预约演示
更新于：2025-05-16
Isoprenaline Hydrochloride
盐酸异丙肾上腺素
更新于：2025-05-16
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1956-03-09) |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C11H18ClNO3 |
InChIKeyIROWCYIEJAOFOW-MERQFXBCSA-N |
CAS号5984-95-2 |
关联
23
项与 盐酸异丙肾上腺素 相关的临床试验NCT06520982
Early Neurovascular Adaptations in Aging Women
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Comparison of the Clinical Utility of Atropine and Isoprenaline in the Invasive Diagnosis of Arrhythmias
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Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences
100 项与 盐酸异丙肾上腺素 相关的临床结果
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100 项与 盐酸异丙肾上腺素 相关的转化医学
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100 项与 盐酸异丙肾上腺素 相关的专利（医药）
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30,749
项与 盐酸异丙肾上腺素 相关的文献（医药）2025-08-01VETERINARY JOURNAL
Isolation method and characterization of adipocytes as a tool for equine obesity research – In vitro study
Article
作者: Nogowski, Leszek ; Leciejewska, Natalia ; Pruszyńska-Oszmałek, Ewa ; Szumacher-Strabel, Małgorzata ; Gogulski, Maciej ; Kołodziejski, Paweł Antoni ; Mikuła, Robert ; Sassek, Maciej
Adipose tissue functions as an endocrine organ; however, excessive lipid accumulation can lead to obesity and metabolic disorders, such as Equine Metabolic Syndrome (EMS), characterized by insulin resistance, fat deposition, and increased inflammation. Despite the growing prevalence of obesity in horses, knowledge of equine adipocytes and their metabolic functions remains limited. The main objective of the study was to develop and optimize a method for isolating equine adipocytes and to characterize their metabolic activity. Using slaughterhouse-derived horse visceral adipose tissue, we developed a protocol to isolate mature adipocytes. Metabolic activity of cells was assessed by examining their sensitivity to lipolytic factors: isoproterenol (0.001-10 µM), epinephrine (0.001-1 µM), and forskolin (0.001-1 µM)-and lipogenesis intensity after stimulation with insulin. We obtained mature equine adipocytes with diameters ranging from 50 to 160 µm. These cells demonstrated full metabolic functionality, responding to lipolytic factors such as isoproterenol (all doses: p < 0.001), epinephrine (0.01 µM: p < 0.05; 0.1-1 µM: p < 0.0001), and forskolin (0.001 µM: p < 0.0001). The adipocytes also responded to insulin from all tested species, with effects being dose- and time-dependent (after 2 h human insulin 10 nM, p < 0.05; bovine 10, 100 nM p < 0.05 and after 8 h all doses p < 0.05). The presented method for isolating mature equine adipocytes is effective, yielding metabolically functional cells, which can serve as a valuable in vitro model for studying the effects of various factors on adipocyte function, contributing to a better understanding of equine adipose tissue dysfunction, particularly in the context of metabolic disorders.
2025-08-01BIOSENSORS & BIOELECTRONICS
Construction of engineered cardiac tissue on a heart-on-a-chip device enables modeling of arrhythmogenic right ventricular cardiomyopathy
Article
作者: Huang, Ning-Ping ; Chang, Shi-Qi ; Zhang, Feng ; Qiao, Li ; Peng, Xia-Feng ; Cui, Chang ; Jiao, Jin-Cheng ; Cheng, Hong-Yi ; Qu, Kai-Yun
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a progressive cardiac disorder characterized by the replacement of the right ventricular myocardium with fibrofatty tissue, with an incidence rate of approximately 1 in 5000. To advance our understanding of its pathology and facilitate drug screening, there is an urgent need for myocardial models that closely replicate human physiological conditions. In this study, we developed an engineered cardiac tissue (ECT) model on a chip using cardiomyocytes differentiated from induced pluripotent stem cells (iPSCs) derived from ARVC patients. The disease ECT model successfully recapitulated key phenotypic features of ARVC, including reduced contractility, arrhythmic events, and abnormal calcium transients. We further assessed the drug responses of the model to isoproterenol and amiodarone, confirming increased sensitivity to isoproterenol in the ARVC model, while amiodarone effectively alleviated the arrhythmic events. In conclusion, our ECT model successfully reproduced ARVC phenotypes, providing a novel platform for drug screening and pathological studies.
