita Nature Medicine volume 32（2）, pages394–395 8 Lessons from Rwanda’s response to the Marburg virus outbreak 卢旺达应对马尔堡病毒爆发的经验教训 Sabin NsanzimanaYvan ButeraTsion Firew Nature Medicine volume 32（2）, pages396–397 World View（国际视野） 9 US vaccine policy must put America first 美国疫苗政策必须将美国置于首位 Angela L. Rasmussen Nature Medicine volume 32（2）, pages398-399 Comment（述评） 10 Building a code of conduct for AI-driven clinical consultations 制定人工智能驱动临床咨询的行为准则 Ernest LimArun ThirunavukarasuIbrahim Habli Nature Medicine volume 32（2）, pages400–403 11 How to interpret ‘zero-shot’ results from generative EHR models 如何解读生成式电子健康记录模型的“零样本”结果 Suhana BediJason Alan FriesNigam H. Shah Nature Medicine volume 32（2）, pages404–406 12 The ethics of multi-cancer screening 多癌种筛查的伦理问题 Thomas CallenderAnne MackieAnne-Marie Slowther Nature Medicine volume 32（2）, pages407–409 13 Identifying ultra-processed foods for policy 为制定政策定义超加工食品 Alyssa J. MoranNeha KhandpurChristina A. Roberto Nature Medicine volume 32（2）, pages410–413 News & Views（新闻与观点） 14 Housing modifications for heat adaptation 用以适应高温的房屋改造 Salum MshamuLorenz von SeidleinJakob Brandberg Knudsen Nature Medicine volume 32（2）, pages414–415 15 Placebo effect influences vaccine responses 安慰剂效应影响疫苗反应 Kyungdeok KimBen TitleJonathan Kipnis Nature Medicine volume 32（2）, pages416–417 16 Practical solutions to weight management in primary care 初级医疗保健中体重管理的实用解决方案 Nerys AstburyElizabeth Morris Nature Medicine volume 32（2）, pages418–419 17 Going beyond genomics in precision oncology 精准肿瘤学正在超越基因组学 Irene PaassenMark A. Rubin Nature Medicine volume 32（2）, pages420–422 Research Briefings（研究简报） 18 Integration of health check-ups into school and healthcare systems can improve adolescent health in LMICs 将健康检查纳入学校和医疗保健系统可改善中低收入国家青少年的健康状况 Nature Medicine volume 32（2）, pages423–424 19 PD-1 blockade reprograms antiviral immunity and reduces the HIV reservoir PD-1阻断可重编码抗病毒免疫并减少HIV储存库 Nature Medicine volume 32（2）, pages425–426 20 A low-toxicity linezolid analog has potential for use in all patients with tuberculosis 一种低毒性的利奈唑胺类似物有潜力用于所有结核病患者 Nature Medicine volume 32（2）, pages427–428 21 Capillary blood sampling for detecting biomarkers of Alzheimer’s disease 利用毛细血管采血检测阿尔茨海默病生物标志物 Nature Medicine volume 32（2）, pages429–430 22 Immune cells in circulation serve as living biomarkers for inflammatory diseases 循环中的免疫细胞可作为炎症性疾病的活体生物标志物 Nature Medicine volume 32（2）, pages431–432 23 Large-scale analysis identifies metabolites associated with type 2 diabetes 大规模分析确定与2型糖尿病相关的代谢物 Nature Medicine volume 32（2）, pages433–434 24 Clinically relevant variants from the Mexican biobank show striking diversity across Hispanic people 来自墨西哥生物样本库的临床相关变异在西班牙裔人群中呈现出惊人的多样性 Nature Medicine volume 32（2）, pages435–436 25 Blood biomarkers reveal pathways associated with multimorbidity 血液生物标志物揭示与多种共病相关的通路 Nature Medicine volume 32（2）, pages437–438 Perspectives（观点） 26 Scaling medical AI across clinical contexts 跨临床场景扩展医学人工智能应用规模 Michelle M. LiBen Y. ReisMarinka Zitnik Nature Medicine volume 32（2）, pages439–448 Review Articles（综述） 27 The science of psychedelic medicine 迷幻药医学的科学研究 Joshua S. SiegelConor ListonMichael P. Bogenschutz Nature Medicine volume 32（2）, pages449–462 Matters Arising（待议问题） 28 Concerns over conclusions in an ultra-processed food trial 对一项超加工食品试验结论的担忧 David S. LudwigWalter C. WillettMary E. Putt Nature Medicine volume 32（2）, pages463–464 29 Concerns around evidence that food processing should be included in dietary guidance 对将食品加工纳入膳食指南这一证据的质疑 Eric RobinsonCiarán G. Forde Nature Medicine volume 32（2）, pages465–467 30 Concerns about attributing weight change to processing in a crossover feeding trial 对一项交叉喂养试验中将体重变化归因于食品加工的担忧 Zixuan WangCan Peng Nature Medicine volume 32（2）, pages468–469 31 Reply to Ludwig, D. S. et al.; Robinson, E. & Forde, C. G.; Wang, Z. & Peng, C. 对Ludwig, D. S.等人、Robinson, E. & Forde, C. G.、Wang, Z. & Peng, C.的回复 Samuel J. DickenAdrian BrownRachel L. Batterham Nature Medicine volume 32（2）, pages470–471 Brief Communications（简讯） 32 Contaminating plasmid sequences and disrupted vector genomes in the liver following adeno-associated virus gene therapy 腺相关病毒基因治疗后肝脏中出现污染性质粒序列和被破坏的载体基因组 Sarah BuddleLi-An K. BrownJudith Breuer Nature Medicine volume 32（2）, pages472–480 Articles（论著） 33 Intrathecal onasemnogene abeparvovec in treatment-naive patients with spinal muscular atrophy: a phase 3, randomized controlled trial 在未接受治疗的脊髓性肌萎缩症患者中鞘内注射onasemnogene abeparvovec：一项3期随机对照试验 Crystal M. ProudDũng ChíVũYuh-Jyh Jong Nature Medicine volume 32（2）, pages481–487 34 Intrathecal onasemnogene abeparvovec for treatment-experienced patients with spinal muscular atrophy: a phase 3b, open-label trial 在已接受治疗的脊髓性肌萎缩症患者中鞘内注射onasemnogene abeparvovec：一项3b期开放标签试验 Jennifer M. KwonFrancina MunellW. Ludo van der Pol Nature Medicine volume 32（2）, pages488–493 35 Implementation and evaluation of the Y-Check comprehensive adolescent health check-up intervention in Zimbabwe: a pre−post mixed-methods study 在津巴布韦实施并评估Y-Check综合青少年健康检查干预措施：一项前后混合方法研究 Aoife M. DoyleFarirai NzvereRashida A. Ferrand Nature Medicine volume 32（2）, pages494–504 36 Innate antiviral and immune functions associated with the HIV reservoir decay after anti-PD-1 therapy 抗PD-1疗法后与HIV储存库衰减相关的天然抗病毒和免疫功能 Aarthi TallaJoao L. L. C. AzevedoRafick-Pierre Sekaly Nature Medicine volume 32（2）, pages505–517 37 Housing modifications for heat adaptation, thermal comfort and malaria vector control in rural African settlements 在非洲农村定居点进行房屋改造以适应高温、提高热舒适度并控制疟疾媒介 Bernard Abong’oDaniel KwaroMartina Anna Maggioni Nature Medicine volume 32（2）, pages518–526 38 Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study 1990 - 2023年全球204个国家安非他明、大麻、可卡因和阿片类药物使用负担：一项全球疾病负担研究 Jiseung KangHyeon Jin KimDong Keon Yon Nature Medicine volume 32（2）, pages527–544 39 Estimating the number of incorrect tuberculosis diagnoses in low- and middle-income countries 估算中低收入国家结核病误诊数量 Ana van Lieshout TitanPeter J. DoddNicolas A. Menzies Nature Medicine volume 32（2）, pages545–552 40 Discovery and development of a new oxazolidinone with reduced toxicity for the treatment of tuberculosis 发现并开发一种用于治疗结核病的低毒性新型恶酮类药物 Brendan M. CrowleyHelena I. BoshoffDavid B. Olsen Nature Medicine volume 32（2）, pages553–560 41 Live-attenuated chikungunya vaccine in children: a randomized phase 2 trial 儿童用减毒活基孔肯雅疫苗：一项随机2期试验 Petronela WeisováSusanne ScheiblauerJuan Carlos Jaramillo Nature Medicine volume 32（2）, pages561–571 42 Upregulation of reward mesolimbic activity and immune response to vaccination: a randomized controlled trial 奖励性中脑边缘系统活动上调与疫苗接种免疫反应：一项随机对照试验 Nitzan LubianikerTamar KorenTalma Hendler Nature Medicine volume 32（2）, pages572–581 43 External trigeminal nerve stimulation in youth with ADHD: a randomized, sham-controlled, phase 2b trial 对患有注意力缺陷多动障碍的青少年进行外部三叉神经刺激：一项随机、假对照、2b期试验 Aldo Alberto ContiNatali BozhilovaKatya Rubia Nature Medicine volume 32（2）, pages582–590 44 A short-acting psychedelic intervention for major depressive disorder: a phase IIa randomized placebo-controlled trial 针对重度抑郁症的短效迷幻药干预措施：一项IIa期随机安慰剂对照试验 David ErritzoeTommaso BarbaEllen James Nature Medicine volume 32（2）, pages591–598 45 A minimally invasive dried blood spot biomarker test for the detection of Alzheimer’s disease pathology 一种用于检测阿尔茨海默病病理学的微创干血斑生物标志物检测方法 Hanna HuberLaia Montoliu-GayaNicholas J. Ashton Nature Medicine volume 32（2）, pages599–608 46 Reliability of LLMs as medical assistants for the general public: a randomized preregistered study 大语言模型作为面向普通大众的医疗助手时的可靠性：一项随机预注册研究 Andrew M. BeanRebecca Elizabeth PayneAdam Mahdi Nature Medicine volume 32（2）, pages609–615 47 A large language model for complex cardiology care 用于复杂心脏病护理的大语言模型 Jack W. O’SullivanAnil PalepuTao Tu Nature Medicine volume 32（2）, pages616–623 48 Anti-inflammatory therapy with low-dose IL-2 in acute coronary syndromes: a randomized phase 2 trial 急性冠状动脉综合征低剂量白细胞介素-2抗炎治疗：一项随机2期试验 Rouchelle S. Sriranjan-RothwellTian X. ZhaoLeanne Masters Nature Medicine volume 32（2）, pages624–632 49 Interpretable inflammation landscape of