抑制剂信息 然而上市的药物由于安全性问题被大规模撤回适应症。2021年Secura Bio 撤销了duvelisib 复发性或难治性FL的适应症,2022年6月30日,FDA再一次对duvelisib可能会增加慢性血癌(CLL/SLL)患者的死亡和严重副作用风险发出安全性警告,同年9月23日,FDA召开审议duvelisib与奥法木单抗(ofatumumab)治疗复发性/难治性CLL/
突变位点的选择性,希望能够减少毒副作用,提高安全性。 References 1.Yan He, Miao Miao Sun, Guo Geng Zhang, Jing Yang, Kui Sheng Chen, Wen Wen Xu and Bin Li, Targeting PI3K/Akt signal transduction for cancer therapy, Signal Transduction and Targeted Therapy (2021) 6:425) 2.https://www.fda.gov/media/161777/download. 3.Discovery and characterization of RLY-2608, the first allosteric, mutant, and isoform-selective inhibitor of PI3Kα. 4.https://www.loxooncology.com/docs/publications/sabcs2022_puca.pdf 5.Scorpion Therapeutics Announces First Patient Dosed in Phase 1/2 Clinical Trial of STX-478, Its Mutant-Selective PI3Kα Inhibitor for the Treatment of Breast Cancer and Other Solid Tumors – Scorpion Therapeutics (scorpiontx.com).智药研习社近期课程报名来源:CPHI制药在线声明:本文仅代表作者观点,并不代表制药在线立场。本网站内容仅出于传递更多信息之目的。如需转载,请务必注明文章来源和作者。投稿邮箱:Kelly.Xiao@imsinoexpo.com▼更多制药资讯,请关注CPHI制药在线▼点击阅读原文,进入智药研习社~