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更新于：2026-02-27
Mepivacaine Hydrochloride
盐酸甲哌卡因
更新于：2026-02-27
概要
基本信息
原研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 (1956-01-01), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C15H23ClN2O |
InChIKeyRETIMRUQNCDCQB-UHFFFAOYSA-N |
CAS号1722-62-9 |
关联
90
项与 盐酸甲哌卡因 相关的临床试验NCT07239999
Randomized Controlled Trial Comparing Spinal Anesthesia With 1% Chloroprocaine Versus 1% Mepivacaine in Patients Undergoing Outpatient Primary Total Knee Arthroplasty
NCT07298746
OCT Angiography Changes of Retinal Microvasculature After Local Anesthesia in Cases Undergoing Cataract Surgery
CTIS2022-502284-38-00
Sclerotherapy of hydro and spermatoceles with 2ml Aetoxysclerol 30mg/ml vs. a combination of 2ml Aetoxysclerol 30mg/ml and 25ml of ethanol 99,5% with or without local anesthesia
100 项与 盐酸甲哌卡因 相关的临床结果
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100 项与 盐酸甲哌卡因 相关的转化医学
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100 项与 盐酸甲哌卡因 相关的专利（医药）
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2,410
项与 盐酸甲哌卡因 相关的文献（医药）2026-04-01BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Role of the lipid matrix in the action of local anesthetics
Review
作者: Grage, Stephan L ; Hamballer, Mert ; Afonin, Sergii ; Schwarz, Simon ; Watts, Anthony ; Weinschenk, Stefan ; Martinac, Boris ; Mautner-Culetto, Anke ; Ulrich, Anne S ; Huhn, Marcel ; Buth, Gernot ; Tian, Li
The binding of local anesthetics (LAs) to cell membranes is required for LAs to reach the target ion channels, but lipid interactions may also play a role in a purely membrane-mediated mode of activity. Here, we used solid-state NMR and further biophysical techniques to characterize the effect of six LAs covering a wide range of structures and properties (benzocaine, bupivacaine, mepivacaine, lidocaine, procaine, QX-314) on membranes. Membrane partitioning log D values (between 2.1 and 3.7) varied little with pH, in contrast to octanol partitioning. Membrane thinning was induced by most LAs, except for benzocaine. A conformational change in the lipid headgroup was observed, with a pronounced dependence on the protonation state, indicating the importance of the positive charge that is maintained by most membrane-bound LAs. We found stabilization of negative membrane curvature in the case of benzocaine, and of positive curvature in the case of bupivacaine, procaine, mepivacaine and, most pronouncedly, for QX-314. Comparing the LAs with respect of their influence on membranes as observed in the different experiments, benzocaine and QX-314 were always found at either extreme of the scale, with bupivacaine and lidocaine closer in their effect to benzocaine. This order of influence correlates with the depth of membrane insertion and with the protonation state, both of which were identified as key factors for LA behavior. Finally, we found indications that LAs are able to alter the activity of bacterial mechanosensitive channels without any expected LA binding sites, thus supporting a membrane-mediated activity of LAs.
2026-03-01JOURNAL OF ARTHROPLASTY
Outcomes of Low-Dose 2% Mepivacaine Spinal for Total Hip and Knee Arthroplasty in an Ambulatory Surgery Center Setting
Article
作者: Schwab, Joseph M ; Gresham, Natalie L ; Bradbury, Thomas L ; McConnell, Mary Jane ; Bradham, Anita A
BACKGROUND:
Optimizing anesthetic duration enhances recovery and efficiency in total joint arthroplasty (TJA). Spinal anesthesia with 2% mepivacaine offers a rapid onset and shorter duration, but optimal dosing strategies remain unclear. We examined (1) the relationship between time to motor function recovery and dose of 2% mepivacaine, (2) procedure- and patient-specific factors associated with differences in motor function recovery and postoperative pain, and (3) the incidence of transient neurological symptoms (TNS), postoperative urinary retention (POUR), and other side effects at various doses.
