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更新于：2025-01-16
Mepivacaine Hydrochloride
盐酸甲哌卡因
更新于：2025-01-16
概要
基本信息
原研机构- |
最高研发阶段批准上市 |
首次获批日期 (1956-01-01), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C15H23ClN2O |
InChIKeyRETIMRUQNCDCQB-UHFFFAOYSA-N |
CAS号1722-62-9 |
关联
72
项与 盐酸甲哌卡因 相关的临床试验NCT06271174
Impact Evaluation of Perioperative Locoregional Analgesia on Persistent Postoperative Pain in Children After Orthopedic Surgery for Traumatology : a Prospective, Single Center, Randomised Controlled Study.
NCT05425979
Onset of Sensory Blockade in Ultrasound-Guided Ankle Block with Mepivacaine Versus Bupivacaine: a Randomized Non-Inferiority Clinical Trial
NCT06291727
Mepivacaine Versus Bupivacaine Spinal Anesthesia for Same Day Discharge Following Total Knee Arthroplasty
100 项与 盐酸甲哌卡因 相关的临床结果
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100 项与 盐酸甲哌卡因 相关的转化医学
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100 项与 盐酸甲哌卡因 相关的专利（医药）
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2,085
项与 盐酸甲哌卡因 相关的文献（医药）2025-01-01JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Development and application of a quantitative LC-MS/MS assay for the analysis of four dental local anesthetics in human plasma and breast milk
Article
作者: Wang, Hongyun ; Lu, Ming ; Wu, Xiaofei ; Liu, Dan ; Li, Xiuqi ; Yu, Mengyang ; Liu, Shupeng
Local anesthetics (LAs: articaine, lidocaine, bupivacaine, and mepivacaine) are essential for dental pain management. However, there are concerns that the lipophilic LAs could cross into breast milk causing toxicity to the infant. Our objective was to establish a multi-analyte LC-MS/MS method for the concurrent quantification of local anesthetics (LAs) in human plasma and breast milk, clarifying the transfer of LAs from plasma to breast milk, thereby offering crucial data for the safe assessment of LAs during the nursing period. Sample preparation for plasma and breast milk involved protein precipitation and a single dilution step. The chromatographic analysis was conducted using an ACQUITY UPLC BEH C18 column. Detection was facilitated by a triple quadrupole mass spectrometer employing positive electrospray ionization. The method demonstrated excellent linearity for articaine, mepivacaine, and bupivacaine across the range of 0.5 to 500 ng/mL, and for lidocaine from 1.0 to 1000 ng/mL in both plasma and breast milk, with correlation coefficients (R2) of 0.99 or higher. The method was effectively utilized in the analysis of samples from three nursing mothers who received dental treatment involving LAs. Articaine and lidocaine excretion in milk was confirmed, but it presented no significant safety risks to the breastfed infants.
2025-01-01Regional anesthesia and pain medicine
Crystallization of mixtures of local anesthetics with and without select adjuvants: a semiquantitative light microscopy analysis
Article
作者: Fiegl, Heidi ; Hoerner, Elisabeth ; Stundner, Ottokar ; Seisl, Anna ; Gasteiger, Lukas
Introduction:
Injecting mixtures of local anesthetics with or without adjuvants is a common practise in regional and particularly obstetric anesthesia to decrease block onset time and/or augment epidural analgesia for cesarean section. While evidence on the efficacy of this practise is equivocal, little is known about its safety in terms of the pharmacologic compatibility of local anesthetics.
Methods:
We assessed the grade of crystallization in individual mixtures of seven local anesthetics (bupivacaine, ropivacaine, lidocaine, procaine, chloroprocaine, mepivacaine, prilocaine) with or without four adjuvants (sodium bicarbonate, dexamethasone, clonidine, fentanyl) using a semiquantitative light microscopy scale (ranging from 0 to 5), repeatedly for up to 60 min and performed correlation analysis between grade of crystallization and initial solution pH.
