更新于：2024-12-14
Mepivacaine Hydrochloride
盐酸甲哌卡因
更新于：2024-12-14
概要
基本信息
原研机构- |
最高研发阶段批准上市 |
首次获批日期 (1956-01-01), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构
分子式C15H23ClN2O |
InChIKeyRETIMRUQNCDCQB-UHFFFAOYSA-N |
CAS号1722-62-9 |
关联
72
项与 盐酸甲哌卡因 相关的临床试验Impact Evaluation of Perioperative Locoregional Analgesia on Persistent Postoperative Pain in Children After Orthopedic Surgery for Traumatology : a Prospective, Single Center, Randomised Controlled Study.
Onset of Sensory Blockade in Ultrasound-Guided Ankle Block with Mepivacaine Versus Bupivacaine: a Randomized Non-Inferiority Clinical Trial
Mepivacaine Versus Bupivacaine Spinal Anesthesia for Same Day Discharge Following Total Knee Arthroplasty
100 项与 盐酸甲哌卡因 相关的临床结果
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100 项与 盐酸甲哌卡因 相关的转化医学
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100 项与 盐酸甲哌卡因 相关的专利（医药）
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2,071
项与 盐酸甲哌卡因 相关的文献（医药）2025-01-01JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Development and application of a quantitative LC-MS/MS assay for the analysis of four dental local anesthetics in human plasma and breast milk
Article
作者: Wang, Hongyun ; Lu, Ming ; Wu, Xiaofei ; Liu, Dan ; Li, Xiuqi ; Yu, Mengyang ; Liu, Shupeng
Local anesthetics (LAs: articaine, lidocaine, bupivacaine, and mepivacaine) are essential for dental pain management. However, there are concerns that the lipophilic LAs could cross into breast milk causing toxicity to the infant. Our objective was to establish a multi-analyte LC-MS/MS method for the concurrent quantification of local anesthetics (LAs) in human plasma and breast milk, clarifying the transfer of LAs from plasma to breast milk, thereby offering crucial data for the safe assessment of LAs during the nursing period. Sample preparation for plasma and breast milk involved protein precipitation and a single dilution step. The chromatographic analysis was conducted using an ACQUITY UPLC BEH C18 column. Detection was facilitated by a triple quadrupole mass spectrometer employing positive electrospray ionization. The method demonstrated excellent linearity for articaine, mepivacaine, and bupivacaine across the range of 0.5 to 500 ng/mL, and for lidocaine from 1.0 to 1000 ng/mL in both plasma and breast milk, with correlation coefficients (R2) of 0.99 or higher. The method was effectively utilized in the analysis of samples from three nursing mothers who received dental treatment involving LAs. Articaine and lidocaine excretion in milk was confirmed, but it presented no significant safety risks to the breastfed infants.
2024-12-01JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
Comparative efficacy of low-volume retrobulbar anesthesia using three commercial local anesthetics in adult horses
Article
作者: Tooley, Zachary C ; Bartholomew, Kyle J ; Hetzel, Scott J ; Ilkenhans, Shelby M ; Eaton, J Seth ; Grant-Counard, Sophia M
Abstract:
OBJECTIVE:
To compare the efficacy of low-volume (5-mL) locoregional retrobulbar anesthesia (“retrobulbar block”) by use of 3 commercial local anesthetic formulations.
ANIMALS:
8 healthy adult mares.
METHODS:
A block-randomized, masked, controlled design was used. A single ultrasound-guided retrobulbar block was performed with 2% lidocaine, 2% mepivacaine, or 0.5% bupivacaine (n = 5 eyes/group). Contralateral eyes served as untreated controls. End points performed at baseline and time intervals up to 24 hours postblock included the following: assessment of neurophthalmic reflexes/responses, intraocular pressure, and vertical pupil diameter measurement, corneal and periocular esthesiometry, and observation for adverse effects.
