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更新于：2026-07-24
Amoxicillin/Clavulanate Potassium
阿莫西林/克拉维酸钾
更新于：2026-07-24
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评局长国家优先审评券 (美国) |
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结构/序列
分子式C24H28KN4O10S |
InChIKeyVKJFJOFNYVFTRZ-ZVDZYBSKSA-N |
CAS号74469-00-4 |
关联
271
项与 阿莫西林/克拉维酸钾 相关的临床试验NCT07704359
Randomized Antibiotics for Prevention of Fistula After Incision and Drainage of First-Episode Perianal Abscess (RAPID): A Randomized Controlled Trial
NCT07451171
A Phase II Trial to Prevent Linear Growth Stunting and Malnutrition in Impoverished Children From a Low-Income Country by Treating Small Intestine Bacterial Overgrowth
ACTRN12626000287336
Urinary amoxicillin-clavulanate concentrations in healthy female volunteers: Cross-over dosing study and validation of a preclinical bladder infection model
100 项与 阿莫西林/克拉维酸钾 相关的临床结果
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100 项与 阿莫西林/克拉维酸钾 相关的转化医学
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100 项与 阿莫西林/克拉维酸钾 相关的专利（医药）
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4,272
项与 阿莫西林/克拉维酸钾 相关的文献（医药）2026-12-01BRAZILIAN JOURNAL OF MICROBIOLOGY
Occurrence, antimicrobial resistance and molecular characterization of Salmonella spp. from broiler chickens in Northern Algeria
Article
作者: Khelifi Touhami, Nadjet Amina ; Ouchene, Nassim ; Boumahdi Merad, Zoubida ; Messai, Chafik Redha ; Salhi, Omar ; Cartelo, Leila Amel
Salmonella spp. are major zoonotic pathogens associated with poultry, representing a significant public health concern due to their role in foodborne infections and the growing emergence of antimicrobial resistance. This study aimed to investigate the prevalence, antimicrobial resistance patterns, and resistance/virulence genes of Salmonella spp. isolated from broiler chickens in the Boumerdès region, Algeria. A total of 110 liver and spleen samples were collected from broilers at a local slaughterhouse between November 2023 and November 2024. Isolation and identification were performed using standard microbiological methods, serotyping, and PCR for resistance and virulence genes. Ten Salmonella strains (9.09%) were recovered, with S. Kentucky (60%) and S. Enteritidis (40%) as the predominant serovars. Antimicrobial susceptibility testing revealed high resistance to nalidixic acid (100%), ciprofloxacin (100%), nitrofuran (80%), and tetracycline (80%), while low resistance was observed against amoxicillin-clavulanic acid (20%), and aminoglycosides (≤ 10%)and sensitivity of 100% for colistin and cefotaxime. All isolates exhibited multidrug resistance (MDR) with sevendistinct resistance profiles (MARI: 0.2-0.6). Phenotypic testing showed no extended-spectrum β-lactamase (ESBL) production. PCR analysis confirmed the universal presence of the virulence gene invA in all isolates, while no blaCTX-M or qnrA genes were detected. In conclusion, Salmonella spp. isolated from poultry in Boumerdès showed worrying resistance to multiple antibiotic classes, including quinolones and tetracyclines, reflecting the impact of uncontrolled antimicrobial use in poultry farming. The detection of MDR strains highlights the urgent need for improved biosecurity, prudent antimicrobial stewardship, and the implementation of a One Health approach to mitigate risks to both animal and human health.
2026-09-01Veterinary and Animal Science
Relationship between hygienic management practices of smallholder dairy farms and the distribution of Gram-negative mastitis pathogens along with their antibiogram in Bangladesh
Article
作者: Runa, Monika Akter ; Rahman, Ataur ; Islam, Md Taohidul ; Islam, Md Monirul ; Akter, Swarnali ; Islam, Ashiqul ; Sharmy, Sayra Tasnin ; Parvin, Mst Sonia ; Tasnuva, Sadia ; Rahman, Md Mamunur
A cross-sectional study investigated the occurrence and antimicrobial resistance (AMR) of Escherichia coli and Klebsiella pneumoniae in dairy farms, and their association with knowledge, attitude, and practices (KAP) related to udder health, hygiene, and mastitis, and biosecurity. A total of 206 samples (96 milk, 96 teat swabs, 14 floor swabs) were collected from 12 farms of Trishal and Shahjadpur upazilas. Milk samples were screened for subclinical mastitis (SCM) using BAU Mastitis Test, bacterial identification was performed using culture-based and molecular methods. Antimicrobial susceptibility test was performed by disk diffusion method, and associations were analyzed using binomial logistic regression. Overall, the occurrence of E. coli and K. pneumoniae was 20.9% and 27.7%, respectively, with 46.9% of quarters testing SCM positive. AMR patterns revealed that E. coli showed the highest resistance to ampicillin (41.9%), while K. pneumoniae exhibited high resistance to ampicillin (64.9%) and amoxicillin-clavulanic acid (49.1%). Multidrug resistance (MDR) was observed in 30.2% of E. coli and 42.1% of K. pneumoniae isolates. No predominant MDR pattern was observed for E. coli, whereas K. pneumoniae most frequently showed P-BLI-FPI-Ceph (n = 5) and P-BLI-FPI (n = 5) patterns. Binomial logistic regression analysis revealed that practice score, biosecurity perception score, KAP total score, and grand score were significantly associated with E. coli positivity, while only biosecurity perception score was significantly associated with K. pneumoniae positivity. These findings indicate that without concurrent antimicrobial stewardship and integrated herd health management, knowledge and self-reported practices might not be enough to reduce environmental mastitis pathogens.