circulating immune cells 循环免疫细胞可解释的炎症特征 Laura Jiménez-GraciaDavide MasperoHolger Heyn Nature Medicine volume 32（2）, pages633–644 50 Implementation and effectiveness of a care process to prioritize weight management in primary care: a stepped-wedge cluster-randomized trial 初级医疗保健以体重管理为优先的护理流程的实施及有效性：一项阶梯式整群随机试验 Leigh PerreaultQing PanJodi Summers Holtrop Nature Medicine volume 32（2）, pages645–652 51 Tirzepatide on obstructive sleep apnea-related cardiometabolic risk: secondary outcomes of the SURMOUNT-OSA randomized trial 替西帕肽对阻塞性睡眠呼吸暂停相关心代谢风险的影响：SURMOUNT-OSA随机试验的次要结局 Atul MalhotraRonald GrunsteinJosef Bednarik Nature Medicine volume 32（2）, pages653–659 52 Circulating metabolites, genetics and lifestyle factors in relation to future risk of type 2 diabetes 循环代谢物、遗传因素和生活方式因素与未来2型糖尿病风险的关系 Jun LiJie HuQibin Qi Nature Medicine volume 32（2）, pages660–670 53 Soluble MAdCAM-1 as a biomarker in metastatic renal cell carcinoma 可溶性黏膜地址素细胞黏附分子-1作为转移性肾细胞癌的生物标志物 Carolina Alves Costa SilvaMarc MachaalaniLaurence Albiges Nature Medicine volume 32（2）, pages671–681 54 Repotrectinib in NTRK fusion–positive advanced solid tumors: a phase 1/2 trial 瑞普替尼治疗NTRK融合阳性晚期实体瘤：一项1/2期试验 Benjamin BesseJessica J. LinBenjamin J. Solomon Nature Medicine volume 32（2）, pages682–689 55 Real-world clinical utility of comprehensive genomic profiling in advanced solid tumors 综合基因组测序在晚期实体瘤中的现实临床应用价值 Yuki SaitoSara HorieKeisuke Kataoka Nature Medicine volume 32（2）, pages690–701 56 CD4+ T cells mediate CAR-T cell-associated immune-related adverse events after BCMA CAR-T cell therapy BCMA CAR-T细胞治疗后，CD4+ T细胞介导CAR-T细胞相关免疫相关不良事件 Matthew HoLuca ParuzzoJoseph A. Fraietta Nature Medicine volume 32（2）, pages702–716 57 Abemaciclib in meningiomas with somatic NF2 or CDK pathway alterations: the phase 2 Alliance A071401 trial 阿贝西利治疗伴有体细胞NF2或CDK通路改变的脑膜瘤：2期联盟A071401试验 Priscilla K. BrastianosKatharine DooleyEvanthia Galanis Nature Medicine volume 32（2）, pages717–724 58 Clinical genetic variation across Hispanic populations in the Mexican Biobank 墨西哥生物样本库中西班牙裔人群的临床遗传变异 Carmina Barberena-JonasSantiago G. Medina-MuñozAndrés Moreno-Estrada Nature Medicine volume 32（2）, pages725–735 59 Shared and specific blood biomarkers for multimorbidity 多种共病的共有和特异性血液生物标志物 Alice Margherita OrnagoCaterina GregorioDavide Liborio Vetrano Nature Medicine volume 32（2）, pages736–745 60 Eliminating opioid prescriptions from outpatient minimally invasive gynecologic surgery: a randomized trial 在门诊微创妇科手术中取消阿片类药物处方：一项随机试验 Andrew ZakhariJade DésiletsFady W. Mansour Nature Medicine volume 32（2）, pages746–751 61 A multimodal sleep foundation model for disease prediction 用于疾病预测的多模态睡眠基础模型 Rahul ThapaMagnus Ruud KjaerJames Zou Nature Medicine volume 32（2）, pages752–762 Amendments & Corrections（修订与更正） 62 Author Correction: Intrathecal onasemnogene abeparvovec for treatment-experienced patients with spinal muscular atrophy: a phase 3b, open-label trial 作者更正：在已接受治疗的脊髓性肌萎缩症患者中鞘内注射onasemnogene abeparvovec：一项3b期开放标签试验 Jennifer M. KwonFrancina MunellW. Ludo van der Pol Nature Medicine volume 32（2）, page763 63 Author Correction: Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma 作者更正：联合抑制BET家族蛋白和组蛋白去乙酰化酶作为基于表观遗传学的胰腺导管腺癌潜在治疗方法 Pawel K. MazurAlexander HernerJens T. Siveke Nature Medicine volume 32（2）, pages763–764 64 Publisher Correction: Interpretable inflammation landscape of circulating immune cells 出版商更正：循环免疫细胞可解释的炎症特征 Laura Jiménez-GraciaDavide MasperoHolger Heyn Nature Medicine volume 32（2）, page765 65 Publisher Correction: argeting of HIF2-driven cachexia in kidney cancer 出版商更正：针对肾癌中缺氧诱导因子2（HIF2）驱动的恶病质的治疗 Muhannad Abu-RemailehLaura A. StranskyWilliam G. Kaelin Jr Nature Medicine volume 32（2）, page766 66 Publisher Correction: Anticoagulation to prevent ischemic stroke and neurocognitive impairment in atrial fibrillation: the BRAIN-AF randomized clinical trial 出版商更正：房颤患者抗凝治疗预防缺血性脑卒中及神经认知障碍：BRAIN-AF随机临床试验 Léna RivardPaul KhairyWilliam Liang Nature Medicine volume 32（2）, page767 67 Editorial Expression of Concern: Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization 编辑关切声明：miR-200s直接靶向Sec23a影响癌细胞分泌组并促进转移性定植 Manav KorpalBrian J. EllYibin Kang Nature Medicine volume 32（2）, page768 Nature Medicine volume 32 Issue 3 自然医学 32卷 3期 https://www.nature.com/nm/volumes/32/issues/3 Editorial（社论） 1 Keep up the momentum for gene therapies 保持基因疗法的强劲势头 Nature Medicine volume 32(3),page769 News（新闻） 2 Blood tests for Alzheimer’s disease could reshape research and care 阿尔茨海默病的血液检测或可重塑研究与护理模式 Natalie Healey Nature Medicine volume 32(3), page770-771 News Feature（新闻特写） 3 The AI co-scientist is here 人工智能合作科学家已登场 David Adam Nature Medicine volume 32(3),pages772–775 Correspondence（读者来信） 4 Unintended risks of sarcopenic obesity during weight-loss interventions in older people 老年人在减肥干预过程中出现肌肉减少性肥胖的意外风险 John A. BatsisLorenzo M. DoniniCarla M. Prado Nature Medicine volume 32(3),pages776–777 5 PRIMARY-AI: outcomes-based standards to safeguard primary care in the AI era PRIMARY-AI：基于结果的标准用以保障人工智能时代的基础医疗 Dian ZengLorainne Tudor CarTien Yin Wong Nature Medicine volume 32(3),pages778–781 6 Professional medical associations as catalytic pathways for advancing women in academic medicine and promoting leadership 专业医学协会：推动女性在医学学术领域发展及提升领导力的催化途径 Fawad A. KhanMargaret T. GopaulMargot Savoy Nature Medicine volume 32(3),pages782–784 7 An urgent need to build climate and health intervention trial capacity 构建气候与健康干预试验能力的迫切需求 Andy HainesAna BonellZulfiqar Bhutta Nature Medicine volume 32(3),pages785–786 8 Student-led efforts promoting inclusivity and belonging in US medical schools 美国医学院学生主导促进包容性与归属感的行动 Briana MacedoFelipe Rosero CastroCésar A. Briceño Nature Medicine volume 32(3),pages787–788 World View（国际视角） 9 Whose ethics govern global health research? 全球卫生研究由谁的伦理规范来主导？ Boghuma Titanji Nature Medicine volume 32(3), pages789-790 Comment（述评） 10 The new vision from the National Institute of Allergy and Infectious Diseases (NIAID) 美国国家过敏与传染病研究所（NIAID）的新愿景 Jeffery K. TaubenbergerJohn H. PowersJay Bhattacharya Nature Medicine volume 32(3),pages791–792 11 Asia Pacific perspectives on global health architecture reform 亚太地区对全球卫生架构改革的看法 Indira Dewi KantianaAprajita KaushikAfifah Rahman-Shepherd Nature Medicine volume 32(3),pages793–796 12 Adults with type 1 diabetes define what matters to them in stem-cell derived islet cell therapy 1型糖尿病成人患者对干细胞衍生胰岛细胞治疗的需求界定 Jane SpeightSufyan HussainMichael Vallis Nature Medicine volume 32(3),pages797–801 13 Principles to guide clinical AI readiness and move from benchmarks to real-world evaluation 指导临床人工智能准备就绪的原则，以及从基准测试转向真实世界评估的转变 Tej D. AzadHarlan M. KrumholzSuchi Saria Nature Medicine volume 32(3),pages802–804 News & Views（新闻与观点） 14 Making antibiotic stewardship guidelines work in real-world settings 让抗生素管理指南在现实环境中发挥作用 Ye ZhangPeipei ZhaoDan Wu Nature Medicine volume 32(3),pages805–806 15 Preventive vaccines for hereditary cancer syndromes 遗传性癌症综合征的预防性疫苗 Yonina R. Murciano-GoroffZsofia K. Stadler Nature Medicine volume 32(3),pages807–809 16 A daily multivitamin slows the ticking of epigenetic clocks 每日服用复合维生素可减缓表观遗传时钟的“滴答”速度 Daniel W. BelskyCalen P. Ryan Nature Medicine volume 32(3),pages810–811 17 Base editing milestone for familial hypercholesterolemia 家族性高胆固醇血症的碱基编辑里程碑 Robert S. RosensonSascha N. Goonewardena Nature Medicine volume 32(3),pages812–813 Research Briefings（研究简报） 18 Somatic loss of the Y chromosome complements polygenic risk scores for type 2 diabetes risk prediction 体细胞Y染色体缺失可补充多基因风险评分用于2型糖尿病风险预测 Nature Medicine volume 32(3),pages814–815 19 Extracorporeal cross-circulation with genetically modified pig livers in a human decedent model 在人类遗体模型中利用基因编辑猪肝脏进行体外交叉循环 Nature Medicine volume 32(3),pages816–817 20 DOPA decarboxylase levels in the cerebrospinal fluid as a diagnostic marker of Lewy body disorders 脑脊液中多巴脱羧酶水平作为路易体病诊断标志物 Nature Medicine volume 32(3),pages818–819 Perspectives（观点） 21 A clinical environment simulator for dynamic AI evaluation 用于动态人工智能评估的临床环境模拟器 Luyang LuoSung Eun KimPranav Rajpurkar Nature Medicine volume 32(3),pages820–827 