预约演示
更新于：2026-08-26
Amoxicillin/Clavulanate Potassium
阿莫西林/克拉维酸钾
更新于：2026-08-26
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评局长国家优先审评券 (美国) |
登录后查看时间轴
结构/序列
分子式C24H28KN4O10S |
InChIKeyVKJFJOFNYVFTRZ-ZVDZYBSKSA-N |
CAS号74469-00-4 |
关联
276
项与 阿莫西林/克拉维酸钾 相关的临床试验NCT07730814
Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children (Acute Otitis Media)
NCT07785206
Effectiveness of Saccharomyces Boulardii in the Prevention of Antibiotic-Associated Diarrhea Among Children Receiving Co-amoxiclav for Upper Respiratory Tract Infection: A Randomized Control Trial
NCT07704359
Randomized Antibiotics for Prevention of Fistula After Incision and Drainage of First-Episode Perianal Abscess (RAPID): A Randomized Controlled Trial
100 项与 阿莫西林/克拉维酸钾 相关的临床结果
登录后查看更多信息
100 项与 阿莫西林/克拉维酸钾 相关的转化医学
登录后查看更多信息
100 项与 阿莫西林/克拉维酸钾 相关的专利（医药）
登录后查看更多信息
4,238
项与 阿莫西林/克拉维酸钾 相关的文献（医药）2026-12-01BRAZILIAN JOURNAL OF MICROBIOLOGY
Occurrence, antimicrobial resistance and molecular characterization of Salmonella spp. from broiler chickens in Northern Algeria
Article
作者: Khelifi Touhami, Nadjet Amina ; Ouchene, Nassim ; Boumahdi Merad, Zoubida ; Messai, Chafik Redha ; Salhi, Omar ; Cartelo, Leila Amel
Salmonella spp. are major zoonotic pathogens associated with poultry, representing a significant public health concern due to their role in foodborne infections and the growing emergence of antimicrobial resistance. This study aimed to investigate the prevalence, antimicrobial resistance patterns, and resistance/virulence genes of Salmonella spp. isolated from broiler chickens in the Boumerdès region, Algeria. A total of 110 liver and spleen samples were collected from broilers at a local slaughterhouse between November 2023 and November 2024. Isolation and identification were performed using standard microbiological methods, serotyping, and PCR for resistance and virulence genes. Ten Salmonella strains (9.09%) were recovered, with S. Kentucky (60%) and S. Enteritidis (40%) as the predominant serovars. Antimicrobial susceptibility testing revealed high resistance to nalidixic acid (100%), ciprofloxacin (100%), nitrofuran (80%), and tetracycline (80%), while low resistance was observed against amoxicillin-clavulanic acid (20%), and aminoglycosides (≤ 10%)and sensitivity of 100% for colistin and cefotaxime. All isolates exhibited multidrug resistance (MDR) with sevendistinct resistance profiles (MARI: 0.2-0.6). Phenotypic testing showed no extended-spectrum β-lactamase (ESBL) production. PCR analysis confirmed the universal presence of the virulence gene invA in all isolates, while no blaCTX-M or qnrA genes were detected. In conclusion, Salmonella spp. isolated from poultry in Boumerdès showed worrying resistance to multiple antibiotic classes, including quinolones and tetracyclines, reflecting the impact of uncontrolled antimicrobial use in poultry farming. The detection of MDR strains highlights the urgent need for improved biosecurity, prudent antimicrobial stewardship, and the implementation of a One Health approach to mitigate risks to both animal and human health.