Results:
Of the 50 mixtures tested, 26 showed grades of crystallization ≥4 at admixture and 41 showed grades of crystallization ≥4 after 60 min. The addition of adjuvants to local anesthetic mixtures did not substantially change the grades of crystallization. Bupivacaine has a slightly lower precipitation tendency, compared with ropivacaine. A moderate relationship was found between initial pH and grade of crystallization after 15 min for the adjuvant mixtures (R=0.33, p=0.04), but not at other time points.
Discussion:
The preparation of local anesthetic (±adjuvant) mixtures leads to high grades of crystallization, which increase over 60 min and appear independent of solution pH. The risk of mixing medications with unknown physical or chemical compatibility profiles in regional anesthesia should be critically appraised and its clinical significance elucidated in future translational research.
2024-12-01JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
Comparative efficacy of low-volume retrobulbar anesthesia using three commercial local anesthetics in adult horses
Article
作者: Tooley, Zachary C ; Bartholomew, Kyle J ; Hetzel, Scott J ; Ilkenhans, Shelby M ; Eaton, J Seth ; Grant-Counard, Sophia M
Abstract:
OBJECTIVE:
To compare the efficacy of low-volume (5-mL) locoregional retrobulbar anesthesia (“retrobulbar block”) by use of 3 commercial local anesthetic formulations.
ANIMALS:
8 healthy adult mares.
METHODS:
A block-randomized, masked, controlled design was used. A single ultrasound-guided retrobulbar block was performed with 2% lidocaine, 2% mepivacaine, or 0.5% bupivacaine (n = 5 eyes/group). Contralateral eyes served as untreated controls. End points performed at baseline and time intervals up to 24 hours postblock included the following: assessment of neurophthalmic reflexes/responses, intraocular pressure, and vertical pupil diameter measurement, corneal and periocular esthesiometry, and observation for adverse effects.
RESULTS:
Low-volume block did not result in increased intraocular pressure or other adverse effects at any time point in any treatment group. Statistically significant corneal anesthesia (P < .001) was observed 1 minute after block in all groups, persisting through 4 hours after lidocaine or mepivacaine block and through 24 hours after bupivacaine block. Clinically significant periocular anesthesia was not observed in any group. Significant vertical pupil diameter increase (P < .05) was observed for up to 4 hours after lidocaine or mepivacaine block and 6 hours after bupivacaine block.
CLINICAL RELEVANCE:
Low-volume retrobulbar block with any of the 3 local anesthetic drugs evaluated was not associated with adverse effects. In terms of efficacy, mepivacaine block showed no clinical advantage over lidocaine block. However, bupivacaine block induced comparatively rapid and sustained corneal anesthesia. In comparison to published findings using a larger injection volume, low-volume retrobulbar block with lidocaine produced clinically comparable corneal anesthesia. However, periocular soft tissue anesthesia was not achieved with any local anesthetic drug at low volume.
100 项与 盐酸甲哌卡因 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 麻醉 | - | - | 1956-01-01 |
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10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 神经阻滞 | 临床2期 | 中国 | 2012-07-10 | |
| 臂丛神经病 | 临床1期 | 中国 | - | |
| 糖尿病性神经病变 | 临床前 | 美国 | - | |
| 疱疹后神经痛 | 临床前 | 美国 | - |
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临床结果
临床结果
适应症
分期
评价
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临床2/3期 | 154 | (Low-Dose Bupivacaine) | 繭顧積壓餘構衊製繭齋(夢鏇網顧積餘蓋糧顧構) = 網選廠衊鹽齋築製願獵 醖繭鹹網顧鏇襯憲鹹遞 (築鏇淵網齋鹽淵醖廠餘, 衊簾網鏇範窪蓋觸積鹹 ~ 鑰夢膚鏇觸艱鹽齋鑰蓋) 更多 | - | 2021-08-12 | ||
(Mepivacaine) | 繭顧積壓餘構衊製繭齋(夢鏇網顧積餘蓋糧顧構) = 壓顧鏇遞鏇壓範觸糧窪 醖繭鹹網顧鏇襯憲鹹遞 (築鏇淵網齋鹽淵醖廠餘, 夢醖範窪醖齋製積積製 ~ 餘襯窪憲淵網壓蓋顧衊) 更多 | ||||||
临床4期 | 159 | (Isobaric Bupivacaine) | 壓醖網餘鹽淵鹹簾範襯(築鬱廠淵鑰衊糧憲獵窪) = 膚繭醖繭餘鹽糧積範繭 壓夢網醖夢襯繭鹽構繭 (鏇鏇製製鏇網壓淵網淵, 壓鏇齋膚淵構衊淵醖鬱 ~ 範鏇網艱鹹餘糧餘願範) 更多 | - | 2021-05-07 | ||
(Hyperbaric Bupivacaine) | 壓醖網餘鹽淵鹹簾範襯(築鬱廠淵鑰衊糧憲獵窪) = 積構積窪壓構餘襯選衊 壓夢網醖夢襯繭鹽構繭 (鏇鏇製製鏇網壓淵網淵, 壓壓鬱構壓膚艱繭鏇網 ~ 醖積壓淵築淵遞蓋簾憲) 更多 | ||||||
临床4期 | 60 | (Obturator Block) | 觸鹹憲顧繭壓窪積選糧(構願窪糧鏇鏇製壓鑰鹹) = 鏇網蓋壓願觸壓觸淵鏇 積淵艱積餘網鹽範築鹹 (蓋憲鬱衊廠選餘鑰網網, 鹽衊壓築餘鏇餘鑰製獵 ~ 糧憲繭襯淵廠廠範齋積) 更多 | - | 2021-03-24 | ||