Review Articles（综述） 22 Clinical development of cancer vaccines 癌症疫苗的临床开发 John B. HaanenTon N. M. SchumacherCatherine J. Wu Collection: Cancer at Nature Portfolio 系列专题：自然出版集团癌症专题 Nature Medicine volume 32(3),pages828–840 Articles（论著） 23 Effects of a comprehensive antibiotic stewardship program on antibiotic prescribing for acute respiratory infections in rural facilities: a cluster randomized trial 综合性抗生素管理计划对农村医疗机构急性呼吸道感染抗生素处方的影响：一项整群随机试验 Xiaolin WeiChao ZhuoNanshan Zhong Nature Medicine volume 32(3),pages841–848 24 Genotype-stratified adjunctive dexamethasone for tuberculous meningitis in HIV-negative adults: a randomized controlled phase 3 trial HIV阴性成人结核性脑膜炎的基因型分层辅助地塞米松治疗：一项随机对照3期试验 Joseph DonovanNguyen Duc BangGuy E. Thwaites Nature Medicine volume 32(3),pages849–858 25 Mass azithromycin distribution and antibiotic resistance in the gut and nasopharynx: a cluster-randomized trial 大规模阿奇霉素分发对肠道和鼻咽部抗生素耐药性的影响：一项整群随机试验 Thuy DoanDaisy YanThomas M. Lietman Nature Medicine volume 32(3),pages859–868 26 Bimagrumab plus semaglutide alone or in combination for the treatment of obesity: a randomized phase 2 trial Bimagrumab与司美格鲁肽单独或联合治疗肥胖：一项随机2期试验 Steven B. HeymsfieldLouis J. AronneKenneth M. Attie Nature Medicine volume 32(3),pages869–882 27 An oral, liver-restricted LXR inverse agonist for dyslipidemia: preclinical development and phase 1 trial 一种口服、肝脏限制性LXR反向激动剂治疗血脂异常：临床前开发和1期试验 Xiaoxu LiGiorgia BenegiamoJohan Auwerx Nature Medicine volume 32(3),pages883–893 28 Genetic regulation across germline and somatic variation on the Y chromosome contributes to type 2 diabetes Y染色体生殖细胞和体细胞变异的遗传调控对2型糖尿病的影响 Go SatoYuji YamamotoYukinori Okada Nature Medicine volume 32(3),pages894–905 29 Microfluidic automation improves oocyte recovery from follicular fluid of patients undergoing in vitro fertilization 微流控自动化技术提高体外受精患者卵泡液中卵母细胞的回收率 Baris R. MutluSabrina C. CivaleEmre Ozkumur Nature Medicine volume 32(3),pages906–914 30 Lay community health worker-led care with mobile decision support for uncontrolled hypertension: a cluster-randomized trial 非专业社区卫生工作者主导、移动决策支持辅助的未控制高血压护理：一项整群随机试验 Felix GerberGiuliana Sanchez-SamaniegoNiklaus Daniel Labhardt Nature Medicine volume 32(3),pages915–923 31 Remote monitoring of heart failure exacerbations using a smartwatch 使用智能手表远程监测心力衰竭加重情况 Yuan GaoYasbanoo MoayediHeather J. Ross Nature Medicine volume 32(3),pages924–933 32 An LLM chatbot to facilitate primary-to-specialist care transitions: a randomized controlled trial 一款大型语言模型聊天机器人助力初级到专科诊疗过渡：一项随机对照试验 Xinge TaoShuya ZhouShasha Han Nature Medicine volume 32(3),pages934–942 33 Holistic evaluation of large language models for medical tasks with MedHELM 使用MedHELM对大型语言模型进行医学任务整体评估 Suhana BediHejie CuiNigam H. Shah Nature Medicine volume 32(3),pages943–951 34 Neoadjuvant ipilimumab plus nivolumab in melanoma: 5-year survival and biomarker analysis from the phase 2 PRADO-trial 黑色素瘤新辅助伊匹木单抗联合纳武利尤单抗治疗：2期PRADO试验的5年生存率和生物标志物分析 Lotte L. HoeijmakersPetros DimitriadisChristian U. Blank Nature Medicine volume 32(3),pages952–963 35 Multimodal antigenic escape to GPRC5D-targeted T cell engagers in multiple myeloma 多发性骨髓瘤对GPRC5D靶向T细胞衔接器的多模态抗原逃逸 Holly LeeSungwoo AhnNizar J. Bahlis Nature Medicine volume 32(3),pages964–977 36 Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade 针对肿瘤抗原的体液IgG1反应是免疫检查点阻断临床疗效的基础 Edgar Gonzalez-KozlovaRobert SweeneySacha Gnjatic Nature Medicine volume 32(3),pages978–991 37 Linavonkibart and pembrolizumab in immune checkpoint blockade-resistant advanced solid tumors: a phase 1 trial Linavonkibart联合帕博利珠单抗治疗免疫检查点阻断耐药性晚期实体瘤：一项1期试验 Timothy A. YapRandy F. SweisLu Gan Nature Medicine volume 32(3),pages992–1001 38 Nous-209 neoantigen vaccine for cancer prevention in Lynch syndrome carriers: a phase 1b/2 trial Nous-209新抗原疫苗预防Lynch综合征携带者癌症：一项1b/2期试验 Anna Morena D’AliseJason WillisEduardo Vilar Nature Medicine volume 32(3),pages1002–1011 39 Effects of daily multivitamin–multimineral and cocoa extract supplementation on epigenetic aging clocks in the COSMOS randomized clinical trial 在COSMOS随机临床试验中，每日补充复合维生素-矿物质和可可提取物对表观遗传衰老时钟的影响 Sidong LiRikuta HamayaHoward D. Sesso Nature Medicine volume 32(3),pages1012–1022 40 A fasting-mimicking diet in patients with mild-to-moderate Crohn’s disease: a randomized controlled trial 模拟禁食饮食对轻中度克罗恩病患者的影响：一项随机对照试验 C. KulkarniT. FardeenS. R. Sinha Nature Medicine volume 32(3),pages1023–1033 41 Extracorporeal liver cross-circulation using transgenic xenogeneic pig livers with brain-dead human decedents 使用转基因异种猪肝脏对脑死亡人类遗体进行体外肝脏交叉循环 Abraham ShakedAlex SagarPeter Friend Nature Medicine volume 32(3),pages1034–1044 42 In vivo base editing gene therapy for heterozygous familial hypercholesterolemia: a phase 1 trial 杂合子家族性高胆固醇血症体内碱基编辑基因疗法：一项1期试验 Ping WanSiyuan TangQiang Xia Nature Medicine volume 32(3),pages1045–1051 43 Obicetrapib in patients with heterozygous familial hypercholesterolemia: the BROOKLYN randomized clinical trial Obicetrapib治疗杂合子家族性高胆固醇血症：BROOKLYN随机临床试验 Stephen J. NichollsAdam J. NelsonMichael H. Davidson Nature Medicine volume 32(3),pages1052–1060 44 Single-cell atlas of the developing Down syndrome brain cortex 发育中唐氏综合征大脑皮层的单细胞图谱 Michael LattkeWee Leng TanVincenzo De Paola Nature Medicine volume 32(3),pages1061–1072 45 A quantitative DOPA decarboxylase biomarker for diagnosis in Lewy body disorders 用于路易体病诊断的定量多巴脱羧酶生物标志物 Katharina BolsewigGiovanni BellomoCharlotte E. Teunissen Nature Medicine volume 32(3),pages1073–1084 46 Predicting onset of symptomatic Alzheimerʼs disease with plasma p-tau217 clocks 利用血浆p-tau217时钟预测症状性阿尔茨海默病的发病 Kellen K. PetersenMarta Milà-AlomàSuzanne E. Schindler Nature Medicine volume 32(3),pages1085–1094 47 High-dose nusinersen for spinal muscular atrophy: a phase 3 randomized trial 高剂量诺西那生钠治疗脊髓性肌萎缩症：一项3期随机试验 Richard S. FinkelThomas O. CrawfordStephanie Fradette Nature Medicine volume 32(3),pages1095–1104 48 Anti-CD19 CAR T cells for pediatric patients with treatment-refractory autoimmune diseases 抗CD19嵌合抗原受体T细胞治疗儿科难治性自身免疫性疾病 Marco BecilliMarkus MetzlerFranco Locatelli Nature Medicine volume 32(3),pages1105–1117 49 BCMA-directed mRNA CAR-T cell therapy for myasthenia gravis: exploratory biomarker analysis of a placebo-controlled phase 2b trial BCMA导向的mRNA嵌合抗原受体T细胞疗法治疗重症肌无力：一项2b期安慰剂对照试验的探索性生物标志物分析 Renee R. FedakRachel N. RuggerieKelly Gwathmey Nature Medicine volume 32(3),pages1118–1130 50 BCMA-directed mRNA CAR T cell therapy for myasthenia gravis: a randomized, double-blind, placebo-controlled phase 2b trial BCMA导向的mRNA嵌合抗原受体T细胞疗法治疗重症肌无力：一项随机、双盲、安慰剂对照的2b期试验 Tuan VuHacer DurmusJames F. Howard Jr Nature Medicine volume 32(3),pages1131–1141 51 CD19 CAR-T cells for treatment-refractory autoimmune diseases: the phase 1/2 CASTLE basket trial CD19嵌合抗原受体T细胞治疗难治性自身免疫性疾病：1/2期CASTLE篮式试验 Fabian MüllerMelanie HagenGeorg Schett Nature Medicine volume 32(3),pages1142–1151 Analysis（分析） 52 LLM-assisted systematic review of large language models in clinical medicine 大型语言模型在临床医学中应用的LLM辅助系统综述 Sully F. ChenAnton AlyakinEric K. Oermann Nature Medicine volume 32(3),pages1152–1159 Amendments & Corrections（修订与更正） 53 Author Correction: Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study 作者更正：1990 - 2023年全球、区域和国家慢性呼吸系统疾病负担及新冠肺炎疫情的影响：一项全球疾病负担研究 Jiyeon OhSoeun KimDong Keon Yon Nature Medicine volume 32(3),page1160 54 Author Correction: Detection of undiagnosed liver cirrhosis via AI-enabled electrocardiogram: a pragmatic, cluster-randomized clinical trial 作者更正：通过人工智能心电图检测未诊断的肝硬化：一项实用、整群随机临床试验 Douglas A. SimonettoDavid RushlowVijay H. Shah Nature Medicine volume 32(3),page1160 55 Editorial Expression of Concern: Rescue of Hippo coactivator YAP1 triggers DNA damage–induced apoptosis in hematological cancers 编辑表达关切：拯救Hippo共激活因子YAP1会触发血液系统癌症中DNA损伤诱导的细胞凋亡 Francesca CottiniTeru HideshimaGiovanni Tonon Nature Medicine volume 32(3),page1161 Nature Medicine Volume 32 Issue 4 自然医学 32卷 4期 https://www.nature.com/nm/volumes/32/issues/4 Editorial（社论） 1 Show us the evidence for the value of medical AI 展示医疗人工智能价值的证据 Nature Medicine volume 32（4）, page 