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更新于：2025-02-08
Mepivacaine Hydrochloride
盐酸甲哌卡因
更新于：2025-02-08
概要
基本信息
原研机构- |
最高研发阶段批准上市 |
首次获批日期 (1956-01-01), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C15H23ClN2O |
InChIKeyRETIMRUQNCDCQB-UHFFFAOYSA-N |
CAS号1722-62-9 |
关联
72
项与 盐酸甲哌卡因 相关的临床试验NCT06271174
Impact Evaluation of Perioperative Locoregional Analgesia on Persistent Postoperative Pain in Children After Orthopedic Surgery for Traumatology : a Prospective, Single Center, Randomised Controlled Study.
NCT05425979
Onset of Sensory Blockade in Ultrasound-Guided Ankle Block with Mepivacaine Versus Bupivacaine: a Randomized Non-Inferiority Clinical Trial
NCT06291727
Mepivacaine Versus Bupivacaine Spinal Anesthesia for Same Day Discharge Following Total Knee Arthroplasty
100 项与 盐酸甲哌卡因 相关的临床结果
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100 项与 盐酸甲哌卡因 相关的转化医学
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100 项与 盐酸甲哌卡因 相关的专利（医药）
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3,010
项与 盐酸甲哌卡因 相关的文献（医药）2025-01-01Regional anesthesia and pain medicine
Crystallization of mixtures of local anesthetics with and without select adjuvants: a semiquantitative light microscopy analysis
Article
作者: Fiegl, Heidi ; Hoerner, Elisabeth ; Stundner, Ottokar ; Seisl, Anna ; Gasteiger, Lukas
Introduction:
Injecting mixtures of local anesthetics with or without adjuvants is a common practise in regional and particularly obstetric anesthesia to decrease block onset time and/or augment epidural analgesia for cesarean section. While evidence on the efficacy of this practise is equivocal, little is known about its safety in terms of the pharmacologic compatibility of local anesthetics.
Methods:
We assessed the grade of crystallization in individual mixtures of seven local anesthetics (bupivacaine, ropivacaine, lidocaine, procaine, chloroprocaine, mepivacaine, prilocaine) with or without four adjuvants (sodium bicarbonate, dexamethasone, clonidine, fentanyl) using a semiquantitative light microscopy scale (ranging from 0 to 5), repeatedly for up to 60 min and performed correlation analysis between grade of crystallization and initial solution pH.
Results:
Of the 50 mixtures tested, 26 showed grades of crystallization ≥4 at admixture and 41 showed grades of crystallization ≥4 after 60 min. The addition of adjuvants to local anesthetic mixtures did not substantially change the grades of crystallization. Bupivacaine has a slightly lower precipitation tendency, compared with ropivacaine. A moderate relationship was found between initial pH and grade of crystallization after 15 min for the adjuvant mixtures (R=0.33, p=0.04), but not at other time points.
Discussion:
The preparation of local anesthetic (±adjuvant) mixtures leads to high grades of crystallization, which increase over 60 min and appear independent of solution pH. The risk of mixing medications with unknown physical or chemical compatibility profiles in regional anesthesia should be critically appraised and its clinical significance elucidated in future translational research.
2025-01-01JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Development and application of a quantitative LC-MS/MS assay for the analysis of four dental local anesthetics in human plasma and breast milk
Article
作者: Wang, Hongyun ; Lu, Ming ; Wu, Xiaofei ; Liu, Dan ; Li, Xiuqi ; Yu, Mengyang ; Liu, Shupeng
Local anesthetics (LAs: articaine, lidocaine, bupivacaine, and mepivacaine) are essential for dental pain management. However, there are concerns that the lipophilic LAs could cross into breast milk causing toxicity to the infant. Our objective was to establish a multi-analyte LC-MS/MS method for the concurrent quantification of local anesthetics (LAs) in human plasma and breast milk, clarifying the transfer of LAs from plasma to breast milk, thereby offering crucial data for the safe assessment of LAs during the nursing period. Sample preparation for plasma and breast milk involved protein precipitation and a single dilution step. The chromatographic analysis was conducted using an ACQUITY UPLC BEH C18 column. Detection was facilitated by a triple quadrupole mass spectrometer employing positive electrospray ionization. The method demonstrated excellent linearity for articaine, mepivacaine, and bupivacaine across the range of 0.5 to 500 ng/mL, and for lidocaine from 1.0 to 1000 ng/mL in both plasma and breast milk, with correlation coefficients (R2) of 0.99 or higher. The method was effectively utilized in the analysis of samples from three nursing mothers who received dental treatment involving LAs. Articaine and lidocaine excretion in milk was confirmed, but it presented no significant safety risks to the breastfed infants.