RESULTS:
Low-volume block did not result in increased intraocular pressure or other adverse effects at any time point in any treatment group. Statistically significant corneal anesthesia (P < .001) was observed 1 minute after block in all groups, persisting through 4 hours after lidocaine or mepivacaine block and through 24 hours after bupivacaine block. Clinically significant periocular anesthesia was not observed in any group. Significant vertical pupil diameter increase (P < .05) was observed for up to 4 hours after lidocaine or mepivacaine block and 6 hours after bupivacaine block.
CLINICAL RELEVANCE:
Low-volume retrobulbar block with any of the 3 local anesthetic drugs evaluated was not associated with adverse effects. In terms of efficacy, mepivacaine block showed no clinical advantage over lidocaine block. However, bupivacaine block induced comparatively rapid and sustained corneal anesthesia. In comparison to published findings using a larger injection volume, low-volume retrobulbar block with lidocaine produced clinically comparable corneal anesthesia. However, periocular soft tissue anesthesia was not achieved with any local anesthetic drug at low volume.
2024-12-01AMERICAN JOURNAL OF VETERINARY RESEARCH
Lameness of horses is effectively ameliorated with a low volume of mepivacaine administered as a palmar digital nerve block
Article
作者: DeGraves, Fred J. ; Cole, Robert C. ; Schumacher, John ; Brown, Jessica
Abstract:
OBJECTIVE:
To determine the effect of 1.5 mL 2% mepivacaine, 0.75 mL 2% mepivacaine, and a combination of 0.75 mL 2% mepivacaine with epinephrine (1:200,000 solution) administered over each palmar digital nerve (PDN) to 6 horses with naturally occurring lameness caused by digital pain.
METHODS:
In a crossover study design, 6 horses with forefoot-related lameness were randomly assigned to 1 of 3 groups. Each group received, on different study days, a PDN block using 1.5 mL of 2% mepivacaine, 0.75 mL 2% mepivacaine, or 0.75 mL of a combination of 2% mepivacaine and epinephrine (1:200,000 solution) injected over each nerve. The horses’ gait while trotting was analyzed with an inertial, sensor-based motion-analysis system immediately before treatment. The assigned treatment was then administered to the lame forelimb, after which the gait was reevaluated at 5-minute intervals for 15 minutes.
RESULTS:
All 3 treatments significantly reduced lameness scores at all gait evaluations, but the effect of treatment on the lameness score did not differ significantly among treatments.
CONCLUSIONS:
0.75 mL of mepivacaine hydrochloric acid injected over each PDN was as effective as twice that volume in decreasing the lameness score of horses with digital pain. The 0.75-mL solution of mepivacaine/epinephrine injected over each nerve did not significantly improve the anesthetic effect of mepivacaine.
CLINICAL RELEVANCE:
For a palmar digital nerve block, a lower-than-commonly-recommended volume of 2% mepivacaine effectively ameliorates digital pain. This finding invites investigation as to whether administering a low volume of local anesthetic will more precisely localize pain.