1163 News（新闻） 2 Mosquito-borne viruses, vaccine-borne hope 蚊媒病毒：疫苗带来希望 Mike May Nature Medicine volume 32（4）, pages 1164-1165 News Feature（新闻特写） 3 The patient is now in the room 患者已在房间内 Barbara Nasto Nature Medicine volume 32（4）, pages1166–1169 Correspondence（读者来信） 4 A blueprint to accelerate rare pediatric gene therapy approvals 加速罕见儿科基因疗法审批的蓝图 Mohamed Abou-el-EneinMark C. WaltersDonald B. Kohn Nature Medicine volume 32（4）, pages1170–1171 5 Physicians as context engineers in the era of generative AI 生成式人工智能时代，医生作为情境工程师 Ivan NenadicMarat FudimJonathan Piccini Nature Medicine volume 32（4）, pages1172–1173 6 Surviving as a health equity researcher amidst a shifting political climate 在不断变化的政治气候中作为医疗公平研究者的生存 Annesa FlentjeBrian Mustanski Nature Medicine volume 32（4）, pages1174–1175 7 Precision nutrition must consider cost-effectiveness to deliver benefits to patients 精准营养必须考虑成本效益，才能为患者带来益处 Nicola GuessDan PollardPenny Breeze Nature Medicine volume 32（4）, pages1176–1177 8 Advancing a new generation of heat-health warning system in China 推进中国新一代高温健康预警系统建设 Tiantian LiRunmei MaHongbing Shen Nature Medicine volume 32（4）, pages1178–1179 9 Quality health information for all is a fundamental determinant of health 人人享有优质健康信息是健康的根本决定因素 Lawrence O. GostinScott C. RatzanCarolina Batista Nature Medicine volume 32（4）, pages1180–1181 10 Is AI actually improving healthcare? 人工智能真的在改善医疗保健吗？ Anna GoldenbergJenna Wiens Nature Medicine volume 32（4）, pages1182–1183 World View（世界观点） 11 Hope, hard lessons and the path to better nutrition 希望、惨痛教训与改善营养之路 Purnima Menon Nature Medicine volume 32（4）, page1184 Comment（评论） 12 Embedding equity in clinical research governance 将公平性融入临床研究治理 Johanna M. C. BlomCiara StauntonMelodie Labuschaigne Nature Medicine volume 32（4）, pages1185–1187 13 The role of strategy units in guiding research institutions through complexity 战略部门在引导研究机构应对复杂局面中的作用 Michela Giulia BerteroKatrine Sonne-HansenTeresa Sanchis Nature Medicine volume 32（4）, pages1188–1190 14 Clinically distinct genetic diseases converge on shared, druggable nodes 临床特征不同的遗传病汇聚于共同的、可药物作用的节点 Jillian L. ShawAnna Greka Nature Medicine volume 32（4）, pages1191–1193 News & Views（新闻与观点） 15 Engineering in vivo CAR-T cells 体内工程化CAR-T细胞 Beatrice GrecoMatteo DoglioMonica Casucci Nature Medicine volume 32（4）, pages1194–1195 16 Microbiome modulation in cancer immunotherapy 癌症免疫治疗中的微生物组调节 Sumanta K. PalDiwakar Davar Nature Medicine volume 32（4）, pages1196–1198 17 Integrating health equity into energy transitions and climate governance 将健康公平性融入能源转型和气候治理 Tiantian LiHang DuPeng Du Nature Medicine volume 32（4）, pages1199–1200 Research Briefings（研究简报） 18 Modifiable risk factors drive a large share of the global cancer burden 可改变的风险因素是全球癌症负担的主要驱动因素 Nature Medicine volume 32（4）, pages1201–1202 19 The gut microbiome as a fingerprint of antibiotic use history 肠道微生物组是抗生素使用历史的“指纹” Nature Medicine volume 32（4）, pages1203–1204 20 How inadequate dietary patterns affect global burden of ischemic heart disease 不合理的饮食模式如何影响全球缺血性心脏病的负担 Nature Medicine volume 32（4）, pages1205–1206 21 An atlas to navigate environmental factors and health 一张指引环境因素与健康关系的图谱 Nature Medicine volume 32（4）, pages1207–1208 22 Genes that increase the risk of autism are shared across ancestries 增加自闭症风险的基因在不同族裔中共享 Nature Medicine volume 32（4）, pages1209–1210 Perspectives（观点） 23 Five tenets for advancing evidence-based precision medicine 推进循证精准医学的五大原则 Daniel E. CoralJennifer L. SargentPaul W. Franks Nature Medicine volume 32（4）, pages1211–1222 24 Target product profiles for treatments to delay or prevent symptomatic Alzheimer’s disease 延缓或预防有症状阿尔茨海默病的治疗的目标产品特征 Jeffrey L. CummingsMichael G. AgadjanyanGeorge Vradenburg Nature Medicine volume 32（4）, pages1223–1232 Articles（论著） 25 Time-of-day immunochemotherapy in non-small cell lung cancer: a randomized phase 3 trial 非小细胞肺癌日时段免疫化疗：一项随机3期试验 Zhe HuangLiang ZengYongchang Zhang Nature Medicine volume 32（4）, pages1233–1240 26 Ipilimumab and nivolumab followed by chemoradiotherapy as bladder-sparing treatment in muscle-invasive bladder cancer: a phase 2 trial 肌肉浸润性膀胱癌中，伊匹木单抗和纳武利尤单抗联合放化疗用作保膀胱治疗：一项2期试验 Jan-Jaap J. MellemaChantal F. StockemMichiel S. van der Heijden Nature Medicine volume 32（4）, pages1241–1248 27 A small-molecule inverse agonist of PPARγfor advanced solid tumors: a phase 1 trial 一种用于晚期实体瘤的PPARγ小分子反向激动剂：一项1期试验 Matthew D. GalskyCharlene MantiaXin Gao Nature Medicine volume 32（4）, pages1249–1256 28 In vivo generation of anti-BCMA CAR-T cells in relapsed or refractory multiple myeloma: a phase 1 study 复发或难治性多发性骨髓瘤中体内生成抗BCMA CAR-T细胞：一项1期研究 Ning AnDi WangChunrui Li Nature Medicine volume 32（4）, pages1257–1266 29 Quemliclustat and chemotherapy with or without zimberelimab in metastatic pancreatic adenocarcinoma: a randomized phase 1 trial Quemliclustat联合化疗有或无zimberelimab治疗转移性胰腺腺癌：一项随机1期试验 Zev A. WainbergGulam A. ManjiEileen M. O’Reilly Nature Medicine volume 32（4）, pages1267–1277 30 Colonoscopy and fecal immunochemical testing versus usual care in diagnostic colorectal cancer screening: the SCREESCO randomized controlled trial 结肠镜检查和粪便免疫化学检测与常规诊疗在结直肠癌诊断性筛查中的对比：SCREESCO随机对照试验 Marcus WesterbergJonas F. LudvigssonAnna Forsberg Nature Medicine volume 32（4）, pages1278–1285 31 Real-world clinical utility of tumor whole-genome sequencing in solid cancers 实体癌肿瘤全基因组测序在现实中的临床应用价值 Jeffrey van PuttenPetur SnaebjornssonKim Monkhorst Nature Medicine volume 32（4）, pages1286–1295 32 AI-based triage and decision support in mammography and digital tomosynthesis for breast cancer screening: a paired, noninferiority trial 基于人工智能的乳腺癌筛查中乳腺X线摄影和数字断层融合的分级和决策支持：一项配对、非劣效性试验 Esperanza Elías-CabotSara Romero-MartínMarina Álvarez-Benito Nature Medicine volume 32（4）, pages1296–1305 33 Global and regional cancer burden attributable to modifiable risk factors to inform prevention 可改变的风险因素导致的全球和区域癌症负担，为预防提供依据 Hanna FinkOliver LangseliusIsabelle Soerjomataram Nature Medicine volume 32（4）, pages1306–1315 34 Fecal microbiota transplantation plus pembrolizumab and axitinib in metastatic renal cell carcinoma: the randomized phase 2 TACITO trial 粪便微生物群移植联合帕博利珠单抗和阿昔替尼治疗转移性肾细胞癌：随机2期TACITO试验 Serena PorcariChiara CiccareseGianluca Ianiro Nature Medicine volume 32（4）, pages1316–1324 35 Fecal microbiota transplantation plus immunotherapy in metastatic renal cell carcinoma: the phase 1 PERFORM trial 粪便微生物群移植联合免疫疗法治疗转移性肾细胞癌：1期PERFORM试验 Ricardo FernandesBehnam JabbarizadehSaman Maleki Vareki Nature Medicine volume 32（4）, pages1325–1336 36 Fecal microbiota transplantation plus immunotherapy in non-small cell lung cancer and melanoma: the phase 2 FMT-LUMINate trial 粪便微生物群移植联合免疫疗法治疗非小细胞肺癌和黑色素瘤：2期FMT-LUMINate试验 Sreya DuttaguptaMeriem MessaoudeneArielle Elkrief Nature Medicine volume 32（4）, pages1337–1350 37 Antibiotic use and gut microbiome composition links from individual-level prescription data of 14,979 individuals 基于14979例个人处方数据的抗生素使用与肠道微生物群组成关联分析 Gabriel BaldanziAnna LarssonTove Fall Nature Medicine volume 32（4）, pages1351–1361 38 Evaluation of antimicrobial resistance governance across 193 countries to inform the 2026 Global Action Plan update 对193个国家抗菌药物耐药性治理情况评估，为2026年全球行动计划更新提供依据 Weiye ChenYige ZengYongzhang Zhu Nature Medicine volume 32（4）, pages1362–1373 39 Deciphering the etiology of the 2024 outbreak of undiagnosed febrile illness in Panzi, Democratic Republic of the Congo 解析刚果民主共和国潘济地区2024年不明原因发热疫情的病因 Tony Wawina-BokalangaJean-Claude Makangara-CigoloJean-Jacques Muyembe-Tamfum Nature Medicine volume 32（4）, pages1374–1382 40 Transmission dynamics of Oropouche virus in Latin America and the Caribbean 奥罗普切病毒在拉丁美洲和加勒比地区的传播动态 Erika R. ManuliXinyi HuaWilliam M. de Souza Nature Medicine volume 32（4）, pages1383–1392 41 Long-term efficacy and safety of the single-dose tetravalent Butantan dengue vaccine 单剂量四价布坦坦登革热疫苗的长期有效性和安全性 Esper G. KallásJosé A. MoreiraMarcus Vínicius Guimarães de Lacerda Nature Medicine volume 32（4）, pages1393–1400 42 A structure-based mRNA vaccine for Nipah virus in healthy adults: a phase 1 trial 基于结构的健康成人尼帕病毒mRNA疫苗：1期试验 