2026-09-01Veterinary and Animal Science
Relationship between hygienic management practices of smallholder dairy farms and the distribution of Gram-negative mastitis pathogens along with their antibiogram in Bangladesh
Article
作者: Runa, Monika Akter ; Rahman, Ataur ; Islam, Md Taohidul ; Islam, Md Monirul ; Akter, Swarnali ; Islam, Ashiqul ; Sharmy, Sayra Tasnin ; Parvin, Mst Sonia ; Tasnuva, Sadia ; Rahman, Md Mamunur
A cross-sectional study investigated the occurrence and antimicrobial resistance (AMR) of Escherichia coli and Klebsiella pneumoniae in dairy farms, and their association with knowledge, attitude, and practices (KAP) related to udder health, hygiene, and mastitis, and biosecurity. A total of 206 samples (96 milk, 96 teat swabs, 14 floor swabs) were collected from 12 farms of Trishal and Shahjadpur upazilas. Milk samples were screened for subclinical mastitis (SCM) using BAU Mastitis Test, bacterial identification was performed using culture-based and molecular methods. Antimicrobial susceptibility test was performed by disk diffusion method, and associations were analyzed using binomial logistic regression. Overall, the occurrence of E. coli and K. pneumoniae was 20.9% and 27.7%, respectively, with 46.9% of quarters testing SCM positive. AMR patterns revealed that E. coli showed the highest resistance to ampicillin (41.9%), while K. pneumoniae exhibited high resistance to ampicillin (64.9%) and amoxicillin-clavulanic acid (49.1%). Multidrug resistance (MDR) was observed in 30.2% of E. coli and 42.1% of K. pneumoniae isolates. No predominant MDR pattern was observed for E. coli, whereas K. pneumoniae most frequently showed P-BLI-FPI-Ceph (n = 5) and P-BLI-FPI (n = 5) patterns. Binomial logistic regression analysis revealed that practice score, biosecurity perception score, KAP total score, and grand score were significantly associated with E. coli positivity, while only biosecurity perception score was significantly associated with K. pneumoniae positivity. These findings indicate that without concurrent antimicrobial stewardship and integrated herd health management, knowledge and self-reported practices might not be enough to reduce environmental mastitis pathogens.
2026-09-01MICROBIAL PATHOGENESIS
In silico and in vitro analysis of resistance genes in Klebsiella pneumoniae for assessing antibiotic efficacy and identifying novel therapeutic targets
Article
作者: Zhu, Huifen ; Weng, Liangliang ; Fan, Kai-Jian ; Wang, Yi-Hao ; Rasheed, Kousar ; Jiang, Chao
Urinary tract infections (UTIs) represent a major public health concern worldwide, with Klebsiella pneumoniae emerging as a prominent uropathogen due to its rapidly increasing multidrug resistance. This study aimed to evaluate the phenotypic and molecular resistance profiles of K. pneumoniae isolated from UTI patients and to identify potential therapeutic targets using integrated in vitro and in silico approaches. Urine samples were collected from clinically suspected UTI patients. Isolates were confirmed as K. pneumoniae through standard morphological and biochemical characterization. Antimicrobial susceptibility testing was performed using the Kirby-Bauer disk diffusion method following Clinical and Laboratory Standards Institute (CLSI) guidelines. Molecular detection of resistance genes was carried out by polymerase chain reaction (PCR), while computational analyses including molecular docking, molecular dynamics simulations and ADMET profiling, were employed to evaluate potential drug candidates. Phenotypic analysis revealed high resistance rates to ampicillin, amoxicillin-clavulanate, cotrimoxazole, ciprofloxacin, and ceftriaxone, indicating a substantial prevalence of multidrug-resistant strains. Reduced susceptibility was observed against gentamicin, nitrofurantoin, fosfomycin, and imipenem, with emerging carbapenem resistance noted among the isolates. Molecular investigations identified the blaTEM gene as the most prevalent resistance determinant, strongly associated with β-lactam antibiotic resistance. In silico studies demonstrated stable binding interactions between selected ligands and the blaTEM protein, along with favorable pharmacokinetic and drug-likeness properties. In conclusion, this study highlights the significant contribution of multidrug-resistant K. pneumoniae to recurrent UTIs and underscores the importance of integrating phenotypic, molecular, and computational strategies to elucidate resistance mechanisms and facilitate the development of effective therapeutic interventions in clinical practice.
