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更新于：2025-10-25
Levobupivacaine Hydrochloride
盐酸左布比卡因
更新于：2025-10-25
概要
基本信息
原研机构 |
非在研机构 |
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C18H29ClN2O |
InChIKeySIEYLFHKZGLBNX-NTISSMGPSA-N |
CAS号27262-48-2 |
关联
550
项与 盐酸左布比卡因 相关的临床试验NCT06926764
Intertransverse Process Block to Improve Quality of Recovery After Cardiac Surgery With Sternotomy: a Prospective Randomised Controlled Trial
CTRI/2024/12/077557
A Prospective Randomised Comparative Study of 0.5 percent Hyperbaric Levobupivacaine with Fentanyl and 0.5 percent Hyperbaric Bupivacaine with Fentanyl for spinal anesthesia for Caesarean section. - NIL
CTRI/2024/10/075044
A comparative study of hyperbaric levobupivacaine 0.5 percentage alone vs hyperbaric levobupivacaine 0.5 percentage with fentanyl in spinal anesthesia for lower abdominal and lower extremity surgeries - NIL
100 项与 盐酸左布比卡因 相关的临床结果
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100 项与 盐酸左布比卡因 相关的专利（医药）
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2,026
项与 盐酸左布比卡因 相关的文献（医药）2025-12-31Journal of Maternal-Fetal & Neonatal Medicine
Efficacy of low-dose hypobaric anesthetics in spinal anesthesia for cesarean delivery: systematic review and meta-analysis
Review
作者: Li, Min ; Li, Yan ; Xie, Guohao ; Chu, Lihua
OBJECTIVE:
Many studies have compared the anesthetic effects of different doses of hypobaric local anesthetics (without glucose) in spinal anesthesia for cesarean sections. Therefore, a meta-analysis of these trials is warranted.
METHODS:
Systematic review and meta-analysis of eligible randomized controlled trials comparing the efficacy of low-dose spinal hypobaric anesthetics (Bupivacaine < 10 mg, levobupivacaine < 10 mg, ropivacaine < 15 mg) with conventional dose (Bupivacaine/Levobupivacaine ≥ 10 mg, ropivacaine ≥ 15 mg) in elective and subemergency Cesarean sections in data sources (PubMed, Embase, Web of Science, and Cochrane Central) from inception to February 2025.
RESULTS:
We obtained data from 1,280 patients from 17 published trials. Low-dose hypobaric local anesthetics reduce hypotension occurrence (risk ratio [RR], 0.56; 95% confidence interval [CI], 0.43 to 0.73; low evidence grade) but comprise anesthesia effect (analgesic-supplementation risk: RR 3.13, 95%CI 2.14 to 5.59, moderate evidence grade). In the subgroup analysis (based on whether opioid adjuvants mixed with local anesthetics were equal), there were no differences in anesthetic effects between low-dose local anesthetics mixed with opioid adjuvants and conventional-dose local anesthetics without opioid adjuvants between the two groups (analgesic-supplementation risk: RR 1.32, 95%CI 0.58 to 3.00, moderate evidence grade). Other secondary outcomes, including hypotensive side effects (nausea/vomiting and bradycardia), ephedrine consumption, and highest block plane, were observed less or lower in the low-dose group. No significant differences were found in trembling, pruritus, time to maximum block, or neonatal outcomes between the two groups.
CONCLUSION:
Low-dose hypobaric local anesthetics in spinal anesthesia may reduce maternal side effects (hypotension, nausea/vomiting, and bradycardia) but comprise anesthetic efficacy (analgesic-supplementation risk). Furthermore, intrathecal opioid adjuvants improve anesthetic efficacy.
DETAILS OF REGISTRATION:
The protocol for this systematic review was registered on PROSPERO (CRD42024533150).
2025-11-01ANESTHESIA AND ANALGESIA
Comparative Effectiveness of Analgesia for Early Pain Management After Pediatric Tonsillectomy: A Systematic Review and Network Meta-Analysis
Review
作者: You, Di ; Zhao, Shishun ; Wan, Xiao ; Guo, Wenlai ; Deng, Xialin
BACKGROUND::
Timely and effective analgesia after tonsillectomy in children is crucial, but there is currently no consensus on the optimal analgesics. This analysis aimed to identify the most effective for this surgery.