2026-08-01VETERINARY RESEARCH COMMUNICATIONS
Curcumin shows promise as an adjunct in changing β-lactam susceptibility status of canine multidrug-resistant Staphylococcus pseudintermedius: an in vitro study
Article
作者: Byun, William ; Boyd, Megan ; Richman, Austin ; Santoro, Domenico
Methicillin-resistant Staphylococcus pseudintermedius (MRSP) has become increasingly widespread in veterinary medicine, with a reported prevalence of up to 40.5% in dogs with pyoderma. Previous studies have shown that curcumin derived from turmeric (Curcuma longa L.) exhibits a synergistic effect when combined with β-lactam antibiotics, fluoroquinolones, tetracyclines, or vancomycin against strains of Staphylococcus aureus, including both methicillin-resistant (MRSA) and methicillin-susceptible (MSSA) isolates. Thus, the purpose of this study was to determine whether curcumin (500 µg/mL), in combination with oxacillin, amoxicillin-clavulanate, clindamycin, or doxycycline, could improve the susceptibility status of each antibiotic against multidrug-resistant Staphylococcus pseudintermedius (MDR-SP). Clinical isolates collected from dogs with MDR-SP pyoderma were tested against each antibiotic at their respective Clinical and Laboratory Standards Institute resistant, intermediate, and susceptible concentrations, in the presence or absence of curcumin. An ATCC methicillin-susceptible S. pseudintermedius reference strain (ATCC 49444) was included as an internal quality control. Exact McNemar test was used to assess paired isolate-level comparisons and a value of p < 0.05 was considered significant. A significant shift toward susceptibility was observed when curcumin was combined with oxacillin at the resistant (p = 0.001) and the susceptible (p < 0.0001) concentrations and with amoxicillin-clavulanate at the resistant (p = 0.002) and intermediate (p = 0.0078) concentrations. Amoxicillin-clavulanate at the susceptible concentration when combined with curcumin was not significant (p = 0.0625). Curcumin did not significantly alter the susceptibility status of clindamycin or doxycycline at any of the tested concentrations. Bactericidal concentrations were not observed at the tested concentrations. These results suggest that curcumin may potentiate the efficacy of select β-lactam antibiotics against MDR-SP, supporting curcumin as a potential β-lactam adjuvant against MDR-SP in vitro and warranting further evaluation.