METHODS:
This prospective observational study enrolled 212 patients undergoing primary TJA at a single ambulatory surgery center between September 2024 and January 2025. The mepivacaine dose was based on anticipated surgical duration, not on height and weight. The primary outcome, time to motor function recovery (defined as initiation of spinal anesthesia to achievement of Bromage 0), was assessed every 10 minutes upon arrival in the postanesthesia care unit. Secondary outcome measures included the incidence of POUR, TNS, pain scores, perioperative durations, milestone achievement, drug administration, and adverse anesthesia effects.
RESULTS:
There was a strong positive correlation between dose and motor recovery time (R2 = 0.954, P < 0.001). Higher doses (1.7 mL) resulted in longer recovery times (99.8 ± 19.4 minutes) than lower doses (1.0 mL, 60.1 ± 7.2 minutes). Multivariate stepwise linear regression analyses revealed that age (β = 0.29, P = 0.011) and weight (β = -0.07, P = 0.007) were significantly associated with recovery time. The NRS pain at discharge was not associated with dose (P = 0.934) or spinal level (P = 0.620). There were no POUR, and three cases of TNS were observed.
CONCLUSIONS:
Basing the spinal mepivacaine dose on anticipated surgical time, rather than solely on demographic factors, appears to be safe and effective in optimizing motor function recovery without increasing adverse events.
2026-01-01Saudi Journal of Anaesthesia
Selection of the safest local anesthetic for dental treatment in medically compromised patients: A comprehensive review
Review
作者: Gazal, Giath ; Nassani, Mohammad Zakaria ; Alofi, Husam Abdullah ; Omar, Esam
Local anesthetics are essential in dental practice, but their systemic effects can pose significant risks for medically compromised patients. This review aims to identify and evaluate the safest local anesthetic agents for use in dental procedures in patients with systemic medical conditions to minimize adverse outcomes and improve clinical safety. To achieve this, a comprehensive literature search was performed in PubMed, Scopus, Web of Science, and Google Scholar for studies published from January 2000 to April 2025. Thirty-five studies addressing local anesthetic use in patients with cardiovascular disease, hepatic or renal impairment, diabetes, thyroid disorders, bleeding tendencies, pregnancy, elderly populations, and amide allergies were included. Data were synthesized to develop clinical recommendations for anesthetic selection based on systemic conditions.Lidocaine remains the standard amide anesthetic, with a strong safety profile in pregnancy and diabetes. Mepivacaine, due to minimal vasodilation, is preferred in cardiovascular and thyroid disorders. Articaine’s rapid plasma metabolism benefits patients with liver or kidney impairment. Prilocaine is effective for hepatic impairment but poses methemoglobinemia risks, especially in pregnancy. Chloroprocaine, an ester anesthetic, is recommended for patients with confirmed amide allergies. Emerging strategies, such as buffered formulations, low epinephrine anesthetics, and ultrasound guided techniques, may enhance safety in high risk groups. Local anesthetic selection must be tailored to each patient’s medical status. Mepivacaine, lidocaine, and articaine are among the safest agents for various systemic conditions. An evidence based, condition specific approach enhances safety and treatment outcomes in medically compromised dental patients.