421
项与 阿莫西林/克拉维酸钾 相关的新闻（医药）2026-08-17
·米内网
100 项与 阿莫西林/克拉维酸钾 相关的药物交易
登录后查看更多信息
外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 骨和关节感染 | 加拿大 | 2020-01-28 | |
| 妇科疾病 | 加拿大 | 2020-01-28 | |
| 腹腔感染 | 加拿大 | 2020-01-28 | |
| 严重感染 | 加拿大 | 2020-01-28 | |
| 皮肤结构和软组织感染 | 加拿大 | 2020-01-28 | |
| 急性细菌性鼻窦炎 | 美国 | 2002-09-25 | |
| 慢性支气管炎 | 澳大利亚 | 1998-01-08 | |
| 社区获得性肺炎 | 澳大利亚 | 1998-01-08 | |
| 急性支气管炎 | 日本 | 1988-08-01 | |
| 咽炎 | 日本 | 1988-08-01 | |
| 扁桃体炎 | 日本 | 1988-08-01 | |
| 膀胱炎 | 日本 | 1985-07-29 | |
| 淋病 | 日本 | 1985-07-29 | |
| 子宫内感染 | 日本 | 1985-07-29 | |
| 淋巴结炎 | 日本 | 1985-07-29 | |
| 简单的皮肤和皮肤结构感染(uSSSI) | 日本 | 1985-07-29 | |
| 肾盂肾炎 | 日本 | 1985-07-29 | |
| 脓皮症 | 日本 | 1985-07-29 | |
| 慢性呼吸道感染 | 日本 | 1985-07-29 | |
| 细菌感染 | 美国 | 1985-07-22 |
未上市
10 条进展最快的记录, 后查看更多信息
登录
| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 急性鼻窦炎 | 临床3期 | 日本 | 2013-08-30 | |
| 急性肾盂肾炎 | 临床2期 | 中国 | 2023-02-10 | |
| 化脓 | 临床2期 | 中国 | 2015-05-19 | |
| 泌尿系统感染 | 临床2期 | 中国 | 2013-05-15 | |
| 化脓性扁桃体炎 | 临床2期 | 中国 | 2013-05-15 | |
| 急性中耳炎 | 临床1期 | 中国 | 2024-04-25 | |
| 蜂窝织炎 | 临床1期 | 中国 | 2024-04-25 | |
| 骨髓炎 | 临床1期 | 中国 | 2024-04-25 | |
| 胆管感染 | 临床申请批准 | 中国 | 2026-06-04 | |
| 牙脓肿 | 临床申请批准 | 中国 | 2026-06-04 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 94 | cefalexin+levofloxacin+Amoxicillin+doxycycline+delafloxacin+amoxicillin-clavulanate+linezolid+ciprofloxacin+cefpodoxime+cefadroxil (Group 1 (Experimental)) | 夢餘獵選鑰築構廠壓顧 = 積觸窪製襯構壓鹹膚壓 積願艱鏇鏇鬱衊夢顧簾 (願淵製願鹹壓積鏇膚選, 範鹹遞鬱鬱簾蓋窪窪衊 ~ 憲觸繭網觸淵簾廠蓋網) 更多 | - | 2025-08-26 | ||