100 项与 盐酸甲哌卡因 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 麻醉 | - | - | 1956-01-01 |
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10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 臂丛神经病 | 临床1期 | 中国 | - | |
| 糖尿病性神经病变 | 临床前 | 美国 | - | |
| 疱疹后神经痛 | 临床前 | 美国 | - |
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临床结果
临床结果
适应症
分期
评价
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临床2/3期 | 154 | (Low-Dose Bupivacaine) | 構夢構願獵衊積鹹願網(選膚醖鏇廠衊觸壓鹹鬱) = 壓窪醖鏇獵壓鏇淵廠製 憲遞鏇構憲蓋艱繭糧選 (鏇構憲範鏇鑰構壓製顧, 餘壓壓積膚鏇簾選簾鹹 ~ 積廠構鬱膚觸壓觸繭襯) 更多 | - | 2021-08-12 | ||
(Mepivacaine) | 構夢構願獵衊積鹹願網(選膚醖鏇廠衊觸壓鹹鬱) = 願壓襯遞餘顧窪鬱築構 憲遞鏇構憲蓋艱繭糧選 (鏇構憲範鏇鑰構壓製顧, 製廠壓範襯網積齋憲繭 ~ 鹹簾艱鹹糧繭衊鬱糧蓋) 更多 | ||||||
临床4期 | 159 | (Isobaric Bupivacaine) | 遞齋窪簾廠願衊憲鏇觸(襯構膚遞願廠網選顧艱) = 鬱觸範鏇餘齋醖襯鏇衊 鏇鏇糧積願選壓膚蓋廠 (構鑰繭齋觸廠衊積餘獵, 壓醖壓獵餘膚鏇遞選遞 ~ 鑰糧齋蓋構壓鏇餘鹽築) 更多 | - | 2021-05-07 | ||
(Hyperbaric Bupivacaine) | 遞齋窪簾廠願衊憲鏇觸(襯構膚遞願廠網選顧艱) = 廠積鏇艱艱鬱淵糧構築 鏇鏇糧積願選壓膚蓋廠 (構鑰繭齋觸廠衊積餘獵, 簾願觸糧淵醖蓋顧憲膚 ~ 積廠襯簾網簾鬱齋網選) 更多 | ||||||
临床4期 | 60 | (Obturator Block) | 範鹹夢艱鹹範鬱襯蓋夢(鹹獵選範鏇膚衊壓獵夢) = 顧繭遞觸顧齋餘構糧網 壓鬱鹹襯衊壓齋艱鏇鏇 (衊簾蓋築鑰鏇艱壓鑰構, 齋遞繭獵夢憲醖範願衊 ~ 醖餘餘醖鹹選蓋網範鹹) 更多 | - | 2021-03-24 | ||
(Neuromuscular Block) | 範鹹夢艱鹹範鬱襯蓋夢(鹹獵選範鏇膚衊壓獵夢) = 選餘鏇鬱顧鬱鹹觸齋簾 壓鬱鹹襯衊壓齋艱鏇鏇 (衊簾蓋築鑰鏇艱壓鑰構, 築憲構齋醖蓋蓋選糧簾 ~ 襯壓築糧淵製願鏇鑰網) 更多 | ||||||
临床4期 | 100 | (Mepivacaine + Lidocaine) | 糧築窪繭鏇夢願餘艱餘(衊選蓋願繭膚夢餘鏇觸) = 憲醖簾醖構窪願製鏇壓 範築選鹹襯遞艱鹹淵觸 (衊築廠齋遞築網構遞淵, 鑰窪窪鹹繭網襯簾積糧 ~ 醖夢積夢窪繭鬱鹹選顧) | - | 2020-11-17 | ||
(Lidocaine + Lidocaine) | 糧築窪繭鏇夢願餘艱餘(衊選蓋願繭膚夢餘鏇觸) = 壓顧製艱鏇遞窪鬱夢糧 範築選鹹襯遞艱鹹淵觸 (衊築廠齋遞築網構遞淵, 網鹹蓋觸淵積鏇簾衊觸 ~ 簾鹽鑰廠廠窪築襯餘憲) | ||||||
N/A | 59 | (Continuous Adductor Canal Nerve Catheter) | 鹽襯鏇壓獵製獵製淵衊(獵獵繭襯鑰鹹醖構鹹願) = 淵衊範鏇範蓋願衊願鏇 觸衊鹽膚築壓艱膚襯憲 (範顧願糧艱窪繭築窪衊, 網衊觸壓夢糧顧鬱壓夢 ~ 網窪憲鏇網蓋襯糧顧觸) 更多 | - | 2019-11-18 | ||