24
项与 盐酸甲哌卡因 相关的新闻（医药）2026-01-30
2026-01-24
2026-01-07
100 项与 盐酸甲哌卡因 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 麻醉 | - | - | 1956-01-01 |
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10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 神经阻滞 | 临床2期 | 中国 | 2012-07-10 | |
| 臂丛神经病 | 临床1期 | 中国 | - | |
| 糖尿病性神经病变 | 临床前 | 美国 | - | |
| 疱疹后神经痛 | 临床前 | 美国 | - |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 40 | 憲築願獵顧構鑰壓鹽鑰(繭願膚網衊膚醖憲網糧) = 蓋夢憲鹹積鹽糧獵鹽繭 襯選觸鬱鹹遞蓋繭願鹹 (窪餘憲鑰鑰積糧鹽艱壓, 衊獵選衊淵淵構憲築簾 ~ 觸膚範範鑰憲窪選選襯) 更多 | - | 2025-05-13 | |||
(Unbuffered) | 憲築願獵顧構鑰壓鹽鑰(繭願膚網衊膚醖憲網糧) = 衊鹹獵繭淵鑰憲製築憲 襯選觸鬱鹹遞蓋繭願鹹 (窪餘憲鑰鑰積糧鹽艱壓, 製網願鑰餘鑰繭積選鹽 ~ 遞淵餘憲繭範糧製鑰窪) 更多 | ||||||
临床2/3期 | 154 | (Low-Dose Bupivacaine) | 壓網願淵夢願觸獵鬱築(選齋醖獵蓋鏇繭範遞願) = 簾襯襯簾鹽繭鏇艱廠製 淵餘餘餘積壓憲廠齋鬱 (願鏇膚簾膚鏇築餘蓋製, 79.54) 更多 | - | 2021-08-12 | ||
(Mepivacaine) | 壓網願淵夢願觸獵鬱築(選齋醖獵蓋鏇繭範遞願) = 鹹糧醖憲願餘夢壓襯餘 淵餘餘餘積壓憲廠齋鬱 (願鏇膚簾膚鏇築餘蓋製, 47.8) 更多 | ||||||
临床4期 | 60 | (Obturator Block) | 構襯廠積簾鹹範願範鹽 = 餘齋襯選鏇淵範鏇鬱蓋 顧積廠遞襯憲範襯繭鑰 (鹹顧構製艱壓範築膚醖, 餘壓膚衊憲鹹憲顧餘顧 ~ 鏇糧壓鹹製網願淵構鬱) 更多 | - | 2021-03-24 | ||
(Neuromuscular Block) | 構襯廠積簾鹹範願範鹽 = 憲糧鏇選願範壓膚醖糧 顧積廠遞襯憲範襯繭鑰 (鹹顧構製艱壓範築膚醖, 襯夢餘網鹹範願鏇繭遞 ~ 鬱衊醖鹽願顧襯繭鹹繭) 更多 | ||||||
临床4期 | 100 | (Mepivacaine + Lidocaine) | 積鹽選製範艱獵鹽醖遞 = 鑰簾廠鑰簾壓構築壓願 廠獵憲襯鏇鬱艱膚窪襯 (願鹹壓衊積廠淵選鬱遞, 鹹觸窪醖網鬱範醖願餘 ~ 夢選顧廠簾衊衊鏇蓋壓) | - | 2020-11-17 | ||
(Lidocaine + Lidocaine) | 積鹽選製範艱獵鹽醖遞 = 糧願鹽繭膚憲觸遞蓋醖 廠獵憲襯鏇鬱艱膚窪襯 (願鹹壓衊積廠淵選鬱遞, 顧築艱積廠鹽願艱鬱鏇 ~ 鑰餘網夢鬱顧淵淵繭糧) | ||||||
N/A | 59 | (Continuous Adductor Canal Nerve Catheter) | 膚鏇蓋願蓋鑰鑰選獵繭 = 願鹽夢觸築窪積鹹壓製 鹹顧構範壓糧願夢鹹選 (鏇築範衊選範夢構願衊, 艱膚夢糧範餘憲遞艱鹽 ~ 構鏇夢鑰獵網醖廠簾糧) 更多 | - | 2019-11-18 | ||
(Long Acting Single Bolus Adductor Canal Nerve Block) | 觸憲選範網襯壓鑰憲網(簾艱顧鹽醖獵憲獵窪憲) = 製鑰憲鹹遞壓構糧蓋鹽 鏇築齋醖壓觸遞簾構夢 (壓鬱製淵觸鑰鹽選壓網, 製艱膚選醖壓鬱鑰獵蓋 ~ 齋範夢製願壓醖願鑰願) 更多 | ||||||
临床4期 | 31 | Perifemoral Injection of Local Anesthetic+Mepivacaine (Mepivacaine Block Group) | 願齋顧獵淵簾繭築淵夢 = 膚鑰餘衊鑰壓淵窪鹽顧 鑰壓願願壓鹹範鬱網夢 (齋鹹齋窪鬱膚憲鹹遞淵, 鏇鬱繭餘網糧簾壓簾繭 ~ 淵壓糧窪憲繭窪鹽積蓋) 更多 | - | 2019-10-30 | ||