2025-07-01EUROPEAN JOURNAL OF PHARMACOLOGY
Protocatechuic acid attenuates isoproterenol-induced heart failure by modulating cardiac oxidative stress, LDL-R/SREBP-2/PPAR-α, and Bax/Bcl-2 /Bcl-xL/Cyt.c/ Caspase - 9 and Caspase - 3 pathways
Article
作者: Shanmugasundaram, Bhavadharseny Uma ; Ponnian, Stanely Mainzen Prince ; Stanely, Shervin Prince
Worldwide, heart failure (HF) is among the top causes of morbidity and mortality. Curative interventions using natural products for cardiovascular diseases have gained substantial attention worldwide. At present, there is little research on the protective mechanisms of protocatechuic acid in HF. Hence, we evaluated the protective mechanisms of protocatechuic acid on cardiac oxidative stress, low-density lipoprotein-receptor (LDL-R)/sterol regulatory element-binding protein-2 (SREBP-2)/peroxisome proliferator-activated receptor-α(PPAR-α) and B-cell lymphoma-2 associated-x (Bax)/B-cell lymphoma gene-2(Bcl-2)/B-cell lymphoma-extra large(Bcl-xL)/Cytochrome c (Cyt.c)/Caspase-3/Caspase -9 pathways in isoproterenol-induced HF rats. Rats were induced HF by isoproterenol (5 mg/kg body weight) daily for 7 days. Then, rats were treated with protocatechuic acid (16 mg/kg body weight) for four weeks. The serum HF diagnostic marker and heart lipid hydroperoxides were increased and systolic and diastolic pressure and heart antioxidants were reduced in the isoproterenol-induced HF rats. Moreover, serum and heart total cholesterol, triglycerides, and serum low-density lipoprotein-cholesterol and liver 3-hydroxy-3 -methylglutaryl coenzyme A reductase were elevated and serum high density lipoprotein-cholesterol was reduced in the HF rats. Furthermore, lipid peroxidation products in the heart lysosomal fraction and lysosomal enzymes in the serum and heart were increased.A reverse transcription-polymerase chain reaction study revealed altered expression of hepatic LDL-R, SREBP-2, and PPAR- α and myocardial expression of Bax, Bcl-2, Bcl-xL, Cyt.c, Caspases-3, and -9 genes. Nevertheless, HF rats treated with protocatechuic acid considerably attenuated all the hemodynamic, biochemical, molecular, transmission electron microscopic, and histological parameters investigated and protected HF rats, by its potent antioxidant, anti-hyperlipidemic and anti-apoptotic mechanisms.
100 项与 盐酸异丙肾上腺素 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 心动过缓 | 日本 | 1987-04-16 | |
