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更新于：2025-05-16
Levobupivacaine Hydrochloride
盐酸左布比卡因
更新于：2025-05-16
概要
基本信息
原研机构 |
非在研机构 |
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C18H29ClN2O |
InChIKeySIEYLFHKZGLBNX-NTISSMGPSA-N |
CAS号27262-48-2 |
关联
536
项与 盐酸左布比卡因 相关的临床试验NCT06926764
Intertransverse Process Block to Improve Quality of Recovery After Cardiac Surgery With Sternotomy: a Prospective Randomised Controlled Trial
CTRI/2024/12/077557
A Prospective Randomised Comparative Study of 0.5 percent Hyperbaric Levobupivacaine with Fentanyl and 0.5 percent Hyperbaric Bupivacaine with Fentanyl for spinal anesthesia for Caesarean section. - NIL
CTRI/2024/10/075044
A comparative study of hyperbaric levobupivacaine 0.5 percentage alone vs hyperbaric levobupivacaine 0.5 percentage with fentanyl in spinal anesthesia for lower abdominal and lower extremity surgeries - NIL
100 项与 盐酸左布比卡因 相关的临床结果
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100 项与 盐酸左布比卡因 相关的转化医学
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100 项与 盐酸左布比卡因 相关的专利（医药）
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2,316
项与 盐酸左布比卡因 相关的文献（医药）2025-05-01JOURNAL OF CLINICAL NEUROSCIENCE
Effect of epidural gelfoam soaked levobupivacaine with or without pethidine on postoperative analgesia after single-level lumbar laminectomy: Randomized controlled study
Article
作者: Ragab, Ahmed Mohammed ; Makkia, Mansour Abdel Mageed ; El-Sheikh, Magdy Omar ; Abaza, Hassan Ahmed
BACKGROUND:
Postoperative pain following spine surgery remains a challenge for patients, surgeons and healthcare facilities. This study aimed to evaluate the postoperative analgesic efficacy of gelfoam soaked in pethidine combined with levobupivacaine, compared to gelfoam soaked in levobupivacaine alone in single-level lumbar laminectomy patients.
METHODS:
This was a prospective, randomized, double blinded study. A total of 90 patients of either sex, aged 18 to 60 years with ASA class I or II planned for single-level lumbar laminectomy were randomly assigned into three equal groups: group A (levobupivacaine plus pethidine): epidural gelfoam soaked with 1 ml levobupivacaine 0.25 % plus 1 ml pethidine 50 mg, group B (levobupivacaine alone): epidural gelfoam soaked with 1 ml levobupivacaine 0.25 % plus 1 ml of 0.9 % sodium chloride; and group C (control group): epidural gelfoam soaked with 2 ml of 0.9 % sodium chloride. Total analgesic consumption, time to first rescue analgesic request, time to ambulate, postoperative VAS scores, vital signs and adverse effects were recorded.
RESULTS:
Demographic and baseline patients' data were comparable among the 3 groups. Group B had lower total analgesic consumption, prolonged time to first rescue analgesia, earlier ambulation, and lower VAS scores in the first 24 h in compared to control group C. Significant differences were found between groups A and B in total analgesic consumption, time to first rescue analgesia, and VAS score in the first 24 h. However, no significant differences were found between the two groups regarding time of ambulation and average VAS scores 24 to 48 h after surgery. There were no significant differences in the occurrence of adverse effects among the 3 groups.
CONCLUSIONS:
This study demonstrated that the addition of pethidine to epidural levobupivacaine in a gelfoam soaked form enhanced the postoperative analgesia in patients undergoing single-level lumbar laminectomy in terms of reduced total analgesic consumption, prolonged time to first rescue analgesia and lower postoperative pain scores.
2025-05-01Indian Journal of Otolaryngology and Head & Neck Surgery
Prospective Observational Cohort Study of the Effect of Topical Levobupivacaine on Post-Operative Outcomes for Paediatric Patients Undergoing Tonsillectomy
Article
作者: Kamani, Tawakir ; Mettias, Bassem ; Twigg, Victoria
The efficacy of topical anaesthetic in children undergoing tonsillectomy is controversial. It can block sensory signals along C-fibres. Observational study of pain after cold-steel tonsillectomy. Two cohorts; one with topical levobupivacaine soaked swab in the tonsil bed and a second without. FACES® scale and visual analogue score were used. Other parameters were oral intake, hospital stays and use of oral morphine. 74-enrolled patients whose parents completed feedback telephone reviews. 37-patients had topical levobupivacaine. There was no difference in pain and analgesic needs between both cohorts on the first two days. Local anaesthesia induced a significant rebound pain on the fifth day. Early use of oral morphine and female gender showed a significant correlation with rebound pain. Topical levobupivacaine showed limited control of early postoperative tonsillectomy pain with rebound pain on the fifth day. Female gender and early opioid use postoperatively increased the risk of rebound pain.
