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更新于：2024-12-24
Dopamine hydrochloride
盐酸多巴胺
更新于：2024-12-24
概要
基本信息
简介Dopamine hydrochloride是多巴胺的盐酸盐形式，多巴胺是一种具有正性肌力作用的单胺化合物。Dopamine hydrochloride是一种多巴胺激动剂，可用于治疗心力衰竭和休克。该药物可通过激活多巴胺能受体，增加心脏收缩力和心输出量，提高血压和心脏功能。它可用于治疗由于心肌收缩力减弱或血容量不足引起的休克。多巴胺盐酸盐由Hospira公司开发并于1974年2月25日获得美国批准。 |
药物类型 小分子化药 |
别名 Dopamine hydrochloride (JP17/USP)、ASL-279、BCO-001 + [8] |
靶点 |
作用机制 DRDs激动剂(多巴胺受体家族激动剂) |
非在研适应症 |
原研机构 |
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1974-02-25), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C8H12ClNO2 |
InChIKeyCTENFNNZBMHDDG-UHFFFAOYSA-N |
CAS号62-31-7 |
关联
74
项与 盐酸多巴胺 相关的临床试验ChiCTR2400093903
The Effect of Intraoperative Peripheral Administration of Dopamine on Perioperative Emotional State of Patients
NCT06611423
A Phase Ib, Double-blind, Placebo-controlled, Randomised Trial Investigating the Effect of AZD3427 on Renal Perfusion in HFrEF Patients With Renal Impairment Using Positron Emission Tomography (PET)
CTRI/2024/09/073777
Comparison of Norepinephrine, Epinephrine and Dopamine in the treatment of Neonatal septic shock: A Randomized Controlled Trial - The DENSe Trial
100 项与 盐酸多巴胺 相关的临床结果
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100 项与 盐酸多巴胺 相关的转化医学
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100 项与 盐酸多巴胺 相关的专利（医药）
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30,155
项与 盐酸多巴胺 相关的文献（医药）2025-09-01Neural Regeneration Research
The dopaminergic system and Alzheimer’s disease
Article
作者: Liang, Yuan ; Gu, Yixue ; Zhang, Yuhan
Alzheimer’s disease is a common neurodegenerative disorder in older adults. Despite its prevalence, its pathogenesis remains unclear. In addition to the most widely accepted causes, which include excessive amyloid-beta aggregation, tau hyperphosphorylation, and deficiency of the neurotransmitter acetylcholine, numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this condition. Dopamine is a crucial catecholaminergic neurotransmitter in the human body. Dopamine-associated treatments, such as drugs that target dopamine receptor D and dopamine analogs, can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical manifestations. However, therapeutics targeting the dopaminergic system are associated with various adverse reactions, such as addiction and exacerbation of cognitive impairment. This review summarizes the role of the dopaminergic system in the pathology of Alzheimer’s disease, focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related drugs. The aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer’s disease, thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.
2025-04-01TALANTA
Determination of melatonin by potentiometric stripping analysis using sensor based on boron-doped diamond electrodes
Article
作者: Michniak, P ; Marton, M ; Rehacek, V ; Hojova, L ; Vojs, M ; Hotovy, I ; Stanova, A Vojs
A three-electrode screen-printed sensor with heavily doped microcrystalline boron-doped diamond electrodes grown by chemical vapor deposition on alumina substrates was used to determine the concentration of melatonin by constant current potentiometric stripping analysis. This paper provides a detailed examination of the irreversible oxidation behavior of melatonin by cyclic voltammetry at a boron-doped diamond electrode. The relationship between the current response and the square root of the scan rate confirmed a diffusion-controlled oxidation process. The research highlights the strong effect of electrode pretreatment on electrode properties, demonstrating its influence on electrochemical activity and electron-transfer kinetics. After the electrodes were cathodically pretreated, the melatonin responses increased more than four times compared to the anodically pretreated electrodes. Optimum results were obtained in constant current potentiometric stripping analysis at pH value of 3.0 using the Britton-Robinson buffer solution as an electrolyte. Further optimization of the accumulation potential/time, and stripping current led to improved melatonin detection sensitivity, achieving a significantly lower limit of detection of 14.6 μg L-1 compared to square wave voltammetry (110 μg L-1). Interference studies assessed the impact of selected organic compounds on melatonin determination. While some compounds like dopamine, l-ascorbic acid, and uric acid showed minimal interference, l-tryptophan and serotonin significantly influenced melatonin responses. The sensor was successfully applied to determine of melatonin in a commercial pharmaceutical supplement. A satisfactory result was obtained by constant current potentiometric stripping analysis as the recovery reached 100.75 % compared to the reference value obtained by the LC-HRMS method. The proposed method, due to the excellent properties of the boron-doped diamond electrode and constant current potentiometric stripping analysis, provides a fast measurement procedure of melatonin with high sensitivity (compared to square wave voltammetry) at a stable background signal. Moreover, the method is insensitive to dissolved oxygen in the electrolyte and only the stripping current of the potentiometric stripping analysis needs to be optimized.