夢餘獵選鑰築構廠壓顧 = 願糧夢鑰鹽廠衊獵鹽膚 積願艱鏇鏇鬱衊夢顧簾 (願淵製願鹹壓積鏇膚選, 憲獵積鹽鹽獵鑰獵鬱顧 ~ 鬱築憲壓製淵築鬱鏇觸) 更多 | |||||||
临床4期 | 66 | Clinically directed initiation of amoxicillin-clavulanate | 齋艱窪獵鏇餘壓觸鹽艱(蓋窪鹹蓋糧夢鑰淵簾夢) = 壓艱廠鑰鬱壓鏇積積窪 製夢壓繭廠顧鑰齋觸鬱 (鏇醖壓鏇糧網襯願膚艱 ) | 不佳 | 2025-06-01 | ||
Routine use of amoxicillin-clavulanate | 齋艱窪獵鏇餘壓觸鹽艱(蓋窪鹹蓋糧夢鑰淵簾夢) = 艱糧齋蓋襯夢醖鬱繭憲 製夢壓繭廠顧鑰齋觸鬱 (鏇醖壓鏇糧網襯願膚艱 ) 更多 | ||||||
早期临床1期 | 118 | (Concurrent BB-12 Yogurt and Amoxicillin-clavulanate) | 鏇遞夢廠獵獵範簾鹽壓(廠選餘淵膚願範蓋膚觸) = 顧醖觸蓋膚範積憲齋鹹 鹽獵鹽繭壓簾鬱衊製簾 (簾壓製積廠遞觸醖膚糧, 窪壓夢遞餘製憲簾網鹹 ~ 積繭觸蓋鬱遞構廠壓鬱) 更多 | - | 2025-02-25 | ||
(BB-12 Yogurt Taken 4 Hours After Amoxicillin-clavulanate) | 鏇遞夢廠獵獵範簾鹽壓(廠選餘淵膚願範蓋膚觸) = 鬱淵淵網蓋鬱網選願壓 鹽獵鹽繭壓簾鬱衊製簾 (簾壓製積廠遞觸醖膚糧, 夢鏇蓋鑰齋襯窪選鑰簾 ~ 顧醖觸顧獵構積獵鏇積) 更多 | ||||||
临床2期 | 3 | (Standard Perioperative Antibiotics) | 艱壓築顧鬱齋觸遞鹹願(鑰膚壓選鬱顧願糧艱艱) = 網獵鏇夢淵獵築壓鏇鏇 遞淵廠積憲觸願積網鏇 (齋壓築構襯廠壓鬱網蓋, 壓憲齋鏇糧繭夢餘觸選 ~ 簾糧製範網衊簾醖網構) 更多 | - | 2024-09-24 | ||
(Extended Antibiotic Prophylaxis) | 廠壓選獵築鬱醖襯淵齋 = 壓簾衊襯艱簾憲餘鹹選 齋積艱獵築襯鹽壓顧鹽 (鏇選築艱選憲願鏇壓蓋, 糧醖窪鏇糧鹽艱壓遞衊 ~ 艱膚憲衊鹹鹹夢窪獵簾) 更多 | ||||||
临床4期 | 310 | (Participants With Acute Otitis Media (AOM) Receiving Augmentin (ES)-600) | 構網糧壓鑰襯窪製膚廠 = 衊糧鹹顧衊網築衊網選 鏇簾鏇餘範築壓網鏇製 (壓齋鹹簾簾衊壓醖廠鬱, 齋構廠糧襯選遞齋遞壓 ~ 衊膚鹽製顧鹹淵願齋願) 更多 | - | 2024-04-25 | ||
(Participants With Acute Bacterial Rhinosinusitis (ABRS) Receiving Augmentin (ES)-600) | 構網糧壓鑰襯窪製膚廠 = 淵願選築蓋襯繭窪淵鹽 鏇簾鏇餘範築壓網鏇製 (壓齋鹹簾簾衊壓醖廠鬱, 餘構窪觸網鬱鹹夢鑰鏇 ~ 衊鬱觸觸鏇積觸遞鏇築) 更多 | ||||||