Aurélie PloquinRosemarie D. MasonTongqing Zhou Nature Medicine volume 32（4）, pages 1401–1410 43 Antisense oligonucleotide-mediated knockdown therapy in two infants with severe KCNT1 epileptic encephalopathy 针对两例严重KCNT1癫痫性脑病患儿的反义寡核苷酸介导的基因敲低疗法 Tojo NakayamaChristelle M. El AchkarTimothy W. Yu Nature Medicine volume 32（4）, pages1411–1420 44 LRRK2-targeting antisense oligonucleotide in Parkinson’s disease: a phase 1 randomized controlled trial 针对LRRK2的反义寡核苷酸治疗帕金森病：1期随机对照试验 Omar S. MabroukBen TichlerDanielle L. Graham Nature Medicine volume 32（4）, pages1421–1431 45 Zodasiran for cholesterol and triglyceride lowering in patients with hyperlipidemia: final report of phase 1 basket trial Zodasiran用于高脂血症患者降低胆固醇和甘油三酯：1期篮式试验最终报告 Gerald F. WattsRussell ScottChristie M. Ballantyne Nature Medicine volume 32（4）, pages1432–1443 46 Pulsed field ablation versus conventional thermal ablation for paroxysmal atrial fibrillation: 4-year outcomes in the ADVENT-LTO study 脉冲场消融与传统热消融治疗阵发性心房颤动：ADVENT-LTO研究4年结果 Vivek Y. ReddyEdward P. GerstenfeldMoussa Mansour Nature Medicine volume 32（4）, pages1444–1453 47 Global, regional and national burden of ischemic heart disease attributable to suboptimal diet, 1990–2023: a Global Burden of Disease study 1990 - 2023年因饮食不理想导致的全球、区域和国家缺血性心脏病负担：一项全球疾病负担研究 Sooji LeeHayeon LeeDong Keon Yon Nature Medicine volume 32（4）, pages1454–1478 48 Physical activity for public health in the 21st century 21世纪面向公众健康的身体活动 Deborah SalvoInacio Crochemore-SilvaJames Sallis Nature Medicine volume 32（4）, pages1479–1489 49 Socioeconomic and energy transition disparities in air pollution-related mortality across Europe 欧洲空气污染相关死亡的社会经济和能源转型差异 Zhao-Yue ChenHicham AchebakJoan Ballester Nature Medicine volume 32（4）, pages1490–1500 50 An atlas of exposome–phenome associations in health and disease risk 健康和疾病风险中暴露组 - 表型组关联图谱 Chirag J. PatelJohn P. A. IoannidisArjun K. Manrai Nature Medicine volume 32（4）, pages1501–1510 51 Citywide premarital genomic screening in a Middle Eastern population 中东人群的城市范围婚前基因组筛查 Khulood AlblooshiRadwa SharafAhmad Abou Tayoun Nature Medicine volume 32（4）, pages1511–1518 52 Deleterious coding variation associated with autism is shared across ancestries 与自闭症相关的有害编码变异在不同族裔中共享 Marina Natividad AvilaSeulgi JungJoseph D. Buxbaum Nature Medicine volume 32（4）, pages1519–1529 53 Bispecific T cell engagers for treatment-refractory autoimmune connective tissue diseases 双特异性T细胞衔接器治疗难治性自身免疫性结缔组织病 Christina DüsingAndrea-Hermina GyörfiJörg H. W. Distler Nature Medicine volume 32（4）, pages1530–1542 54 An international mega-analysis of psychedelic drug effects on brain circuit function 迷幻药对大脑回路功能影响的国际大型分析 Manesh GirnManoj K. DossDanilo Bzdok Nature Medicine volume 32（4）, pages1543–1554 Amendments & Corrections（修正与更正） 55 Author Correction: Real-world clinical utility of tumor whole-genome sequencing in solid cancers 作者更正：实体癌肿瘤全基因组测序在现实中的临床应用价值 Jeffrey van PuttenPetur SnaebjornssonKim Monkhorst Nature Medicine volume 32（4）, page 1555 56 Author Correction: Wiskott–Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma 作者更正：Wiskott-Aldrich综合征蛋白（WASP）是T细胞淋巴瘤中的肿瘤抑制因子 Matteo MenottiChiara AmbrogioRoberto Chiarle Nature Medicine volume 32（4）, page 1555 57 Author Correction: Real-time surveillance system for patient deterioration: a pragmatic cluster-randomized controlled trial 作者更正：患者病情恶化实时监测系统：一项实用的整群随机对照试验 Sarah C. RossettiPatricia C. DykesKenrick D. Cato Nature Medicine volume 32（4）, page 1556 58 Publisher Correction: Clinical development of cancer vaccines 出版商更正：癌症疫苗的临床开发 John B. HaanenTon N. M. SchumacherCatherine J. Wu Nature Medicine volume 32（4）, page 1557 Nature Medicine Volume 32 Issue 5 自然医学 32卷 5期 https://www.nature.com/nm/volumes/32/issues/5 Editorial（社论） 1 Combating infectious diseases in a fragmented world 在碎片化的世界中抗击传染病 Editorial Nature Medicine volume 32（5）, page1559 News（新闻） 2 Hope for control of a centuries-old epidemic 控制一场持续数百年的流行病的希望 Barbara Nasto Nature Medicine volume 32（5）, pages1560-1562 News Feature（新闻专题） 3 Brazil’s big bet on mosquitos 巴西在蚊子身上的重大赌注 Anita Makri Nature Medicine volume 32（5）, pages1563–1566 Correspondence（读者来信） 4 A reasonably likely surrogate endpoint for metabolic dysfunction–associated steatohepatitis 代谢功能障碍相关脂肪性肝炎的一个可能的合理替代终点 Arun J. SanyalMichelle T. LongTheresa Perney Nature Medicine volume 32（5）, pages1567–1568 5 The rise and fall of US federally funded human fetal tissue research 美国联邦资助的人类胎儿组织研究的兴衰 Dylan P. ReichertAaron D. Levine Nature Medicine volume 32（5）, pages1569–1570 6 Making infectious disease data local and as accessible as the weather forecast 让传染病数据像天气预报一样本地化且易于获取 Natalie E. DeanCaitlin M. Rivers Nature Medicine volume 32（5）, pages1571–1572 7 Local control, remote expertise: governing therapeutic telemedicine in wartime 本地控制，远程专家：战时治疗性远程医疗的治理 Andrea CusumanoOleg ParkhomenkoMarco Lombardo Nature Medicine volume 32（5）, pages1573–1574 8 Brazilian elimination of mother-to-child HIV transmission: lessons for large-scale global health systems 巴西消除母婴艾滋病毒传播：对大规模全球卫生体系的启示 Emilia M. JalilValdiléa G. VelosoBeatriz Grinsztejn Nature Medicine volume 32（5）, pages1575–1576 9 An international and independent scientific foundation for AI governance 一个用于人工智能治理的国际性独立科学基金会 Bilal A. Mateen Nature Medicine volume 32（5）, pages1577–1578 World View（世界观点） 10 Africa’s moment for health security 非洲卫生安全的关键时刻 Jean Kaseya Nature Medicine volume 32（5）, pages1579 Comment（评论） 11 A genomics health strategy for the Arabian Gulf 阿拉伯海湾地区的基因组学健康战略 Hamad AliBarrak AlahmadAhmad Abou Tayoun Nature Medicine volume 32（5）, pages1580–1582 12 HPV vaccines, 20 years on HPV疫苗，二十年回顾 Karen Canfell Nature Medicine volume 32（5）, pages1583–1585 13 Closing the gap on antifungal resistance 缩小抗真菌耐药性的差距 Paul E. VerweijAna Alastruey-IzquierdoDarius Armstrong‑James Nature Medicine volume 32（5）, pages1586–1591 News & Views（新闻与观点） 14 Uncovering risk factors in the exposome for early-onset colorectal cancer 揭示早发性结直肠癌暴露组中的风险因素 David J. LeeSylvan BacaKimmie Ng Nature Medicine volume 32（5）, pages1592–1593 15 Modifying exposure to plastic-associated chemicals in daily living 在日常生活中减少塑料相关化学品的暴露 Eliane El HayekMatthew CampenBethany Jorgensen Nature Medicine volume 32（5）, pages1594–1595 16 Rethinking triage for febrile children in low-resource settings 重新思考资源匮乏地区发热儿童的分诊策略 Mihir R. AtreyaLuregn J. Schlapbach Nature Medicine volume 32（5）, pages1596–1597 17 The ghost of tuberculosis past 结核病的昔日幽灵 Anete TrajmanJonathon R. Campbell Nature Medicine volume 32（5）, pages1598–1599 Research Briefings（研究简报） 18 ChatGPT Health triage advice falls short in key cases ChatGPT健康分诊建议在关键病例中表现不佳 Nature Medicine volume 32（5）, pages1600–1601 19 A biomarker of Alzheimer’s disease could be a useful diagnostic tool for other amyloidoses 阿尔茨海默病的生物标志物可作为其他淀粉样变性的有用诊断工具 Nature Medicine volume 32（5）, pages1602–1603 20 Early kidney risk prediction in APOL1 high-risk genotype carriers APOL1高风险基因型携带者的早期肾脏风险预测 Nature Medicine volume 32（5）, pages1604–1605 21 Intestinal metaplasia is the only precursor to esophageal adenocarcinoma 肠化生是食管腺癌的唯一癌前病变 Nature Medicine volume 32（5）, pages1606–1607 22 Exposure to negative physical and social factors accelerates brain aging 暴露于身体和社会负面因素会加速大脑衰老 Nature Medicine volume 32（5）, pages1608–1609 Perspectives（观点） 23 Global vaccine development 全球疫苗开发 Jerome H. KimNicaise Ndembi Nature Medicine volume 32（5）, pages1610–1622 24 The future of diagnostics in Africa 非洲诊断学的未来 Yenew KebedeNqobile NdlovuTrevor Peter Nature Medicine volume 32（5）, pages1623–1633 Review Articles（综述） 25 Climate change and infectious diseases 气候变化与传染病 Rachel E. BakerAleksandra R. StamperC. Jessica E. Metcalf Nature Medicine volume 32（5）, pages1634–1645 26 Global approaches to infectious disease surveillance and modeling 传染病监测和建模的全球方法 Mark P. KhuranaJoseph L.