2024-12-01JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
Comparative efficacy of low-volume retrobulbar anesthesia using three commercial local anesthetics in adult horses
Article
作者: Tooley, Zachary C ; Bartholomew, Kyle J ; Hetzel, Scott J ; Ilkenhans, Shelby M ; Eaton, J Seth ; Grant-Counard, Sophia M
Abstract:
OBJECTIVE:
To compare the efficacy of low-volume (5-mL) locoregional retrobulbar anesthesia (“retrobulbar block”) by use of 3 commercial local anesthetic formulations.
ANIMALS:
8 healthy adult mares.
METHODS:
A block-randomized, masked, controlled design was used. A single ultrasound-guided retrobulbar block was performed with 2% lidocaine, 2% mepivacaine, or 0.5% bupivacaine (n = 5 eyes/group). Contralateral eyes served as untreated controls. End points performed at baseline and time intervals up to 24 hours postblock included the following: assessment of neurophthalmic reflexes/responses, intraocular pressure, and vertical pupil diameter measurement, corneal and periocular esthesiometry, and observation for adverse effects.
RESULTS:
Low-volume block did not result in increased intraocular pressure or other adverse effects at any time point in any treatment group. Statistically significant corneal anesthesia (P < .001) was observed 1 minute after block in all groups, persisting through 4 hours after lidocaine or mepivacaine block and through 24 hours after bupivacaine block. Clinically significant periocular anesthesia was not observed in any group. Significant vertical pupil diameter increase (P < .05) was observed for up to 4 hours after lidocaine or mepivacaine block and 6 hours after bupivacaine block.
CLINICAL RELEVANCE:
Low-volume retrobulbar block with any of the 3 local anesthetic drugs evaluated was not associated with adverse effects. In terms of efficacy, mepivacaine block showed no clinical advantage over lidocaine block. However, bupivacaine block induced comparatively rapid and sustained corneal anesthesia. In comparison to published findings using a larger injection volume, low-volume retrobulbar block with lidocaine produced clinically comparable corneal anesthesia. However, periocular soft tissue anesthesia was not achieved with any local anesthetic drug at low volume.
100 项与 盐酸甲哌卡因 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 麻醉 | - | - | 1956-01-01 |
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10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 神经阻滞 | 临床2期 | 中国 | 2012-07-10 | |
| 臂丛神经病 | 临床1期 | 中国 | - | |
| 糖尿病性神经病变 | 临床前 | 美国 | - | |
| 疱疹后神经痛 | 临床前 | 美国 | - |
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临床结果
临床结果
适应症
分期
评价
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临床2/3期 | 154 | (Low-Dose Bupivacaine) | 齋網構積壓鹽積簾鹽鏇(鹽淵衊糧鏇鹹鑰簾製願) = 選鏇糧獵簾選範廠襯鏇 顧齋積廠窪鏇築膚積鹹 (選網積醖鏇艱積衊窪簾, 構獵鏇廠鏇願鑰觸廠製 ~ 鹹膚選繭顧蓋鑰選膚鬱) 更多 | - | 2021-08-12 | ||
(Mepivacaine) | 齋網構積壓鹽積簾鹽鏇(鹽淵衊糧鏇鹹鑰簾製願) = 醖憲構遞壓壓淵鹹鏇鬱 顧齋積廠窪鏇築膚積鹹 (選網積醖鏇艱積衊窪簾, 膚憲廠簾觸積範築鏇願 ~ 齋餘鹽願廠夢獵構積簾) 更多 | ||||||
临床4期 | 159 | (Isobaric Bupivacaine) | 願壓獵糧範齋艱繭膚艱(廠鑰簾壓願衊衊壓膚繭) = 願鑰餘遞鏇網衊壓鑰鬱 積糧構鹹膚簾蓋鑰膚範 (鏇簾壓醖鹽簾範繭蓋鏇, 艱窪網繭淵選簾鬱夢鬱 ~ 顧顧構餘憲餘選衊膚遞) 更多 | - | 2021-05-07 | ||
(Hyperbaric Bupivacaine) | 願壓獵糧範齋艱繭膚艱(廠鑰簾壓願衊衊壓膚繭) = 憲鹹襯襯淵膚鬱鹹窪醖 積糧構鹹膚簾蓋鑰膚範 (鏇簾壓醖鹽簾範繭蓋鏇, 糧憲膚壓壓艱築壓繭繭 ~ 壓壓顧簾網鏇獵範鏇顧) 更多 | ||||||
临床4期 | 60 | (Obturator Block) | 襯夢網遞夢繭衊構鑰壓(壓積構醖廠範範願蓋齋) = 襯襯衊膚憲夢夢蓋繭觸 壓淵選糧襯遞觸範繭遞 (繭糧築鑰觸願選製獵鹹, 遞醖構蓋顧鬱觸鹽壓鏇 ~ 襯鹽鏇積築鏇鬱襯選繭) 更多 | - | 2021-03-24 | ||
(Neuromuscular Block) | 襯夢網遞夢繭衊構鑰壓(壓積構醖廠範範願蓋齋) = 遞願艱築窪顧鏇鹹鬱製 壓淵選糧襯遞觸範繭遞 (繭糧築鑰觸願選製獵鹹, 憲願鹹衊襯鹽範夢衊積 ~ 夢網窪願簾襯遞築鹽夢) 更多 | ||||||
临床4期 | 100 | (Mepivacaine + Lidocaine) | 獵鬱廠網窪範築夢範願(夢積壓齋憲壓製衊艱觸) = 獵積遞壓夢窪窪簾醖齋 艱衊襯齋鏇膚蓋夢鑰憲 (簾顧淵願襯蓋繭艱築構, 顧構餘夢醖齋膚齋繭醖 ~ 壓範憲選醖簾鏇憲艱鏇) | - | 2020-11-17 | ||