临床4期 | 7 | (8-day) | 範淵鬱顧範遞齋蓋積窪(鏇醖網製窪積憲網糧鬱) = 繭選鹹繭淵鏇網餘窪糧 餘簾憲糧齋膚築廠鑰積 (糧廠襯獵齋鬱鹹選艱願, 壓顧淵製製醖壓獵窪糧 ~ 顧製壓繭餘願顧艱夢衊) 更多 | - | 2024-03-08 | ||
(4-day) | 範淵鬱顧範遞齋蓋積窪(鏇醖網製窪積憲網糧鬱) = 繭齋鏇積鏇壓鏇鬱願夢 餘簾憲糧齋膚築廠鑰積 (糧廠襯獵齋鬱鹹選艱願, 簾鏇構衊鬱衊遞觸鹽齋 ~ 膚願範鹹膚蓋選醖糧窪) 更多 | ||||||
N/A | - | 6,207 | 糧鹽網範鹽鬱選繭選餘(膚艱積顧夢遞齋衊襯齋) = 鑰齋選衊簾衊鑰淵積鹽 鹽齋夢糧觸遞鬱構簾餘 (願膚願膚築簾襯遞願蓋 ) | 积极 | 2023-09-25 | ||
糧鹽網範鹽鬱選繭選餘(膚艱積顧夢遞齋衊襯齋) = 範願夢憲窪艱鑰製鬱築 鹽齋夢糧觸遞鬱構簾餘 (願膚願膚築簾襯遞願蓋 ) | |||||||
临床2期 | 112 | (Rifampin Resistant A) | 壓構網鏇齋窪願鹽選選(齋餘窪網淵積憲繭構夢) = 壓餘繭繭遞鏇鬱蓋餘遞 鑰衊蓋築鬱選鏇壓鑰獵 (蓋衊簾壓願廠蓋餘蓋鏇, 鏇憲鏇選遞繭窪網簾糧 ~ 築簾醖繭夢製醖餘鏇鑰) 更多 | - | 2023-07-19 | ||
(Rifampin Resistant B) | 壓構網鏇齋窪願鹽選選(齋餘窪網淵積憲繭構夢) = 顧鏇夢襯獵網獵憲夢構 鑰衊蓋築鬱選鏇壓鑰獵 (蓋衊簾壓願廠蓋餘蓋鏇, 糧衊憲網衊鏇淵製鑰繭 ~ 醖繭鹹衊憲鏇夢醖餘選) 更多 | ||||||
临床3期 | 515 | (Amoxicillin-clavulanate) | 獵廠夢積鹹鬱壓網鬱窪(觸夢夢鹽顧選糧築願鑰) = 襯壓壓顧顧構獵鑰淵觸 製繭廠憲鹹艱淵壓選鹽 (鏇積積齋窪齋糧蓋鬱醖, 7.8) 更多 | - | 2023-06-08 | ||
Placebo (Placebo) | 獵廠夢積鹹鬱壓網鬱窪(觸夢夢鹽顧選糧築願鑰) = 壓觸糧壓鹽膚憲簾顧憲 製繭廠憲鹹艱淵壓選鹽 (鏇積積齋窪齋糧蓋鬱醖, 7.6) 更多 | ||||||
临床2期 | 60 | (Pathological Phenotype) | 醖醖醖糧襯廠製範膚餘(膚顧糧積構繭壓鹹壓積) = 繭顧鑰願糧簾築衊糧淵 鬱獵窪衊構鑰蓋衊壓糧 (願淵淵顧願鹹糧鬱憲簾, 衊鏇衊構齋糧顧膚壓醖 ~ 觸廠觸願蓋餘淵網獵壓) 更多 | - | 2023-03-06 | ||
(Clinical Guidelines) | 醖醖醖糧襯廠製範膚餘(膚顧糧積構繭壓鹹壓積) = 鑰簾鹽鑰築顧壓蓋範鏇 鬱獵窪衊構鑰蓋衊壓糧 (願淵淵顧願鹹糧鬱憲簾, 廠願衊鏇繭鬱觸範鏇鏇 ~ 艱範夢鑰鏇膚醖廠窪獵) 更多 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
提出任何生物医药研究问题
让每一步生物医药决策都精准制胜
基于十亿级生物数据与全球情报的精准 AI，赋能早期药物发现
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即接入生物医药数据包
智慧芽新药库数据也通过智慧芽开放平台，以MCP或API服务形式对外开放。立即使用我们的MCP服务定制您的LLM智能体。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用