-H. TsuiMoritz U. G. Kraemer Nature Medicine volume 32（5）, pages1646–1660 Brief Communications（短评） 27 Rapid expansion of genotype D1.1A(H5N1) influenza viruses in wild birds across North America during the 2024 migratory season 2024年迁徙季节期间D1.1 A(H5N1)基因型流感病毒在北美野鸟中的快速扩张 Walter N. HarringtonAnthony SignoreRichard J. Webby Nature Medicine volume 32（5）, pages1661–1665 28 Evidence of monkeypox virus clade IIb lineage A.2.2 in the Republic of the Congo and co-circulation of clade Ia, Ib and clade IIb 刚果共和国发现猴痘病毒IIb分支A.2.2系以及Ia、Ib和IIb分支的共同传播的证据 Felix Koukouikila-KoussoundaClaude Kwe YindaFabien Roch Niama Nature Medicine volume 32（5）, pages1666–1670 29 ChatGPT Health performance in a structured test of triage recommendations ChatGPT健康在结构化分诊建议测试中的表现 Ashwin RamaswamyAlvira TyagiGirish N. Nadkarni Nature Medicine volume 32（5）, pages1671–1675 30 Blood phosphorylated tau elevation as a biomarker in immunoglobulin light chain and transthyretin amyloidosis 血液磷酸化tau升高作为免疫球蛋白轻链和转甲状腺素蛋白淀粉样变性的生物标志物 Stephan A. KaeserStephanie A. SchultzMathias Jucker Nature Medicine volume 32（5）, pages1676–1681 31 Glucagon-like peptide-1 receptor agonists for major cardiovascular and kidney outcomes in type 1 diabetes 胰高血糖素样肽-1受体激动剂对1型糖尿病患者主要心血管和肾脏预后的影响 Yunwen XuNatalie Daya MalekJung-Im Shin Nature Medicine volume 32（5）, pages1682–1685 Articles（论著） 32 Semaglutide on liver fibrosis and heart outcomes in patients at high risk of liver fibrosis: a prespecified analysis of the SELECT randomized trial 塞马格鲁肽对肝纤维化高风险患者肝脏纤维化和心脏预后的影响：SELECT随机试验的预设分析 Sebastian M. MeyhöferBertrand CariouChristoffer W. Tornøe Nature Medicine volume 32（5）, pages1686–1693 33 The NPR1 agonist antibody XXB750 in heart failure: a phase 2 randomized trial NPR1激动剂抗体XXB750治疗心力衰竭：一项2期随机试验 Scott D. SolomonJohn J. V. McMurrayMartin P. Lefkowitz Nature Medicine volume 32（5）, pages1694–1700 34 Proteomic risk score for early prediction of kidney disease progression in individuals with APOL1 high-risk genotypes 蛋白质组学风险评分用于APOL1高风险基因型个体肾病进展的早期预测 Chenyu LiShola M. RichardsKatalin Susztak Nature Medicine volume 32（5）, pages1701–1707 35 The TREM2 agonistic antibody AL002 in early Alzheimer’s disease: a phase 2 randomized trial TREM2激动性抗体AL002治疗早期阿尔茨海默病：一项2期随机试验 Catherine J. MummeryArthur J. MayorgaGiacomo Salvadore Nature Medicine volume 32（5）, pages1708–1716 36 A cognitive layer architecture to support large-language model performance in psychotherapy interactions 支持大语言模型在心理治疗交互中表现的认知层架构 Max RollwageJessica McFadyenRoss Harper Nature Medicine volume 32（5）, pages1717–1725 37 Advancing conversational diagnostic AI with multimodal reasoning 利用多模态推理推进会话式诊断人工智能 Khaled SaabChunjong ParkRyutaro Tanno Nature Medicine volume 32（5）, pages1726–1736 38 AI-based chest X-ray prioritization in the lung cancer diagnostic pathway: the LungIMPACT randomized controlled trial 基于人工智能的胸部X线在肺癌诊断路径中的优先级排序：LungIMPACT随机对照试验 Nick WoznitzaLesley SmithDavid R. Baldwin Nature Medicine volume 32（5）, pages1737–1744 39 Enhanced dynamic risk stratification of smoldering multiple myeloma 冒烟型多发性骨髓瘤的增强动态风险分层 Floris ChabrunDaniel E. SchwartzIrene M. Ghobrial Nature Medicine volume 32（5）, pages1745–1753 40 Liquid biopsy for the diagnosis of EBV-positive Burkitt’s lymphoma in endemic areas 液体活检用于地方性区域EBV阳性伯基特淋巴瘤的诊断 Clara ChambaHeavenlight ChristopherAnna Schuh Nature Medicine volume 32（5）, pages1754–1762 41 CRISPR−Cas9 CD33-deleted allogeneic hematopoietic cell transplantation with gemtuzumab ozogamicin maintenance in AML: a phase 1/2 trial CRISPR-Cas9 CD33敲除异基因造血干细胞移植联合吉妥珠单抗 Ozogamicin 维持治疗AML：一项1/2期试验 John F. DiPersioGuenther KoehneBrenda W. Cooper Nature Medicine volume 32（5）, pages1763–1772 42 Isatuximab, carfilzomib, lenalidomide and dexamethasone in newly diagnosed multiple myeloma: a randomized phase 3 trial 伊沙妥昔单抗、卡非佐米、来那度胺和地塞米松治疗新诊断多发性骨髓瘤：一项随机3期试验 Francesca GayWilfried RoeloffzenAnnemiek Broijl Nature Medicine volume 32（5）, pages1773–1782 43 Pembrolizumab and olaparib in homologous-recombination-deficient metastatic pancreatic cancer: the phase 2 POLAR trial 帕博利珠单抗和奥拉帕利治疗同源重组缺陷转移性胰腺癌：2期POLAR试验 Wungki ParkCatherine A. O’ConnorEileen M. O’Reilly Nature Medicine volume 32（5）, pages1783–1793 44 Elraglusib and chemotherapy in metastatic pancreatic ductal adenocarcinoma: a randomized controlled phase 2 trial Elraglusib联合化疗治疗转移性胰腺导管腺癌：一项随机对照2期试验 Devalingam MahalingamRachna T. ShroffTanios S. Bekaii-Saab Nature Medicine volume 32（5）, pages1794–1804 45 Integrated epidemiological and molecular data inform the relationship between precancer and cancer states of esophageal adenocarcinoma 整合流行病学和分子数据揭示食管腺癌癌前状态与癌症状态之间的关系 Shahriar A. ZamaniLianlian WuRebecca C. Fitzgerald Nature Medicine volume 32（5）, pages1805–1816 46 Implementation of the NHS England Lung Cancer Screening Programme over 5 years NHS英格兰肺癌筛查计划五年实施情况 Richard W. LeeArjun NairTim Windle Nature Medicine volume 32（5）, pages1817–1826 47 Epigenetic fingerprints link early-onset colon and rectal cancer to pesticide exposure 表观遗传指纹将早发性结直肠癌与农药暴露联系起来 Silvana C. E. MaasIosune BaraibarJose A. Seoane Nature Medicine volume 32（5）, pages1827–1837 48 The exposome of brain aging across 34 countries 横跨34个国家的大脑衰老暴露组 Agustina LegazSebastian MoguilnerAgustin Ibanez Nature Medicine volume 32（5）, pages1838–1851 49 A deep joint-learning proteomics model for diagnosis of six conditions associated with dementia 一种深度联合学习蛋白质组学模型用于诊断六种与痴呆相关的疾病 Lijun AnAlexa Pichet BinetteJacob W. Vogel Nature Medicine volume 32（5）, pages1852–1864 50 Intravitreal photoswitch therapy in advanced retinitis pigmentosa: a phase 1 open-label trial 玻璃体内光开关疗法治疗晚期视网膜色素变性：一项1期开放标签试验 Robert J. CassonEric DanielsRussell N. Van Gelder Nature Medicine volume 32（5）, pages1865–1870 51 Low-plastic diet and urinary levels of plastic-associated phthalates and bisphenols: the randomized controlled PERTH Trial 低塑料饮食与尿液中塑料相关邻苯二甲酸酯和双酚水平：随机对照PERTH试验 Amelia J. HarrayAndrew D. LucasMichaela Lucas Nature Medicine volume 32（5）, pages1871–1883 52 Diet–microbiome associations in 10,068 individuals from the Human Phenotype Project to guide personalized nutrition 来自人类表型项目的10,068例个体的饮食-微生物组关联分析，以指导个性化营养 Tomer SegevDaniel BarakEran Segal Nature Medicine volume 32（5）, pages1884–1894 53 Cross-reactive anti-prophage antibodies and bacterial heteroresistance implicated in phage therapeutic failure 交叉反应性抗前噬菌体抗体和细菌异质性耐药与噬菌体治疗失败有关 F. Gordillo AltamiranoD. SubediA. Y. Peleg Nature Medicine volume 32（5）, pages1895–1906 54 Predicting referral need for febrile children in low-resource community settings in South and Southeast Asia 预测南亚和东南亚资源匮乏社区环境中发热儿童的转诊需求 Arjun ChandnaConstantinos KoshiarisSakib Burza Nature Medicine volume 32（5）, pages1907–1916 55 Genomic epidemiology of the 2025 mpox epidemic in Sierra Leone 2025年塞拉利昂猴痘流行的基因组流行病学 Allan K. O. CampbellJohn Demby SandiDonald S. Grant Nature Medicine volume 32（5）, pages1917–1926 56 Long-term risk of death after tuberculosis diagnosis and treatment 结核病诊断和治疗后的长期死亡风险 Thiago Cerqueira-SilvaViviane Sampaio BoaventuraJulia M. Pescarini Nature Medicine volume 32（5）, pages1927–1934 Amendments & Corrections（修订与更正） 57 Author Correction: Obicetrapib in patients with heterozygous familial hypercholesterolemia: the BROOKLYN randomized clinical trial 作者更正：Obicetrapib治疗杂合子家族性高胆固醇血症患者：BROOKLYN随机临床试验 Stephen J. NichollsAdam J. NelsonMichael H. Davidson Nature Medicine volume 32（5）, page1935 58 Author Correction: High-dose nusinersen for spinal muscular atrophy: a phase 3 randomized trial 作者更正：高剂量努西奈森治疗脊髓性肌萎缩症：一项3期随机试验 Richard S. FinkelThomas O. CrawfordStephanie Fradette Nature Medicine volume 32（5）, page1936 59 Publisher Correction: Reliability of LLMs as medical assistants for the general public: a randomized preregistered study 出版商更正：大语言模型作为公众医疗助手的可靠性：一项随机预注册研究 Andrew M. BeanRebecca Elizabeth PayneAdam Mahdi Nature Medicine volume 32（5）, page1937 60 Editorial Expression of Concern: Isolated small intestinal segments support auxiliary livers with maintenance of hepatic functions 社论关注表达：孤立小肠段支持辅助肝脏并维持肝功能 Brigid JosephEkaterine BerishviliSanjeev Gupta Nature Medicine volume 32（5）, page1938 Nature Medicine Volume 32 Issue 6 自然医学 32卷 6期 https://www.nature.com/nm/volumes/32/issues/6 Editorial（社论） 1 Medical innovation in LMICs: can India lead the way? 中低收入国家的医疗创新：印度能否引领发展？ Nature Medicine volume 32（6）, page1939 News（新闻） 2 At last, a pipeline for treating kidney disease 肾病治疗药物管线终于建成 Carrie Arnold Nature Medicine volume 32（6）, pages1940-1941 News Feature（新闻专题） 3 Who owns my health data? 我的健康数据归谁所有？ Paul Webster Nature Medicine volume 32（6）, pages 1942–1945 Correspondence（读者来信） 4 The Q-MONSTAR consortium: advancing fault-tolerant quantum computing for precision oncology Q-MONSTAR联盟：研发容错量子计算技术助力精准肿瘤学 Mitsuho ImaiRiu YamashitaTakayuki Yoshino Nature Medicine volume 32（6）, pages1946–1947 5 How to meaningfully evaluate AI in clinical medicine 如何对临床医学人工智能开展有实际意义的评估 Mahmud OmarReem AgbareiaGirish N. Nadkarni Nature Medicine volume 32（6）, pages1948–1949 6 Ten lessons from a decade of scientific translation at the Crick 克里克研究所十年科研转化的十条经验 Stephen MayhewDave AllenDavid Roblin Nature Medicine volume 32（6）, pages1950–1951 7 The value of patient-focused drug development 以患者为中心开展药物研发的价值 Allison MartinRuss Paulsen Nature Medicine volume 32（6）, pages1952–1953 8 The TARGET guideline for reporting observational studies of interventions 干预性观察研究报告规范TARGET指南 Harrison J. HansfordJames H. McAuleyAidan G. Cashin Nature Medicine volume 32（6）, pages1954–1955 9 Naming in medicine: how disease nomenclature shapes diagnosis, research and patient lives 医学命名：疾病命名体系如何影响临床诊断、科研进展与患者生活 Helena TeedeRachel MormanElisabet Stener-Victorin Nature Medicine volume 32（6）, pages1956–1957 World View（全球视野） 10 When cure exists but access does not 有药可医，却无药可用 Ali T. Taher Nature Medicine volume 32（6）, page1958 Comment（评论） 11 Data-Driven Decision Support in Obesity Management Commission: enabling more equitable and personalized obesity care 肥胖管理数据决策支持委员会：推动更加公平、个体化的肥胖诊疗 Paul W. FranksSara G. I. SulimanCarel W. le Roux Nature Medicine volume 32（6）, pages1959–1961 12 Framework for the pharmacological treatment of obesity and its complications from the European Association for the Study of Obesity (EASO): 2026 update 欧洲肥胖研究学会（EASO）肥胖及其并发症药物治疗框架：2026版更新 Andreea CiudinJennifer L. BakerBarbara McGowan Nature Medicine volume 32（6）, pages1962–1966 13 The arrival of digital twins and in silico trials in drug development 数字孪生与虚拟临床试验走进药物研发领域 Ashley L. EadieHolly Fernandez LynchRavi B. Parikh Nature Medicine volume 32（6）, pages1967–1971 14 Clinical trials for continuously monitored and updated AI systems 面向持续监测与迭代更新人工智能系统的临床试验设计 Wouter A. C. van AmsterdamMichael OberstAnna Goldenberg Nature Medicine volume 32（6）, pages1972–1974 News & Views（新闻与观点） 15 Translating ‘food is medicine’ from concept to reality 把“食物即是良药”从理念落地为现实 Juliet CushingWendelin SlusserTannaz Moin Nature Medicine volume 32（6）, pages1975–1976 16 A new treatment for preterm pre-eclampsia could benefit mother and child 早产子痫前期新疗法有望惠及母婴双方 Meryam SugulleAnne Cathrine Staff Nature Medicine volume 32（6）, pages1977–1978 17 Harnessing the power of biomarkers for diffuse intrinsic pontine gliomas 挖掘生物标志物价值，用于弥漫性内生型桥脑胶质瘤研究 Jasia Mahdi Collection: Cancer at Nature Portfolio 专题合集：自然旗下期刊肿瘤研究专辑 Nature Medicine volume 32（6）, pages1979–1980 18 Integrating public health into house design 将公共卫生理念融入住宅设计 Nelli WestercampJohn E. Gimnig Nature Medicine volume 32（6）, pages1981–1982 Research Briefings（研究简报） 19 Microglia at a key inflection point in Alzheimer’s disease 小胶质细胞迎来阿尔茨海默病研究的关键转折点 Nature Medicine volume 32（6）, pages1983–1984 20 Blood signatures of cell type-specific aging forecast disease risk and resilience 细胞特异性衰老血液特征可预测患病风险与机体抗逆能力 Nature Medicine volume 32（6）, pages1985–1986 21 Gut microbiome screens could identify risk of Parkinson’s disease years before symptoms appear 肠道微生物筛查可在帕金森病出现症状多年前识别患病风险 Nature Medicine volume 32（6）, pages1987–1988 22 A data-driven risk stratification framework for clinical obesity 面向肥胖临床诊疗的数据驱动型风险分层体系 Nature Medicine volume 32（6）, pages1989–1990 23 Pathogenic germline variants identify elevated cancer risk in pediatric patients referred for genetic testing 致病性生殖系变异可提升接受基因检测儿童患者的肿瘤患病风险检出率 Nature Medicine volume 32（6）, pages1991–1992 24 Autonomous pathology research using agentic AI shows potential in oncology 智能自主AI助力病理学研究，在肿瘤领域展现应用前景 Nature Medicine volume 32（6）, pages1993–1994 25 The Hong Kong Genome Project is a flagship initiative for precision medicine in Chinese populations 香港基因组计划：华人人群精准医学的旗舰项目 Nature Medicine volume 32（6）, pages1995–1996 Perspectives（观点） 26 AI-induced never-skilling in medical education AI引发医学教育中的“技能零习得”困境 Yuhe KeLiyuan JinNan Liu Nature Medicine volume 32（6）, pages1997–2006 Review Articles（综述） 27 Resetting autoimmune disease with CAR cell therapies 利用CAR细胞疗法重塑自身免疫病治疗格局 Georg SchettHuji Xu Nature Medicine volume 32（6）, pages2007–2016 Articles（论著） 28 Benralizumab versus placebo for hypereosinophilic syndrome: a randomized, placebo-controlled phase 3 trial 贝那利珠单抗对比安慰剂治疗嗜酸性粒细胞增多综合征：一项随机、安慰剂对照III期临床试验 Princess U. OgboguFlorence RoufosseAmy D. Klion Nature Medicine volume 32（6）, pages2017–2025 29 Low-dose oral nicotinamide mononucleotide for immune thrombocytopenia: a phase 1/2 trial 低剂量口服烟酰胺单核苷酸治疗免疫性血小板减少症：I/II期临床试验 Huiyuan LiYuan XuLei Zhang Nature Medicine volume 32（6）, pages2026–2036 30 Performance of traumatic encephalopathy syndrome criteria in identifying individuals with chronic traumatic encephalopathy 创伤性脑病综合征诊断标准对慢性创伤性脑病患者的识别效能 John D. ArenaWilliam StewartDouglas H. Smith Nature Medicine volume 32（6）, pages2037–2046 31 Human microglial transitions at the Aβ–tau inflection point associate with divergent pathways to dementia and resilience β淀粉样蛋白-tau病理拐点处人类小胶质细胞的转化特征，对应痴呆发病与疾病抵抗的不同通路 Ashley LuWei-Ting ChenBart De Strooper Nature Medicine volume 32（6）, pages2047–2059 32 Plasma proteomic signatures of cellular aging predict human disease Daisy Yi DingVeronica Augustina BotTony Wyss-Coray 细胞衰老的血浆蛋白质组学特征可预测人类疾病发生风险 Series: Global Neurodegeneration Proteomics Consortium 系列专题：全球神经退行性疾病蛋白质组学联盟 Nature Medicine volume 32（6）, pages2060–2072 33 A multimodal biomarker strategy to enhance diagnostic precision in neurodegenerative parkinsonism 多模态生物标志物方案提升神经退行性帕金森病的诊断精准度 Ivan Martinez-ValbuenaMaziar EmamikhahAnthony E. Lang Nature Medicine volume 32（6）, pages2073–2082 34 An acetylated Tau-174 CSF biomarker discriminates between TDP-43 and tau pathology in patients with frontotemporal lobar degeneration 脑脊液乙酰化Tau-174生物标志物可区分额颞叶变性患者的TDP-43蛋白与tau蛋白病理类型 Madison I. J. HoneyYanaika S. Hok-A-HinCharlotte E. Teunissen Nature Medicine volume 32（6）, pages2083–2095 35 Microbiome signature of Parkinson’s disease in healthy and genetically at-risk individuals 健康人群及高遗传风险人群中帕金森病的微生物组特征 Elisa MenozziYani RenAnthony H. V. Schapira Nature Medicine volume 32（6）, pages2096–2106 36 Pasteurized Akkermansia muciniphila MucT for weight loss maintenance in people with overweight and obesity: a controlled randomized trial 灭活嗜黏蛋白阿克曼菌MucT用于超重与肥胖人群的体重维持：一项随机对照试验 Sarah MountEmanuel E. CanforaEllen E. Blaak Nature Medicine volume 32（6）, pages2107–2116 37 Data-driven prioritization of high-risk individuals for weight loss interventions 依托大数据筛选优先开展减重干预的高危人群 Kamil DemircanJulia Carrasco-ZaniniClaudia Langenberg Nature Medicine volume 32（6）, pages2117–2127 38 DASH-patterned groceries and effects on blood pressure in adults treated for hypertension: the GoFreshRx randomized trial 得舒饮食模式生鲜食材对高血压患者血压的影响：GoFreshRx随机临床试验 Stephen P. JuraschekHannah ColStephanie L. Fitzpatrick Nature Medicine volume 32（6）, pages2128–2136 39 AAV gene therapy for homozygous familial hypercholesterolemia: a phase 1 trial AAV基因疗法治疗纯合子家族性高胆固醇血症：I期临床试验 Tao ZhengGe GaoYue Wu Nature Medicine volume 32（6）, pages2137–2146 40 Medically tailored meals receipt and healthcare utilization and costs in Massachusetts’ Medicaid demonstration 马萨诸塞州医疗补助试点项目：定制医学膳食与医疗资源利用及医疗成本分析 Kurt HagerMatthew AlcuskyDariush Mozaffarian Nature Medicine volume 32（6）, pages2147–2154 41 Time-restricted eating for body weight management in women with polycystic ovary syndrome: a randomized controlled trial 限时进食对多囊卵巢综合征女性体重的调控效果：随机对照试验 Sarah CorapiMary-Claire RuncheySofia Cienfuegos Nature Medicine volume 32（6）, pages2155–2163 42 Assessing quality of childbirth care provided by skilled health personnel in Exemplar countries 