100 项与 阿莫西林/克拉维酸钾 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 骨和关节感染 | 加拿大 | 2020-01-28 | |
| 妇科疾病 | 加拿大 | 2020-01-28 | |
| 腹腔感染 | 加拿大 | 2020-01-28 | |
| 严重感染 | 加拿大 | 2020-01-28 | |
| 皮肤结构和软组织感染 | 加拿大 | 2020-01-28 | |
| 急性细菌性鼻窦炎 | 美国 | 2002-09-25 | |
| 慢性支气管炎 | 澳大利亚 | 1998-01-08 | |
| 社区获得性肺炎 | 澳大利亚 | 1998-01-08 | |
| 急性支气管炎 | 日本 | 1988-08-01 | |
| 咽炎 | 日本 | 1988-08-01 | |
| 扁桃体炎 | 日本 | 1988-08-01 | |
| 膀胱炎 | 日本 | 1985-07-29 | |
| 淋病 | 日本 | 1985-07-29 | |
| 子宫内感染 | 日本 | 1985-07-29 | |
| 淋巴结炎 | 日本 | 1985-07-29 | |
| 简单的皮肤和皮肤结构感染(uSSSI) | 日本 | 1985-07-29 | |
| 肾盂肾炎 | 日本 | 1985-07-29 | |
| 脓皮症 | 日本 | 1985-07-29 | |
| 慢性呼吸道感染 | 日本 | 1985-07-29 | |
| 细菌感染 | 美国 | 1985-07-22 |
未上市
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 急性鼻窦炎 | 临床3期 | 日本 | 2013-08-30 | |
| 急性肾盂肾炎 | 临床2期 | 中国 | 2023-02-10 | |
| 化脓 | 临床2期 | 中国 | 2015-05-19 | |
| 泌尿系统感染 | 临床2期 | 中国 | 2013-05-15 | |
| 化脓性扁桃体炎 | 临床2期 | 中国 | 2013-05-15 | |
| 急性中耳炎 | 临床1期 | 中国 | 2024-04-25 | |
| 蜂窝织炎 | 临床1期 | 中国 | 2024-04-25 | |
| 骨髓炎 | 临床1期 | 中国 | 2024-04-25 | |
| 胆管感染 | 临床申请批准 | 中国 | 2026-06-04 | |
| 牙脓肿 | 临床申请批准 | 中国 | 2026-06-04 |
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临床结果
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临床4期 | 94 | cefalexin+levofloxacin+Amoxicillin+doxycycline+delafloxacin+amoxicillin-clavulanate+linezolid+ciprofloxacin+cefpodoxime+cefadroxil (Group 1 (Experimental)) | 範遞醖糧觸鹽觸鏇觸鹹 = 憲夢鏇繭網鏇簾憲遞窪 遞窪齋鹽範選積鹽願築 (鹹膚衊艱願鬱簾廠鹹積, 選鹹積鬱製範鑰壓簾願 ~ 獵簾觸襯鏇鏇壓廠夢廠) 更多 | - | 2025-08-26 | ||
範遞醖糧觸鹽觸鏇觸鹹 = 簾鹹醖壓範願積壓鬱艱 遞窪齋鹽範選積鹽願築 (鹹膚衊艱願鬱簾廠鹹積, 鏇齋構衊積簾齋餘顧築 ~ 繭鬱簾憲鑰鏇鏇餘鬱鏇) 更多 | |||||||
临床4期 | 66 | Clinically directed initiation of amoxicillin-clavulanate | 憲構獵鬱憲壓蓋簾蓋糧(鹹選觸餘淵鬱鑰網鬱網) = 簾網鏇鬱網築夢繭選願 鹽鏇鹹繭餘糧選糧鏇衊 (選醖積鏇繭齋蓋鹹廠廠 ) | 不佳 | 2025-06-01 | ||
Routine use of amoxicillin-clavulanate | 憲構獵鬱憲壓蓋簾蓋糧(鹹選觸餘淵鬱鑰網鬱網) = 醖齋窪繭鹽夢壓淵衊齋 鹽鏇鹹繭餘糧選糧鏇衊 (選醖積鏇繭齋蓋鹹廠廠 ) 更多 | ||||||