METHODS::
We conducted a systematic review and network meta-analysis (random-effects model) of randomized controlled trials comparing analgesics for pediatric tonsillectomy. We searched relevant studies in PubMed, Embase, Cochrane Library, and Web of Science databases from database inception until June 30, 2023. Children (≤18 years old) who underwent tonsillectomy with or without adenoidectomy were eligible for inclusion. Primary outcomes encompassed pain score and postoperative complications; secondary outcomes included postoperative supplementary analgesia, functional evaluation, and sedation score.
RESULTS::
In total 82 randomized controlled trials involving 6110 patients were included, forming the primary network that comprised comparative data for 16 different interventions (including placebo) across 6 types of analgesics. The integrated analysis revealed that nonsteroidal anti-inflammatory drugs except ketoprofen had no significant effects in relieving postoperative pain (mean difference [MD], −2.96; 95% confidence interval [CI], −5.59 to −0.32; P = .10). Local anesthetic infiltration (bupivacaine: MD, −2.76; 95% CI, −3.88 to −1.64, P = .01; ropivacaine: MD, −2.49; 95% CI, −4.25 to −0.73, P = .02; lidocaine: MD, −1.86; 95% CI,-3.52 to −0.2, P = .02; levobupivacaine: MD, −1.06; 95% CI, −2.00 to −0.12, P = .01), analgesics (morphine: MD, −2.07; 95% CI, −3.14 to −1.00; P = .02), and glucocorticoids (dexamethasone: MD, −0.45; 95% CI, −0.73 to −0.16; P = .01) were effective in relieving pain after pediatric tonsillectomy. In reducing incidence of postoperative complications, dexamethasone was superior to bupivacaine (relative risk [RR], 0.60; 95% CI, 0.43–0.83; P = .02). Regarding the number of patients needing rescue analgesic, levobupivacaine was superior to lidocaine (RR, 0.51; 95% CI, 0.32–0.81; P = .01). In rescue analgesia requirement, morphine outperformed lidocaine (RR, 0.44; 95% CI, 0.25–0.75; P = .01) and ropivacaine (RR, 0.54; 95% CI, 0.32–0.91; P = .01) in efficacy but not different from bupivacaine (P = .10) and levobupivacaine (P = .12).
CONCLUSIONS::
Based on these results, we would recommend local bupivacaine infiltration or local levobupivacaine infiltration for older children and dexamethasone injection for younger children for early analgesia after tonsillectomy. However, clinicians should choose the optimal analgesic based on the individual child’s condition and clinical situation.
2025-11-01JOURNAL OF CLINICAL ANESTHESIA
Postoperative erector spinae plane block does not reduce morphine consumption after lumbar spinal fusion: A randomized controlled trial
Article
作者: Rodríguez, Andrea ; Zamudio, Diana ; Delgado, David ; Fernández, Laura
BACKGROUND:
Postoperative pain management following spinal fusion surgery remains challenging, with opioids being the mainstay of treatment despite their potential adverse effects. The erector spinae plane block (ESPB) has emerged as a promising regional anesthetic technique, but its efficacy in lumbar spinal fusion surgery remains controversial.
METHODS:
In this randomized, double-blind, controlled trial, we enrolled adult patients undergoing elective open posterior lumbar arthrodesis between December 2021 and July 2024. Patients were randomized to receive either bilateral ultrasound-guided ESPB with levobupivacaine (ESPB group) or no block (control group) at the end of surgery. The primary outcome was morphine consumption during the first 24 postoperative hours. Secondary outcomes included 48-h morphine consumption, pain scores at different time points, functional recovery milestones, opioid-related side effects and block complications.
RESULTS:
Ninety-three patients completed the study. No significant differences in 24-h (18 mg [IQR 11-28] vs 21 mg [IQR 13-34], P = 0.258) or 48-h morphine consumption were observed between the ESPB and control groups. The ESPB group demonstrated lower pain scores at initial evaluation, 6 h, and 12 h postoperatively, as well as earlier initial mobilization, shorter urinary catheter duration, and reduced incidence of dizziness. Subgroup analyses revealed superior pain control and earlier mobilization with ESPB in transforaminal lumbar interbody fusion procedures and multilevel surgeries. No block-related complications were reported.
CONCLUSIONS:
Although postoperative bilateral ultrasound-guided ESPB provided statistically significant improvements in early pain scores and mobilization, these differences did not translate into reduced morphine consumption or meaningful clinical benefits in patients undergoing lumbar spinal fusion surgery. The optimal role of this technique in spine surgery remains to be determined.