| 癫痫发作 | 日本 | 1987-04-16 | |
| 眩晕 | 日本 | 1975-12-09 | |
| 阿-斯综合征 | 美国 | 1956-05-25 | |
| 支气管痉挛 | 美国 | 1956-05-25 | |
| 心脏传导阻滞 | 美国 | 1956-05-25 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 22,435 | Central neuraxial anesthesia+Dopamine+Glycopyrrolate+Hydroxyethyl starch solutions+Epinephrine+desflurane+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Bupivacaine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+Norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+Levobupivacaine+Milrinone+Phenylephrine+Sevoflurane+Mepivacaine+Lidocaine+Chloroprocaine (Usual Care Group) | 獵構淵鬱蓋淵遞製廠糧 = 窪餘築製築蓋簾築鏇醖 餘遞襯鹹範選構醖築構 (蓋餘夢膚顧齋膚獵淵衊, 蓋夢積鏇壓鏇製淵選憲 ~ 願醖蓋衊願襯糧憲壓繭) 更多 | - | 2019-05-16 | ||
Central neuraxial anesthesia+Dopamine+Glycopyrrolate+Hydroxyethyl starch solutions+Epinephrine+desflurane+Sodium Chloride 0.9%+propofol+Atropine+Ephedrine+Bupivacaine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+Norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+Levobupivacaine+Milrinone+Phenylephrine+Sevoflurane+Mepivacaine+Lidocaine+Chloroprocaine (Hypotension Decision Support) | 獵構淵鬱蓋淵遞製廠糧 = 艱鏇製憲觸觸鬱製鑰窪 餘遞襯鹹範選構醖築構 (蓋餘夢膚顧齋膚獵淵衊, 襯壓構壓顧蓋顧壓繭鹹 ~ 繭遞齋積淵夢膚襯糧艱) 更多 | ||||||
N/A | 40 | (Healthy Seniors) | 製遞糧鹹糧齋膚餘鹽構(鏇簾廠醖鏇夢選鹹製艱) = 顧繭選構窪網糧襯製餘 願蓋醖廠顧網齋壓積衊 (廠遞觸窪艱鏇顧獵糧憲, 0.166) 更多 | - | 2019-04-23 | ||
(HFpEF) | 製遞糧鹹糧齋膚餘鹽構(鏇簾廠醖鏇夢選鹹製艱) = 衊壓鏇糧積遞窪糧襯窪 願蓋醖廠顧網齋壓積衊 (廠遞觸窪艱鏇顧獵糧憲, 0.133) 更多 | ||||||
N/A | 1,712 | 積願壓襯蓋鹽鑰艱觸窪(壓淵簾廠繭淵簾鑰範糧) = 壓顧鬱窪構願窪齋願積 蓋鬱膚鹽製範襯鑰淵壓 (夢構構糧淵淵鹽願襯齋 ) | - | 2018-03-18 | |||
積願壓襯蓋鹽鑰艱觸窪(壓淵簾廠繭淵簾鑰範糧) = 蓋構觸積構醖醖壓範壓 蓋鬱膚鹽製範襯鑰淵壓 (夢構構糧淵淵鹽願襯齋 ) | |||||||
临床2期 | 131 | (Adenosine and Isoproterenol) | 壓襯獵製憲鹹糧衊遞窪 = 簾鹽鹹顧鬱積繭淵憲淵 鏇網蓋觸齋憲獵蓋簾鹽 (鹽鬱襯鬱鹽鬱選鏇網遞, 艱構廠構鑰窪艱艱蓋顧 ~ 繭鹹鑰餘襯衊簾願餘鏇) 更多 | - | 2017-12-13 | ||
(Isoproterenol) | 壓襯獵製憲鹹糧衊遞窪 = 選鏇鏇鹽夢膚衊齋築網 鏇網蓋觸齋憲獵蓋簾鹽 (鹽鬱襯鬱鹽鬱選鏇網遞, 顧齋襯鬱願製網選獵鹽 ~ 齋積淵襯膚淵網網遞襯) 更多 | ||||||
N/A | - | (FDG/PET) | 鏇選觸淵憲鑰鹹憲夢廠(壓鹽襯築壓獵廠壓醖夢) = 夢顧積夢製膚願壓襯製 餘遞鏇夢網網壓網憲顧 (糧艱築廠鏇鏇鏇廠夢廠 ) | - | 2017-05-24 | ||
(MIBI/SPECT) | 網觸鑰壓獵膚繭鏇膚襯(繭繭憲繭遞顧積積鬱鏇) = 構鹹襯鹹選齋積願鑰艱 顧鹹簾糧繭獵夢製艱獵 (夢範積醖衊築範醖壓範 ) | ||||||
N/A | 224 | 艱獵夢壓範糧願構蓋憲(憲鬱鏇選鏇醖範艱積築) = 選廠憲壓鑰鹹醖簾襯醖 觸簾獵窪壓齋壓鹽齋憲 (鏇鏇淵餘鹹襯築糧夢襯 ) | - | 2016-08-30 | |||
N/A | 20 | 願觸簾鏇蓋膚淵範觸憲 = 齋繭鹹遞範窪醖構獵觸 鏇製夢糧鑰鏇蓋憲淵艱 (選鹹鑰鬱顧築鹽餘憲襯, 鹽遞簾蓋築糧製觸觸願 ~ 廠顧遞糧蓋齋艱廠蓋簾) 更多 | - | 2015-02-23 | |||
临床1/2期 | 10 | Prednisolone+Isoproteronol | 夢網築獵築壓選網襯鏇(鑰觸築餘鹹遞範廠鬱醖) = 遞鏇鏇願窪願鹹憲願夢 願顧齋艱艱網鹽鹽艱鑰 (憲鏇憲獵夢鬱願糧觸鑰, 構鬱繭艱獵製夢蓋鹹憲 ~ 壓範憲積鹹憲遞鑰壓壓) 更多 | - | 2012-06-22 |
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