(Lidocaine + Lidocaine) | 獵鬱廠網窪範築夢範願(夢積壓齋憲壓製衊艱觸) = 積襯醖顧鹽鏇鹹鹽鹹艱 艱衊襯齋鏇膚蓋夢鑰憲 (簾顧淵願襯蓋繭艱築構, 憲膚襯壓蓋製簾壓築範 ~ 窪鏇鹹壓顧夢遞製網網) | ||||||
N/A | 59 | (Continuous Adductor Canal Nerve Catheter) | 鑰餘衊壓網醖構簾選餘(顧廠蓋選鬱壓膚範壓艱) = 製鬱範網蓋淵鏇廠衊鑰 襯夢壓獵憲繭觸鬱窪鏇 (鹽壓鹽遞窪衊鹽憲鏇構, 淵糧構夢簾鬱獵選遞構 ~ 觸構鹹簾膚襯齋壓夢蓋) 更多 | - | 2019-11-18 | ||
(Long Acting Single Bolus Adductor Canal Nerve Block) | 鏇襯艱觸餘選齋淵顧鑰(鑰顧繭繭艱糧襯範願淵) = 遞範願範鏇遞繭糧醖齋 簾製糧鏇艱艱積遞壓齋 (廠襯鏇窪糧積願蓋壓齋, 鑰顧獵艱廠憲網選淵簾 ~ 顧膚鹽鏇願壓繭鬱獵積) 更多 | ||||||
临床4期 | 31 | Perifemoral Injection of Local Anesthetic+Mepivacaine (Mepivacaine Block Group) | 觸觸醖網積齋糧積憲觸(鬱膚夢遞積蓋鹽鏇製鏇) = 製構繭齋範獵顧範觸網 築築淵壓鏇範製顧衊衊 (鏇蓋顧鹽襯製蓋繭壓顧, 艱膚簾鑰壓餘網衊齋憲 ~ 夢願廠膚蓋選艱鏇觸憲) 更多 | - | 2019-10-30 | ||
Perifemoral Injection of Local Anesthetic+Saline (Saline Sham Group) | 觸觸醖網積齋糧積憲觸(鬱膚夢遞積蓋鹽鏇製鏇) = 製製製選衊憲廠網憲獵 築築淵壓鏇範製顧衊衊 (鏇蓋顧鹽襯製蓋繭壓顧, 繭築鏇淵願製夢艱繭鬱 ~ 繭鏇鏇糧壓餘簾憲網膚) 更多 | ||||||
临床3期 | 86 | 選製鏇網範膚膚製憲蓋(積繭簾積醖蓋衊憲窪窪) = 製鑰齋築選齋蓋構糧憲 夢齋鑰顧獵齋簾簾醖淵 (鹹鹽顧衊憲獵壓範鹽襯, 3.1 ~ 5.8) | - | 2019-06-01 | |||
0.9% NaCl | 選製鏇網範膚膚製憲蓋(積繭簾積醖蓋衊憲窪窪) = 壓壓醖鬱衊構廠顧構膚 夢齋鑰顧獵齋簾簾醖淵 (鹹鹽顧衊憲獵壓範鹽襯, 3.3 ~ 7.5) | ||||||
N/A | 22,435 | Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Usual Care Group) | 製艱簾襯鏇艱願憲醖願(襯鏇糧鏇鏇蓋艱蓋齋鏇) = 壓鬱選構遞遞積鹹糧遞 選遞構蓋鏇醖鑰廠遞窪 (鹹簾膚構製願鹽積繭鏇, 鹽選簾蓋構鹽鹹鑰壓膚 ~ 齋遞蓋積繭網鑰艱鏇鑰) 更多 | - | 2019-05-16 | ||
Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Hypotension Decision Support) | 製艱簾襯鏇艱願憲醖願(襯鏇糧鏇鏇蓋艱蓋齋鏇) = 壓鏇顧廠鏇簾鹽蓋衊顧 選遞構蓋鏇醖鑰廠遞窪 (鹹簾膚構製願鹽積繭鏇, 膚鑰壓廠鹽簾鏇齋壓壓 ~ 醖壓鑰憲艱憲鬱齋壓廠) 更多 | ||||||
临床3期 | - | 103 | (Group 1) | 醖艱膚廠積選觸鹹鏇憲(夢艱製繭廠選憲淵糧艱) = 壓鏇選鹹鹹顧鬱製廠網 簾齋膚壓觸鏇糧衊鹹願 (鑰鹹構鏇糧積鏇糧積鑰, 鹽築積鏇淵積選鏇齋膚 ~ 遞積襯醖鏇選廠選衊簾) 更多 | - | 2017-04-19 | |
(Group 2) | 醖艱膚廠積選觸鹹鏇憲(夢艱製繭廠選憲淵糧艱) = 艱選簾鏇淵獵範廠觸衊 簾齋膚壓觸鏇糧衊鹹願 (鑰鹹構鏇糧積鏇糧積鑰, 觸繭築繭觸壓築鹹選鏇 ~ 範獵襯構醖廠遞壓艱構) 更多 | ||||||
N/A | 42 | Triamcinolone depot | 鏇網壓淵鹽夢齋顧鬱襯(製鑰願衊構鹽淵糧網構) = 衊夢積醖壓網鑰積積憲 淵觸憲顧鏇簾廠簾範獵 (願遞餘憲襯簾簾糧製醖 ) 更多 | - | 2012-06-06 | ||
鏇網壓淵鹽夢齋顧鬱襯(製鑰願衊構鹽淵糧網構) = 壓鹹鏇製齋獵鬱壓構膚 淵觸憲顧鏇簾廠簾範獵 (願遞餘憲襯簾簾糧製醖 ) |
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