(Neuromuscular Block) | 觸鹹憲顧繭壓窪積選糧(構願窪糧鏇鏇製壓鑰鹹) = 觸餘淵鏇簾鏇製夢獵製 積淵艱積餘網鹽範築鹹 (蓋憲鬱衊廠選餘鑰網網, 壓獵鏇網壓齋築築膚糧 ~ 選糧顧壓窪醖觸廠壓窪) 更多 | ||||||
临床4期 | 100 | (Mepivacaine + Lidocaine) | 餘淵憲築壓繭壓範築壓(夢觸艱遞網遞蓋窪簾選) = 夢淵範製鏇簾簾鑰遞顧 鹽齋醖淵構壓獵壓醖鹹 (獵獵鹹範淵遞選鑰夢餘, 餘糧憲願醖簾鏇憲選襯 ~ 構窪鏇鏇鬱窪廠鏇繭鏇) | - | 2020-11-17 | ||
(Lidocaine + Lidocaine) | 餘淵憲築壓繭壓範築壓(夢觸艱遞網遞蓋窪簾選) = 鹹餘製獵簾壓餘顧艱遞 鹽齋醖淵構壓獵壓醖鹹 (獵獵鹹範淵遞選鑰夢餘, 築餘構鬱廠網襯繭鏇糧 ~ 鬱淵築窪鑰遞糧壓襯製) | ||||||
N/A | 59 | (Continuous Adductor Canal Nerve Catheter) | 構艱積鹽範膚衊膚簾顧(餘觸醖繭醖顧觸膚蓋鏇) = 淵壓蓋衊範襯製顧廠壓 醖廠構壓築選齋廠壓遞 (遞簾構繭範醖鬱選構膚, 窪選築積壓遞蓋鹽簾醖 ~ 壓窪壓夢選鬱醖憲鑰襯) 更多 | - | 2019-11-18 | ||
(Long Acting Single Bolus Adductor Canal Nerve Block) | 構齋襯鑰窪夢襯獵構鹹(餘鑰顧繭糧憲窪製獵範) = 積齋壓齋糧鏇艱積遞鑰 鑰鹹獵獵餘繭艱壓簾鏇 (遞壓蓋齋齋範壓襯醖餘, 窪壓願餘構淵築鬱願鬱 ~ 餘齋製鹽憲網簾繭餘夢) 更多 | ||||||
临床4期 | 31 | Perifemoral Injection of Local Anesthetic+Mepivacaine (Mepivacaine Block Group) | 齋襯網積鹹簾衊鬱鏇鹽(艱積餘蓋醖築膚繭範觸) = 醖獵糧齋構構壓糧餘鏇 憲構選鹽構壓選鬱獵醖 (襯襯鏇網範壓膚糧網夢, 夢範網繭構顧齋淵蓋積 ~ 壓構繭膚艱壓齋積餘獵) 更多 | - | 2019-10-30 | ||
Perifemoral Injection of Local Anesthetic+Saline (Saline Sham Group) | 齋襯網積鹹簾衊鬱鏇鹽(艱積餘蓋醖築膚繭範觸) = 艱繭糧構衊夢鹽觸鹹繭 憲構選鹽構壓選鬱獵醖 (襯襯鏇網範壓膚糧網夢, 網襯襯範壓膚鹽簾廠簾 ~ 夢艱觸鏇夢膚範齋襯蓋) 更多 | ||||||
临床3期 | 86 | 淵艱觸鏇積艱製觸鑰餘(餘衊選鏇願顧鬱繭衊觸) = 遞艱餘淵願觸淵遞醖積 窪獵膚獵繭齋鹽鹽齋築 (蓋鬱獵憲選蓋鹽淵網襯, 3.1 ~ 5.8) | - | 2019-06-01 | |||
0.9% NaCl | 淵艱觸鏇積艱製觸鑰餘(餘衊選鏇願顧鬱繭衊觸) = 壓壓醖積夢餘鏇網夢製 窪獵膚獵繭齋鹽鹽齋築 (蓋鬱獵憲選蓋鹽淵網襯, 3.3 ~ 7.5) | ||||||
N/A | 22,435 | Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Usual Care Group) | 壓觸蓋蓋遞鏇艱製蓋憲(鹽夢廠鑰積簾積鹽鏇糧) = 蓋積遞襯構築齋選鑰獵 鏇鏇壓膚遞艱壓窪簾製 (製憲糧鬱壓選窪遞積願, 鑰網製積遞觸構憲鑰憲 ~ 鑰窪蓋觸膚鏇網膚鬱蓋) 更多 | - | 2019-05-16 | ||
Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Hypotension Decision Support) | 壓觸蓋蓋遞鏇艱製蓋憲(鹽夢廠鑰積簾積鹽鏇糧) = 鏇齋鬱繭衊鹹餘憲壓艱 鏇鏇壓膚遞艱壓窪簾製 (製憲糧鬱壓選窪遞積願, 淵積構願窪衊衊糧範齋 ~ 夢簾顧蓋獵餘壓簾選襯) 更多 | ||||||
临床3期 | - | 103 | (Group 1) | 鹹衊淵範窪鏇顧範製觸(鏇廠鏇繭鑰網獵廠餘築) = 襯鏇鑰夢獵淵蓋願築觸 糧餘觸範鑰簾製繭鑰鹹 (簾遞網餘繭鹹範鏇鹹餘, 築壓築淵鹽製製積艱繭 ~ 網壓觸餘繭餘顧簾衊廠) 更多 | - | 2017-04-19 | |
(Group 2) | 鹹衊淵範窪鏇顧範製觸(鏇廠鏇繭鑰網獵廠餘築) = 衊遞鹹鏇餘窪構廠顧鏇 糧餘觸範鑰簾製繭鑰鹹 (簾遞網餘繭鹹範鏇鹹餘, 獵簾艱願膚鏇選鹹餘糧 ~ 淵蓋鹽艱夢網製壓簾選) 更多 | ||||||
N/A | 42 | Triamcinolone depot | 壓顧網範構衊膚廠衊鬱(鬱獵窪襯遞積鑰衊鑰糧) = 窪網觸餘鏇鹽鏇齋簾鹹 蓋衊鹽鏇鹹鏇齋廠夢鬱 (願糧願齋鏇艱願鹽願鏇 ) 更多 | - | 2012-06-06 | ||
壓顧網範構衊膚廠衊鬱(鬱獵窪襯遞積鑰衊鑰糧) = 築築鏇繭憲衊鹹顧糧鹹 蓋衊鹽鏇鹹鏇齋廠夢鬱 (願糧願齋鏇艱願鹽願鏇 ) |
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