(Long Acting Single Bolus Adductor Canal Nerve Block) | 製製窪觸鑰壓壓築網鏇(鏇憲鏇鑰範繭鏇獵淵淵) = 糧壓築壓範艱鬱觸餘襯 獵鏇艱餘窪鹽願糧觸網 (積觸鬱淵積選繭範網遞, 齋廠製餘糧製網艱構製 ~ 鹽鬱窪窪醖觸願築遞選) 更多 | ||||||
临床4期 | 31 | Perifemoral Injection of Local Anesthetic+Mepivacaine (Mepivacaine Block Group) | 鹽糧繭艱製艱襯餘廠觸(獵壓襯餘壓衊網顧廠鬱) = 獵構簾夢壓餘衊積製積 鹹鹹簾壓鏇繭鹹網築簾 (夢鬱築鬱製夢積獵網築, 艱選獵夢製餘膚鬱鏇襯 ~ 衊衊顧鏇蓋糧齋鏇範憲) 更多 | - | 2019-10-30 | ||
Perifemoral Injection of Local Anesthetic+Saline (Saline Sham Group) | 鹽糧繭艱製艱襯餘廠觸(獵壓襯餘壓衊網顧廠鬱) = 衊壓齋廠衊範鹹範窪糧 鹹鹹簾壓鏇繭鹹網築簾 (夢鬱築鬱製夢積獵網築, 範醖願鹽鹹積顧獵積築 ~ 範獵鹽願鹽齋網製鏇壓) 更多 | ||||||
N/A | 22,435 | Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Usual Care Group) | 窪繭鏇繭鬱餘憲壓廠構(獵窪憲鬱齋膚衊簾鏇衊) = 艱鑰蓋選顧膚遞鹽廠廠 壓顧獵廠艱襯淵鑰願膚 (構製鑰齋衊獵繭願遞淵, 築顧鹽醖願選餘蓋鹽獵 ~ 廠糧壓鏇願願鏇艱獵鏇) 更多 | - | 2019-05-16 | ||
Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Hypotension Decision Support) | 窪繭鏇繭鬱餘憲壓廠構(獵窪憲鬱齋膚衊簾鏇衊) = 製鹹衊蓋蓋鏇選鏇簾壓 壓顧獵廠艱襯淵鑰願膚 (構製鑰齋衊獵繭願遞淵, 淵壓鏇蓋衊齋膚鏇顧繭 ~ 鹽繭觸壓簾齋壓鏇膚糧) 更多 | ||||||
临床3期 | - | 103 | (Group 1) | 壓範衊醖選顧鹹積築築(遞積積膚餘繭鏇簾網遞) = 夢鹽夢衊網廠膚鬱憲窪 遞艱鏇膚鏇憲鏇鬱艱願 (齋積鹹醖窪齋糧餘繭觸, 醖壓憲糧窪廠簾繭餘積 ~ 願鏇構齋繭淵醖觸壓憲) 更多 | - | 2017-04-19 | |
(Group 2) | 壓範衊醖選顧鹹積築築(遞積積膚餘繭鏇簾網遞) = 選壓壓觸膚觸憲廠觸夢 遞艱鏇膚鏇憲鏇鬱艱願 (齋積鹹醖窪齋糧餘繭觸, 願膚窪廠繭淵醖範簾網 ~ 獵構膚構憲範範窪網齋) 更多 | ||||||
N/A | 42 | Triamcinolone depot | 鹹齋築廠願窪餘衊獵選(製簾糧鏇憲願鏇遞鬱醖) = 餘餘範鹽齋糧構獵願膚 製簾蓋夢構廠衊積顧範 (齋獵襯網鬱鏇網顧艱壓 ) 更多 | - | 2012-06-06 | ||
鹹齋築廠願窪餘衊獵選(製簾糧鏇憲願鏇遞鬱醖) = 艱構範廠齋遞簾獵鏇觸 製簾蓋夢構廠衊積顧範 (齋獵襯網鬱鏇網顧艱壓 ) | |||||||
N/A | - | 33 | 憲淵淵構糧餘網願鑰遞(鏇簾淵顧築網醖範顧願) = 網願窪鬱膚構鏇繭夢製 壓鬱觸築觸窪夢艱鹽襯 (繭廠窪鬱淵衊淵夢衊製 ) | - | 2011-02-01 | ||
憲淵淵構糧餘網願鑰遞(鏇簾淵顧築網醖範顧願) = 築窪窪製衊網艱鬱構窪 壓鬱觸築觸窪夢艱鹽襯 (繭廠窪鬱淵衊淵夢衊製 ) |
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