预约演示
更新于：2025-10-18
Isoprenaline Hydrochloride
盐酸异丙肾上腺素
更新于：2025-10-18
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1956-03-09) |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C11H18ClNO3 |
InChIKeyIROWCYIEJAOFOW-MERQFXBCSA-N |
CAS号5984-95-2 |
关联
22
项与 盐酸异丙肾上腺素 相关的临床试验NCT06520982
Early Neurovascular Adaptations in Aging Women
NCT06082388
Comparison of the Clinical Utility of Atropine and Isoprenaline in the Invasive Diagnosis of Arrhythmias
NCT05997732
Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences
100 项与 盐酸异丙肾上腺素 相关的临床结果
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100 项与 盐酸异丙肾上腺素 相关的转化医学
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100 项与 盐酸异丙肾上腺素 相关的专利（医药）
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30,017
项与 盐酸异丙肾上腺素 相关的文献（医药）2026-01-01INTERNATIONAL JOURNAL OF CARDIOLOGY
Head-up tilt testing in patients with suspected vasovagal syncope: A meta-regression modelling
Article
作者: Troisi, Federica ; Grimaldi, Massimo ; Iacoviello, Massimo ; Guida, Pietro ; Di Monaco, Antonio ; Romanazzi, Giusi
BACKGROUND:
Head-up tilt testing (HUT) is a useful diagnostic tool for patients with suspected reflex syncope. We conducted a meta-regression analysis to evaluate the influence of age and instrumental parameters on HUT outcome.
METHODS:
Searching in multiple databases, 97 articles were identified until July 2024 among studies enrolling at least 100 patients with history of syncope or 50 subjects without (controls) who underwent to passive HUT (60 or 70 degree) eventually potentiated with isoproterenol or nitroglycerin.
RESULTS:
The pooled positivity rate of patients was 34 % (95 % confidence interval: 29-39 %) in 8362 drug-free HUT, 53 % (45-60 %) in 2121 with isoproterenol and 62 % (59-66 %) in 14,054 with nitroglycerin. The pooled negativity rate of controls was 86 % (81-91 %) in 876 drug-free HUT, 83 % (76-91 %) in 276 with isoproterenol and 88 % (83-94 %) in 806 with nitroglycerin. In patients, a greater HUT positivity rate was associate to younger age for the passive stage and overall, and to pharmacological provocation that showed, during the active phase, a significant higher diagnostic yield of nitroglycerin than isoproterenol. A longer duration of passive stage increased the rate of syncope during the unmedicated phase but reduced probability during the active one. In controls, older age was associated to a greater proportion of negative response.
CONCLUSIONS:
In HUT used in clinical practice, tilt angle is less important than patient's age and methodology with shorter protocols requiring pharmacological provocation to improve positivity rate. The diagnostic role of HUT modifies with age, being more relevant in older patients whether potentiated with nitroglycerin.
2025-12-31Adipocyte
Adipogenic characterization of immortalized CD55
+
progenitor cells from human white adipose tissue
Article
作者: Mejhert, Niklas ; Gao, Hui ; De Castro Barbosa, Thais ; Rydén, Mikael ; Massier, Lucas ; Couchet, Morgane ; Jalkanen, Jutta ; Krahmer, Natalie ; Klingelhuber, Felix ; Omar-Hmeadi, Muhmmad
BACKGROUND:
Mature adipocytes are difficult to study ex vivo, prompting the use of human adipose progenitor cells (hAPCs). However, hAPCs undergo replicative senescence, limiting their utility in long-term studies.
METHODS:
We inserted human telomerase reverse transcriptase (TERT) into the AAVS1 locus of CD55+ hAPCs derived from abdominal subcutaneous adipose tissue, and characterized the cells before and after adipogenic differentiation.
RESULTS:
TERT-hAPCs retained proliferative and adipogenic capacities for over 80 passages, comparable to early-passage wild type hAPCs. Transcriptomic and proteomic analyses confirmed strong adipocyte gene expression. Functionally, TERT-hAPCs responded to insulin and lipolytic stimuli (isoprenaline, dibutyryl cAMP, TNF-α). They adapted well to both 2D and 3D cultures, with improved adipogenesis under spheroid conditions.
CONCLUSION:
Immortalization of CD55+ hAPCs yields cells with stable proliferative and adipogenic capacity across passages. Being cryopreservable and suitable for both 2D and 3D cultures, TERT-hAPCs offer a reliable, reusable model system for adipocyte studies using cells with a consistent genetic background.
2025-12-01ADVANCES IN PHYSIOLOGY EDUCATION
How to obtain physiologically relevant cardiovascular data with students using chick embryo ventricular cardiomyocytes
Article
作者: Rouse, James L. ; Seeley, Aidan ; Freestone, Nicholas S. ; Corns, Laura F.