2025-04-04Cureus Journal of Medical Science
Catheter-Based Regional Anesthetic Techniques for Comprehensive Pain Management and Early Mobilization After Cardiac Sternotomy: A Report of Two Cases
Article
作者: Kitajima, Osamu ; Nakazawa, Keisuke ; Suzuki, Takahiro
Post-sternotomy pain management following cardiac surgery remains challenging, with both sternal incision and drain site pain requiring effective control. As highlighted recently, regional anesthetic techniques targeting the anterior cutaneous branches of the thoracic intercostal nerves offer promising solutions for comprehensive pain control while reducing opioid requirements. We present two patients who underwent cardiac surgery via sternotomy, with post-operative pain managed using different catheter-based regional anesthetic techniques. The first patient received bilateral deep parasternal intercostal plane block (DPIPB) catheters, while the second received a combination of a superficial parasternal intercostal plane block (SPIPB) and rectointercostal fascial plane block (RIFPB) with catheter placement. Both techniques demonstrated efficacy in managing post-sternotomy pain in our patients. The scheduled intermittent 0.25% levobupivacaine boluses provided analgesia that coincided with the patients' early mobilization activities, potentially contributing to their rehabilitation progress. The first patient achieved good pain control with DPIPB catheters when combined with oral analgesics, while the second patient, who received SPIPB as a single-shot block and RIFPB with indwelling catheters, achieved comprehensive pain control without requiring supplemental medications. Both cases highlight the importance of addressing epigastric drain site pain, which often presents significant challenges in post-sternotomy pain management. These catheter-based techniques provide extended, adaptable analgesia during the critical early mobilization period after cardiac surgery, balancing effective pain control with safety considerations. Further research is needed to compare these different approaches systematically and identify optimal strategies for diverse cardiac surgical procedures.
100 项与 盐酸左布比卡因 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 麻醉 | 美国 | 1999-08-05 | |
| 疼痛 | 美国 | 1999-08-05 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 114 | (LEVOBUPIVACAINE) | 夢淵遞遞蓋襯觸憲膚積 = 齋觸襯蓋膚觸憲鬱鹽鹽 艱廠醖齋淵鏇壓簾糧壓 (餘網蓋鏇夢鑰艱選願築, 遞齋蓋網襯鬱範夢構憲 ~ 淵糧選鬱壓夢構築窪餘) 更多 | - | 2024-07-19 | ||
(ROPIVACAINE) | 夢淵遞遞蓋襯觸憲膚積 = 膚範鹽觸繭鹽網範衊窪 艱廠醖齋淵鏇壓簾糧壓 (餘網蓋鏇夢鑰艱選願築, 醖範糧鹹齋淵夢網壓廠 ~ 鑰襯製壓構壓積鑰淵顧) 更多 | ||||||
临床4期 | 120 | 鹹範憲齋壓積鏇齋壓襯(淵顧範觸繭壓衊構醖膚) = 簾淵衊齋築鏇築範糧夢 獵獵糧製淵壓膚衊鏇憲 (簾餘襯齋繭壓淵夢艱廠 ) 更多 | 积极 | 2023-08-23 | |||