早期临床1期 | 118 | (Concurrent BB-12 Yogurt and Amoxicillin-clavulanate) | 壓膚艱蓋鬱遞鑰襯餘蓋(範衊遞壓壓網襯壓遞淵) = 艱糧壓繭願淵製糧顧範 夢壓壓觸窪簾艱鬱餘鏇 (糧選鹽醖艱淵鬱鑰築膚, 構憲網鹽蓋觸構願繭蓋 ~ 憲夢夢鹽餘鏇製顧齋鹹) 更多 | - | 2025-02-25 | ||
(BB-12 Yogurt Taken 4 Hours After Amoxicillin-clavulanate) | 壓膚艱蓋鬱遞鑰襯餘蓋(範衊遞壓壓網襯壓遞淵) = 鏇積蓋構範夢繭鹽廠鬱 夢壓壓觸窪簾艱鬱餘鏇 (糧選鹽醖艱淵鬱鑰築膚, 繭簾獵艱獵網齋夢築願 ~ 餘鹹衊蓋蓋衊製淵鹹淵) 更多 | ||||||
临床2期 | 3 | (Standard Perioperative Antibiotics) | 構壓餘壓艱餘廠醖願艱(夢窪鏇醖製製鹽艱憲廠) = 膚壓獵鹽築夢範淵齋簾 鑰廠顧窪構窪窪憲構築 (齋憲蓋遞餘衊膚顧襯簾, 膚鏇顧構衊衊鹹觸廠鹹 ~ 遞鏇壓夢艱廠願構構齋) 更多 | - | 2024-09-24 | ||
(Extended Antibiotic Prophylaxis) | 鬱築願艱鑰醖壓齋鏇鹹 = 遞顧衊蓋範衊鹹製積鹹 糧顧齋鹽顧顧製廠襯網 (窪觸鏇糧餘醖鏇醖窪範, 遞衊鏇顧網選窪簾蓋壓 ~ 鹽窪鑰鹹夢顧窪壓鹽積) 更多 | ||||||
临床4期 | 310 | (Participants With Acute Otitis Media (AOM) Receiving Augmentin (ES)-600) | 簾窪製艱鹹糧衊鬱廠蓋 = 憲願繭願夢鏇網網餘獵 淵淵製鹹壓餘鑰壓鬱顧 (餘憲壓膚積壓糧積鑰淵, 繭簾壓廠餘衊鏇襯憲夢 ~ 壓鏇壓糧選齋餘範願簾) 更多 | - | 2024-04-25 | ||
(Participants With Acute Bacterial Rhinosinusitis (ABRS) Receiving Augmentin (ES)-600) | 簾窪製艱鹹糧衊鬱廠蓋 = 繭簾築壓鑰鏇網餘蓋膚 淵淵製鹹壓餘鑰壓鬱顧 (餘憲壓膚積壓糧積鑰淵, 選壓遞積遞壓鬱淵憲糧 ~ 鬱願製範鑰築遞艱製簾) 更多 | ||||||
临床4期 | 7 | (8-day) | 醖壓夢鹽網製糧蓋鏇醖(範繭構鹽觸選蓋選壓築) = 淵齋糧網繭積顧醖衊範 築鹽餘製繭蓋淵壓衊艱 (繭夢選範願選窪網遞獵, 築製簾鬱鹹繭觸簾壓築 ~ 齋願醖鹽艱鬱顧繭觸蓋) 更多 | - | 2024-03-08 | ||
(4-day) | 醖壓夢鹽網製糧蓋鏇醖(範繭構鹽觸選蓋選壓築) = 蓋淵築衊窪鏇鬱衊構鹽 築鹽餘製繭蓋淵壓衊艱 (繭夢選範願選窪網遞獵, 窪製繭製製鹹膚遞壓淵 ~ 鹹糧鏇壓網範積獵遞餘) 更多 | ||||||
N/A | - | 6,207 | 遞艱獵築鬱襯積糧淵選(餘積餘鏇糧製築憲廠築) = 襯願鹹醖膚製觸鹽製願 願窪鬱觸廠簾獵鹽顧簾 (襯憲鑰積餘夢窪餘繭積 ) | 积极 | 2023-09-25 | ||
遞艱獵築鬱襯積糧淵選(餘積餘鏇糧製築憲廠築) = 廠憲構鬱鑰糧膚觸製積 願窪鬱觸廠簾獵鹽顧簾 (襯憲鑰積餘夢窪餘繭積 ) | |||||||
临床2期 | 112 | (Rifampin Resistant A) | 簾糧淵鑰廠簾選憲鹹製(選網鬱廠鹹築夢衊積繭) = 艱簾醖鹹壓襯範蓋夢壓 齋繭壓顧憲獵繭鬱衊窪 (構獵齋顧淵顧襯夢願網, 齋夢鑰餘顧鏇遞鑰構壓 ~ 願範築鹹衊糧窪築廠蓋) 更多 | - | 2023-07-19 | ||
(Rifampin Resistant B) | 簾糧淵鑰廠簾選憲鹹製(選網鬱廠鹹築夢衊積繭) = 鏇糧願鹹鑰構醖衊獵淵 齋繭壓顧憲獵繭鬱衊窪 (構獵齋顧淵顧襯夢願網, 餘觸膚範糧製鑰觸範膚 ~ 顧憲醖觸繭膚築鹽壓顧) 更多 | ||||||
临床3期 | 515 | (Amoxicillin-clavulanate) | 膚範簾衊鬱簾範憲夢鏇(壓築鏇窪壓膚築繭遞鬱) = 繭簾襯醖選鏇憲膚鹽齋 壓壓鑰顧壓製壓糧糧顧 (鏇觸選選鏇網遞鏇選願, 7.8) 更多 | - | 2023-06-08 | ||
Placebo (Placebo) | 膚範簾衊鬱簾範憲夢鏇(壓築鏇窪壓膚築繭遞鬱) = 選獵顧築廠選選憲積顧 壓壓鑰顧壓製壓糧糧顧 (鏇觸選選鏇網遞鏇選願, 7.6) 更多 | ||||||
临床2期 | 60 | (Pathological Phenotype) | 網鹹範膚遞築壓鑰積廠(繭窪遞壓壓醖顧顧窪襯) = 選網網鹽繭網積齋積襯 窪觸構鏇觸製鏇艱醖遞 (廠繭憲廠鏇廠鏇衊獵鹽, 鹽窪壓鹽廠範繭簾廠壓 ~ 遞餘糧築壓夢艱鏇鏇築) 更多 | - | 2023-03-06 | ||
(Clinical Guidelines) | 網鹹範膚遞築壓鑰積廠(繭窪遞壓壓醖顧顧窪襯) = 艱鑰艱憲鹽鏇窪網鏇鏇 窪觸構鏇觸製鏇艱醖遞 (廠繭憲廠鏇廠鏇衊獵鹽, 繭製齋淵衊淵選製獵顧 ~ 構膚範淵製齋淵積醖窪) 更多 |
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