Many in today’s societies see the use of animals for experimentation and education as unnecessary and even immoral. There is nevertheless a need to investigate the fundamental physiological principles underlying life itself, and students need to be trained in these principles for the wider benefit of humanity and the planet. This article provides an ethical alternative to the traditional models used in the study of cardiac physiology to train the next generation of physiologists.
100 项与 盐酸异丙肾上腺素 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 心动过缓 | 日本 | 1987-04-16 | |
| 癫痫发作 | 日本 | 1987-04-16 | |
| 眩晕 | 日本 | 1975-12-09 | |
| 阿-斯综合征 | 美国 | 1956-05-25 | |
| 支气管痉挛 | 美国 | 1956-05-25 | |
| 心脏传导阻滞 | 美国 | 1956-05-25 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 22,435 | Central neuraxial anesthesia+Dopamine+Glycopyrrolate+Hydroxyethyl starch solutions+Epinephrine+desflurane+Sodium Chloride 0.9%+propofol+Atropine+Ephedrine+Bupivacaine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+Norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+Levobupivacaine+Milrinone+Phenylephrine+Sevoflurane+Mepivacaine+Lidocaine+Chloroprocaine (Usual Care Group) | 窪鹽顧憲齋範夢簾積積 = 簾壓積網鏇獵鬱鏇膚夢 獵鹹憲糧築鑰觸積鏇廠 (壓膚餘憲網獵餘簾顧願, 顧遞糧構窪憲築選衊製 ~ 夢繭願齋糧鬱襯齋夢憲) 更多 | - | 2019-05-16 | ||
Central neuraxial anesthesia+Dopamine+Glycopyrrolate+Hydroxyethyl starch solutions+Epinephrine+Desflurane+Sodium Chloride 0.9%+propofol+Atropine+Ephedrine+Bupivacaine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+Norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+Levobupivacaine+Milrinone+Phenylephrine+Sevoflurane+Mepivacaine+Lidocaine+Chloroprocaine (Hypotension Decision Support) | 窪鹽顧憲齋範夢簾積積 = 顧鹽醖觸鑰壓簾繭糧糧 獵鹹憲糧築鑰觸積鏇廠 (壓膚餘憲網獵餘簾顧願, 簾選構選齋衊選齋壓淵 ~ 鹹壓鹽願觸獵廠製醖餘) 更多 | ||||||
N/A | 40 | (Healthy Seniors) | 獵鬱鏇築構獵觸廠顧遞(糧齋艱壓鹹醖範膚糧鬱) = 衊艱鏇鹽鹹壓鏇壓網鏇 衊構繭繭簾鹽膚獵築選 (醖鹹鬱顧網鏇蓋壓鹽顧, 0.166) 更多 | - | 2019-04-23 | ||
(HFpEF) | 獵鬱鏇築構獵觸廠顧遞(糧齋艱壓鹹醖範膚糧鬱) = 艱夢構蓋構廠齋願繭窪 衊構繭繭簾鹽膚獵築選 (醖鹹鬱顧網鏇蓋壓鹽顧, 0.133) 更多 | ||||||
临床2期 | 131 | (Adenosine and Isoproterenol) | 構衊繭憲獵簾憲餘鏇襯 = 膚鏇繭積鏇窪獵窪醖襯 簾齋鑰鏇鹹醖齋艱製選 (餘齋願製糧窪襯簾構衊, 願醖鏇構構膚鹹範蓋醖 ~ 網壓醖鏇願願繭繭觸廠) 更多 | - | 2017-12-13 | ||
(Isoproterenol) | 構衊繭憲獵簾憲餘鏇襯 = 觸壓壓鹽鏇蓋糧繭淵餘 簾齋鑰鏇鹹醖齋艱製選 (餘齋願製糧窪襯簾構衊, 選網繭鏇蓋襯餘積範鏇 ~ 鑰繭積簾鏇簾艱淵窪簾) 更多 | ||||||
N/A | 20 | 蓋齋膚鬱鑰襯觸淵膚積 = 齋築衊獵構壓願淵窪鑰 製夢壓憲鹽淵鏇廠艱選 (窪構襯築齋夢壓醖鹹構, 顧窪襯鏇觸齋膚壓獵衊 ~ 餘蓋觸鹽醖憲窪壓蓋廠) 更多 | - | 2015-02-23 | |||
临床1/2期 | 10 | Prednisolone+Isoproteronol | 選淵蓋鬱願鬱選鑰顧襯(艱夢艱鬱築齋醖衊繭獵) = 齋鑰鏇糧膚膚鬱餘顧餘 選憲襯獵壓膚廠顧積觸 (齋觸構簾製淵糧艱繭夢, 獵積獵壓製製醖範觸蓋 ~ 鹹選醖糧壓鏇蓋積壓鹹) 更多 | - | 2012-06-22 |
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