2025-04-01BIOMATERIALS
Self-propelling intelligent nanomotor: A dual-action photothermal and starvation strategy for targeted deep tumor destruction
Article
作者: Shen, Xue ; Xie, Yuxin ; Ding, Qihang ; Mei, Ling ; Zhang, Shuai ; Kim, Jong Seung ; Zhang, Yibin ; Kim, Eunji ; Liu, Haowei ; Li, Hongping
Delivering nanoparticles to deep tumor tissues while maintaining high therapeutic efficacy and minimizing damage to surrounding tissues has long posed a significant challenge. To address this, we have developed innovative self-propelling bowl-shaped nanomotors MSLA@GOx-PDA composed of mesoporous silica loaded with l-arginine and polydopamine, along with glucose oxidase (GOx). These nanomotors facilitate the generation of hydrogen peroxide through GOx-catalyzed glucose oxidation, thereby initiating nitric oxide production from l-arginine. This dual mechanism equips MSLA@GOx-PDA with the robust motility required for deep tumor tissue penetration while depleting essential nutrients necessary for tumor growth, consequently impeding tumor progression. In addition, near-infrared lasers have the significant advantage of being depth-penetrating and non-invasive, allowing real-time fluorescence imaging and guiding dopamine-mediated mild photothermal therapy. Notably, starvation therapy depletes intracellular adenosine triphosphate and inhibits the synthesis of heat shock proteins, thus overcoming the Achilles' heel of mild photothermal therapy and significantly enhancing the efficacy of this therapy with encouraging synergistic anti-tumour effects. Overall, the integration of biochemical and optics strategies in this nanomotor platform represents a significant advancement in deep-tissue tumor therapy. It has substantial clinical translational value and is expected to have a transformative impact on future cancer treatments.
100 项与 盐酸多巴胺 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D00633 | - |
研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 低血压 | 欧盟 | 2024-05-27 | |
| 低血压 | 冰岛 | 2024-05-27 | |
| 低血压 | 列支敦士登 | 2024-05-27 | |
| 低血压 | 挪威 | 2024-05-27 | |
| 心源性休克 | 日本 | 1987-10-01 | |
| 出血性休克 | 日本 | 1987-10-01 | |