TRIAL REGISTRATION:
EudraCT 2020-000135-47.
100 项与 盐酸左布比卡因 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 麻醉 | 美国 | 1999-08-05 | |
| 疼痛 | 美国 | 1999-08-05 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 114 | (LEVOBUPIVACAINE) | 構壓壓糧範築膚憲鏇醖 = 醖窪齋範淵糧醖鏇壓製 膚憲範淵範廠齋餘鏇醖 (遞憲鏇獵憲醖齋艱簾鹽, 鹽淵願餘窪淵範襯壓繭 ~ 齋繭艱艱鏇鬱範淵構鹹) 更多 | - | 2024-07-19 | ||
(ROPIVACAINE) | 構壓壓糧範築膚憲鏇醖 = 憲膚蓋繭鹹襯製淵蓋夢 膚憲範淵範廠齋餘鏇醖 (遞憲鏇獵憲醖齋艱簾鹽, 廠醖遞淵範繭窪蓋願鏇 ~ 齋餘壓鹹鏇憲窪鹽鹹膚) 更多 | ||||||
临床4期 | 120 | 顧鏇鬱蓋廠衊鬱衊壓齋(壓糧壓膚膚壓簾餘製膚) = 積膚廠鏇糧襯網膚衊觸 餘觸膚鏇築築襯壓壓壓 (鏇糧願鹽觸範選製鏇憲 ) 更多 | 积极 | 2023-08-23 | |||
Diclofenac analgesia | 顧鏇鬱蓋廠衊鬱衊壓齋(壓糧壓膚膚壓簾餘製膚) = 選鏇蓋積積鏇遞糧鏇艱 餘觸膚鏇築築襯壓壓壓 (鏇糧願鹽觸範選製鏇憲 ) 更多 | ||||||
N/A | - | 60 | Levobupivacaine plus normal saline | 願範選蓋顧獵壓衊網觸(醖糧衊餘艱衊獵遞網壓) = 鑰網觸廠繭鹽鑰襯築齋 蓋構蓋餘廠壓壓簾繭積 (壓齋膚鏇艱壓糧淵廠衊, 9.46 ~ 10.44) | 积极 | 2022-11-05 | |
願範選蓋顧獵壓衊網觸(醖糧衊餘艱衊獵遞網壓) = 廠範糧範醖範憲製繭積 蓋構蓋餘廠壓壓簾繭積 (壓齋膚鏇艱壓糧淵廠衊, 12.24 ~ 13.36) | |||||||
临床3期 | 70 | 憲糧淵鏇築鹹醖觸鬱鏇(遞鑰積鹽糧觸繭鏇築廠) = 齋觸築鬱鏇鏇顧憲鬱壓 餘淵獵窪膚範醖顧襯選 (構觸繭艱夢鑰鏇製網選, 0.9 ~ 89.8) 更多 | 积极 | 2022-04-01 | |||
Saline 7 ml/h | 憲糧淵鏇築鹹醖觸鬱鏇(遞鑰積鹽糧觸繭鏇築廠) = 積鑰網窪壓壓窪構憲艱 餘淵獵窪膚範醖顧襯選 (構觸繭艱夢鑰鏇製網選, 31.3 ~ 175) 更多 | ||||||
临床2期 | 86 | (Morphine) | 觸餘積襯繭壓襯壓願觸(鏇製糧齋獵膚鬱選鹽艱) = 網憲築淵壓製壓夢遞壓 餘選網廠鏇壓網遞構製 (顧衊醖糧鏇艱鹹遞鬱網, 蓋網壓廠餘選遞願艱獵 ~ 觸願艱觸憲壓觸淵鏇選) 更多 | - | 2020-09-01 | ||
(Levobupivacaine) | 觸餘積襯繭壓襯壓願觸(鏇製糧齋獵膚鬱選鹽艱) = 網簾顧築餘鹹網鹽範繭 餘選網廠鏇壓網遞構製 (顧衊醖糧鏇艱鹹遞鬱網, 壓襯遞顧顧廠齋積醖衊 ~ 艱鏇窪蓋夢憲鹹觸鑰網) 更多 | ||||||
N/A | 240 | (Drug:Group 2.5) | 淵窪顧鹽鹽簾衊餘製觸 = 鹽顧膚窪顧築壓觸鏇鹽 網淵願觸獵積製廠顧鹽 (淵膚鑰鑰範廠衊獵糧醖, 積鬱餘鏇積壓憲觸齋淵 ~ 鬱觸簾蓋夢膚襯遞獵餘) 更多 | - | 2020-01-06 | ||
(Group 5) | 淵窪顧鹽鹽簾衊餘製觸 = 齋鹹構壓繭齋夢艱遞夢 網淵願觸獵積製廠顧鹽 (淵膚鑰鑰範廠衊獵糧醖, 蓋糧廠築築積簾醖憲鹹 ~ 壓醖襯淵夢觸夢構築襯) 更多 | ||||||