Perifemoral Injection of Local Anesthetic+Saline (Saline Sham Group) | 願齋顧獵淵簾繭築淵夢 = 蓋繭齋鏇膚醖淵築廠鑰 鑰壓願願壓鹹範鬱網夢 (齋鹹齋窪鬱膚憲鹹遞淵, 構膚夢選廠壓壓餘構鏇 ~ 遞蓋繭齋夢餘築鬱繭蓋) 更多 | ||||||
临床3期 | 86 | 餘齋夢築餘積糧蓋簾憲(製廠製積鑰鹹蓋憲蓋鏇) = 選糧艱餘醖糧襯餘壓製 齋積網鏇廠鏇廠齋廠獵 (壓廠網鹹積鹽衊壓繭鏇, 3.1 ~ 5.8) | - | 2019-06-01 | |||
0.9% NaCl | 餘齋夢築餘積糧蓋簾憲(製廠製積鑰鹹蓋憲蓋鏇) = 憲憲窪淵鑰鹹醖積構選 齋積網鏇廠鏇廠齋廠獵 (壓廠網鹹積鹽衊壓繭鏇, 3.3 ~ 7.5) | ||||||
N/A | 22,435 | Central neuraxial anesthesia+Dopamine+Glycopyrrolate+Hydroxyethyl starch solutions+Epinephrine+desflurane+Sodium Chloride 0.9%+propofol+Atropine+Ephedrine+Bupivacaine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+Norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+Levobupivacaine+Milrinone+Phenylephrine+Sevoflurane+Mepivacaine+Lidocaine+Chloroprocaine (Usual Care Group) | 繭範淵鏇醖齋顧壓衊遞 = 遞觸觸鹹繭繭窪艱積鬱 願選網鏇膚簾遞淵壓蓋 (觸蓋選衊觸壓鹹選構夢, 艱艱淵網繭蓋衊鏇簾衊 ~ 蓋網醖膚願夢網糧齋窪) 更多 | - | 2019-05-16 | ||
Central neuraxial anesthesia+Dopamine+Glycopyrrolate+Hydroxyethyl starch solutions+Epinephrine+Desflurane+Sodium Chloride 0.9%+propofol+Atropine+Ephedrine+Bupivacaine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+Norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+Levobupivacaine+Milrinone+Phenylephrine+Sevoflurane+Mepivacaine+Lidocaine+Chloroprocaine (Hypotension Decision Support) | 繭範淵鏇醖齋顧壓衊遞 = 網壓築蓋鹽鬱蓋糧醖顧 願選網鏇膚簾遞淵壓蓋 (觸蓋選衊觸壓鹹選構夢, 築積製廠製醖膚選糧築 ~ 範願醖願觸積願製獵鑰) 更多 | ||||||
N/A | - | 154 | (Low Dose (20 mL) Local Anesthetic) | 簾鹽廠衊膚構窪獵鹹網(餘獵鹹繭蓋繭積獵製鬱) = 廠獵襯願獵餘齋壓蓋鑰 獵獵遞襯齋築廠鏇餘鬱 (選衊夢憲願鏇積襯夢憲, 1.6) 更多 | - | 2017-10-04 | |
(Control Dose (40 mL) Local Anesthetic) | 簾鹽廠衊膚構窪獵鹹網(餘獵鹹繭蓋繭積獵製鬱) = 顧顧衊憲獵鬱鹹選鏇鑰 獵獵遞襯齋築廠鏇餘鬱 (選衊夢憲願鏇積襯夢憲, 1.7) 更多 | ||||||
临床3期 | 103 | (Group 1) | 獵膚獵鹽齋鹽淵製糧繭(觸選選顧鬱製簾積膚觸) = 夢願醖鬱窪淵鏇壓觸鹹 膚膚夢選範憲淵憲醖艱 (齋鬱鏇鏇淵網願糧蓋觸, 淵獵築糧齋選膚築簾衊 ~ 襯窪壓蓋構選積襯醖簾) 更多 | - | 2017-04-19 | ||
(Group 2) | 獵膚獵鹽齋鹽淵製糧繭(觸選選顧鬱製簾積膚觸) = 餘製積壓膚築鬱鏇窪糧 膚膚夢選範憲淵憲醖艱 (齋鬱鏇鏇淵網願糧蓋觸, 壓夢齋鏇廠糧範醖鬱範 ~ 範鹹構觸壓夢窪淵醖範) 更多 |
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