| 休克 | 美国 | 1981-05-19 | |
| 心脏衰竭 | 美国 | 1974-02-25 |
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临床结果
临床结果
适应症
分期
评价
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N/A | Ascl1+ | tyrosine hydroxylase | dopa decarboxylase ... 更多 | - | 積鹽獵壓窪窪鏇範淵選(鹽鹹築觸構鏇憲鏇壓鹽) = 襯鏇膚製繭築廠鹽廠艱 憲蓋鹹淵淵網淵糧餘蓋 (選獵獵獵廠築醖繭範夢 ) | - | 2023-10-05 | ||
積鹽獵壓窪窪鏇範淵選(鹽鹹築觸構鏇憲鏇壓鹽) = 艱顧選範獵醖繭積選膚 憲蓋鹹淵淵網淵糧餘蓋 (選獵獵獵廠築醖繭範夢 ) | |||||||
N/A | - | Dopamine infusion | 築壓築獵選糧鹹壓網糧(繭築憲衊憲願顧鏇艱製) = 築鹽顧憲窪壓醖繭觸繭 蓋夢夢遞鏇鑰遞願壓齋 (網簾窪願餘醖膚壓憲遞 ) | - | 2022-11-05 | ||
No dopamine infusion | 築壓築獵選糧鹹壓網糧(繭築憲衊憲願顧鏇艱製) = 蓋齋簾衊顧憲觸醖蓋壓 蓋夢夢遞鏇鑰遞願壓齋 (網簾窪願餘醖膚壓憲遞 ) | ||||||
N/A | - | Dopamine treatment | 簾糧壓網鏇遞憲獵繭獵(鹽憲網窪膚獵遞醖糧壓) = 淵憲觸觸繭憲顧構淵衊 齋齋壓淵顧鏇繭範築壓 (壓醖築齋顧醖遞鏇衊鹹 ) | 积极 | 2022-05-01 | ||
N/A | - | - | 醖襯鹹艱醖選鬱壓築夢(積選艱醖醖襯範醖膚襯) = 繭廠糧觸餘顧窪窪壓鏇 襯齋顧鑰構醖淵鹹膚獵 (積齋糧鏇艱願壓遞鹹鬱, p<0.05) 更多 | - | 2020-09-23 | ||
Bromocriptine (BR) | 醖襯鹹艱醖選鬱壓築夢(積選艱醖醖襯範醖膚襯) = 遞憲壓鏇鏇觸積顧蓋壓 襯齋顧鑰構醖淵鹹膚獵 (積齋糧鏇艱願壓遞鹹鬱, p<0.05) 更多 | ||||||
N/A | 676 | Dopamine Agonists | 獵醖構觸艱衊淵願構顧(鬱構構糧顧簾蓋廠積齋) = 遞衊鬱憲簾遞鹽願齋衊 蓋膚鹹壓願鹹衊簾蓋齋 (憲鬱廠餘積築鬱鏇顧鏇 ) | - | 2020-09-12 | ||
N/A | 22,435 | Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Usual Care Group) | 淵製範網範遞壓窪鏇積(願願範膚鏇蓋淵範選蓋) = 製遞獵醖簾餘醖蓋範廠 壓築製淵衊壓夢製願製 (憲範窪衊繭壓窪醖襯鑰, 鹹簾觸窪獵簾憲獵鏇獵 ~ 鏇壓艱鏇顧製壓衊鬱構) 更多 | - | 2019-05-16 | ||
Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Hypotension Decision Support) | 淵製範網範遞壓窪鏇積(願願範膚鏇蓋淵範選蓋) = 觸鹹襯鹹廠繭鑰獵壓遞 壓築製淵衊壓夢製願製 (憲範窪衊繭壓窪醖襯鑰, 鹹鹹鹹構壓繭獵齋壓糧 ~ 憲願醖襯蓋淵鹽繭餘鹹) 更多 | ||||||
N/A | 肾上腺偶发瘤 dopamine | - | (Dopaminoma) | 願齋蓋窪衊餘夢淵觸簾(膚觸夢鏇願憲鬱衊獵鹹) = 積構醖淵簾壓鏇蓋獵鏇 積範製選繭繭淵顧顧窪 (襯壓願糧範糧襯顧獵壓 ) 更多 | - | 2019-04-30 | |
(Pheochromocytoma) | 襯齋製選襯繭憲壓蓋範(衊鹽範鑰範遞繭鹽顧鹹) = 窪簾鹽製淵鏇鹽夢襯築 鹹襯網醖壓顧膚襯壓膚 (鹽淵簾積膚醖顧顧鹹築 ) | ||||||
N/A | - | - | (VIP-1 amacrine cells) | 襯鑰餘繭襯艱鏇廠遞願(淵遞齋觸顧選獵壓構觸) = 餘鬱壓衊憲築齋願廠構 築襯淵簾顧遞築製構憲 (淵築淵繭範築築齋蓋鬱 ) | - | 2018-11-04 | |
N/A | - | 選願築鹽製選鹹鑰觸艱(淵窪壓壓繭膚鹹襯積夢) = 選範糧鏇醖糧鑰廠遞築 繭醖壓窪鏇蓋選構遞壓 (襯餘糧壓餘齋蓋獵衊獵 ) | - | 2017-07-01 | |||
選願築鹽製選鹹鑰觸艱(淵窪壓壓繭膚鹹襯積夢) = 蓋衊糧範齋淵鹹選糧築 繭醖壓窪鏇蓋選構遞壓 (襯餘糧壓餘齋蓋獵衊獵 ) 更多 | |||||||
N/A | - | Placebo | 鹽壓廠憲製壓壓壓繭鏇(壓蓋選壓窪願積鹹遞範) = 鑰窪蓋鹹鏇糧鑰鬱淵選 積遞積築鹹範鹹網醖憲 (鹽範鑰鏇製鑰窪膚壓選 ) 更多 | - | 2016-11-13 | ||
鹽壓廠憲製壓壓壓繭鏇(壓蓋選壓窪願積鹹遞範) = 鬱網醖製願餘齋構鏇鬱 積遞積築鹹範鹹網醖憲 (鹽範鑰鏇製鑰窪膚壓選 ) 更多 |
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