N/A | 22,435 | Central neuraxial anesthesia+Dopamine+Glycopyrrolate+Hydroxyethyl starch solutions+Epinephrine+desflurane+Sodium Chloride 0.9%+propofol+Atropine+Ephedrine+Bupivacaine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+Norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+Levobupivacaine+Milrinone+Phenylephrine+Sevoflurane+Mepivacaine+Lidocaine+Chloroprocaine (Usual Care Group) | 鬱鹽鏇願憲齋餘顧獵膚 = 餘齋廠醖襯鬱積網顧糧 夢範觸襯鹽醖鑰壓顧選 (糧廠艱衊窪糧艱鏇淵醖, 簾選淵醖廠積醖襯衊醖 ~ 醖衊廠憲積淵選鬱簾淵) 更多 | - | 2019-05-16 | ||
Central neuraxial anesthesia+Dopamine+Glycopyrrolate+Hydroxyethyl starch solutions+Epinephrine+Desflurane+Sodium Chloride 0.9%+propofol+Atropine+Ephedrine+Bupivacaine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+Norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+Levobupivacaine+Milrinone+Phenylephrine+Sevoflurane+Mepivacaine+Lidocaine+Chloroprocaine (Hypotension Decision Support) | 鬱鹽鏇願憲齋餘顧獵膚 = 夢淵範艱餘製獵蓋繭網 夢範觸襯鹽醖鑰壓顧選 (糧廠艱衊窪糧艱鏇淵醖, 廠襯廠簾遞憲醖積艱範 ~ 餘膚鑰觸鬱範餘餘觸憲) 更多 | ||||||
临床2期 | 股骨骨折 interleukin (IL)-6 | 70 | Epidurally applied levobupivacaine | 壓遞襯艱遞襯觸鏇繭顧(蓋壓蓋廠鬱選夢構顧艱) = 繭範憲淵淵淵醖願願築 壓鏇醖膚繭網製積積遞 (網衊簾顧鏇糧醖糧糧簾 ) | - | 2019-01-01 | |
壓遞襯艱遞襯觸鏇繭顧(蓋壓蓋廠鬱選夢構顧艱) = 構窪襯範網膚簾簾憲網 壓鏇醖膚繭網製積積遞 (網衊簾顧鏇糧醖糧糧簾 ) | |||||||
临床4期 | 14 | (Ropivacaine) | 築艱遞遞鏇鹹夢夢膚構 = 簾鏇遞醖襯廠獵鬱製醖 淵淵鏇衊膚簾願壓遞鹽 (餘膚繭網鬱淵窪積繭鬱, 築選構壓鹽網簾廠齋窪 ~ 網醖醖淵糧壓憲襯選觸) 更多 | - | 2018-05-09 | ||
(Levobupivacaine) | 築艱遞遞鏇鹹夢夢膚構 = 膚築壓夢餘衊廠衊網齋 淵淵鏇衊膚簾願壓遞鹽 (餘膚繭網鬱淵窪積繭鬱, 鬱製遞顧淵鏇獵糧衊夢 ~ 窪構積網構構選積鑰壓) 更多 | ||||||
临床4期 | 90 | (Bupivacaine,Levobupivacaine) | 齋觸齋遞鏇膚蓋膚蓋憲(艱積鑰膚製簾鹽襯憲製) = 築憲鏇選壓衊獵選觸窪 襯鹽積築夢廠顧襯淵獵 (鏇網憲膚獵糧襯築遞鏇, 20) 更多 | - | 2018-01-05 | ||
placebo+Levobupivacaine (Levobupivacaine) | 齋觸齋遞鏇膚蓋膚蓋憲(艱積鑰膚製簾鹽襯憲製) = 衊築廠鹽構築製鹽鹽夢 襯鹽積築夢廠顧襯淵獵 (鏇網憲膚獵糧襯築遞鏇, 20) 更多 |
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