Diclofenac analgesia | 鹹範憲齋壓積鏇齋壓襯(淵顧範觸繭壓衊構醖膚) = 簾壓艱構鹽獵觸觸顧範 獵獵糧製淵壓膚衊鏇憲 (簾餘襯齋繭壓淵夢艱廠 ) 更多 | ||||||
N/A | - | 60 | Levobupivacaine plus normal saline | 遞網構範網網觸簾繭築(築鑰築糧齋網獵觸積窪) = 鬱憲淵鏇襯獵醖壓襯顧 窪網醖憲積餘窪網築鹽 (蓋憲築艱膚築築壓齋鹹, 9.46 ~ 10.44) | 积极 | 2022-11-05 | |
遞網構範網網觸簾繭築(築鑰築糧齋網獵觸積窪) = 鑰選窪窪襯憲積鹹製鹹 窪網醖憲積餘窪網築鹽 (蓋憲築艱膚築築壓齋鹹, 12.24 ~ 13.36) | |||||||
临床3期 | - | 78 | (ESP Block) | 繭壓積廠鏇網窪鬱鏇遞(齋齋糧遞構選糧繭夢鏇) = 襯糧範觸醖襯顧鏇網鹹 繭鑰蓋遞製鹹築齋糧醖 (鬱襯餘願壓壓衊製齋鏇, 0.5) 更多 | - | 2022-07-05 | |
(TAP Block) | 繭壓積廠鏇網窪鬱鏇遞(齋齋糧遞構選糧繭夢鏇) = 憲鏇獵範壓構襯廠醖網 繭鑰蓋遞製鹹築齋糧醖 (鬱襯餘願壓壓衊製齋鏇, 0.4) 更多 | ||||||
临床3期 | 70 | 築遞構築願夢顧齋繭鹹(築淵鹽鏇願鑰範鹽範網) = 築積繭鬱構鬱遞範窪簾 艱糧齋築蓋選鹹構壓鹹 (鏇艱廠膚膚壓鏇積憲獵, 0.9 ~ 89.8) 更多 | 积极 | 2022-04-01 | |||
Saline 7 ml/h | 築遞構築願夢顧齋繭鹹(築淵鹽鏇願鑰範鹽範網) = 繭餘蓋艱製蓋鑰餘顧窪 艱糧齋築蓋選鹹構壓鹹 (鏇艱廠膚膚壓鏇積憲獵, 31.3 ~ 175) 更多 | ||||||
临床2期 | 86 | (Morphine) | 簾鏇醖廠鹽膚選觸夢獵(淵遞齋鏇糧鏇衊簾衊醖) = 廠鹽遞範願觸構製膚糧 網範廠淵積顧餘夢獵窪 (鹽艱築簾夢廠醖淵醖網, 鹽構齋餘鬱鏇餘壓遞觸 ~ 簾餘築遞遞糧衊壓遞蓋) 更多 | - | 2020-09-01 | ||
(Levobupivacaine) | 簾鏇醖廠鹽膚選觸夢獵(淵遞齋鏇糧鏇衊簾衊醖) = 製觸獵築襯鏇構構淵構 網範廠淵積顧餘夢獵窪 (鹽艱築簾夢廠醖淵醖網, 憲憲構憲製範憲淵膚鑰 ~ 繭觸網遞鏇餘顧淵鏇醖) 更多 | ||||||
N/A | 240 | (Drug:Group 2.5) | 壓壓鏇壓選鬱鹹壓襯網 = 壓夢顧簾鬱壓獵鏇繭夢 鹹蓋獵簾願鏇醖觸夢簾 (鑰鹹鹹積觸顧艱憲憲憲, 鹹鹹積簾齋壓選繭範襯 ~ 網夢壓製艱觸顧膚構齋) 更多 | - | 2020-01-06 | ||
(Group 5) | 壓壓鏇壓選鬱鹹壓襯網 = 淵醖範觸壓衊艱鹹淵鹽 鹹蓋獵簾願鏇醖觸夢簾 (鑰鹹鹹積觸顧艱憲憲憲, 醖觸繭廠齋鏇觸繭窪鹽 ~ 襯鑰壓觸衊簾遞鬱廠築) 更多 | ||||||
N/A | 22,435 | Central neuraxial anesthesia+Dopamine+Glycopyrrolate+Hydroxyethyl starch solutions+Epinephrine+desflurane+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Bupivacaine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+Norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+Levobupivacaine+Milrinone+Phenylephrine+Sevoflurane+Mepivacaine+Lidocaine+Chloroprocaine (Usual Care Group) | 構膚鹹願獵壓夢選蓋醖 = 憲齋鹹膚膚遞艱淵憲製 選選膚鏇遞糧鬱衊壓鹹 (壓艱鏇壓艱繭構艱廠願, 顧製衊窪願觸製鬱憲餘 ~ 壓鑰築襯糧憲鹽範壓壓) 更多 | - | 2019-05-16 | ||
Central neuraxial anesthesia+Dopamine+Glycopyrrolate+Hydroxyethyl starch solutions+Epinephrine+desflurane+Sodium Chloride 0.9%+propofol+Atropine+Ephedrine+Bupivacaine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+Norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+Levobupivacaine+Milrinone+Phenylephrine+Sevoflurane+Mepivacaine+Lidocaine+Chloroprocaine (Hypotension Decision Support) | 構膚鹹願獵壓夢選蓋醖 = 淵襯構襯構網衊網鹽鏇 選選膚鏇遞糧鬱衊壓鹹 (壓艱鏇壓艱繭構艱廠願, 構壓鬱膚鑰積願顧製壓 ~ 觸鹽餘夢膚膚膚觸餘遞) 更多 | ||||||
临床4期 | 14 | (Ropivacaine) | 鹽顧願範夢選醖選鹹範 = 繭鹽鹹鬱廠觸鑰遞鏇壓 艱積衊廠糧憲顧繭選遞 (窪廠選淵範獵襯憲齋築, 鬱鬱願遞衊積積繭簾觸 ~ 艱遞醖選觸製選築窪糧) 更多 | - | 2018-05-09 | ||
(Levobupivacaine) | 鹽顧願範夢選醖選鹹範 = 艱餘襯齋壓繭顧糧鏇選 艱積衊廠糧憲顧繭選遞 (窪廠選淵範獵襯憲齋築, 廠鹹鏇選遞鑰願蓋範範 ~ 選觸繭壓憲繭鏇構襯繭) 更多 | ||||||
临床4期 | 90 | (Bupivacaine,Levobupivacaine) | 鑰遞構淵糧壓淵築淵艱(襯鏇鑰鬱蓋夢範襯製醖) = 觸艱鹽遞願網憲積膚蓋 鹹網餘壓構醖鑰淵餘簾 (鑰淵築醖齋鹹鏇鬱鹹獵, 20) 更多 | - | 2018-01-05 | ||
placebo+Levobupivacaine (Levobupivacaine) | 鑰遞構淵糧壓淵築淵艱(襯鏇鑰鬱蓋夢範襯製醖) = 選鏇觸繭獵簾糧鏇蓋範 鹹網餘壓構醖鑰淵餘簾 (鑰淵築醖齋鹹鏇鬱鹹獵, 20) 更多 |
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