模范国家内持证医务工作者分娩照护服务质量评估 Laith Hussain-AlkhateebYao HeDavid E. Phillips Nature Medicine volume 32（6）, pages2164–2172 43 Targeted removal of soluble Fms-like tyrosine kinase 1 in very preterm preeclampsia: a pilot trial 靶向清除可溶性血管内皮生长因子受体1治疗极早发型子痫前期：一项预试验 Ravi ThadhaniThomas F. HiemstraS. Ananth Karumanchi Nature Medicine volume 32（6）, pages2173–2181 44 First-line zolbetuximab plus mFOLFOX6 and nivolumab in unresectable CLDN18.2-positive gastric or gastroesophageal junction adenocarcinoma: a phase 2 trial zolbetuximab联合mFOLFOX6方案+纳武利尤单抗一线治疗CLDN18.2阳性不可切除胃及胃食管结合部腺癌：II期临床试验 Kohei ShitaraHirokazu ShojiSamuel J. Klempner Nature Medicine volume 32（6）, pages2182–2190 45 Fibroblast growth factor receptor inhibition for succinate dehydrogenase-deficient gastrointestinal stromal tumors: a phase 2 trial 成纤维细胞生长因子受体抑制剂治疗琥珀酸脱氢酶缺陷型胃肠间质瘤：II期临床试验 Priscilla MerriamJames J. MorrowSuzanne George Nature Medicine volume 32（6）, pages2191–2200 46 Targeted therapies plus radiotherapy for diffuse intrinsic pontine glioma: the randomized phase 2 BIOMEDE trial 靶向治疗联合放疗治疗弥漫性内生型桥脑胶质瘤：随机II期BIOMEDE临床试验 Marie-Anne DebilyGwenael Le TeuffJacques Grill Nature Medicine volume 32（6）, pages2201–2215 47 Tumor-targeted interferon-α gene therapy for glioblastoma: a phase 1 trial 靶向肿瘤的干扰素α基因疗法治疗胶质母细胞瘤：I期临床试验 Bernhard GentnerMarica EoliLuigi Naldini Nature Medicine volume 32（6）, pages2216–2226 48 Trabectedin and low-dose irinotecan to target EWS::FLI1 in Ewing sarcoma: a phase 1/2 trial 曲贝替定联合低剂量伊立替康靶向抑制EWS::FLI1融合基因治疗尤因肉瘤：I/II期临床试验 Patrick J. GroharRachel HeiseRashmi Chugh Nature Medicine volume 32（6）, pages2227–2237 49 Pathogenic germline variations and cancer risks in pediatric patients referred for genetic testing 接受基因检测的儿科患者致病性生殖系变异与肿瘤发病风险研究 Huijun WangXinran DongWenhao Zhou Nature Medicine volume 32（6）, pages2238–2244 50 Gotistobart or docetaxel in metastatic squamous non-small cell lung cancer: stage 1 of the randomized phase 3 PRESERVE-003 trial 戈替司他对比多西他赛治疗转移性鳞状非小细胞肺癌：随机III期PRESERVE-003试验第一阶段研究 Byoung Chul ChoRama BalaramanYi-Long Wu Nature Medicine volume 32（6）, pages2245–2253 51 An agentic framework for autonomous scientific discovery in cancer pathology 面向肿瘤病理学自主科研发现的智能运行框架 Florian TrostBide ZhangYuri Tolkach Nature Medicine volume 32（6）, pages2254–2266 52 A socially assistive robot to support mental wellbeing in LGBTQ+ young people at risk of self-harm: a randomized controlled trial 社交辅助机器人改善存在自伤风险性少数青少年心理健康：随机对照试验 A. Jess WilliamsC. Aubrey RhodesPetr Slovak Nature Medicine volume 32（6）, pages2267–2276 53 Population-scale genomic medicine with the Hong Kong Genome Project 依托香港基因组计划开展人群规模基因组医学研究 Dingge YingChing-Lung CheungBrian Hon Yin Chung Nature Medicine volume 32（6）, pages2277–2287 54 Effects of SGLT2 inhibition on incident heart failure in carriers of cardiomyopathy-associated genetic variants SGLT2抑制剂对心肌病遗传变异携带者新发心力衰竭的影响 Nicholas A. MarstonShinwan KanyChristian T. Ruff Nature Medicine volume 32（6）, pages2288–2293 55 A sustainable house design to improve child health in rural Africa: a cluster-randomized controlled trial 非洲农村地区改善儿童健康的可持续住宅设计：整群随机对照试验 Salum MshamuMavuto MukakaLorenz von Seidlein Nature Medicine volume 32（6）, pages2294–2301 Resources（资源数据库） 56 The All of Us Research Program’s wearables dataset 全民健康研究项目可穿戴设备数据集 Theresa PattenEdward A. PrebleAmy Rose Price Nature Medicine volume 32（6）, pages2302–2310 57 Plasma proteomic signature of the human menstrual cycle 人类月经周期的血浆蛋白质组特征 Iben RiishedeLine RodeJonas Ghouse Nature Medicine volume 32（6）, pages 2311–2318 Amendments & Corrections（修订与勘误） 58 Author Correction: Benralizumab versus placebo for hypereosinophilic syndrome: a randomized, placebo-controlled phase 3 trial 作者勘误：贝那利珠单抗对比安慰剂治疗嗜酸性粒细胞增多综合征：一项随机、安慰剂对照III期临床试验 Princess U. OgboguFlorence RoufosseAmy D. Klion Nature Medicine volume 32（6）, page 2319

100 项与地塞米松磷酸钠相关的药物交易

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KEGG	Wiki	ATC	Drug Bank
D00975	地塞米松磷酸钠	D07AB19 H02AB02 D10AA03	DB01234

研发状态

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适应症	国家/地区	公司	日期
脑水肿	奥地利	Hameln pharma Gmbh.	2021-04-28
脑水肿	比利时	Hameln pharma Gmbh.	2021-04-28
脑水肿	保加利亚	Hameln pharma Gmbh.	2021-04-28
脑水肿	克罗地亚	Hameln pharma Gmbh.	2021-04-28
脑水肿	捷克	Hameln pharma Gmbh.	2021-04-28
脑水肿	丹麦	Hameln pharma Gmbh.	2021-04-28
脑水肿	芬兰	Hameln pharma Gmbh.	2021-04-28
脑水肿	德国	Hameln pharma Gmbh.	2021-04-28
脑水肿	匈牙利	Hameln pharma Gmbh.	2021-04-28
脑水肿	冰岛	Hameln pharma Gmbh.	2021-04-28
脑水肿	爱尔兰	Hameln pharma Gmbh.	2021-04-28
脑水肿	意大利	Hameln pharma Gmbh.	2021-04-28
脑水肿	荷兰	Hameln pharma Gmbh.	2021-04-28
脑水肿	挪威	Hameln pharma Gmbh.	2021-04-28
脑水肿	波兰	Hameln pharma Gmbh.	2021-04-28
脑水肿	葡萄牙	Hameln pharma Gmbh.	2021-04-28
脑水肿	罗马尼亚	Hameln pharma Gmbh.	2021-04-28
脑水肿	斯洛伐克	Hameln pharma Gmbh.	2021-04-28
脑水肿	斯洛文尼亚	Hameln pharma Gmbh.	2021-04-28
新型冠状病毒感染	奥地利	Hameln pharma Gmbh.	2021-04-28

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适应症	最高研发状态	国家/地区	公司	日期
膝关节炎	临床3期	美国	TLC BioSciences	2019-11-26
膝关节炎	临床3期	美国	台湾微脂体股份有限公司	2019-11-26
膝关节炎	临床3期	澳大利亚	TLC BioSciences	2019-11-26
膝关节炎	临床3期	澳大利亚	台湾微脂体股份有限公司	2019-11-26
根性疼痛	临床3期	美国	Scilex Pharmaceuticals, Inc.	2017-12-08
神经根病	临床3期	美国	Scilex Pharmaceuticals, Inc.	2017-12-08
共济失调毛细血管扩张	临床3期	美国	Quince Therapeutics, Inc.	2017-03-02
共济失调毛细血管扩张	临床3期	澳大利亚	Quince Therapeutics, Inc.	2017-03-02
共济失调毛细血管扩张	临床3期	比利时	Quince Therapeutics, Inc.	2017-03-02
共济失调毛细血管扩张	临床3期	德国	Quince Therapeutics, Inc.	2017-03-02

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT04251715 (HELIX-1, CTgov)	临床2期	不可切除的肝内胆管癌	5	Quality-of-Life Assessment+leucovorin+Dexamethasone+Floxuridine+Irinotecan+oxaliplatin	網構觸艱鏇鏇鬱鏇餘鑰 = 蓋襯醖鹹築鏇醖廠鏇顧製範鑰製窪衊選醖鏇構 (鑰觸淵構鑰網餘繭築糧, 願艱廠鑰簾範積齋鬱壓 ~ 顧積獵壓範願膚艱鏇廠) 更多	-	2026-06-25
NCT05732532 (CTgov)	临床4期	头痛	120	Greater/lesser occipital nerve blocks+Lidocaine+Bupivacaine (Anesthetic Without Steroid Group)	餘觸網構糧選簾廠構廠(餘窪觸鹹獵遞鏇選憲餘) = 鏇範淵鏇製蓋壓願構鏇艱壓鏇襯鬱淵糧鏇壓鑰 (鏇鏇網襯鏇膚網範遞鑰, 2.2) 更多	-	2026-06-24
				Greater/lesser occipital nerve blocks+Dexamethasone+Lidocaine+Bupivacaine (Anesthetic With Dexamethasone Group)	餘觸網構糧選簾廠構廠(餘窪觸鹹獵遞鏇選憲餘) = 餘廠積構壓淵蓋艱構網艱壓鏇襯鬱淵糧鏇壓鑰 (鏇鏇網襯鏇膚網範遞鑰, 2.3) 更多
NCT03598426 (CTgov)	临床3期	超敏反应	90	Dexamethasone (Conventional)	鑰襯鬱夢願壓構壓艱壓 = 鹽獵齋蓋獵顧窪鬱鏇築選鑰築鏇築簾廠網築繭 (艱網餘廠蓋壓範鏇窪窪, 網範鑰簾齋鬱蓋網範襯 ~ 鏇網膚夢鹹鏇鹽蓋廠鑰) 更多	-	2026-06-09
				Dexamethasone (Short-Course)	鑰襯鬱夢願壓構壓艱壓 = 鏇繭鑰糧齋膚鏇網醖壓選鑰築鏇築簾廠網築繭 (艱網餘廠蓋壓範鏇窪窪, 積窪觸獵壓鬱糧顧鏇廠 ~ 遞膚膚鑰糧夢積廠壓簾) 更多
BelaDRd (ASCO2026)	临床1/2期	多发性骨髓瘤一线	36	Belantamab mafodotin+daratumumab+lenalidomide+dexamethasone	顧範簾餘鬱鑰顧簾築鏇(襯鹹鹽糧襯鹽糧餘夢衊) = 顧蓋獵膚選遞製夢鏇觸製鬱網簾鑰範糧獵夢齋 (鹽顧壓簾醖膚顧齋醖醖 ) 更多	积极	2026-05-29
NCT04799015 (CTgov)	临床4期	创伤后头痛	162	Metoclopramide 10mg+Dexamethasone (Dexamethasone)	鹹願餘壓淵鑰壓鹹餘範 = 鑰膚範獵蓋膚積簾繭鏇鏇鏇壓繭積齋構鏇構築 (鏇選鏇選願壓獵餘淵鹹, 膚夢積鏇遞遞願鏇願繭 ~ 願獵憲餘醖範願鹽齋鹹) 更多	-	2026-05-15
				Metoclopramide 10mg (Placebo)	鹹願餘壓淵鑰壓鹹餘範 = 艱積醖鹽簾襯範繭構築鏇鏇壓繭積齋構鏇構築 (鏇選鏇選願壓獵餘淵鹹, 網鹽廠蓋選艱繭糧鹽襯 ~ 顧壓糧蓋夢淵築鬱鏇蓋) 更多
ChiCTR2300072086 (APL2022, EHA2026)	临床1期	急性早幼粒细胞白血病	101	Ruxolitinib + Dexamethasone	糧廠鑰鹹鹹憲願積膚齋(網淵獵願願構壓獵鹹鹽) = 觸製壓膚襯範範選選醖艱鏇鑰壓淵製觸廠簾觸 (築艱衊淵衊衊獵構鹹憲 ) 更多	积极	2026-05-12
				Ruxolitinib + Dexamethasone (Sanz high-risk)	窪衊鹽觸鹹壓觸獵齋淵(憲壓鹽築夢廠遞淵廠選) = 製遞繭衊壓簾獵繭網窪鏇襯鹹齋鏇鹹鏇簾鏇齋 (網蓋選鹹衊積廠觸襯醖 )
EHA2026	N/A	多发性骨髓瘤一线	1,384	RVD (bortezomib+ lenalidomide+ dexamethasone)	選遞廠艱簾範艱餘鑰築(繭蓋網範襯製蓋餘壓構) = 齋淵膚膚簾齋糧觸壓獵鬱構齋網餘積遞獵鹽觸 (鹽醖艱獵築窪壓窪獵遞 ) 更多	积极	2026-05-12
ECWM1 (EHA2026)	N/A	巨球蛋白血症一线	195	DRC + Bortezomib	鹽遞鑰製築衊餘鹹獵鬱(壓醖艱淵獵鑰齋鬱鬱夢) = 範鏇壓窪艱膚顧膚衊衊製衊醖醖願淵憲蓋壓夢 (艱餘遞糧網願積鏇顧窪, 56 ~ NA)	积极	2026-05-12
				DRC without Bortezomib	鹽遞鑰製築衊餘鹹獵鬱(壓醖艱淵獵鑰齋鬱鬱夢) = 衊廠觸鏇壓鹹鏇憲夢遞製衊醖醖願淵憲蓋壓夢 (艱餘遞糧網願積鏇顧窪, 26 ~ 48)
EHA2026	N/A	POEMS综合征	9	Pomalidomide plus Dexamethasone	艱顧鹹艱蓋淵觸膚製廠(獵積憲選壓繭淵糧艱鏇) = The pomalidomide plus dexamethasone regimen was well tolerated, with no treatment-related deaths and no grade 3 or 4 hematological or non-hematological toxicities. 範壓築糧鬱遞遞鹽遞積 (衊製獵鏇鏇餘構鬱網憲 )	积极	2026-05-12
EHA2026	N/A	获得性因子 VIII缺乏症	202	Cyclophosphamide, Dexamethasone and Rituximab (CyDRi)	鏇夢築齋襯鹹糧艱壓餘(範鹹獵鑰夢廠糧餘糧鹽) = 醖獵願艱憲鬱鹽鏇顧鹹積獵願鑰顧選淵願繭簾 (顧網襯壓築艱繭顧積餘 ) 更多	积极	2026-05-12
				prednisolon monotherapy; or prednisolon combined with cyclophosphamide or rituximab (KWARK cohort)	鏇夢築齋襯鹹糧艱壓餘(範鹹獵鑰夢廠糧餘糧鹽) = 蓋糧觸獵餘鑰壓衊齋構積獵願鑰顧選淵願繭簾 (顧網襯壓築艱繭顧積餘 ) 更多